Motif ID: ESRRA_ESR2

Z-value: 1.541

Transcription factors associated with ESRRA_ESR2:

Gene SymbolEntrez IDGene Name
ESR2 ENSG00000140009.14 ESR2
ESRRA ENSG00000173153.9 ESRRA

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ESRRAhg19_v2_chr11_+_64073699_640739180.611.6e-03Click!
ESR2hg19_v2_chr14_-_64761078_64761128-0.213.2e-01Click!


Activity profile for motif ESRRA_ESR2.

activity profile for motif ESRRA_ESR2


Sorted Z-values histogram for motif ESRRA_ESR2

Sorted Z-values for motif ESRRA_ESR2



Network of associatons between targets according to the STRING database.



First level regulatory network of ESRRA_ESR2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_+_2880157 4.261 ENST00000382280.3
 ZG16B
zymogen granule protein 16B
chr12_+_50355647 3.642 ENST00000293599.6
 AQP5
aquaporin 5
chr20_+_31870927 3.406 ENST00000253354.1
 BPIFB1
BPI fold containing family B, member 1
chr16_+_2880254 3.239 ENST00000570670.1
 ZG16B
zymogen granule protein 16B
chr16_+_2880369 3.107 ENST00000572863.1
 ZG16B
zymogen granule protein 16B
chr19_-_41388657 3.082 ENST00000301146.4
ENST00000291764.3
 CYP2A7

cytochrome P450, family 2, subfamily A, polypeptide 7

chr4_-_16077741 3.019 ENST00000447510.2
ENST00000540805.1
ENST00000539194.1
 PROM1


prominin 1


chr9_-_130637244 3.019 ENST00000373156.1
 AK1
adenylate kinase 1
chr21_+_42688686 2.962 ENST00000398652.3
ENST00000398647.3
 FAM3B

family with sequence similarity 3, member B

chr6_-_32498046 2.928 ENST00000374975.3
 HLA-DRB5
major histocompatibility complex, class II, DR beta 5
chr16_+_2880296 2.904 ENST00000571723.1
 ZG16B
zymogen granule protein 16B
chr19_-_9092018 2.392 ENST00000397910.4
 MUC16
mucin 16, cell surface associated
chr17_-_4689649 2.290 ENST00000441199.2
ENST00000416307.2
 VMO1

vitelline membrane outer layer 1 homolog (chicken)

chr4_-_681114 2.186 ENST00000503156.1
 MFSD7
major facilitator superfamily domain containing 7
chr16_+_67465016 2.186 ENST00000326152.5
 HSD11B2
hydroxysteroid (11-beta) dehydrogenase 2
chr16_-_21289627 2.170 ENST00000396023.2
ENST00000415987.2
 CRYM

crystallin, mu

chr16_+_810728 1.999 ENST00000563941.1
ENST00000545450.2
ENST00000566549.1
 MSLN


mesothelin


chr14_-_106642049 1.915 ENST00000390605.2
 IGHV1-18
immunoglobulin heavy variable 1-18
chr2_-_238499303 1.892 ENST00000409576.1
 RAB17
RAB17, member RAS oncogene family
chr19_-_6433765 1.876 ENST00000321510.6
 SLC25A41
solute carrier family 25, member 41

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 1,089 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 17.6 GO:0001895 retina homeostasis(GO:0001895)
1.3 6.5 GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
0.1 6.0 GO:0016266 O-glycan processing(GO:0016266)
0.4 5.7 GO:0090360 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.1 5.4 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.1 5.2 GO:0006910 phagocytosis, recognition(GO:0006910)
0.1 5.2 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.8 4.7 GO:0010734 protein glutathionylation(GO:0010731) regulation of protein glutathionylation(GO:0010732) negative regulation of protein glutathionylation(GO:0010734)
0.2 4.4 GO:0018298 protein-chromophore linkage(GO:0018298)
0.1 4.4 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991)
0.2 4.1 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.2 3.9 GO:1901750 leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
0.5 3.7 GO:0034144 negative regulation of toll-like receptor 4 signaling pathway(GO:0034144)
0.2 3.7 GO:0003084 positive regulation of systemic arterial blood pressure(GO:0003084)
0.9 3.4 GO:0072139 glomerular parietal epithelial cell differentiation(GO:0072139)
0.1 3.4 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.0 3.2 GO:0002790 peptide secretion(GO:0002790)
0.4 3.1 GO:0018879 biphenyl metabolic process(GO:0018879)
0.0 3.1 GO:0060333 interferon-gamma-mediated signaling pathway(GO:0060333)
0.7 3.0 GO:0046271 phenylpropanoid catabolic process(GO:0046271)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 315 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 11.3 GO:0005796 Golgi lumen(GO:0005796)
0.0 9.4 GO:0031225 anchored component of membrane(GO:0031225)
0.0 9.2 GO:0000139 Golgi membrane(GO:0000139)
0.1 8.6 GO:0043202 lysosomal lumen(GO:0043202)
0.4 7.9 GO:0042613 MHC class II protein complex(GO:0042613)
0.3 6.0 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.1 5.7 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.2 5.0 GO:0097381 photoreceptor disc membrane(GO:0097381)
0.1 4.1 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 4.1 GO:0030426 growth cone(GO:0030426)
0.0 4.0 GO:0031902 late endosome membrane(GO:0031902)
0.0 3.8 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.2 3.7 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 3.5 GO:0031091 platelet alpha granule(GO:0031091)
0.1 3.2 GO:0009925 basal plasma membrane(GO:0009925)
0.3 3.1 GO:0042611 MHC protein complex(GO:0042611)
0.0 3.1 GO:0035578 azurophil granule lumen(GO:0035578)
0.2 2.9 GO:0097433 dense body(GO:0097433)
0.0 2.9 GO:0035577 azurophil granule membrane(GO:0035577)
0.0 2.8 GO:0005770 late endosome(GO:0005770)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 650 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 10.4 GO:0030246 carbohydrate binding(GO:0030246)
0.4 8.8 GO:0070330 aromatase activity(GO:0070330)
0.2 7.6 GO:0042605 peptide antigen binding(GO:0042605)
0.1 6.8 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.1 6.3 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.1 5.6 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 5.1 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 4.8 GO:0019003 GDP binding(GO:0019003)
0.1 4.7 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.3 4.4 GO:0004017 adenylate kinase activity(GO:0004017)
0.2 3.9 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.1 3.6 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 3.3 GO:0051082 unfolded protein binding(GO:0051082)
0.8 3.1 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.2 3.1 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 3.0 GO:0005125 cytokine activity(GO:0005125)
0.2 2.9 GO:0015250 water channel activity(GO:0015250)
0.0 2.7 GO:0070888 E-box binding(GO:0070888)
0.2 2.6 GO:0015217 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.1 2.5 GO:0008320 protein transmembrane transporter activity(GO:0008320)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 66 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.6 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 5.9 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 5.1 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 4.6 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 4.5 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 2.8 ST_GAQ_PATHWAY G alpha q Pathway
0.0 2.6 PID_FAS_PATHWAY FAS (CD95) signaling pathway
0.0 2.6 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.1 2.3 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 2.3 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 2.2 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 1.8 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 1.8 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.0 1.8 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.1 1.7 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0 1.7 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 1.7 PID_PTP1B_PATHWAY Signaling events mediated by PTP1B
0.1 1.6 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.0 1.5 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.1 1.4 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 130 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.0 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.3 7.8 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1 7.7 REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 5.6 REACTOME_GENERIC_TRANSCRIPTION_PATHWAY Genes involved in Generic Transcription Pathway
0.2 5.5 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.2 5.1 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.1 5.1 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.2 4.6 REACTOME_INITIAL_TRIGGERING_OF_COMPLEMENT Genes involved in Initial triggering of complement
0.1 4.5 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.1 4.5 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.3 3.8 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.3 3.6 REACTOME_OPSINS Genes involved in Opsins
0.2 3.1 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.3 2.8 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.2 2.8 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.1 2.5 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.1 2.3 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.1 2.2 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 2.2 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 2.2 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription