Motif ID: E4F1

Z-value: 0.353


Transcription factors associated with E4F1:

Gene SymbolEntrez IDGene Name
E4F1 ENSG00000167967.11 E4F1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E4F1hg19_v2_chr16_+_2273558_2273637-0.184.1e-01Click!


Activity profile for motif E4F1.

activity profile for motif E4F1


Sorted Z-values histogram for motif E4F1

Sorted Z-values for motif E4F1



Network of associatons between targets according to the STRING database.



First level regulatory network of E4F1

PNG image of the network

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Top targets:


Showing 1 to 20 of 138 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_216300784 1.168 ENST00000421182.1
ENST00000432072.2
ENST00000323926.6
ENST00000336916.4
ENST00000357867.4
ENST00000359671.1
ENST00000346544.3
ENST00000345488.5
ENST00000357009.2
ENST00000446046.1
ENST00000356005.4
ENST00000443816.1
ENST00000426059.1
ENST00000354785.4
 FN1













fibronectin 1













chr4_+_75310851 0.685 ENST00000395748.3
ENST00000264487.2
 AREG

amphiregulin

chr4_+_75311019 0.662 ENST00000502307.1
 AREG
amphiregulin
chr20_+_58179582 0.445 ENST00000371015.1
ENST00000395639.4
 PHACTR3

phosphatase and actin regulator 3

chr17_+_41476327 0.403 ENST00000320033.4
 ARL4D
ADP-ribosylation factor-like 4D
chr19_+_1941117 0.391 ENST00000255641.8
 CSNK1G2
casein kinase 1, gamma 2
chr1_-_8086343 0.386 ENST00000474874.1
ENST00000469499.1
ENST00000377482.5
 ERRFI1


ERBB receptor feedback inhibitor 1


chr10_+_95256356 0.352 ENST00000371485.3
 CEP55
centrosomal protein 55kDa
chr20_+_34203794 0.345 ENST00000374273.3
 SPAG4
sperm associated antigen 4
chr4_-_122744998 0.288 ENST00000274026.5
 CCNA2
cyclin A2
chr20_-_44420507 0.254 ENST00000243938.4
 WFDC3
WAP four-disulfide core domain 3
chr6_+_64282447 0.250 ENST00000370650.2
ENST00000578299.1
 PTP4A1

protein tyrosine phosphatase type IVA, member 1

chr6_-_163148700 0.242 ENST00000366894.1
ENST00000338468.3
 PARK2

parkin RBR E3 ubiquitin protein ligase

chr12_+_107168418 0.233 ENST00000392839.2
ENST00000548914.1
ENST00000355478.2
ENST00000552619.1
ENST00000549643.1
 RIC8B




RIC8 guanine nucleotide exchange factor B




chr12_+_107168342 0.226 ENST00000392837.4
 RIC8B
RIC8 guanine nucleotide exchange factor B
chr20_+_44420570 0.222 ENST00000372622.3
 DNTTIP1
deoxynucleotidyltransferase, terminal, interacting protein 1
chr3_+_150126101 0.222 ENST00000361875.3
ENST00000361136.2
 TSC22D2

TSC22 domain family, member 2

chr20_-_5591626 0.220 ENST00000379019.4
 GPCPD1
glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae)
chr20_+_44420617 0.210 ENST00000449078.1
ENST00000456939.1
 DNTTIP1

deoxynucleotidyltransferase, terminal, interacting protein 1

chr9_+_131644398 0.210 ENST00000372599.3
 LRRC8A
leucine rich repeat containing 8 family, member A

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.3 GO:0060744 thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744)
0.4 1.2 GO:0052047 interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047)
0.1 0.6 GO:0002329 pre-B cell differentiation(GO:0002329)
0.0 0.5 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.0 0.4 GO:1903243 negative regulation of cardiac muscle adaptation(GO:0010616) negative regulation of cardiac muscle hypertrophy in response to stress(GO:1903243)
0.1 0.3 GO:0071314 cellular response to cocaine(GO:0071314)
0.0 0.3 GO:0045903 positive regulation of translational fidelity(GO:0045903)
0.0 0.3 GO:0090286 cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.1 0.2 GO:1904862 inhibitory synapse assembly(GO:1904862)
0.1 0.2 GO:2000687 negative regulation of rubidium ion transport(GO:2000681) negative regulation of rubidium ion transmembrane transporter activity(GO:2000687)
0.0 0.2 GO:0038169 somatostatin receptor signaling pathway(GO:0038169) somatostatin signaling pathway(GO:0038170)
0.0 0.2 GO:1902527 positive regulation of protein monoubiquitination(GO:1902527)
0.0 0.2 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.0 0.2 GO:0019368 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.2 GO:0032790 ribosome disassembly(GO:0032790)
0.0 0.2 GO:0016926 protein desumoylation(GO:0016926)
0.1 0.1 GO:0060067 cervix development(GO:0060067)
0.0 0.1 GO:0032911 negative regulation of transforming growth factor beta1 production(GO:0032911)
0.0 0.1 GO:0021526 medial motor column neuron differentiation(GO:0021526)
0.0 0.1 GO:0009996 negative regulation of cell fate specification(GO:0009996)

Gene overrepresentation in cellular_component category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.6 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.1 1.2 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.4 GO:0090543 Flemming body(GO:0090543)
0.1 0.3 GO:0097124 cyclin A2-CDK2 complex(GO:0097124)
0.0 0.3 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.1 0.2 GO:0097447 dendritic tree(GO:0097447)
0.0 0.1 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.0 0.1 GO:0035032 phosphatidylinositol 3-kinase complex, class III(GO:0035032)
0.0 0.1 GO:0005642 annulate lamellae(GO:0005642)
0.0 0.1 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.0 0.1 GO:0001739 sex chromatin(GO:0001739)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.3 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 1.3 GO:0016504 peptidase activator activity(GO:0016504)
0.0 0.6 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.0 0.5 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.4 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.3 GO:0004741 [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
0.0 0.3 GO:1990932 5.8S rRNA binding(GO:1990932)
0.0 0.3 GO:0043495 protein anchor(GO:0043495)
0.1 0.2 GO:0047389 glycerophosphocholine phosphodiesterase activity(GO:0047389)
0.1 0.2 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0 0.2 GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.0 0.2 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0 0.2 GO:0004994 somatostatin receptor activity(GO:0004994)
0.0 0.2 GO:0070139 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.0 0.2 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 0.2 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.0 0.2 GO:0017070 U6 snRNA binding(GO:0017070)
0.0 0.1 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0 0.1 GO:0001003 polymerase III regulatory region sequence-specific DNA binding(GO:0000992) RNA polymerase III type 1 promoter sequence-specific DNA binding(GO:0001002) RNA polymerase III type 2 promoter sequence-specific DNA binding(GO:0001003)
0.0 0.1 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)

Gene overrepresentation in C2:CP category:

Showing 1 to 3 of 3 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.3 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 1.2 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.7 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.2 REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTERGRINS_ Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0 0.4 REACTOME_TRYPTOPHAN_CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.3 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.3 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 0.2 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated