Motif ID: EN1_ESX1_GBX1

Z-value: 0.524

Transcription factors associated with EN1_ESX1_GBX1:

Gene SymbolEntrez IDGene Name
EN1 ENSG00000163064.6 EN1
ESX1 ENSG00000123576.5 ESX1
GBX1 ENSG00000164900.4 GBX1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
GBX1hg19_v2_chr7_-_150864635_150864785-0.433.7e-02Click!
EN1hg19_v2_chr2_-_119605253_119605264-0.135.4e-01Click!
ESX1hg19_v2_chrX_-_103499602_103499617-0.096.6e-01Click!


Activity profile for motif EN1_ESX1_GBX1.

activity profile for motif EN1_ESX1_GBX1


Sorted Z-values histogram for motif EN1_ESX1_GBX1

Sorted Z-values for motif EN1_ESX1_GBX1



Network of associatons between targets according to the STRING database.



First level regulatory network of EN1_ESX1_GBX1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_169013666 1.222 ENST00000359299.3
 ANXA10
annexin A10
chr5_+_135394840 1.030 ENST00000503087.1
 TGFBI
transforming growth factor, beta-induced, 68kDa
chr17_+_59489112 0.992 ENST00000335108.2
 C17orf82
chromosome 17 open reading frame 82
chr12_-_28122980 0.977 ENST00000395868.3
ENST00000534890.1
 PTHLH

parathyroid hormone-like hormone

chr5_+_31193847 0.971 ENST00000514738.1
ENST00000265071.2
 CDH6

cadherin 6, type 2, K-cadherin (fetal kidney)

chr17_-_39211463 0.948 ENST00000542910.1
ENST00000398477.1
 KRTAP2-2

keratin associated protein 2-2

chr12_-_89746173 0.845 ENST00000308385.6
 DUSP6
dual specificity phosphatase 6
chr12_-_28123206 0.790 ENST00000542963.1
ENST00000535992.1
 PTHLH

parathyroid hormone-like hormone

chr20_+_3776371 0.786 ENST00000245960.5
 CDC25B
cell division cycle 25B
chr12_-_10978957 0.781 ENST00000240619.2
 TAS2R10
taste receptor, type 2, member 10
chr5_+_52776228 0.730 ENST00000256759.3
 FST
follistatin
chr2_+_158114051 0.710 ENST00000259056.4
 GALNT5
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)
chr1_+_209878182 0.638 ENST00000367027.3
 HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chrX_-_153602991 0.630 ENST00000369850.3
ENST00000422373.1
 FLNA

filamin A, alpha

chr11_-_121986923 0.610 ENST00000560104.1
 BLID
BH3-like motif containing, cell death inducer
chr6_+_130339710 0.594 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
 L3MBTL3


l(3)mbt-like 3 (Drosophila)


chr5_+_52776449 0.577 ENST00000396947.3
 FST
follistatin
chr12_+_107712173 0.567 ENST00000280758.5
ENST00000420571.2
 BTBD11

BTB (POZ) domain containing 11

chr4_-_57547870 0.551 ENST00000381260.3
ENST00000420433.1
ENST00000554144.1
ENST00000557328.1
 HOPX



HOP homeobox



chr4_-_57547454 0.544 ENST00000556376.2
 HOPX
HOP homeobox

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 121 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.6 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.0 1.4 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.1 1.3 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.0 1.2 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.3 0.8 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.1 0.8 GO:0007144 female meiosis I(GO:0007144)
0.1 0.7 GO:0050776 regulation of immune response(GO:0050776)
0.0 0.7 GO:0007252 I-kappaB phosphorylation(GO:0007252)
0.1 0.6 GO:0007079 mitotic chromosome movement towards spindle pole(GO:0007079)
0.1 0.6 GO:0016479 negative regulation of transcription from RNA polymerase I promoter(GO:0016479)
0.0 0.6 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.6 GO:0006704 glucocorticoid biosynthetic process(GO:0006704)
0.0 0.6 GO:0006346 methylation-dependent chromatin silencing(GO:0006346)
0.0 0.6 GO:0048305 immunoglobulin secretion(GO:0048305)
0.1 0.5 GO:0006689 ganglioside catabolic process(GO:0006689)
0.0 0.5 GO:0048733 sebaceous gland development(GO:0048733)
0.0 0.5 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.1 0.4 GO:0002644 negative regulation of tolerance induction(GO:0002644) positive regulation of interleukin-4 biosynthetic process(GO:0045404)
0.1 0.4 GO:0014034 neural crest cell fate commitment(GO:0014034)
0.1 0.4 GO:0090119 vesicle-mediated cholesterol transport(GO:0090119)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.9 GO:0045095 keratin filament(GO:0045095)
0.1 0.7 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 0.7 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.2 0.6 GO:0031523 Myb complex(GO:0031523)
0.0 0.6 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.6 GO:0008385 IkappaB kinase complex(GO:0008385)
0.1 0.5 GO:0005889 hydrogen:potassium-exchanging ATPase complex(GO:0005889)
0.1 0.5 GO:0016013 syntrophin complex(GO:0016013)
0.0 0.5 GO:0033093 Weibel-Palade body(GO:0033093)
0.0 0.4 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.1 0.3 GO:0005607 laminin-2 complex(GO:0005607)
0.0 0.3 GO:0030897 HOPS complex(GO:0030897)
0.0 0.3 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.3 GO:0031089 platelet dense granule lumen(GO:0031089)
0.0 0.3 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.0 0.3 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.3 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.0 0.2 GO:0005863 striated muscle myosin thick filament(GO:0005863)
0.0 0.2 GO:0036449 microtubule minus-end(GO:0036449)
0.0 0.2 GO:0030123 AP-3 adaptor complex(GO:0030123)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 75 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.8 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.0 1.5 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 1.4 GO:0033038 bitter taste receptor activity(GO:0033038)
0.1 1.3 GO:0048185 activin binding(GO:0048185)
0.0 1.0 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.8 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.7 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.7 GO:0004383 guanylate cyclase activity(GO:0004383)
0.2 0.6 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.2 0.6 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
0.1 0.6 GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828)
0.0 0.6 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.0 0.6 GO:0008327 methyl-CpG binding(GO:0008327)
0.1 0.5 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.0 0.5 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.5 GO:0017166 vinculin binding(GO:0017166)
0.1 0.4 GO:0047374 methylumbelliferyl-acetate deacetylase activity(GO:0047374)
0.0 0.4 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 0.4 GO:0031489 myosin V binding(GO:0031489)
0.0 0.4 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)

Gene overrepresentation in C2:CP category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.2 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.2 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.0 1.2 PID_BMP_PATHWAY BMP receptor signaling
0.0 1.2 PID_TCR_PATHWAY TCR signaling in naïve CD4+ T cells
0.0 1.0 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.1 0.8 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.8 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 0.7 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.0 0.7 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.0 0.4 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.4 PID_LPA4_PATHWAY LPA4-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.9 REACTOME_AMYLOIDS Genes involved in Amyloids
0.0 1.7 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 0.9 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.0 0.9 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 0.8 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 0.8 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.6 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.5 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.0 0.5 REACTOME_STEROID_HORMONES Genes involved in Steroid hormones
0.0 0.5 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.5 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.0 0.4 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 0.4 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.4 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.4 REACTOME_CD28_DEPENDENT_VAV1_PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.4 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.3 REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.0 0.3 REACTOME_IRAK1_RECRUITS_IKK_COMPLEX Genes involved in IRAK1 recruits IKK complex
0.0 0.2 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.2 REACTOME_ABACAVIR_TRANSPORT_AND_METABOLISM Genes involved in Abacavir transport and metabolism