Motif ID: EOMES

Z-value: 0.639


Transcription factors associated with EOMES:

Gene SymbolEntrez IDGene Name
EOMES ENSG00000163508.8 EOMES

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
EOMEShg19_v2_chr3_-_27763803_277638220.184.0e-01Click!


Activity profile for motif EOMES.

activity profile for motif EOMES


Sorted Z-values histogram for motif EOMES

Sorted Z-values for motif EOMES



Network of associatons between targets according to the STRING database.



First level regulatory network of EOMES

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_116937636 1.734 ENST00000368581.4
ENST00000229554.5
ENST00000368580.4
 RSPH4A


radial spoke head 4 homolog A (Chlamydomonas)


chr22_-_50970506 1.333 ENST00000428989.2
ENST00000403326.1
 ODF3B

outer dense fiber of sperm tails 3B

chr14_+_96858433 1.197 ENST00000267584.4
 AK7
adenylate kinase 7
chr19_-_55677920 1.162 ENST00000524407.2
ENST00000526003.1
ENST00000534170.1
 DNAAF3


dynein, axonemal, assembly factor 3


chr15_-_56757329 1.144 ENST00000260453.3
 MNS1
meiosis-specific nuclear structural 1
chr7_+_6793740 1.043 ENST00000403107.1
ENST00000404077.1
ENST00000435395.1
ENST00000418406.1
 RSPH10B2



radial spoke head 10 homolog B2 (Chlamydomonas)



chr7_-_6010263 1.022 ENST00000455618.2
ENST00000405415.1
ENST00000404406.1
ENST00000542644.1
 RSPH10B



radial spoke head 10 homolog B (Chlamydomonas)



chr16_-_66959429 0.976 ENST00000420652.1
ENST00000299759.6
 RRAD

Ras-related associated with diabetes

chr6_+_163148973 0.863 ENST00000366888.2
 PACRG
PARK2 co-regulated
chr11_-_8615507 0.848 ENST00000431279.2
ENST00000418597.1
 STK33

serine/threonine kinase 33

chr17_-_19266045 0.812 ENST00000395616.3
 B9D1
B9 protein domain 1
chr3_-_113775328 0.760 ENST00000483766.1
ENST00000545063.1
ENST00000491000.1
ENST00000295878.3
 KIAA1407



KIAA1407



chr7_+_94285637 0.733 ENST00000482108.1
ENST00000488574.1
 PEG10

paternally expressed 10

chr7_+_89874524 0.683 ENST00000497910.1
 C7orf63
chromosome 7 open reading frame 63
chr4_-_16085314 0.657 ENST00000510224.1
 PROM1
prominin 1
chr7_+_89874483 0.651 ENST00000389297.4
ENST00000316089.8
 C7orf63

chromosome 7 open reading frame 63

chr8_+_81397876 0.646 ENST00000430430.1
 ZBTB10
zinc finger and BTB domain containing 10
chr4_-_16085340 0.634 ENST00000508167.1
 PROM1
prominin 1
chrY_+_15016725 0.621 ENST00000336079.3
 DDX3Y
DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
chr3_-_137834436 0.606 ENST00000327532.2
ENST00000467030.1
 DZIP1L

DAZ interacting zinc finger protein 1-like


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 121 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.0 GO:0035082 axoneme assembly(GO:0035082)
0.0 1.7 GO:0042733 embryonic digit morphogenesis(GO:0042733)
0.0 1.4 GO:0015949 nucleobase-containing small molecule interconversion(GO:0015949)
0.3 1.3 GO:2000768 glomerular parietal epithelial cell differentiation(GO:0072139) positive regulation of nephron tubule epithelial cell differentiation(GO:2000768)
0.0 1.3 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.1 1.1 GO:0070986 left/right axis specification(GO:0070986)
0.2 1.0 GO:1901842 negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.0 1.0 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.1 0.9 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.1 0.7 GO:0007079 mitotic chromosome movement towards spindle pole(GO:0007079)
0.1 0.7 GO:0070070 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.0 0.7 GO:0032703 negative regulation of interleukin-2 production(GO:0032703)
0.2 0.6 GO:1902361 mitochondrial pyruvate transport(GO:0006850) mitochondrial pyruvate transmembrane transport(GO:1902361)
0.1 0.6 GO:0000492 box C/D snoRNP assembly(GO:0000492)
0.0 0.6 GO:0034587 piRNA metabolic process(GO:0034587)
0.0 0.6 GO:0070493 thrombin receptor signaling pathway(GO:0070493)
0.1 0.5 GO:0090202 transcriptional activation by promoter-enhancer looping(GO:0071733) gene looping(GO:0090202) dsDNA loop formation(GO:0090579)
0.1 0.5 GO:2000490 negative regulation of hepatic stellate cell activation(GO:2000490)
0.1 0.5 GO:0038110 interleukin-2-mediated signaling pathway(GO:0038110)
0.0 0.5 GO:0032878 regulation of establishment or maintenance of cell polarity(GO:0032878)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 1.7 GO:0001534 radial spoke(GO:0001534)
0.1 1.7 GO:0036038 MKS complex(GO:0036038)
0.1 1.3 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.1 1.0 GO:0097255 R2TP complex(GO:0097255)
0.0 0.9 GO:0097225 sperm midpiece(GO:0097225)
0.1 0.7 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.1 0.7 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.0 0.7 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.6 GO:0031304 intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
0.0 0.5 GO:0060293 P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)
0.1 0.4 GO:0031933 telomeric heterochromatin(GO:0031933)
0.1 0.4 GO:0036396 MIS complex(GO:0036396) mRNA editing complex(GO:0045293)
0.0 0.4 GO:0005883 neurofilament(GO:0005883)
0.0 0.4 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0 0.4 GO:0043020 NADPH oxidase complex(GO:0043020)
0.0 0.4 GO:0005922 connexon complex(GO:0005922)
0.0 0.4 GO:0001741 XY body(GO:0001741)
0.0 0.4 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.4 GO:0032982 myosin filament(GO:0032982)
0.1 0.3 GO:0044305 calyx of Held(GO:0044305)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 82 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.9 GO:0042805 actinin binding(GO:0042805)
0.2 1.7 GO:0008158 hedgehog receptor activity(GO:0008158)
0.2 1.4 GO:0004127 cytidylate kinase activity(GO:0004127)
0.0 1.3 GO:0051018 protein kinase A binding(GO:0051018)
0.0 1.3 GO:0008186 ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186)
0.1 1.1 GO:0043141 ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.0 0.8 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 0.8 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.0 0.7 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.1 0.6 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.1 0.6 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.1 0.5 GO:0004911 interleukin-2 receptor activity(GO:0004911) interleukin-2 binding(GO:0019976)
0.1 0.5 GO:0047888 fatty acid peroxidase activity(GO:0047888)
0.0 0.5 GO:0008171 O-methyltransferase activity(GO:0008171)
0.1 0.4 GO:0097363 protein O-GlcNAc transferase activity(GO:0097363)
0.1 0.4 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.0 0.4 GO:0016842 amidine-lyase activity(GO:0016842)
0.0 0.4 GO:0015232 heme transporter activity(GO:0015232)
0.0 0.4 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0 0.4 GO:0003688 DNA replication origin binding(GO:0003688)

Gene overrepresentation in C2:CP category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.7 PID_MYC_PATHWAY C-MYC pathway
0.0 1.7 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 0.8 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 0.8 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.4 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.1 REACTOME_EXTENSION_OF_TELOMERES Genes involved in Extension of Telomeres
0.0 1.1 REACTOME_IRON_UPTAKE_AND_TRANSPORT Genes involved in Iron uptake and transport
0.0 0.5 REACTOME_IL_RECEPTOR_SHC_SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 0.4 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.0 0.4 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.4 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.4 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.3 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.3 REACTOME_REVERSIBLE_HYDRATION_OF_CARBON_DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.0 0.3 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.2 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.2 REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.0 0.2 REACTOME_IRAK1_RECRUITS_IKK_COMPLEX Genes involved in IRAK1 recruits IKK complex
0.0 0.2 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 0.2 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 0.1 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol