Motif ID: EGR1_EGR4

Z-value: 0.998

Transcription factors associated with EGR1_EGR4:

Gene SymbolEntrez IDGene Name
EGR1 ENSG00000120738.7 EGR1
EGR4 ENSG00000135625.6 EGR4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
EGR1hg19_v2_chr5_+_137801160_1378011790.761.5e-05Click!
EGR4hg19_v2_chr2_-_73520667_73520833-0.116.0e-01Click!


Activity profile for motif EGR1_EGR4.

activity profile for motif EGR1_EGR4


Sorted Z-values histogram for motif EGR1_EGR4

Sorted Z-values for motif EGR1_EGR4



Network of associatons between targets according to the STRING database.



First level regulatory network of EGR1_EGR4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_-_57634475 8.076 ENST00000393825.1
 NDUFA4L2
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
chr6_-_4135825 5.166 ENST00000380118.3
ENST00000413766.2
ENST00000361538.2
 ECI2


enoyl-CoA delta isomerase 2


chr1_-_9189229 4.816 ENST00000377411.4
 GPR157
G protein-coupled receptor 157
chr19_-_51472031 4.702 ENST00000391808.1
 KLK6
kallikrein-related peptidase 6
chr19_-_51472222 4.075 ENST00000376851.3
 KLK6
kallikrein-related peptidase 6
chr15_-_80263506 3.427 ENST00000335661.6
 BCL2A1
BCL2-related protein A1
chr15_+_39873268 3.397 ENST00000397591.2
ENST00000260356.5
 THBS1

thrombospondin 1

chr1_+_65886244 3.125 ENST00000344610.8
 LEPR
leptin receptor
chr6_+_151646800 3.101 ENST00000354675.6
 AKAP12
A kinase (PRKA) anchor protein 12
chr6_-_4135693 3.057 ENST00000495548.1
ENST00000380125.2
ENST00000465828.1
 ECI2


enoyl-CoA delta isomerase 2


chr6_+_86159821 3.002 ENST00000369651.3
 NT5E
5'-nucleotidase, ecto (CD73)
chr2_-_27718052 2.937 ENST00000264703.3
 FNDC4
fibronectin type III domain containing 4
chr1_+_23695680 2.778 ENST00000454117.1
ENST00000335648.3
ENST00000518821.1
ENST00000437367.2
 C1orf213



chromosome 1 open reading frame 213



chr11_-_2160180 2.769 ENST00000381406.4
 IGF2
insulin-like growth factor 2 (somatomedin A)
chr10_-_129924611 2.763 ENST00000368654.3
 MKI67
marker of proliferation Ki-67
chr6_+_43739697 2.749 ENST00000230480.6
 VEGFA
vascular endothelial growth factor A
chr15_-_90039805 2.669 ENST00000544600.1
ENST00000268122.4
 RHCG

Rh family, C glycoprotein

chr1_+_65886326 2.654 ENST00000371059.3
ENST00000371060.3
ENST00000349533.6
ENST00000406510.3
 LEPR



leptin receptor



chr6_+_86159765 2.616 ENST00000369646.3
ENST00000257770.3
 NT5E

5'-nucleotidase, ecto (CD73)

chr15_+_74833518 2.605 ENST00000346246.5
 ARID3B
AT rich interactive domain 3B (BRIGHT-like)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 397 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 8.7 GO:0016540 protein autoprocessing(GO:0016540)
0.3 8.3 GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
0.0 6.6 GO:1902600 hydrogen ion transmembrane transport(GO:1902600)
0.4 5.8 GO:0060019 radial glial cell differentiation(GO:0060019)
1.4 5.6 GO:0046086 adenosine biosynthetic process(GO:0046086)
0.4 5.4 GO:0033210 leptin-mediated signaling pathway(GO:0033210)
0.6 5.1 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.3 4.9 GO:0051639 actin filament network formation(GO:0051639)
0.4 3.5 GO:0003065 positive regulation of heart rate by epinephrine(GO:0003065)
1.1 3.4 GO:0002605 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581) negative regulation of dendritic cell antigen processing and presentation(GO:0002605)
0.1 3.4 GO:0008053 mitochondrial fusion(GO:0008053)
0.1 3.4 GO:0008088 axo-dendritic transport(GO:0008088)
0.2 3.1 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.9 2.7 GO:1903570 regulation of protein kinase D signaling(GO:1903570) positive regulation of protein kinase D signaling(GO:1903572)
0.9 2.7 GO:0070634 transepithelial ammonium transport(GO:0070634)
0.3 2.7 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.2 2.7 GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.4 2.5 GO:0007386 compartment pattern specification(GO:0007386)
0.3 2.4 GO:0021842 directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842)
0.0 2.4 GO:0050690 regulation of defense response to virus by virus(GO:0050690)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 153 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.7 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.5 8.3 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.1 7.1 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.1 5.9 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 5.9 GO:0043235 receptor complex(GO:0043235)
0.3 4.9 GO:0035253 ciliary rootlet(GO:0035253)
0.2 4.2 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 4.0 GO:0005938 cell cortex(GO:0005938)
0.0 3.8 GO:0030863 cortical cytoskeleton(GO:0030863)
0.3 3.4 GO:0005577 fibrinogen complex(GO:0005577)
0.1 2.9 GO:0030673 axolemma(GO:0030673)
0.2 2.8 GO:0005916 fascia adherens(GO:0005916)
0.1 2.7 GO:0035371 microtubule plus-end(GO:0035371)
0.2 2.6 GO:0031209 SCAR complex(GO:0031209)
0.0 2.6 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 2.5 GO:0001891 phagocytic cup(GO:0001891)
0.0 2.5 GO:0060170 ciliary membrane(GO:0060170)
0.0 2.4 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.3 2.3 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.3 2.2 GO:0005587 collagen type IV trimer(GO:0005587)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 240 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 9.1 GO:0004252 serine-type endopeptidase activity(GO:0004252)
2.1 8.2 GO:0004165 dodecenoyl-CoA delta-isomerase activity(GO:0004165)
0.2 8.0 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 6.8 GO:0004896 cytokine receptor activity(GO:0004896)
0.2 6.5 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.1 6.0 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.3 5.7 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 4.3 GO:0017048 Rho GTPase binding(GO:0017048)
0.1 4.2 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 3.9 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.2 3.8 GO:0051400 BH domain binding(GO:0051400)
0.1 3.8 GO:0046965 retinoid X receptor binding(GO:0046965)
1.1 3.4 GO:0070052 collagen V binding(GO:0070052)
0.2 3.4 GO:0008179 adenylate cyclase binding(GO:0008179)
0.1 3.4 GO:0030506 ankyrin binding(GO:0030506)
0.1 3.4 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 3.3 GO:0003777 microtubule motor activity(GO:0003777)
0.0 3.0 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 2.9 GO:0017166 vinculin binding(GO:0017166)
0.0 2.9 GO:0008565 protein transporter activity(GO:0008565)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 64 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 10.8 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.1 6.9 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.2 6.6 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.1 6.3 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 5.1 PID_PTP1B_PATHWAY Signaling events mediated by PTP1B
0.1 5.1 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 4.6 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 4.3 PID_LKB1_PATHWAY LKB1 signaling events
0.0 4.2 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 3.7 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 3.1 PID_RAC1_PATHWAY RAC1 signaling pathway
0.1 2.9 PID_IL5_PATHWAY IL5-mediated signaling events
0.1 2.8 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.1 2.5 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.0 2.5 NABA_COLLAGENS Genes encoding collagen proteins
0.1 2.2 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 2.2 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.1 2.0 PID_NFKAPPAB_ATYPICAL_PATHWAY Atypical NF-kappaB pathway
0.1 2.0 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.1 2.0 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 90 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 5.2 REACTOME_PYRIMIDINE_CATABOLISM Genes involved in Pyrimidine catabolism
0.2 4.9 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 4.4 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.1 4.4 REACTOME_KINESINS Genes involved in Kinesins
0.1 4.2 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 3.7 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 2.9 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.1 2.7 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 2.5 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 2.4 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1 2.3 REACTOME_P38MAPK_EVENTS Genes involved in p38MAPK events
0.1 2.3 REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING Genes involved in Spry regulation of FGF signaling
0.0 2.2 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 2.1 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 2.1 REACTOME_G_ALPHA1213_SIGNALLING_EVENTS Genes involved in G alpha (12/13) signalling events
0.1 1.9 REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 1.9 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.1 1.8 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 1.7 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 1.6 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)