Motif ID: EGR3_EGR2

Z-value: 0.618

Transcription factors associated with EGR3_EGR2:

Gene SymbolEntrez IDGene Name
EGR2 ENSG00000122877.9 EGR2
EGR3 ENSG00000179388.8 EGR3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
EGR3hg19_v2_chr8_-_22550815_225508440.341.0e-01Click!
EGR2hg19_v2_chr10_-_64576105_64576133-0.155.0e-01Click!


Activity profile for motif EGR3_EGR2.

activity profile for motif EGR3_EGR2


Sorted Z-values histogram for motif EGR3_EGR2

Sorted Z-values for motif EGR3_EGR2



Network of associatons between targets according to the STRING database.



First level regulatory network of EGR3_EGR2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_-_51472031 1.171 ENST00000391808.1
 KLK6
kallikrein-related peptidase 6
chr19_-_51472222 1.083 ENST00000376851.3
 KLK6
kallikrein-related peptidase 6
chr15_+_39873268 1.038 ENST00000397591.2
ENST00000260356.5
 THBS1

thrombospondin 1

chr1_-_9189229 0.942 ENST00000377411.4
 GPR157
G protein-coupled receptor 157
chr5_-_176924562 0.913 ENST00000359895.2
ENST00000355572.2
ENST00000355841.2
ENST00000393551.1
ENST00000505074.1
ENST00000356618.4
ENST00000393546.4
 PDLIM7






PDZ and LIM domain 7 (enigma)






chrX_+_130192318 0.885 ENST00000370922.1
 ARHGAP36
Rho GTPase activating protein 36
chr14_-_69445968 0.806 ENST00000438964.2
 ACTN1
actinin, alpha 1
chrX_+_130192216 0.756 ENST00000276211.5
 ARHGAP36
Rho GTPase activating protein 36
chr18_+_33877654 0.748 ENST00000257209.4
ENST00000445677.1
ENST00000590592.1
ENST00000359247.4
 FHOD3



formin homology 2 domain containing 3



chr6_-_4135825 0.745 ENST00000380118.3
ENST00000413766.2
ENST00000361538.2
 ECI2


enoyl-CoA delta isomerase 2


chr10_-_129924611 0.727 ENST00000368654.3
 MKI67
marker of proliferation Ki-67
chr14_-_69445793 0.694 ENST00000538545.2
ENST00000394419.4
 ACTN1

actinin, alpha 1

chr11_-_125366089 0.687 ENST00000366139.3
ENST00000278919.3
 FEZ1

fasciculation and elongation protein zeta 1 (zygin I)

chr15_+_74833518 0.681 ENST00000346246.5
 ARID3B
AT rich interactive domain 3B (BRIGHT-like)
chr6_+_43739697 0.680 ENST00000230480.6
 VEGFA
vascular endothelial growth factor A
chr9_+_34989638 0.676 ENST00000453597.3
ENST00000335998.3
ENST00000312316.5
 DNAJB5


DnaJ (Hsp40) homolog, subfamily B, member 5


chr8_+_32405728 0.653 ENST00000523079.1
ENST00000338921.4
ENST00000356819.4
ENST00000287845.5
ENST00000341377.5
 NRG1




neuregulin 1




chr2_+_30454390 0.647 ENST00000395323.3
ENST00000406087.1
ENST00000404397.1
 LBH


limb bud and heart development


chr19_+_44037546 0.646 ENST00000601282.1
 ZNF575
zinc finger protein 575
chrX_-_48814810 0.593 ENST00000376488.3
ENST00000396743.3
ENST00000156084.4
 OTUD5


OTU domain containing 5



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 229 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.9 GO:0051639 actin filament network formation(GO:0051639)
0.1 2.4 GO:0016540 protein autoprocessing(GO:0016540)
0.3 1.9 GO:0021842 directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842)
0.1 1.5 GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.1 1.2 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.0 1.2 GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
0.3 1.0 GO:0002605 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581) negative regulation of dendritic cell antigen processing and presentation(GO:0002605)
0.1 0.9 GO:0060019 radial glial cell differentiation(GO:0060019)
0.0 0.9 GO:1900273 positive regulation of long-term synaptic potentiation(GO:1900273)
0.0 0.9 GO:0042267 natural killer cell mediated cytotoxicity(GO:0042267)
0.2 0.8 GO:0046086 adenosine biosynthetic process(GO:0046086)
0.1 0.8 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.0 0.8 GO:0014887 muscle hypertrophy in response to stress(GO:0003299) cardiac muscle adaptation(GO:0014887) cardiac muscle hypertrophy in response to stress(GO:0014898)
0.0 0.8 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
0.2 0.7 GO:1903570 regulation of protein kinase D signaling(GO:1903570) positive regulation of protein kinase D signaling(GO:1903572)
0.2 0.7 GO:1902460 regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
0.1 0.7 GO:0060024 rhythmic synaptic transmission(GO:0060024)
0.1 0.7 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931)
0.1 0.7 GO:2001300 lipoxin metabolic process(GO:2001300)
0.0 0.7 GO:0035020 regulation of Rac protein signal transduction(GO:0035020)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 78 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.8 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 2.1 GO:0005916 fascia adherens(GO:0005916)
0.0 2.0 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 1.9 GO:0030673 axolemma(GO:0030673)
0.0 1.9 GO:0043195 terminal bouton(GO:0043195)
0.1 1.4 GO:0031209 SCAR complex(GO:0031209)
0.0 1.2 GO:0035371 microtubule plus-end(GO:0035371)
0.0 1.1 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 1.1 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 1.0 GO:0044327 dendritic spine head(GO:0044327)
0.1 1.0 GO:0005641 nuclear envelope lumen(GO:0005641)
0.1 0.9 GO:0005577 fibrinogen complex(GO:0005577)
0.1 0.8 GO:0005642 annulate lamellae(GO:0005642)
0.0 0.8 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 0.7 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 0.5 GO:0016600 flotillin complex(GO:0016600)
0.0 0.5 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.0 0.5 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.5 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.5 GO:0030057 desmosome(GO:0030057)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 136 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.1 GO:0017166 vinculin binding(GO:0017166)
0.2 1.9 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.0 1.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.3 1.2 GO:0004165 dodecenoyl-CoA delta-isomerase activity(GO:0004165)
0.1 1.1 GO:0019237 centromeric DNA binding(GO:0019237)
0.0 1.1 GO:0048365 Rac GTPase binding(GO:0048365)
0.3 1.0 GO:0070052 collagen V binding(GO:0070052)
0.0 1.0 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 1.0 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.9 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.9 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.9 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.9 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.8 GO:0017070 U6 snRNA binding(GO:0017070)
0.0 0.8 GO:0070300 phosphatidic acid binding(GO:0070300)
0.0 0.8 GO:0043015 gamma-tubulin binding(GO:0043015)
0.2 0.7 GO:0016404 15-hydroxyprostaglandin dehydrogenase (NAD+) activity(GO:0016404)
0.1 0.7 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.0 0.7 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 0.6 GO:0051721 protein phosphatase 2A binding(GO:0051721)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.4 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.1 3.3 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.1 3.0 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 1.6 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 1.2 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 1.2 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 1.0 PID_LKB1_PATHWAY LKB1 signaling events
0.0 0.9 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 0.8 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.8 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 0.7 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 0.6 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 0.6 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.6 PID_PTP1B_PATHWAY Signaling events mediated by PTP1B
0.0 0.5 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.4 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.4 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 0.4 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.0 0.3 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.0 0.3 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.4 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 2.0 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 1.9 REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.0 1.3 REACTOME_KINESINS Genes involved in Kinesins
0.0 1.0 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.9 REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.1 0.8 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.0 0.7 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.7 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.6 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.0 0.6 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 0.5 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 0.5 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.0 0.5 REACTOME_TRANSPORT_OF_RIBONUCLEOPROTEINS_INTO_THE_HOST_NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.0 0.4 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.0 0.4 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.3 REACTOME_MEMBRANE_BINDING_AND_TARGETTING_OF_GAG_PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.0 0.3 REACTOME_HIGHLY_CALCIUM_PERMEABLE_POSTSYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
0.0 0.3 REACTOME_PROCESSIVE_SYNTHESIS_ON_THE_LAGGING_STRAND Genes involved in Processive synthesis on the lagging strand
0.0 0.3 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism