Motif ID: EBF3

Z-value: 0.493


Transcription factors associated with EBF3:

Gene SymbolEntrez IDGene Name
EBF3 ENSG00000108001.9 EBF3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
EBF3hg19_v2_chr10_-_131762105_131762105-0.116.0e-01Click!


Activity profile for motif EBF3.

activity profile for motif EBF3


Sorted Z-values histogram for motif EBF3

Sorted Z-values for motif EBF3



Network of associatons between targets according to the STRING database.



First level regulatory network of EBF3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_+_38420783 0.801 ENST00000422612.2
ENST00000286824.6
ENST00000545599.1
 TSPAN7


tetraspanin 7


chr1_-_204116078 0.798 ENST00000367198.2
ENST00000452983.1
 ETNK2

ethanolamine kinase 2

chr16_-_85784718 0.692 ENST00000602766.1
 C16orf74
chromosome 16 open reading frame 74
chr15_+_90728145 0.675 ENST00000561085.1
ENST00000379122.3
ENST00000332496.6
 SEMA4B


sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B


chr16_-_85784557 0.650 ENST00000602675.1
 C16orf74
chromosome 16 open reading frame 74
chr16_-_85784634 0.639 ENST00000284245.4
ENST00000602914.1
 C16orf74

chromosome 16 open reading frame 74

chr10_+_11784360 0.617 ENST00000379215.4
ENST00000420401.1
 ECHDC3

enoyl CoA hydratase domain containing 3

chr22_-_37640277 0.611 ENST00000401529.3
ENST00000249071.6
 RAC2

ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)

chr10_+_77056134 0.610 ENST00000528121.1
ENST00000416398.1
 ZNF503-AS1

ZNF503 antisense RNA 1

chr5_-_146833222 0.592 ENST00000534907.1
 DPYSL3
dihydropyrimidinase-like 3
chr5_-_146833485 0.581 ENST00000398514.3
 DPYSL3
dihydropyrimidinase-like 3
chrX_+_69509927 0.566 ENST00000374403.3
 KIF4A
kinesin family member 4A
chr22_-_37640456 0.563 ENST00000405484.1
ENST00000441619.1
ENST00000406508.1
 RAC2


ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)


chr11_+_111126707 0.520 ENST00000280325.4
 C11orf53
chromosome 11 open reading frame 53
chrX_+_38420623 0.500 ENST00000378482.2
 TSPAN7
tetraspanin 7
chr1_-_26197744 0.497 ENST00000374296.3
 PAQR7
progestin and adipoQ receptor family member VII
chr3_-_189840223 0.491 ENST00000427335.2
 LEPREL1
leprecan-like 1
chr5_+_154393260 0.483 ENST00000435029.4
 KIF4B
kinesin family member 4B
chr16_+_67233007 0.477 ENST00000360833.1
ENST00000393997.2
 ELMO3

engulfment and cell motility 3

chr3_-_145878954 0.467 ENST00000282903.5
ENST00000360060.3
 PLOD2

procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 119 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.2 GO:0060753 regulation of mast cell chemotaxis(GO:0060753)
0.0 1.2 GO:0051764 actin crosslink formation(GO:0051764)
0.1 1.1 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.0 0.8 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.2 0.7 GO:0000412 histone peptidyl-prolyl isomerization(GO:0000412)
0.2 0.7 GO:0071469 cellular response to alkaline pH(GO:0071469)
0.0 0.7 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.0 0.7 GO:0050919 negative chemotaxis(GO:0050919)
0.1 0.6 GO:0006218 uridine catabolic process(GO:0006218)
0.0 0.6 GO:2000291 regulation of myoblast proliferation(GO:2000291)
0.2 0.5 GO:0046947 hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
0.2 0.5 GO:1903570 regulation of protein kinase D signaling(GO:1903570) positive regulation of protein kinase D signaling(GO:1903572)
0.0 0.5 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0 0.5 GO:0007176 regulation of epidermal growth factor-activated receptor activity(GO:0007176)
0.1 0.4 GO:0060474 positive regulation of sperm motility involved in capacitation(GO:0060474)
0.1 0.4 GO:0051639 actin filament network formation(GO:0051639)
0.1 0.3 GO:0003099 positive regulation of the force of heart contraction by chemical signal(GO:0003099) regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.1 0.3 GO:0019085 early viral transcription(GO:0019085)
0.1 0.3 GO:1903966 monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.1 0.3 GO:0090038 negative regulation of protein kinase C signaling(GO:0090038)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.2 GO:0045171 intercellular bridge(GO:0045171)
0.0 1.2 GO:0031941 filamentous actin(GO:0031941)
0.0 1.1 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.0 0.6 GO:0000791 euchromatin(GO:0000791)
0.1 0.5 GO:0070435 Shc-EGFR complex(GO:0070435)
0.1 0.4 GO:1990742 microvesicle(GO:1990742)
0.1 0.3 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.0 0.3 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.0 0.3 GO:0005614 interstitial matrix(GO:0005614)
0.1 0.2 GO:0045160 myosin I complex(GO:0045160)
0.0 0.2 GO:0035838 growing cell tip(GO:0035838)
0.0 0.2 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.0 0.2 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0 0.2 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.1 GO:0000939 nuclear MIS12/MIND complex(GO:0000818) condensed chromosome inner kinetochore(GO:0000939)
0.0 0.1 GO:0048787 presynaptic active zone membrane(GO:0048787) synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.0 0.1 GO:0005608 laminin-3 complex(GO:0005608)
0.0 0.1 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.0 0.1 GO:0032002 interleukin-28 receptor complex(GO:0032002)
0.0 0.1 GO:0072558 NLRP1 inflammasome complex(GO:0072558)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 73 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.0 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.1 0.9 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.1 0.8 GO:0004305 ethanolamine kinase activity(GO:0004305)
0.1 0.7 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.0 0.7 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.7 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.2 0.6 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.1 0.6 GO:0004850 uridine phosphorylase activity(GO:0004850)
0.2 0.5 GO:0033823 procollagen-lysine 5-dioxygenase activity(GO:0008475) procollagen glucosyltransferase activity(GO:0033823)
0.1 0.5 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.1 0.5 GO:0048408 epidermal growth factor binding(GO:0048408)
0.1 0.5 GO:0015526 hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.0 0.5 GO:0030371 translation repressor activity(GO:0030371)
0.1 0.4 GO:0098782 mechanically-gated potassium channel activity(GO:0098782)
0.1 0.4 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
0.1 0.4 GO:0036132 13-prostaglandin reductase activity(GO:0036132) 15-oxoprostaglandin 13-oxidase activity(GO:0047522)
0.0 0.4 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.0 0.4 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.1 0.3 GO:0031708 endothelin B receptor binding(GO:0031708)
0.1 0.3 GO:0016215 stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)

Gene overrepresentation in C2:CP category:

Showing 1 to 4 of 4 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.2 PID_IL8_CXCR2_PATHWAY IL8- and CXCR2-mediated signaling events
0.0 0.5 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 0.5 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 0.5 PID_IL3_PATHWAY IL3-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.2 REACTOME_GPVI_MEDIATED_ACTIVATION_CASCADE Genes involved in GPVI-mediated activation cascade
0.0 1.1 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.0 1.0 REACTOME_KINESINS Genes involved in Kinesins
0.0 1.0 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 0.8 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.7 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE
0.0 0.6 REACTOME_PYRIMIDINE_CATABOLISM Genes involved in Pyrimidine catabolism
0.0 0.5 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.5 REACTOME_SHC_MEDIATED_SIGNALLING Genes involved in SHC-mediated signalling
0.0 0.5 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 0.4 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.4 REACTOME_BETA_DEFENSINS Genes involved in Beta defensins
0.0 0.3 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 0.3 REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.3 REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 0.2 REACTOME_RECYCLING_OF_BILE_ACIDS_AND_SALTS Genes involved in Recycling of bile acids and salts
0.0 0.1 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.1 REACTOME_DESTABILIZATION_OF_MRNA_BY_AUF1_HNRNP_D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)