Motif ID: E2F6

Z-value: 0.711


Transcription factors associated with E2F6:

Gene SymbolEntrez IDGene Name
E2F6 ENSG00000169016.12 E2F6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2F6hg19_v2_chr2_-_11606275_116062890.193.8e-01Click!


Activity profile for motif E2F6.

activity profile for motif E2F6


Sorted Z-values histogram for motif E2F6

Sorted Z-values for motif E2F6



Network of associatons between targets according to the STRING database.



First level regulatory network of E2F6

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_-_76183111 1.915 ENST00000405273.1
ENST00000590862.1
ENST00000590430.1
ENST00000586613.1
 TK1



thymidine kinase 1, soluble



chr1_-_109825751 1.483 ENST00000369907.3
ENST00000438534.2
ENST00000369909.2
ENST00000409138.2
 PSRC1



proline/serine-rich coiled-coil 1



chr1_-_109825719 1.453 ENST00000369904.3
ENST00000369903.2
ENST00000429031.1
ENST00000418914.2
ENST00000409267.1
 PSRC1




proline/serine-rich coiled-coil 1




chr6_+_31126291 1.260 ENST00000376257.3
ENST00000376255.4
 TCF19

transcription factor 19

chr2_+_174219548 1.118 ENST00000347703.3
ENST00000392567.2
ENST00000306721.3
ENST00000410101.3
ENST00000410019.3
 CDCA7




cell division cycle associated 7




chr2_+_10262857 1.075 ENST00000304567.5
 RRM2
ribonucleotide reductase M2
chr5_+_68485433 1.065 ENST00000502689.1
 CENPH
centromere protein H
chr11_-_125366089 0.998 ENST00000366139.3
ENST00000278919.3
 FEZ1

fasciculation and elongation protein zeta 1 (zygin I)

chr1_+_150480551 0.947 ENST00000369049.4
ENST00000369047.4
 ECM1

extracellular matrix protein 1

chr1_+_150480576 0.931 ENST00000346569.6
 ECM1
extracellular matrix protein 1
chr7_-_148581360 0.911 ENST00000320356.2
ENST00000541220.1
ENST00000483967.1
ENST00000536783.1
 EZH2



enhancer of zeste homolog 2 (Drosophila)



chr7_-_148581251 0.908 ENST00000478654.1
ENST00000460911.1
ENST00000350995.2
 EZH2


enhancer of zeste homolog 2 (Drosophila)


chr19_-_51466681 0.835 ENST00000456750.2
 KLK6
kallikrein-related peptidase 6
chr12_-_120315074 0.829 ENST00000261833.7
ENST00000392521.2
 CIT

citron (rho-interacting, serine/threonine kinase 21)

chr7_+_143078652 0.796 ENST00000354434.4
ENST00000449423.2
 ZYX

zyxin

chr12_-_51785182 0.790 ENST00000356317.3
ENST00000603188.1
ENST00000604847.1
ENST00000604506.1
 GALNT6



UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6)



chr10_+_50822480 0.788 ENST00000455728.2
 CHAT
choline O-acetyltransferase
chr5_+_126112794 0.770 ENST00000261366.5
ENST00000395354.1
 LMNB1

lamin B1

chr8_+_95653427 0.734 ENST00000454170.2
 ESRP1
epithelial splicing regulatory protein 1
chr12_-_58131931 0.731 ENST00000547588.1
 AGAP2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 468 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.1 GO:0031116 positive regulation of microtubule polymerization(GO:0031116)
0.5 1.9 GO:0046125 thymidine metabolic process(GO:0046104) pyrimidine deoxyribonucleoside metabolic process(GO:0046125)
0.1 1.9 GO:0030502 negative regulation of bone mineralization(GO:0030502)
0.6 1.8 GO:0036333 hepatocyte homeostasis(GO:0036333) response to tetrachloromethane(GO:1904772)
0.1 1.7 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.3 1.5 GO:0033567 DNA replication, Okazaki fragment processing(GO:0033567)
0.2 1.5 GO:0003065 positive regulation of heart rate by epinephrine(GO:0003065)
0.1 1.5 GO:0060753 regulation of mast cell chemotaxis(GO:0060753)
0.1 1.5 GO:0051382 kinetochore assembly(GO:0051382)
0.3 1.4 GO:0061358 negative regulation of Wnt protein secretion(GO:0061358)
0.0 1.4 GO:0090140 regulation of mitochondrial fission(GO:0090140)
0.3 1.3 GO:0021798 forebrain dorsal/ventral pattern formation(GO:0021798)
0.2 1.3 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
0.0 1.3 GO:0032456 endocytic recycling(GO:0032456)
0.1 1.2 GO:0051639 actin filament network formation(GO:0051639)
0.1 1.2 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.0 1.2 GO:0043044 ATP-dependent chromatin remodeling(GO:0043044)
0.4 1.1 GO:0051780 mevalonate transport(GO:0015728) behavioral response to nutrient(GO:0051780)
0.4 1.1 GO:0071790 spindle pole body duplication(GO:0030474) spindle pole body organization(GO:0051300) spindle pole body localization(GO:0070631) establishment of spindle pole body localization(GO:0070632) spindle pole body localization to nuclear envelope(GO:0071789) establishment of spindle pole body localization to nuclear envelope(GO:0071790)
0.2 1.1 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 159 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.5 GO:0005876 spindle microtubule(GO:0005876)
0.0 3.4 GO:0000793 condensed chromosome(GO:0000793)
0.0 2.7 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.1 2.3 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.1 2.0 GO:0031089 platelet dense granule lumen(GO:0031089)
0.2 1.9 GO:0032133 chromosome passenger complex(GO:0032133)
0.0 1.8 GO:0031985 Golgi cisterna(GO:0031985)
0.3 1.7 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.1 1.7 GO:0045120 pronucleus(GO:0045120)
0.2 1.5 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.2 1.3 GO:0005587 collagen type IV trimer(GO:0005587)
0.0 1.2 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 1.2 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.4 1.1 GO:0070762 nuclear pore transmembrane ring(GO:0070762)
0.1 1.1 GO:0000796 condensin complex(GO:0000796)
0.1 1.0 GO:0008091 spectrin(GO:0008091)
0.0 1.0 GO:0045171 intercellular bridge(GO:0045171)
0.0 1.0 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 1.0 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.1 0.9 GO:0032437 cuticular plate(GO:0032437)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 299 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.4 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 2.0 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.6 1.9 GO:0004797 thymidine kinase activity(GO:0004797)
0.3 1.9 GO:0043515 kinetochore binding(GO:0043515)
0.2 1.9 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.3 1.7 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.2 1.7 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.1 1.6 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
0.2 1.5 GO:0003910 DNA ligase (ATP) activity(GO:0003910)
0.0 1.5 GO:0005080 protein kinase C binding(GO:0005080)
0.3 1.4 GO:0038047 beta-endorphin receptor activity(GO:0004979) morphine receptor activity(GO:0038047)
0.1 1.4 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.1 1.4 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 1.2 GO:0045499 chemorepellent activity(GO:0045499)
0.1 1.2 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 1.2 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 1.2 GO:0017048 Rho GTPase binding(GO:0017048)
0.4 1.1 GO:0015130 mevalonate transmembrane transporter activity(GO:0015130)
0.2 1.1 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.1 1.1 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.6 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 3.7 PID_E2F_PATHWAY E2F transcription factor network
0.0 2.1 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 2.0 NABA_COLLAGENS Genes encoding collagen proteins
0.1 1.9 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 1.7 PID_REELIN_PATHWAY Reelin signaling pathway
0.0 1.7 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.0 1.6 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.0 1.3 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.0 1.3 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 1.3 PID_FGF_PATHWAY FGF signaling pathway
0.1 1.2 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 1.2 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.0 1.2 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 1.1 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 1.1 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.1 1.0 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 1.0 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 1.0 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 0.9 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 89 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.3 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 3.1 REACTOME_LAGGING_STRAND_SYNTHESIS Genes involved in Lagging Strand Synthesis
0.0 3.0 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 2.6 REACTOME_PYRIMIDINE_METABOLISM Genes involved in Pyrimidine metabolism
0.0 2.3 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 1.9 REACTOME_G1_PHASE Genes involved in G1 Phase
0.1 1.8 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.0 1.8 REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.1 1.7 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.1 1.6 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.1 1.5 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 1.5 REACTOME_G_PROTEIN_ACTIVATION Genes involved in G-protein activation
0.1 1.3 REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Activation of the pre-replicative complex
0.0 1.3 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 1.2 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.1 1.2 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 1.2 REACTOME_APOPTOTIC_EXECUTION_PHASE Genes involved in Apoptotic execution phase
0.1 1.1 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 1.0 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.0 1.0 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle