Motif ID: EN2_GBX2_LBX2

Z-value: 0.400

Transcription factors associated with EN2_GBX2_LBX2:

Gene SymbolEntrez IDGene Name
EN2 ENSG00000164778.4 EN2
GBX2 ENSG00000168505.6 GBX2
LBX2 ENSG00000179528.11 LBX2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
EN2hg19_v2_chr7_+_155250824_1552508240.174.3e-01Click!
GBX2hg19_v2_chr2_-_237076992_2370770120.087.0e-01Click!


Activity profile for motif EN2_GBX2_LBX2.

activity profile for motif EN2_GBX2_LBX2


Sorted Z-values histogram for motif EN2_GBX2_LBX2

Sorted Z-values for motif EN2_GBX2_LBX2



Network of associatons between targets according to the STRING database.



First level regulatory network of EN2_GBX2_LBX2

PNG image of the network

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Top targets:


Showing 1 to 20 of 186 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_-_39203519 1.524 ENST00000542137.1
ENST00000391419.3
 KRTAP2-1

keratin associated protein 2-1

chr12_+_7013897 0.984 ENST00000007969.8
ENST00000323702.5
 LRRC23

leucine rich repeat containing 23

chr12_+_7014064 0.974 ENST00000443597.2
 LRRC23
leucine rich repeat containing 23
chr1_+_40713573 0.949 ENST00000372766.3
 TMCO2
transmembrane and coiled-coil domains 2
chr1_+_171227069 0.945 ENST00000354841.4
 FMO1
flavin containing monooxygenase 1
chr5_-_35938674 0.836 ENST00000397366.1
ENST00000513623.1
ENST00000514524.1
ENST00000397367.2
 CAPSL



calcyphosine-like



chr16_+_53133070 0.711 ENST00000565832.1
 CHD9
chromodomain helicase DNA binding protein 9
chr4_-_138453606 0.675 ENST00000412923.2
ENST00000344876.4
ENST00000507846.1
ENST00000510305.1
 PCDH18



protocadherin 18



chr2_-_73460334 0.651 ENST00000258083.2
 PRADC1
protease-associated domain containing 1
chr17_-_39211463 0.471 ENST00000542910.1
ENST00000398477.1
 KRTAP2-2

keratin associated protein 2-2

chr6_-_26199471 0.453 ENST00000341023.1
 HIST1H2AD
histone cluster 1, H2ad
chr11_-_40315640 0.429 ENST00000278198.2
 LRRC4C
leucine rich repeat containing 4C
chr6_-_26199499 0.419 ENST00000377831.5
 HIST1H3D
histone cluster 1, H3d
chr8_-_10512569 0.409 ENST00000382483.3
 RP1L1
retinitis pigmentosa 1-like 1
chr9_+_1050331 0.383 ENST00000382255.3
ENST00000382251.3
ENST00000412350.2
 DMRT2


doublesex and mab-3 related transcription factor 2


chr4_-_105416039 0.343 ENST00000394767.2
 CXXC4
CXXC finger protein 4
chr7_-_122339162 0.320 ENST00000340112.2
 RNF133
ring finger protein 133
chr7_-_137028534 0.293 ENST00000348225.2
 PTN
pleiotrophin
chr6_+_39760129 0.287 ENST00000274867.4
 DAAM2
dishevelled associated activator of morphogenesis 2
chr7_-_137028498 0.275 ENST00000393083.2
 PTN
pleiotrophin

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 0.9 GO:0070995 NADPH oxidation(GO:0070995)
0.2 0.6 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) negative regulation of neuromuscular junction development(GO:1904397)
0.1 0.4 GO:0061055 myotome development(GO:0061055)
0.1 0.3 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.0 0.3 GO:0048023 positive regulation of melanin biosynthetic process(GO:0048023) positive regulation of secondary metabolite biosynthetic process(GO:1900378)
0.1 0.2 GO:0021524 visceral motor neuron differentiation(GO:0021524)
0.0 0.2 GO:0010520 regulation of reciprocal meiotic recombination(GO:0010520)
0.0 0.2 GO:0061669 spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.0 0.2 GO:0086016 AV node cell action potential(GO:0086016) AV node cell to bundle of His cell signaling(GO:0086027)
0.0 0.1 GO:1904899 regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
0.0 0.1 GO:0090425 hepatocyte cell migration(GO:0002194) otic placode formation(GO:0043049) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.0 0.1 GO:0015722 canalicular bile acid transport(GO:0015722)
0.0 0.1 GO:2000974 auditory receptor cell fate determination(GO:0042668) negative regulation of pro-B cell differentiation(GO:2000974)
0.0 0.1 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
0.0 0.1 GO:0070092 regulation of glucagon secretion(GO:0070092)
0.0 0.1 GO:0015811 L-alanine transport(GO:0015808) L-cystine transport(GO:0015811)
0.0 0.1 GO:0070901 mitochondrial tRNA methylation(GO:0070901)
0.0 0.1 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.0 0.1 GO:0042816 vitamin B6 metabolic process(GO:0042816)
0.0 0.1 GO:0034058 endosomal vesicle fusion(GO:0034058)

Gene overrepresentation in cellular_component category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.5 GO:0045095 keratin filament(GO:0045095)
0.1 0.2 GO:0032302 MutSbeta complex(GO:0032302)
0.0 0.2 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.0 0.2 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.1 GO:0035841 new growing cell tip(GO:0035841)
0.0 0.1 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 0.1 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.0 0.1 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.0 0.1 GO:0016013 syntrophin complex(GO:0016013)

Gene overrepresentation in molecular_function category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.9 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.1 0.6 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.1 0.2 GO:0000404 heteroduplex DNA loop binding(GO:0000404) double-strand/single-strand DNA junction binding(GO:0000406) dinucleotide repeat insertion binding(GO:0032181)
0.0 0.2 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.0 0.2 GO:0005549 odorant binding(GO:0005549)
0.0 0.1 GO:0005174 CD40 receptor binding(GO:0005174)
0.0 0.1 GO:0005275 amine transmembrane transporter activity(GO:0005275)
0.0 0.1 GO:0015180 L-alanine transmembrane transporter activity(GO:0015180) L-cystine transmembrane transporter activity(GO:0015184) alanine transmembrane transporter activity(GO:0022858)
0.0 0.1 GO:0050692 DBD domain binding(GO:0050692)
0.0 0.1 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)

Gene overrepresentation in C2:CP category:

Showing 1 to 1 of 1 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.6 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 1 of 1 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.8 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening