Motif ID: E2F7_E2F1

Z-value: 3.094

Transcription factors associated with E2F7_E2F1:

Gene SymbolEntrez IDGene Name
E2F1 ENSG00000101412.9 E2F1
E2F7 ENSG00000165891.11 E2F7

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2F7hg19_v2_chr12_-_77459306_774593650.711.0e-04Click!
E2F1hg19_v2_chr20_-_32274179_322742130.501.2e-02Click!


Activity profile for motif E2F7_E2F1.

activity profile for motif E2F7_E2F1


Sorted Z-values histogram for motif E2F7_E2F1

Sorted Z-values for motif E2F7_E2F1



Network of associatons between targets according to the STRING database.



First level regulatory network of E2F7_E2F1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_-_48673552 14.224 ENST00000536218.1
ENST00000596549.1
 LIG1

ligase I, DNA, ATP-dependent

chr19_-_48673580 13.767 ENST00000427526.2
 LIG1
ligase I, DNA, ATP-dependent
chr17_-_76183111 13.191 ENST00000405273.1
ENST00000590862.1
ENST00000590430.1
ENST00000586613.1
 TK1



thymidine kinase 1, soluble



chr5_+_126112794 10.221 ENST00000261366.5
ENST00000395354.1
 LMNB1

lamin B1

chr2_+_10262857 10.205 ENST00000304567.5
 RRM2
ribonucleotide reductase M2
chr7_-_148581251 9.104 ENST00000478654.1
ENST00000460911.1
ENST00000350995.2
 EZH2


enhancer of zeste homolog 2 (Drosophila)


chr7_-_148581360 8.608 ENST00000320356.2
ENST00000541220.1
ENST00000483967.1
ENST00000536783.1
 EZH2



enhancer of zeste homolog 2 (Drosophila)



chr2_+_174219548 8.387 ENST00000347703.3
ENST00000392567.2
ENST00000306721.3
ENST00000410101.3
ENST00000410019.3
 CDCA7




cell division cycle associated 7




chr18_+_657733 8.058 ENST00000323250.5
ENST00000323224.7
 TYMS

thymidylate synthetase

chr1_-_109825751 7.927 ENST00000369907.3
ENST00000438534.2
ENST00000369909.2
ENST00000409138.2
 PSRC1



proline/serine-rich coiled-coil 1



chr1_-_109825719 7.423 ENST00000369904.3
ENST00000369903.2
ENST00000429031.1
ENST00000418914.2
ENST00000409267.1
 PSRC1




proline/serine-rich coiled-coil 1




chr6_+_31126291 7.388 ENST00000376257.3
ENST00000376255.4
 TCF19

transcription factor 19

chr8_-_95907423 7.372 ENST00000396133.3
ENST00000308108.4
 CCNE2

cyclin E2

chr12_-_77459306 6.980 ENST00000547316.1
ENST00000416496.2
ENST00000550669.1
ENST00000322886.7
 E2F7



E2F transcription factor 7



chr7_-_158497431 6.938 ENST00000449727.2
ENST00000409339.3
ENST00000409423.1
ENST00000356309.3
 NCAPG2



non-SMC condensin II complex, subunit G2



chr1_+_91966656 6.793 ENST00000428239.1
ENST00000426137.1
 CDC7

cell division cycle 7

chr9_-_99180597 6.754 ENST00000375256.4
 ZNF367
zinc finger protein 367
chr5_+_68485433 6.729 ENST00000502689.1
 CENPH
centromere protein H
chr1_+_91966384 6.587 ENST00000430031.2
ENST00000234626.6
 CDC7

cell division cycle 7

chr22_+_19467261 6.429 ENST00000455750.1
ENST00000437685.2
ENST00000263201.1
ENST00000404724.3
 CDC45



cell division cycle 45




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 510 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.8 28.8 GO:0033567 DNA replication, Okazaki fragment processing(GO:0033567)
0.7 28.8 GO:0006270 DNA replication initiation(GO:0006270)
3.2 25.7 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
2.5 25.4 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
5.9 17.7 GO:0036333 hepatocyte homeostasis(GO:0036333) response to tetrachloromethane(GO:1904772)
0.7 16.7 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
5.0 15.0 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
0.4 14.4 GO:0031116 positive regulation of microtubule polymerization(GO:0031116)
0.8 13.4 GO:0051382 kinetochore assembly(GO:0051382)
3.3 13.2 GO:0046125 thymidine metabolic process(GO:0046104) pyrimidine deoxyribonucleoside metabolic process(GO:0046125)
1.6 13.1 GO:0010032 meiotic chromosome condensation(GO:0010032)
4.2 12.7 GO:0019860 uracil metabolic process(GO:0019860)
0.4 12.7 GO:0031055 chromatin remodeling at centromere(GO:0031055) CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
1.7 11.8 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.1 10.3 GO:0071349 interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349)
0.1 10.2 GO:0051225 spindle assembly(GO:0051225)
0.1 10.1 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
1.7 10.0 GO:0035407 histone H3-T11 phosphorylation(GO:0035407)
3.1 9.2 GO:0070512 regulation of histone H4-K20 methylation(GO:0070510) positive regulation of histone H4-K20 methylation(GO:0070512)
0.4 8.9 GO:0000732 strand displacement(GO:0000732)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 210 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.3 37.0 GO:0042555 MCM complex(GO:0042555)
0.3 24.1 GO:0005876 spindle microtubule(GO:0005876)
2.3 23.0 GO:0000796 condensin complex(GO:0000796)
0.2 19.8 GO:0000777 condensed chromosome kinetochore(GO:0000777)
1.2 19.7 GO:0045120 pronucleus(GO:0045120)
0.1 18.0 GO:0000793 condensed chromosome(GO:0000793)
0.3 17.7 GO:0045171 intercellular bridge(GO:0045171)
0.0 17.0 GO:0005739 mitochondrion(GO:0005739)
3.2 16.0 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.0 14.1 GO:0005759 mitochondrial matrix(GO:0005759)
3.2 12.9 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
1.6 12.6 GO:0005663 DNA replication factor C complex(GO:0005663)
1.3 11.5 GO:0005638 lamin filament(GO:0005638)
2.7 10.7 GO:0031436 BRCA1-BARD1 complex(GO:0031436)
0.0 10.3 GO:0005667 transcription factor complex(GO:0005667)
0.3 8.7 GO:0005721 pericentric heterochromatin(GO:0005721)
1.3 7.7 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.0 7.5 GO:0000790 nuclear chromatin(GO:0000790)
0.0 6.9 GO:0034702 ion channel complex(GO:0034702)
2.1 6.4 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 339 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.2 31.5 GO:0003910 DNA ligase (ATP) activity(GO:0003910)
0.6 30.1 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
2.0 18.3 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
1.0 17.4 GO:0003688 DNA replication origin binding(GO:0003688)
0.2 17.4 GO:0003684 damaged DNA binding(GO:0003684)
1.2 17.0 GO:1990825 sequence-specific mRNA binding(GO:1990825)
3.2 16.0 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0 13.9 GO:0008017 microtubule binding(GO:0008017)
4.4 13.2 GO:0004797 thymidine kinase activity(GO:0004797)
2.0 12.2 GO:0043515 kinetochore binding(GO:0043515)
1.3 12.0 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.1 11.5 GO:0035064 methylated histone binding(GO:0035064)
0.5 11.2 GO:0035173 histone kinase activity(GO:0035173)
0.4 10.1 GO:0043274 phospholipase binding(GO:0043274)
1.7 10.0 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.1 8.8 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 8.5 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.4 8.0 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.2 7.9 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.1 7.8 GO:0004386 helicase activity(GO:0004386)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 66 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 74.0 PID_E2F_PATHWAY E2F transcription factor network
0.7 41.2 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.3 18.5 PID_AURORA_B_PATHWAY Aurora B signaling
1.2 16.7 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 11.0 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.1 10.6 PID_CMYB_PATHWAY C-MYB transcription factor network
0.3 10.2 PID_ATR_PATHWAY ATR signaling pathway
0.1 7.9 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.1 5.6 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.1 4.9 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.1 4.1 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.5 3.8 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 3.7 PID_MYC_PATHWAY C-MYC pathway
0.0 3.5 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 3.4 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 3.3 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 3.3 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 3.3 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.1 3.2 PID_S1P_S1P1_PATHWAY S1P1 pathway
0.1 3.2 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 104 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.1 51.1 REACTOME_LAGGING_STRAND_SYNTHESIS Genes involved in Lagging Strand Synthesis
2.7 48.5 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
1.6 37.5 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.3 30.6 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
1.1 22.9 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.9 17.4 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.4 16.1 REACTOME_PYRIMIDINE_METABOLISM Genes involved in Pyrimidine metabolism
1.0 13.6 REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Activation of the pre-replicative complex
0.1 12.4 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.7 10.8 REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS Genes involved in Activation of ATR in response to replication stress
0.3 10.1 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.1 9.8 REACTOME_S_PHASE Genes involved in S Phase
0.3 7.7 REACTOME_FANCONI_ANEMIA_PATHWAY Genes involved in Fanconi Anemia pathway
0.0 6.9 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.3 6.7 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.1 6.3 REACTOME_LATE_PHASE_OF_HIV_LIFE_CYCLE Genes involved in Late Phase of HIV Life Cycle
0.1 6.2 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.2 5.7 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.1 5.7 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_GLUCAGON_LIKE_PEPTIDE1 Genes involved in Regulation of Insulin Secretion by Glucagon-like Peptide-1
0.3 5.5 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis