Motif ID: EMX2

Z-value: 0.530


Transcription factors associated with EMX2:

Gene SymbolEntrez IDGene Name
EMX2 ENSG00000170370.10 EMX2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
EMX2hg19_v2_chr10_+_119301928_119301955-0.067.7e-01Click!


Activity profile for motif EMX2.

activity profile for motif EMX2


Sorted Z-values histogram for motif EMX2

Sorted Z-values for motif EMX2



Network of associatons between targets according to the STRING database.



First level regulatory network of EMX2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_63638339 2.853 ENST00000343837.3
ENST00000469440.1
SNTN

sentan, cilia apical structure protein

chr4_-_100356551 2.288 ENST00000209665.4
ADH7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr6_-_33041378 1.785 ENST00000428995.1
HLA-DPA1
major histocompatibility complex, class II, DP alpha 1
chr4_-_100356291 1.571 ENST00000476959.1
ENST00000482593.1
ADH7

alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide

chr2_+_228736335 1.452 ENST00000440997.1
ENST00000545118.1
DAW1

dynein assembly factor with WDR repeat domains 1

chr11_-_26593779 1.381 ENST00000529533.1
MUC15
mucin 15, cell surface associated
chr11_-_63376013 1.157 ENST00000540943.1
PLA2G16
phospholipase A2, group XVI
chr11_-_26593677 1.112 ENST00000527569.1
MUC15
mucin 15, cell surface associated
chr21_-_43735628 1.108 ENST00000291525.10
ENST00000518498.1
TFF3

trefoil factor 3 (intestinal)

chr5_-_137475071 1.079 ENST00000265191.2
NME5
NME/NM23 family member 5
chr11_-_26593649 1.077 ENST00000455601.2
MUC15
mucin 15, cell surface associated
chr19_-_41388657 1.016 ENST00000301146.4
ENST00000291764.3
CYP2A7

cytochrome P450, family 2, subfamily A, polypeptide 7

chr21_-_43735446 0.952 ENST00000398431.2
TFF3
trefoil factor 3 (intestinal)
chr16_-_28634874 0.944 ENST00000395609.1
ENST00000350842.4
SULT1A1

sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1

chr12_-_68696652 0.934 ENST00000539972.1
MDM1
Mdm1 nuclear protein homolog (mouse)
chr3_+_113616317 0.895 ENST00000440446.2
ENST00000488680.1
GRAMD1C

GRAM domain containing 1C

chr12_-_71533055 0.880 ENST00000552128.1
TSPAN8
tetraspanin 8
chr8_-_133687813 0.811 ENST00000250173.1
ENST00000519595.1
LRRC6

leucine rich repeat containing 6

chr1_-_86848760 0.781 ENST00000460698.2
ODF2L
outer dense fiber of sperm tails 2-like
chr8_-_133687778 0.752 ENST00000518642.1
LRRC6
leucine rich repeat containing 6

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 3.9 GO:0010430 fatty acid omega-oxidation(GO:0010430)
0.0 3.5 GO:0016266 O-glycan processing(GO:0016266)
0.2 2.2 GO:0036159 inner dynein arm assembly(GO:0036159)
0.1 1.3 GO:0009756 carbohydrate mediated signaling(GO:0009756)
0.1 1.2 GO:0046485 ether lipid metabolic process(GO:0046485)
0.0 1.2 GO:0032729 positive regulation of interferon-gamma production(GO:0032729)
0.1 1.1 GO:0003351 epithelial cilium movement(GO:0003351)
0.0 1.1 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.1 0.9 GO:0046600 negative regulation of centriole replication(GO:0046600)
0.0 0.9 GO:0006068 ethanol catabolic process(GO:0006068)
0.0 0.9 GO:1900047 negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
0.1 0.7 GO:1990253 cellular response to leucine starvation(GO:1990253)
0.0 0.7 GO:0031573 intra-S DNA damage checkpoint(GO:0031573)
0.2 0.6 GO:0016095 polyprenol catabolic process(GO:0016095)
0.0 0.6 GO:0003298 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 0.5 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.0 0.5 GO:0006491 N-glycan processing(GO:0006491)
0.0 0.5 GO:0000038 very long-chain fatty acid metabolic process(GO:0000038)
0.1 0.4 GO:0060084 synaptic transmission involved in micturition(GO:0060084)
0.0 0.4 GO:0070294 renal sodium ion absorption(GO:0070294)

Gene overrepresentation in cellular_component category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.5 GO:0005796 Golgi lumen(GO:0005796)
0.1 1.8 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 1.4 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.1 0.7 GO:1990131 Gtr1-Gtr2 GTPase complex(GO:1990131)
0.1 0.5 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.0 0.4 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.3 GO:0005579 membrane attack complex(GO:0005579)
0.0 0.2 GO:1990075 kinesin II complex(GO:0016939) periciliary membrane compartment(GO:1990075)
0.0 0.2 GO:0030061 mitochondrial crista(GO:0030061)
0.0 0.2 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.2 GO:0036038 MKS complex(GO:0036038)
0.0 0.2 GO:0016442 RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.0 0.1 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.0 0.1 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 0.1 GO:0045272 plasma membrane respiratory chain complex I(GO:0045272)
0.0 0.1 GO:0044294 dendritic growth cone(GO:0044294)
0.0 0.1 GO:0031313 extrinsic component of external side of plasma membrane(GO:0031232) extrinsic component of endosome membrane(GO:0031313)
0.0 0.0 GO:0000126 transcription factor TFIIIB complex(GO:0000126)
0.0 0.0 GO:0097179 protease inhibitor complex(GO:0097179)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 3.9 GO:0004031 aldehyde oxidase activity(GO:0004031)
0.1 1.8 GO:0032395 MHC class II receptor activity(GO:0032395)
0.2 1.2 GO:0052740 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.0 1.2 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.1 1.1 GO:0008392 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.1 0.9 GO:0050294 flavonol 3-sulfotransferase activity(GO:0047894) steroid sulfotransferase activity(GO:0050294)
0.0 0.8 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.2 0.6 GO:0047751 3-oxo-5-alpha-steroid 4-dehydrogenase activity(GO:0003865) steroid dehydrogenase activity, acting on the CH-CH group of donors(GO:0033765) cholestenone 5-alpha-reductase activity(GO:0047751)
0.0 0.6 GO:0032393 MHC class I receptor activity(GO:0032393)
0.0 0.6 GO:0017081 chloride channel regulator activity(GO:0017081)
0.0 0.6 GO:0016505 peptidase activator activity involved in apoptotic process(GO:0016505)
0.0 0.6 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 0.5 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.0 0.5 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.1 0.4 GO:0004447 iodide peroxidase activity(GO:0004447)
0.1 0.4 GO:0022850 serotonin-gated cation channel activity(GO:0022850)
0.0 0.4 GO:0008417 fucosyltransferase activity(GO:0008417)
0.0 0.4 GO:0070513 death domain binding(GO:0070513)
0.0 0.4 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.1 0.3 GO:0019770 IgG receptor activity(GO:0019770)

Gene overrepresentation in C2:CP category:

Showing 1 to 2 of 2 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.2 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.9 PID_IL4_2PATHWAY IL4-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 4.0 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.1 3.6 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 1.7 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1 1.2 REACTOME_ACYL_CHAIN_REMODELLING_OF_PS Genes involved in Acyl chain remodelling of PS
0.0 0.9 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 0.7 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.0 0.6 REACTOME_ANDROGEN_BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.0 0.4 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.3 REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 0.3 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.3 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.2 REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease