Motif ID: ELF3_EHF

Z-value: 0.981

Transcription factors associated with ELF3_EHF:

Gene SymbolEntrez IDGene Name
EHF ENSG00000135373.8 EHF
ELF3 ENSG00000163435.11 ELF3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ELF3hg19_v2_chr1_+_201979645_2019797210.501.3e-02Click!
EHFhg19_v2_chr11_+_34642656_346426820.481.7e-02Click!


Activity profile for motif ELF3_EHF.

activity profile for motif ELF3_EHF


Sorted Z-values histogram for motif ELF3_EHF

Sorted Z-values for motif ELF3_EHF



Network of associatons between targets according to the STRING database.



First level regulatory network of ELF3_EHF

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_-_19975665 3.519 ENST00000295824.9
ENST00000389256.4
 EFHB

EF-hand domain family, member B

chr7_+_142829162 3.008 ENST00000291009.3
 PIP
prolactin-induced protein
chr20_+_31823792 2.366 ENST00000375413.4
ENST00000354297.4
ENST00000375422.2
 BPIFA1


BPI fold containing family A, member 1


chr9_-_138391692 2.251 ENST00000429260.2
 C9orf116
chromosome 9 open reading frame 116
chr6_-_32557610 2.191 ENST00000360004.5
 HLA-DRB1
major histocompatibility complex, class II, DR beta 1
chr1_-_146696901 2.039 ENST00000369272.3
ENST00000441068.2
 FMO5

flavin containing monooxygenase 5

chr3_-_47324079 2.004 ENST00000352910.4
 KIF9
kinesin family member 9
chr1_-_146697185 1.938 ENST00000533174.1
ENST00000254090.4
 FMO5

flavin containing monooxygenase 5

chr12_-_58329819 1.870 ENST00000551421.1
 RP11-620J15.3
RP11-620J15.3
chr3_-_47324008 1.848 ENST00000425853.1
 KIF9
kinesin family member 9
chr3_-_47324242 1.759 ENST00000456548.1
ENST00000432493.1
ENST00000335044.2
ENST00000444589.2
 KIF9



kinesin family member 9



chr19_+_41497178 1.559 ENST00000324071.4
 CYP2B6
cytochrome P450, family 2, subfamily B, polypeptide 6
chr9_+_34458771 1.544 ENST00000437363.1
ENST00000242317.4
 DNAI1

dynein, axonemal, intermediate chain 1

chr11_+_111789580 1.466 ENST00000278601.5
 C11orf52
chromosome 11 open reading frame 52
chr2_-_28113965 1.459 ENST00000302188.3
 RBKS
ribokinase
chr6_-_109761707 1.433 ENST00000520723.1
ENST00000518648.1
ENST00000417394.2
 PPIL6


peptidylprolyl isomerase (cyclophilin)-like 6


chr3_-_47324060 1.407 ENST00000452770.2
 KIF9
kinesin family member 9
chr1_-_169337176 1.402 ENST00000472647.1
ENST00000367811.3
 NME7

NME/NM23 family member 7

chr1_-_20126365 1.380 ENST00000294543.6
ENST00000375122.2
 TMCO4

transmembrane and coiled-coil domains 4

chr3_+_100354442 1.316 ENST00000475887.1
 GPR128
G protein-coupled receptor 128

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 266 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.8 GO:0071801 regulation of podosome assembly(GO:0071801)
0.7 4.0 GO:0002386 immune response in mucosal-associated lymphoid tissue(GO:0002386)
0.1 3.1 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.1 2.6 GO:0070233 negative regulation of T cell apoptotic process(GO:0070233)
0.0 2.5 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.4 2.2 GO:0002399 MHC class II protein complex assembly(GO:0002399)
0.2 2.2 GO:1990416 cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.1 2.1 GO:0031573 intra-S DNA damage checkpoint(GO:0031573)
0.1 2.0 GO:0036158 outer dynein arm assembly(GO:0036158)
0.6 1.7 GO:0070666 positive regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060369) regulation of mast cell proliferation(GO:0070666) positive regulation of mast cell proliferation(GO:0070668)
0.1 1.7 GO:0009756 carbohydrate mediated signaling(GO:0009756)
0.0 1.7 GO:0042073 intraciliary transport(GO:0042073)
0.0 1.7 GO:0016266 O-glycan processing(GO:0016266)
0.1 1.6 GO:0006895 Golgi to endosome transport(GO:0006895)
0.3 1.5 GO:0019303 D-ribose catabolic process(GO:0019303)
0.0 1.5 GO:0009060 aerobic respiration(GO:0009060)
0.1 1.4 GO:0006228 UTP biosynthetic process(GO:0006228)
0.1 1.4 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.2 1.3 GO:0045819 positive regulation of glycogen catabolic process(GO:0045819)
0.2 1.3 GO:1903237 negative regulation of leukocyte tethering or rolling(GO:1903237)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 109 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.6 GO:0005871 kinesin complex(GO:0005871)
0.0 3.2 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 2.2 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 1.9 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.2 1.8 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.3 1.7 GO:0034666 integrin alpha2-beta1 complex(GO:0034666)
0.1 1.5 GO:0036157 outer dynein arm(GO:0036157)
0.1 1.1 GO:0030991 intraciliary transport particle A(GO:0030991)
0.0 1.1 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 1.1 GO:0042101 T cell receptor complex(GO:0042101)
0.0 1.1 GO:0031228 intrinsic component of Golgi membrane(GO:0031228)
0.0 1.1 GO:0035580 specific granule lumen(GO:0035580)
0.1 1.0 GO:0030870 Mre11 complex(GO:0030870)
0.1 1.0 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.0 0.9 GO:0043197 dendritic spine(GO:0043197) neuron spine(GO:0044309)
0.1 0.8 GO:1902560 GMP reductase complex(GO:1902560)
0.1 0.8 GO:0097255 R2TP complex(GO:0097255)
0.0 0.8 GO:0005813 centrosome(GO:0005813)
0.0 0.8 GO:0014704 intercalated disc(GO:0014704)
0.2 0.7 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 167 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.8 GO:0003777 microtubule motor activity(GO:0003777)
0.6 4.5 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.1 3.1 GO:0008392 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.2 3.0 GO:0019864 IgG binding(GO:0019864)
0.1 2.5 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 2.5 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.0 2.5 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.7 2.2 GO:0004676 3-phosphoinositide-dependent protein kinase activity(GO:0004676)
0.0 1.9 GO:0019843 rRNA binding(GO:0019843)
0.4 1.8 GO:0061628 H3K27me3 modified histone binding(GO:0061628)
0.2 1.8 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.1 1.8 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.2 1.7 GO:0043208 glycosphingolipid binding(GO:0043208)
0.0 1.5 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 1.4 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.1 1.3 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1 1.3 GO:0045504 dynein heavy chain binding(GO:0045504)
0.2 1.2 GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.1 1.2 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.2 1.1 GO:0047756 chondroitin 4-sulfotransferase activity(GO:0047756)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.7 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.1 2.9 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 2.8 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.5 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 1.3 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.2 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 1.0 PID_PI3KCI_PATHWAY Class I PI3K signaling events
0.0 1.0 PID_RB_1PATHWAY Regulation of retinoblastoma protein
0.0 0.9 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 0.8 PID_PTP1B_PATHWAY Signaling events mediated by PTP1B
0.0 0.8 PID_MYC_PATHWAY C-MYC pathway
0.0 0.7 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 0.7 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.6 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.6 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.0 0.5 PID_ARF6_PATHWAY Arf6 signaling events
0.0 0.4 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.4 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.3 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.3 PID_ARF_3PATHWAY Arf1 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.3 REACTOME_KINESINS Genes involved in Kinesins
0.2 3.1 REACTOME_XENOBIOTICS Genes involved in Xenobiotics
0.1 3.1 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1 2.2 REACTOME_CTLA4_INHIBITORY_SIGNALING Genes involved in CTLA4 inhibitory signaling
0.1 2.1 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 1.9 REACTOME_PECAM1_INTERACTIONS Genes involved in PECAM1 interactions
0.0 1.4 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 1.2 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 1.1 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 1.1 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 1.0 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.9 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.8 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.0 0.8 REACTOME_PURINE_SALVAGE Genes involved in Purine salvage
0.0 0.8 REACTOME_INTERFERON_GAMMA_SIGNALING Genes involved in Interferon gamma signaling
0.0 0.7 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 0.7 REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0 0.6 REACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.0 0.5 REACTOME_REVERSIBLE_HYDRATION_OF_CARBON_DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.0 0.5 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase