Motif ID: EP300

Z-value: 1.279


Transcription factors associated with EP300:

Gene SymbolEntrez IDGene Name
EP300 ENSG00000100393.9 EP300

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
EP300hg19_v2_chr22_+_41487711_41487798-0.281.8e-01Click!


Activity profile for motif EP300.

activity profile for motif EP300


Sorted Z-values histogram for motif EP300

Sorted Z-values for motif EP300



Network of associatons between targets according to the STRING database.



First level regulatory network of EP300

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_205419053 6.034 ENST00000367154.1
 LEMD1
LEM domain containing 1
chr1_+_20915409 5.086 ENST00000375071.3
 CDA
cytidine deaminase
chrX_-_153599578 3.342 ENST00000360319.4
ENST00000344736.4
 FLNA

filamin A, alpha

chr18_-_28681950 3.274 ENST00000251081.6
 DSC2
desmocollin 2
chr7_+_48128854 3.235 ENST00000436673.1
ENST00000429491.2
 UPP1

uridine phosphorylase 1

chr4_+_75311019 3.117 ENST00000502307.1
 AREG
amphiregulin
chr4_+_75310851 3.102 ENST00000395748.3
ENST00000264487.2
 AREG

amphiregulin

chr8_+_10530133 2.975 ENST00000304519.5
 C8orf74
chromosome 8 open reading frame 74
chr4_+_75480629 2.973 ENST00000380846.3
 AREGB
amphiregulin B
chr2_-_208030647 2.843 ENST00000309446.6
 KLF7
Kruppel-like factor 7 (ubiquitous)
chr4_+_8201091 2.727 ENST00000382521.3
ENST00000245105.3
ENST00000457650.2
ENST00000539824.1
 SH3TC1



SH3 domain and tetratricopeptide repeats 1



chr22_-_37640456 2.562 ENST00000405484.1
ENST00000441619.1
ENST00000406508.1
 RAC2


ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)


chr7_-_5569588 2.550 ENST00000417101.1
 ACTB
actin, beta
chr11_+_62623544 2.524 ENST00000377890.2
ENST00000377891.2
ENST00000377889.2
 SLC3A2


solute carrier family 3 (amino acid transporter heavy chain), member 2


chr1_-_20812690 2.523 ENST00000375078.3
 CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr11_+_62623621 2.491 ENST00000535296.1
 SLC3A2
solute carrier family 3 (amino acid transporter heavy chain), member 2
chr11_+_62623512 2.479 ENST00000377892.1
 SLC3A2
solute carrier family 3 (amino acid transporter heavy chain), member 2
chr9_-_123638633 2.257 ENST00000456291.1
 PHF19
PHD finger protein 19
chrX_-_107018969 2.167 ENST00000372383.4
 TSC22D3
TSC22 domain family, member 3
chr14_-_55658252 2.166 ENST00000395425.2
 DLGAP5
discs, large (Drosophila) homolog-associated protein 5

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 212 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 7.5 GO:0060356 leucine import(GO:0060356)
0.8 6.2 GO:0060744 thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744)
1.7 5.1 GO:0019858 cytosine metabolic process(GO:0019858)
0.3 4.8 GO:0051639 actin filament network formation(GO:0051639)
0.1 4.1 GO:0006491 N-glycan processing(GO:0006491)
0.4 3.7 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.0 3.4 GO:0021762 substantia nigra development(GO:0021762)
0.6 3.3 GO:0016479 negative regulation of transcription from RNA polymerase I promoter(GO:0016479)
0.4 3.3 GO:0086073 bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
0.8 3.2 GO:0006218 uridine catabolic process(GO:0006218)
0.4 3.1 GO:0014721 voluntary skeletal muscle contraction(GO:0003010) twitch skeletal muscle contraction(GO:0014721) slow-twitch skeletal muscle fiber contraction(GO:0031444)
0.9 2.6 GO:0035623 regulation of pronephros size(GO:0035565) renal glucose absorption(GO:0035623)
0.3 2.6 GO:0060753 regulation of mast cell chemotaxis(GO:0060753)
0.0 2.6 GO:0043268 positive regulation of potassium ion transport(GO:0043268)
0.5 2.4 GO:0002669 positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913) protein K29-linked ubiquitination(GO:0035519)
0.2 2.4 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
0.1 2.4 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.0 2.4 GO:0030049 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.2 2.3 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
0.7 2.2 GO:1903926 signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 92 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.6 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 8.3 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 6.6 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.3 4.8 GO:0005916 fascia adherens(GO:0005916)
0.0 3.9 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 3.9 GO:0005884 actin filament(GO:0005884)
1.1 3.3 GO:0031523 Myb complex(GO:0031523)
0.1 3.3 GO:0005861 troponin complex(GO:0005861)
0.1 3.3 GO:0030057 desmosome(GO:0030057)
0.0 3.0 GO:0030658 transport vesicle membrane(GO:0030658)
0.2 2.9 GO:0097433 dense body(GO:0097433)
0.1 2.8 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.2 2.6 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 2.6 GO:0001650 fibrillar center(GO:0001650)
0.0 2.4 GO:0005938 cell cortex(GO:0005938)
0.1 2.3 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 2.1 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.1 2.1 GO:0034518 mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518)
0.0 2.1 GO:0030027 lamellipodium(GO:0030027)
0.0 2.0 GO:0030864 cortical actin cytoskeleton(GO:0030864)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 150 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.1 GO:0005525 GTP binding(GO:0005525)
0.5 7.5 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.1 7.3 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 5.3 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.7 5.1 GO:0004126 cytidine deaminase activity(GO:0004126)
0.2 4.8 GO:0017166 vinculin binding(GO:0017166)
0.1 4.3 GO:0005080 protein kinase C binding(GO:0005080)
0.4 3.7 GO:0043426 MRF binding(GO:0043426)
0.8 3.3 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
0.4 3.3 GO:0086083 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083)
0.6 3.2 GO:0004850 uridine phosphorylase activity(GO:0004850)
0.2 3.2 GO:0031014 troponin T binding(GO:0031014)
0.2 3.1 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.1 3.1 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 3.0 GO:0035064 methylated histone binding(GO:0035064)
0.0 3.0 GO:0008307 structural constituent of muscle(GO:0008307)
0.2 2.9 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.1 2.6 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.8 2.5 GO:0008427 calcium-dependent protein kinase inhibitor activity(GO:0008427)
0.1 2.4 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.6 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 6.8 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.2 6.0 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.1 4.6 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.1 4.0 PID_IL8_CXCR2_PATHWAY IL8- and CXCR2-mediated signaling events
0.1 3.9 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.0 3.9 PID_E2F_PATHWAY E2F transcription factor network
0.0 3.1 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.0 2.9 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 2.7 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 2.6 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.1 2.5 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 2.2 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 2.2 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 2.1 PID_P73PATHWAY p73 transcription factor network
0.0 2.0 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.1 1.8 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.0 1.7 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.1 1.6 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 1.6 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.3 REACTOME_PYRIMIDINE_METABOLISM Genes involved in Pyrimidine metabolism
0.1 5.4 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.3 4.9 REACTOME_CALNEXIN_CALRETICULIN_CYCLE Genes involved in Calnexin/calreticulin cycle
0.2 4.5 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 4.2 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.1 4.1 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.1 3.7 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 3.1 REACTOME_SCFSKP2_MEDIATED_DEGRADATION_OF_P27_P21 Genes involved in SCF(Skp2)-mediated degradation of p27/p21
0.0 3.0 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.1 2.5 REACTOME_PREFOLDIN_MEDIATED_TRANSFER_OF_SUBSTRATE_TO_CCT_TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.1 2.4 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 2.2 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 2.2 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.0 2.0 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 1.9 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.0 1.8 REACTOME_KINESINS Genes involved in Kinesins
0.1 1.7 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 1.6 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.1 1.6 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 1.6 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions