Motif ID: ELK4_ETV5_ELK1_ELK3_ELF4

Z-value: 2.399

Transcription factors associated with ELK4_ETV5_ELK1_ELK3_ELF4:

Gene SymbolEntrez IDGene Name
ELF4 ENSG00000102034.12 ELF4
ELK1 ENSG00000126767.13 ELK1
ELK3 ENSG00000111145.3 ELK3
ELK4 ENSG00000158711.9 ELK4
ETV5 ENSG00000244405.3 ETV5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ELK3hg19_v2_chr12_+_96588143_96588185-0.752.4e-05Click!
ETV5hg19_v2_chr3_-_185826855_185826911-0.602.1e-03Click!
ELF4hg19_v2_chrX_-_129244655_129244697,
hg19_v2_chrX_-_129244454_129244488		-0.592.6e-03Click!
ELK1hg19_v2_chrX_-_47509887_47509990-0.262.3e-01Click!
ELK4hg19_v2_chr1_-_205601064_2056010900.242.6e-01Click!


Activity profile for motif ELK4_ETV5_ELK1_ELK3_ELF4.

activity profile for motif ELK4_ETV5_ELK1_ELK3_ELF4


Sorted Z-values histogram for motif ELK4_ETV5_ELK1_ELK3_ELF4

Sorted Z-values for motif ELK4_ETV5_ELK1_ELK3_ELF4



Network of associatons between targets according to the STRING database.



First level regulatory network of ELK4_ETV5_ELK1_ELK3_ELF4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_+_80574854 24.973 ENST00000305904.6
ENST00000568035.1
 DYNLRB2

dynein, light chain, roadblock-type 2

chr3_-_47324079 20.233 ENST00000352910.4
 KIF9
kinesin family member 9
chr3_-_47324242 19.977 ENST00000456548.1
ENST00000432493.1
ENST00000335044.2
ENST00000444589.2
 KIF9



kinesin family member 9



chr3_-_47324008 19.685 ENST00000425853.1
 KIF9
kinesin family member 9
chr17_-_19281203 17.559 ENST00000487415.2
 B9D1
B9 protein domain 1
chr17_+_45908974 17.479 ENST00000269025.4
 LRRC46
leucine rich repeat containing 46
chr15_+_71184931 15.406 ENST00000560369.1
ENST00000260382.5
 LRRC49

leucine rich repeat containing 49

chr3_-_47324060 14.292 ENST00000452770.2
 KIF9
kinesin family member 9
chr15_+_71185148 13.307 ENST00000443425.2
ENST00000560755.1
 LRRC49

leucine rich repeat containing 49

chr12_-_58329819 12.467 ENST00000551421.1
 RP11-620J15.3
RP11-620J15.3
chr11_-_47736896 12.190 ENST00000525123.1
ENST00000528244.1
ENST00000532595.1
ENST00000529154.1
ENST00000530969.1
 AGBL2




ATP/GTP binding protein-like 2




chr1_-_169337176 12.094 ENST00000472647.1
ENST00000367811.3
 NME7

NME/NM23 family member 7

chr2_-_99771373 12.093 ENST00000393483.3
 TSGA10
testis specific, 10
chr1_+_217804661 11.036 ENST00000366933.4
 SPATA17
spermatogenesis associated 17
chr3_+_108308513 10.892 ENST00000361582.3
 DZIP3
DAZ interacting zinc finger protein 3
chr17_-_4689649 10.143 ENST00000441199.2
ENST00000416307.2
 VMO1

vitelline membrane outer layer 1 homolog (chicken)

chr3_-_122134882 9.856 ENST00000330689.4
 WDR5B
WD repeat domain 5B
chr3_-_197676740 9.682 ENST00000452735.1
ENST00000453254.1
ENST00000455191.1
 IQCG


IQ motif containing G


chr19_+_32896697 9.394 ENST00000586987.1
 DPY19L3
dpy-19-like 3 (C. elegans)
chr6_+_33048222 9.380 ENST00000428835.1
 HLA-DPB1
major histocompatibility complex, class II, DP beta 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 1,023 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 66.7 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
1.7 66.1 GO:0071801 regulation of podosome assembly(GO:0071801)
7.7 30.7 GO:0072139 glomerular parietal epithelial cell differentiation(GO:0072139)
0.8 26.0 GO:0043968 histone H2A acetylation(GO:0043968)
1.2 25.0 GO:0036158 outer dynein arm assembly(GO:0036158)
0.7 24.9 GO:0003341 cilium movement(GO:0003341)
0.3 24.9 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
1.2 24.3 GO:0019614 catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424)
0.1 20.4 GO:0060271 cilium morphogenesis(GO:0060271)
0.6 19.3 GO:0051131 chaperone-mediated protein complex assembly(GO:0051131)
0.3 19.3 GO:0042733 embryonic digit morphogenesis(GO:0042733)
0.2 17.8 GO:0032729 positive regulation of interferon-gamma production(GO:0032729)
2.2 17.6 GO:0018103 protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.7 15.8 GO:0097034 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.7 15.7 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.1 14.8 GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent(GO:0002479)
1.0 14.2 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.3 14.1 GO:0010501 RNA secondary structure unwinding(GO:0010501)
1.2 13.7 GO:0042073 intraciliary transport(GO:0042073)
1.5 13.3 GO:0007288 sperm axoneme assembly(GO:0007288)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 340 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 50.9 GO:0002102 podosome(GO:0002102)
1.5 42.3 GO:0030992 intraciliary transport particle B(GO:0030992)
3.3 36.1 GO:0036157 outer dynein arm(GO:0036157)
1.9 35.5 GO:0036038 MKS complex(GO:0036038)
0.3 34.7 GO:0005874 microtubule(GO:0005874)
0.2 27.7 GO:0031514 motile cilium(GO:0031514)
0.3 27.0 GO:0036064 ciliary basal body(GO:0036064)
1.2 24.3 GO:0042613 MHC class II protein complex(GO:0042613)
1.1 20.5 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.2 20.2 GO:0005637 nuclear inner membrane(GO:0005637)
0.3 18.6 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.2 18.0 GO:0005813 centrosome(GO:0005813)
0.5 16.3 GO:0032040 small-subunit processome(GO:0032040)
2.3 15.8 GO:0000408 EKC/KEOPS complex(GO:0000408)
1.7 15.5 GO:1990111 spermatoproteasome complex(GO:1990111)
0.2 15.3 GO:0005814 centriole(GO:0005814)
0.1 14.6 GO:0008021 synaptic vesicle(GO:0008021)
0.7 14.4 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.2 14.3 GO:0005801 cis-Golgi network(GO:0005801)
0.2 14.3 GO:0015030 Cajal body(GO:0015030)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 576 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 136.9 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.6 45.2 GO:0003777 microtubule motor activity(GO:0003777)
0.0 38.1 GO:0003677 DNA binding(GO:0003677)
1.0 27.7 GO:0045505 dynein intermediate chain binding(GO:0045505)
2.5 22.9 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
0.3 22.6 GO:0016279 protein-lysine N-methyltransferase activity(GO:0016279)
0.4 21.9 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.3 21.3 GO:0042805 actinin binding(GO:0042805)
0.7 18.9 GO:0000030 mannosyltransferase activity(GO:0000030)
2.0 17.6 GO:0008158 hedgehog receptor activity(GO:0008158)
0.4 17.1 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.1 17.0 GO:0051087 chaperone binding(GO:0051087)
0.5 16.7 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
1.0 16.4 GO:0045503 dynein light chain binding(GO:0045503)
0.2 15.4 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
1.1 14.9 GO:0032395 MHC class II receptor activity(GO:0032395)
0.5 14.9 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
1.9 13.5 GO:0044020 histone methyltransferase activity (H4-R3 specific)(GO:0044020)
0.3 12.7 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.2 12.6 GO:0004402 histone acetyltransferase activity(GO:0004402)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 14.5 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2 14.3 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.3 13.0 PID_MYC_PATHWAY C-MYC pathway
0.1 8.5 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.1 7.6 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.1 6.4 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.2 5.6 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 5.2 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 5.1 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 4.2 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.1 4.2 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.1 3.7 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.1 3.5 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 3.3 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 3.3 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.1 3.0 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1 2.9 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.2 2.8 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.1 2.6 PID_S1P_META_PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.1 2.6 PID_ARF_3PATHWAY Arf1 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 127 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 80.7 REACTOME_GENERIC_TRANSCRIPTION_PATHWAY Genes involved in Generic Transcription Pathway
1.2 45.3 REACTOME_KINESINS Genes involved in Kinesins
0.3 27.4 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.9 21.5 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.2 17.3 REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.5 13.2 REACTOME_FORMATION_OF_INCISION_COMPLEX_IN_GG_NER Genes involved in Formation of incision complex in GG-NER
0.4 11.6 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.3 10.5 REACTOME_EXTENSION_OF_TELOMERES Genes involved in Extension of Telomeres
0.1 10.5 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.3 10.0 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.1 9.0 REACTOME_RNA_POL_I_RNA_POL_III_AND_MITOCHONDRIAL_TRANSCRIPTION Genes involved in RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
0.2 8.6 REACTOME_NEP_NS2_INTERACTS_WITH_THE_CELLULAR_EXPORT_MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.2 8.4 REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.2 8.4 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.3 7.9 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.4 7.1 REACTOME_SIGNALING_BY_NOTCH4 Genes involved in Signaling by NOTCH4
0.2 6.8 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.1 6.5 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.1 6.3 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.5 6.1 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_LATE_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane