Motif ID: ERG
Z-value: 1.065
Transcription factors associated with ERG:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| ERG | ENSG00000157554.14 | ERG |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ERG | hg19_v2_chr21_-_40033618_40033712 | -0.07 | 7.5e-01 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 810 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 14.6 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.1 | 6.6 | GO:0018149 | peptide cross-linking(GO:0018149) |
| 0.2 | 3.7 | GO:0031665 | negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665) |
| 0.7 | 3.5 | GO:0044565 | dendritic cell proliferation(GO:0044565) |
| 0.1 | 3.1 | GO:0051310 | metaphase plate congression(GO:0051310) |
| 0.1 | 3.0 | GO:0007176 | regulation of epidermal growth factor-activated receptor activity(GO:0007176) |
| 0.0 | 2.8 | GO:0070268 | cornification(GO:0070268) |
| 0.0 | 2.8 | GO:0007338 | single fertilization(GO:0007338) |
| 0.2 | 2.7 | GO:0002315 | marginal zone B cell differentiation(GO:0002315) |
| 0.0 | 2.6 | GO:0030574 | collagen catabolic process(GO:0030574) |
| 0.5 | 2.5 | GO:0032929 | negative regulation of superoxide anion generation(GO:0032929) |
| 0.1 | 2.5 | GO:0043001 | Golgi to plasma membrane protein transport(GO:0043001) |
| 0.8 | 2.4 | GO:0032888 | regulation of spindle elongation(GO:0032887) regulation of mitotic spindle elongation(GO:0032888) anastral spindle assembly(GO:0055048) protein localization to spindle pole body(GO:0071988) regulation of protein localization to spindle pole body(GO:1902363) positive regulation of protein localization to spindle pole body(GO:1902365) positive regulation of mitotic spindle elongation(GO:1902846) |
| 0.1 | 2.3 | GO:0050861 | positive regulation of B cell receptor signaling pathway(GO:0050861) |
| 0.1 | 2.3 | GO:0034498 | early endosome to Golgi transport(GO:0034498) |
| 0.1 | 2.3 | GO:0007194 | negative regulation of adenylate cyclase activity(GO:0007194) |
| 0.2 | 2.2 | GO:0060753 | regulation of mast cell chemotaxis(GO:0060753) |
| 0.1 | 2.2 | GO:0019388 | galactose catabolic process(GO:0019388) |
| 0.1 | 2.1 | GO:0006068 | ethanol catabolic process(GO:0006068) |
| 0.1 | 2.1 | GO:0090004 | positive regulation of establishment of protein localization to plasma membrane(GO:0090004) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 293 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.7 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.1 | 7.8 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.0 | 4.7 | GO:0019897 | extrinsic component of plasma membrane(GO:0019897) |
| 0.0 | 4.4 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.0 | 4.4 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.0 | 4.0 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.2 | 3.5 | GO:0005589 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.0 | 3.3 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
| 0.0 | 3.2 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.0 | 3.2 | GO:0000922 | spindle pole(GO:0000922) |
| 0.0 | 3.0 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.0 | 3.0 | GO:0030496 | midbody(GO:0030496) |
| 0.2 | 2.7 | GO:0008250 | oligosaccharyltransferase complex(GO:0008250) |
| 0.3 | 2.6 | GO:0071541 | eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541) |
| 0.0 | 2.6 | GO:0005884 | actin filament(GO:0005884) |
| 0.1 | 2.5 | GO:0030127 | COPII vesicle coat(GO:0030127) |
| 0.8 | 2.4 | GO:0055028 | cortical microtubule(GO:0055028) |
| 0.1 | 2.4 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
| 0.0 | 2.3 | GO:0019898 | extrinsic component of membrane(GO:0019898) |
| 0.0 | 2.3 | GO:0016363 | nuclear matrix(GO:0016363) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 477 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 9.9 | GO:0005198 | structural molecule activity(GO:0005198) |
| 0.1 | 8.9 | GO:0019843 | rRNA binding(GO:0019843) |
| 0.1 | 6.0 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.0 | 5.8 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.2 | 4.4 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 0.0 | 4.4 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.0 | 4.1 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.1 | 3.9 | GO:1990782 | protein tyrosine kinase binding(GO:1990782) |
| 0.0 | 3.8 | GO:0019207 | kinase regulator activity(GO:0019207) |
| 0.0 | 3.4 | GO:0005178 | integrin binding(GO:0005178) |
| 0.8 | 3.3 | GO:0033829 | O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829) |
| 0.0 | 3.0 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.1 | 2.9 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
| 0.0 | 2.9 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.0 | 2.9 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.3 | 2.8 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.0 | 2.8 | GO:0008081 | phosphoric diester hydrolase activity(GO:0008081) |
| 0.0 | 2.8 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.4 | 2.7 | GO:0035614 | snRNA stem-loop binding(GO:0035614) |
| 0.3 | 2.4 | GO:0048495 | Roundabout binding(GO:0048495) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 82 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.8 | PID_TCR_PATHWAY | TCR signaling in naïve CD4+ T cells |
| 0.1 | 6.7 | PID_AURORA_B_PATHWAY | Aurora B signaling |
| 0.1 | 4.7 | NABA_COLLAGENS | Genes encoding collagen proteins |
| 0.1 | 4.1 | PID_INTEGRIN_A4B1_PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.0 | 3.7 | PID_LKB1_PATHWAY | LKB1 signaling events |
| 0.1 | 3.3 | SA_TRKA_RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
| 0.1 | 3.1 | PID_IL8_CXCR2_PATHWAY | IL8- and CXCR2-mediated signaling events |
| 0.1 | 2.9 | SA_B_CELL_RECEPTOR_COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.0 | 2.9 | PID_ERBB1_INTERNALIZATION_PATHWAY | Internalization of ErbB1 |
| 0.1 | 2.8 | ST_GAQ_PATHWAY | G alpha q Pathway |
| 0.1 | 2.4 | PID_IL5_PATHWAY | IL5-mediated signaling events |
| 0.1 | 2.3 | PID_ALPHA_SYNUCLEIN_PATHWAY | Alpha-synuclein signaling |
| 0.2 | 2.2 | SA_G2_AND_M_PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.0 | 2.1 | PID_WNT_NONCANONICAL_PATHWAY | Noncanonical Wnt signaling pathway |
| 0.0 | 2.0 | PID_HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.0 | 1.9 | PID_FCER1_PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 0.0 | 1.9 | PID_PLK1_PATHWAY | PLK1 signaling events |
| 0.0 | 1.9 | PID_AR_PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 1.8 | PID_IL2_1PATHWAY | IL2-mediated signaling events |
| 0.0 | 1.8 | WNT_SIGNALING | Genes related to Wnt-mediated signal transduction |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 120 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 12.9 | REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.1 | 5.9 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
| 0.1 | 4.9 | REACTOME_SMOOTH_MUSCLE_CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.2 | 4.4 | REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.0 | 4.2 | REACTOME_PEPTIDE_CHAIN_ELONGATION | Genes involved in Peptide chain elongation |
| 0.1 | 4.1 | REACTOME_NEF_MEDIATES_DOWN_MODULATION_OF_CELL_SURFACE_RECEPTORS_BY_RECRUITING_THEM_TO_CLATHRIN_ADAPTERS | Genes involved in Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters |
| 0.1 | 3.7 | REACTOME_RAP1_SIGNALLING | Genes involved in Rap1 signalling |
| 0.0 | 3.3 | REACTOME_MITOTIC_PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 3.2 | REACTOME_TIE2_SIGNALING | Genes involved in Tie2 Signaling |
| 0.0 | 3.0 | REACTOME_MRNA_SPLICING | Genes involved in mRNA Splicing |
| 0.1 | 2.9 | REACTOME_SIGNALING_BY_ROBO_RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.0 | 2.9 | REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.0 | 2.8 | REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS | Genes involved in G alpha (q) signalling events |
| 0.1 | 2.6 | REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES | Genes involved in Recruitment of NuMA to mitotic centrosomes |
| 0.1 | 2.5 | REACTOME_CGMP_EFFECTS | Genes involved in cGMP effects |
| 0.0 | 2.5 | REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK | Genes involved in NRAGE signals death through JNK |
| 0.0 | 2.3 | REACTOME_GLYCOLYSIS | Genes involved in Glycolysis |
| 0.1 | 2.2 | REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
| 0.1 | 2.2 | REACTOME_INTEGRIN_ALPHAIIB_BETA3_SIGNALING | Genes involved in Integrin alphaIIb beta3 signaling |
| 0.0 | 2.2 | REACTOME_INTERFERON_ALPHA_BETA_SIGNALING | Genes involved in Interferon alpha/beta signaling |
