Motif ID: EPAS1_BCL3

Z-value: 1.013

Transcription factors associated with EPAS1_BCL3:

Gene SymbolEntrez IDGene Name
BCL3 ENSG00000069399.8 BCL3
EPAS1 ENSG00000116016.9 EPAS1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
EPAS1hg19_v2_chr2_+_46524537_46524553-0.501.4e-02Click!
BCL3hg19_v2_chr19_+_45251804_45251840-0.405.6e-02Click!


Activity profile for motif EPAS1_BCL3.

activity profile for motif EPAS1_BCL3


Sorted Z-values histogram for motif EPAS1_BCL3

Sorted Z-values for motif EPAS1_BCL3



Network of associatons between targets according to the STRING database.



First level regulatory network of EPAS1_BCL3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_+_40643227 1.139 ENST00000448599.2
 PHGR1
proline/histidine/glycine-rich 1
chr1_-_150208320 1.055 ENST00000534220.1
 ANP32E
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr12_+_56415100 1.000 ENST00000547791.1
 IKZF4
IKAROS family zinc finger 4 (Eos)
chr3_-_116163830 0.962 ENST00000333617.4
 LSAMP
limbic system-associated membrane protein
chr1_+_152486950 0.905 ENST00000368790.3
 CRCT1
cysteine-rich C-terminal 1
chr12_+_26348582 0.887 ENST00000535504.1
 SSPN
sarcospan
chr7_-_142247606 0.861 ENST00000390361.3
 TRBV7-3
T cell receptor beta variable 7-3
chr14_+_42077552 0.848 ENST00000554120.1
 LRFN5
leucine rich repeat and fibronectin type III domain containing 5
chr2_-_27341966 0.812 ENST00000402394.1
ENST00000402550.1
ENST00000260595.5
 CGREF1


cell growth regulator with EF-hand domain 1


chr16_+_5008290 0.782 ENST00000251170.7
 SEC14L5
SEC14-like 5 (S. cerevisiae)
chr1_-_75139397 0.718 ENST00000326665.5
 C1orf173
chromosome 1 open reading frame 173
chrX_-_20134990 0.692 ENST00000379651.3
ENST00000443379.3
ENST00000379643.5
 MAP7D2


MAP7 domain containing 2


chr14_-_85996332 0.682 ENST00000380722.1
 RP11-497E19.1
RP11-497E19.1
chr12_+_7023491 0.677 ENST00000541477.1
ENST00000229277.1
 ENO2

enolase 2 (gamma, neuronal)

chr8_+_27348626 0.662 ENST00000517536.1
 EPHX2
epoxide hydrolase 2, cytoplasmic
chr2_+_210444142 0.645 ENST00000360351.4
ENST00000361559.4
 MAP2

microtubule-associated protein 2

chr19_-_11688500 0.624 ENST00000433365.2
 ACP5
acid phosphatase 5, tartrate resistant
chr2_-_219696519 0.606 ENST00000545803.1
ENST00000430489.1
ENST00000392098.3
 PRKAG3


protein kinase, AMP-activated, gamma 3 non-catalytic subunit


chr20_-_43743790 0.594 ENST00000307971.4
ENST00000372789.4
 WFDC5

WAP four-disulfide core domain 5

chr8_+_110098850 0.592 ENST00000518632.1
 TRHR
thyrotropin-releasing hormone receptor

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 227 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.5 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.2 1.4 GO:0021564 vagus nerve development(GO:0021564)
0.1 1.4 GO:0072540 T-helper 17 cell lineage commitment(GO:0072540)
0.0 1.3 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.0 1.2 GO:0061718 NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.2 1.1 GO:0010734 protein glutathionylation(GO:0010731) regulation of protein glutathionylation(GO:0010732) negative regulation of protein glutathionylation(GO:0010734)
0.3 1.0 GO:0046271 phenylpropanoid catabolic process(GO:0046271)
0.1 1.0 GO:0050915 sensory perception of sour taste(GO:0050915)
0.1 1.0 GO:0035641 locomotory exploration behavior(GO:0035641)
0.0 1.0 GO:0042554 superoxide anion generation(GO:0042554)
0.3 0.9 GO:1904328 regulation of myofibroblast contraction(GO:1904328) myofibroblast contraction(GO:1990764)
0.1 0.9 GO:0090240 positive regulation of histone H4 acetylation(GO:0090240)
0.2 0.8 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.1 0.8 GO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196)
0.2 0.7 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.0 0.7 GO:0005978 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.0 0.7 GO:0008088 axo-dendritic transport(GO:0008088)
0.1 0.6 GO:0044208 'de novo' AMP biosynthetic process(GO:0044208)
0.1 0.6 GO:1901731 positive regulation of platelet aggregation(GO:1901731)
0.1 0.6 GO:0006196 AMP catabolic process(GO:0006196)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 66 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.6 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.2 1.1 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 1.1 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 1.0 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 1.0 GO:0030315 T-tubule(GO:0030315)
0.0 1.0 GO:1904813 ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.1 0.9 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.1 0.9 GO:0043020 NADPH oxidase complex(GO:0043020)
0.0 0.9 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.9 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.9 GO:0031143 pseudopodium(GO:0031143)
0.1 0.7 GO:0098843 postsynaptic endocytic zone(GO:0098843)
0.0 0.7 GO:0035253 ciliary rootlet(GO:0035253)
0.0 0.7 GO:0000812 Swr1 complex(GO:0000812)
0.0 0.7 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.2 0.6 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.1 0.6 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.0 0.6 GO:0031209 SCAR complex(GO:0031209)
0.0 0.6 GO:0005861 troponin complex(GO:0005861)
0.1 0.4 GO:0071818 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 150 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.2 GO:0008201 heparin binding(GO:0008201)
0.1 1.5 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 1.5 GO:0019212 phosphatase inhibitor activity(GO:0019212)
0.0 1.3 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.2 1.1 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 1.1 GO:0030507 spectrin binding(GO:0030507)
0.0 1.1 GO:0017080 sodium channel regulator activity(GO:0017080)
0.2 1.0 GO:0042577 lipid phosphatase activity(GO:0042577)
0.2 1.0 GO:0044736 acid-sensing ion channel activity(GO:0044736)
0.1 1.0 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.0 1.0 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.3 0.9 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
0.1 0.9 GO:0008517 folic acid transporter activity(GO:0008517)
0.0 0.9 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 0.8 GO:0008199 ferric iron binding(GO:0008199)
0.0 0.8 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.2 0.7 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.1 0.7 GO:0001641 group II metabotropic glutamate receptor activity(GO:0001641)
0.0 0.7 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.0 0.7 GO:0002162 dystroglycan binding(GO:0002162)

Gene overrepresentation in C2:CP category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.5 PID_LKB1_PATHWAY LKB1 signaling events
0.0 0.8 PID_CXCR3_PATHWAY CXCR3-mediated signaling events
0.0 0.7 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 0.7 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.0 0.6 ST_ADRENERGIC Adrenergic Pathway
0.0 0.4 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 0.4 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 0.4 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 0.2 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 0.2 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 0.1 PID_ER_NONGENOMIC_PATHWAY Plasma membrane estrogen receptor signaling
0.0 0.1 PID_NEPHRIN_NEPH1_PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 0.0 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.4 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 1.2 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.0 1.0 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 1.0 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 1.0 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 0.9 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.8 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 0.7 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.7 REACTOME_KINESINS Genes involved in Kinesins
0.0 0.6 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.6 REACTOME_PURINE_SALVAGE Genes involved in Purine salvage
0.0 0.6 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.0 0.6 REACTOME_DAG_AND_IP3_SIGNALING Genes involved in DAG and IP3 signaling
0.0 0.6 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.6 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 0.5 REACTOME_SEROTONIN_RECEPTORS Genes involved in Serotonin receptors
0.0 0.5 REACTOME_BOTULINUM_NEUROTOXICITY Genes involved in Botulinum neurotoxicity
0.0 0.5 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.5 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.0 0.4 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway