Motif ID: ELF2_GABPA_ELF5

Z-value: 1.546

Transcription factors associated with ELF2_GABPA_ELF5:

Gene SymbolEntrez IDGene Name
ELF2 ENSG00000109381.15 ELF2
ELF5 ENSG00000135374.5 ELF5
GABPA ENSG00000154727.6 GABPA

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
GABPAhg19_v2_chr21_+_27107672_271076980.281.9e-01Click!
ELF2hg19_v2_chr4_-_140005443_1400056500.203.4e-01Click!
ELF5hg19_v2_chr11_-_34535297_34535317-0.135.4e-01Click!


Activity profile for motif ELF2_GABPA_ELF5.

activity profile for motif ELF2_GABPA_ELF5


Sorted Z-values histogram for motif ELF2_GABPA_ELF5

Sorted Z-values for motif ELF2_GABPA_ELF5



Network of associatons between targets according to the STRING database.



First level regulatory network of ELF2_GABPA_ELF5

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_+_50180317 2.363 ENST00000534465.1
 PRMT1
protein arginine methyltransferase 1
chr14_-_21979428 2.168 ENST00000538267.1
ENST00000298717.4
 METTL3

methyltransferase like 3

chr1_-_47779762 2.022 ENST00000371877.3
ENST00000360380.3
ENST00000337817.5
ENST00000447475.2
 STIL



SCL/TAL1 interrupting locus



chr2_+_231191875 2.012 ENST00000444636.1
ENST00000415673.2
ENST00000243810.6
ENST00000396563.4
 SP140L



SP140 nuclear body protein-like



chr1_-_38273840 1.944 ENST00000373044.2
 YRDC
yrdC N(6)-threonylcarbamoyltransferase domain containing
chr8_-_104427313 1.775 ENST00000297578.4
 SLC25A32
solute carrier family 25 (mitochondrial folate carrier), member 32
chr2_+_201390843 1.638 ENST00000357799.4
ENST00000409203.3
 SGOL2

shugoshin-like 2 (S. pombe)

chr1_+_44679113 1.617 ENST00000361745.6
ENST00000446292.1
ENST00000440641.1
ENST00000436069.1
ENST00000437511.1
 DMAP1




DNA methyltransferase 1 associated protein 1




chr17_-_19281203 1.601 ENST00000487415.2
 B9D1
B9 protein domain 1
chr12_-_123215306 1.572 ENST00000356987.2
ENST00000436083.2
 HCAR1

hydroxycarboxylic acid receptor 1

chr20_+_31823792 1.560 ENST00000375413.4
ENST00000354297.4
ENST00000375422.2
 BPIFA1


BPI fold containing family A, member 1


chr5_+_892745 1.546 ENST00000166345.3
 TRIP13
thyroid hormone receptor interactor 13
chr6_+_80714318 1.536 ENST00000369798.2
 TTK
TTK protein kinase
chr12_+_21590549 1.528 ENST00000545178.1
ENST00000240651.9
 PYROXD1

pyridine nucleotide-disulphide oxidoreductase domain 1

chr16_-_31085514 1.505 ENST00000300849.4
 ZNF668
zinc finger protein 668
chrY_+_2709906 1.477 ENST00000430575.1
 RPS4Y1
ribosomal protein S4, Y-linked 1
chr1_+_100598691 1.473 ENST00000370143.1
ENST00000370141.2
 TRMT13

tRNA methyltransferase 13 homolog (S. cerevisiae)

chr1_+_44679159 1.462 ENST00000315913.5
ENST00000372289.2
 DMAP1

DNA methyltransferase 1 associated protein 1

chr5_-_159739532 1.433 ENST00000520748.1
ENST00000393977.3
ENST00000257536.7
 CCNJL


cyclin J-like


chr11_+_61197508 1.426 ENST00000301761.2
ENST00000541135.1
 SDHAF2
RP11-286N22.8
succinate dehydrogenase complex assembly factor 2
Uncharacterized protein

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 1,011 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.8 GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436)
0.1 6.3 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.6 5.9 GO:0000972 transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000972)
0.2 5.7 GO:0034080 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.0 5.5 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.1 5.4 GO:0006361 transcription initiation from RNA polymerase I promoter(GO:0006361)
0.2 5.1 GO:0030488 tRNA methylation(GO:0030488)
0.0 4.9 GO:0007062 sister chromatid cohesion(GO:0007062)
0.6 4.1 GO:0046984 regulation of hemoglobin biosynthetic process(GO:0046984)
0.3 4.1 GO:0000478 endonucleolytic cleavage involved in rRNA processing(GO:0000478)
0.2 4.1 GO:0075713 establishment of integrated proviral latency(GO:0075713)
0.2 4.0 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.0 3.9 GO:0031398 positive regulation of protein ubiquitination(GO:0031398)
0.6 3.8 GO:0002386 immune response in mucosal-associated lymphoid tissue(GO:0002386)
0.1 3.7 GO:0071431 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.2 3.6 GO:0006265 DNA topological change(GO:0006265)
0.2 3.5 GO:0051315 attachment of mitotic spindle microtubules to kinetochore(GO:0051315)
0.1 3.5 GO:0000291 nuclear-transcribed mRNA catabolic process, exonucleolytic(GO:0000291)
0.1 3.4 GO:0043968 histone H2A acetylation(GO:0043968)
0.1 3.4 GO:0000387 spliceosomal snRNP assembly(GO:0000387)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 355 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 35.0 GO:0005654 nucleoplasm(GO:0005654)
0.0 14.6 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 12.7 GO:0005730 nucleolus(GO:0005730)
0.1 11.0 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.0 8.7 GO:0005802 trans-Golgi network(GO:0005802)
0.0 7.2 GO:0005813 centrosome(GO:0005813)
0.1 7.0 GO:0015030 Cajal body(GO:0015030)
0.0 6.4 GO:0005814 centriole(GO:0005814)
0.1 5.7 GO:0005657 replication fork(GO:0005657)
0.0 5.7 GO:0016605 PML body(GO:0016605)
0.5 5.4 GO:0000439 core TFIIH complex(GO:0000439)
0.3 5.2 GO:0034709 methylosome(GO:0034709)
0.1 5.1 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.2 4.8 GO:0032040 small-subunit processome(GO:0032040)
0.1 4.8 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.2 4.7 GO:0042613 MHC class II protein complex(GO:0042613)
0.1 4.3 GO:0005871 kinesin complex(GO:0005871)
0.0 4.1 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 3.9 GO:0005637 nuclear inner membrane(GO:0005637)
0.2 3.6 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 634 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.6 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.2 5.1 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 5.0 GO:0051082 unfolded protein binding(GO:0051082)
0.0 4.9 GO:0043130 ubiquitin binding(GO:0043130)
0.0 4.3 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.6 4.0 GO:0044020 histone methyltransferase activity (H4-R3 specific)(GO:0044020)
0.1 3.7 GO:0000030 mannosyltransferase activity(GO:0000030)
0.0 3.6 GO:0003924 GTPase activity(GO:0003924)
0.1 3.5 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 3.4 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.1 3.4 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 3.3 GO:0008186 RNA-dependent ATPase activity(GO:0008186)
0.2 3.2 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.1 3.2 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.1 3.1 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.1 3.1 GO:0008536 Ran GTPase binding(GO:0008536)
0.1 3.0 GO:0000049 tRNA binding(GO:0000049)
0.0 3.0 GO:0003777 microtubule motor activity(GO:0003777)
0.1 2.9 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 2.8 GO:0003697 single-stranded DNA binding(GO:0003697)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 78 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.2 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.1 9.0 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 6.1 PID_PLK1_PATHWAY PLK1 signaling events
0.0 4.9 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 3.8 PID_E2F_PATHWAY E2F transcription factor network
0.1 3.6 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.1 3.4 PID_ATR_PATHWAY ATR signaling pathway
0.0 2.7 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 2.5 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.0 2.4 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 2.3 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 2.2 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 2.1 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.1 1.9 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.8 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 1.7 PID_S1P_META_PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 1.6 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 1.5 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 1.4 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 1.4 PID_CMYB_PATHWAY C-MYB transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 155 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 14.4 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.2 9.1 REACTOME_TRANSPORT_OF_MATURE_MRNA_DERIVED_FROM_AN_INTRONLESS_TRANSCRIPT Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript
0.2 8.2 REACTOME_RNA_POL_I_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.1 7.2 REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.2 6.8 REACTOME_KINESINS Genes involved in Kinesins
0.0 5.6 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.2 4.7 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.2 4.1 REACTOME_INTEGRATION_OF_PROVIRUS Genes involved in Integration of provirus
0.3 3.6 REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.1 3.6 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.2 3.5 REACTOME_POL_SWITCHING Genes involved in Polymerase switching
0.1 3.4 REACTOME_DOUBLE_STRAND_BREAK_REPAIR Genes involved in Double-Strand Break Repair
0.1 2.8 REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Activation of the pre-replicative complex
0.1 2.7 REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.1 2.7 REACTOME_METABOLISM_OF_NON_CODING_RNA Genes involved in Metabolism of non-coding RNA
0.1 2.5 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.1 2.5 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1 2.5 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.1 2.4 REACTOME_PREFOLDIN_MEDIATED_TRANSFER_OF_SUBSTRATE_TO_CCT_TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.0 2.4 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides