Motif ID: ESRRB_ESRRG

Z-value: 0.852

Transcription factors associated with ESRRB_ESRRG:

Gene SymbolEntrez IDGene Name
ESRRB ENSG00000119715.10 ESRRB
ESRRG ENSG00000196482.12 ESRRG

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ESRRBhg19_v2_chr14_+_76776957_76777061-0.174.2e-01Click!
ESRRGhg19_v2_chr1_-_216896780_216896800,
hg19_v2_chr1_-_217311090_217311097,
hg19_v2_chr1_-_217262933_217262968,
hg19_v2_chr1_-_216978709_216978728,
hg19_v2_chr1_-_217262969_217262995		0.077.6e-01Click!


Activity profile for motif ESRRB_ESRRG.

activity profile for motif ESRRB_ESRRG


Sorted Z-values histogram for motif ESRRB_ESRRG

Sorted Z-values for motif ESRRB_ESRRG



Network of associatons between targets according to the STRING database.



First level regulatory network of ESRRB_ESRRG

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr20_+_58179582 2.044 ENST00000371015.1
ENST00000395639.4
 PHACTR3

phosphatase and actin regulator 3

chr9_-_39239171 1.314 ENST00000358144.2
 CNTNAP3
contactin associated protein-like 3
chr20_+_58152524 1.234 ENST00000359926.3
 PHACTR3
phosphatase and actin regulator 3
chr1_-_207119738 1.129 ENST00000356495.4
 PIGR
polymeric immunoglobulin receptor
chr10_+_81107271 1.114 ENST00000448165.1
 PPIF
peptidylprolyl isomerase F
chr2_+_120189422 1.087 ENST00000306406.4
 TMEM37
transmembrane protein 37
chr6_-_97345689 1.009 ENST00000316149.7
 NDUFAF4
NADH dehydrogenase (ubiquinone) complex I, assembly factor 4
chr11_+_66624527 0.980 ENST00000393952.3
 LRFN4
leucine rich repeat and fibronectin type III domain containing 4
chr4_-_74864386 0.925 ENST00000296027.4
 CXCL5
chemokine (C-X-C motif) ligand 5
chr8_-_110704014 0.834 ENST00000529190.1
ENST00000422135.1
ENST00000419099.1
 SYBU


syntabulin (syntaxin-interacting)


chr22_-_24110063 0.832 ENST00000520222.1
ENST00000401675.3
 CHCHD10

coiled-coil-helix-coiled-coil-helix domain containing 10

chr2_-_31030277 0.741 ENST00000534090.2
ENST00000295055.8
 CAPN13

calpain 13

chr10_+_81107216 0.726 ENST00000394579.3
ENST00000225174.3
 PPIF

peptidylprolyl isomerase F

chr16_+_11038403 0.705 ENST00000409552.3
 CLEC16A
C-type lectin domain family 16, member A
chr18_-_12377283 0.705 ENST00000269143.3
 AFG3L2
AFG3-like AAA ATPase 2
chr17_-_79838860 0.628 ENST00000582866.1
 RP11-498C9.15
RP11-498C9.15
chr2_-_74374995 0.579 ENST00000295326.4
 BOLA3
bolA family member 3
chr9_-_117150243 0.569 ENST00000374088.3
 AKNA
AT-hook transcription factor
chr2_-_209028300 0.566 ENST00000304502.4
 CRYGA
crystallin, gamma A
chr11_+_57480046 0.561 ENST00000378312.4
ENST00000278422.4
 TMX2

thioredoxin-related transmembrane protein 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 151 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.1 GO:0042407 cristae formation(GO:0042407)
0.0 2.8 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.4 2.2 GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
0.6 1.8 GO:2000276 negative regulation of oxidative phosphorylation uncoupler activity(GO:2000276)
0.0 1.4 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.0 1.4 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.2 0.9 GO:1901097 negative regulation of autophagosome maturation(GO:1901097)
0.0 0.9 GO:0090023 positive regulation of neutrophil chemotaxis(GO:0090023)
0.0 0.9 GO:0006754 ATP biosynthetic process(GO:0006754)
0.3 0.8 GO:0006106 fumarate metabolic process(GO:0006106)
0.1 0.8 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.0 0.8 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.8 GO:0051084 'de novo' posttranslational protein folding(GO:0051084)
0.0 0.8 GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178)
0.0 0.8 GO:0016266 O-glycan processing(GO:0016266)
0.2 0.7 GO:0015729 thiosulfate transport(GO:0015709) oxaloacetate transport(GO:0015729) malate transport(GO:0015743) malate transmembrane transport(GO:0071423) oxaloacetate(2-) transmembrane transport(GO:1902356)
0.1 0.7 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.1 0.7 GO:0002191 cap-dependent translational initiation(GO:0002191)
0.0 0.7 GO:0090360 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.2 0.6 GO:0021793 chemorepulsion of branchiomotor axon(GO:0021793)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.1 GO:0005753 mitochondrial proton-transporting ATP synthase complex(GO:0005753)
0.0 2.7 GO:0016363 nuclear matrix(GO:0016363)
0.0 2.1 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 1.5 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 1.5 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 1.2 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 1.2 GO:0035577 azurophil granule membrane(GO:0035577)
0.1 1.0 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.0 0.9 GO:0036020 endolysosome membrane(GO:0036020)
0.0 0.9 GO:0031304 intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
0.1 0.8 GO:1990635 proximal dendrite(GO:1990635)
0.1 0.8 GO:0097433 dense body(GO:0097433)
0.0 0.7 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.1 0.6 GO:0070554 synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554)
0.1 0.6 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.6 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 0.6 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.1 0.5 GO:0042721 mitochondrial inner membrane protein insertion complex(GO:0042721)
0.1 0.5 GO:0061617 MICOS complex(GO:0061617)
0.0 0.5 GO:0042599 lamellar body(GO:0042599)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 115 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.3 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 1.8 GO:0016018 cyclosporin A binding(GO:0016018)
0.0 1.8 GO:0051082 unfolded protein binding(GO:0051082)
0.1 1.6 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 1.6 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 1.4 GO:0019003 GDP binding(GO:0019003)
0.0 1.3 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 1.2 GO:0015266 protein channel activity(GO:0015266)
0.1 1.1 GO:0019763 immunoglobulin receptor activity(GO:0019763)
0.1 1.0 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.1 0.9 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 0.8 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.2 0.7 GO:0015117 thiosulfate transmembrane transporter activity(GO:0015117) oxaloacetate transmembrane transporter activity(GO:0015131)
0.1 0.7 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.7 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.7 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.7 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.6 GO:0004017 adenylate kinase activity(GO:0004017)
0.0 0.6 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 0.5 GO:0043559 insulin binding(GO:0043559)

Gene overrepresentation in C2:CP category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.3 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.0 1.2 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 0.8 ST_GAQ_PATHWAY G alpha q Pathway
0.0 0.4 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K
0.0 0.3 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0 0.1 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.0 ST_PAC1_RECEPTOR_PATHWAY PAC1 Receptor Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.9 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.1 1.8 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 1.5 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.0 1.2 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 1.0 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.9 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.0 0.7 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 0.6 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.6 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.5 REACTOME_MTORC1_MEDIATED_SIGNALLING Genes involved in mTORC1-mediated signalling
0.1 0.4 REACTOME_TRANSFERRIN_ENDOCYTOSIS_AND_RECYCLING Genes involved in Transferrin endocytosis and recycling
0.0 0.4 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 0.4 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.4 REACTOME_RNA_POL_III_CHAIN_ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 0.4 REACTOME_INITIAL_TRIGGERING_OF_COMPLEMENT Genes involved in Initial triggering of complement
0.0 0.4 REACTOME_REGULATORY_RNA_PATHWAYS Genes involved in Regulatory RNA pathways
0.0 0.4 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.0 0.4 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.4 REACTOME_CD28_DEPENDENT_PI3K_AKT_SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.0 0.3 REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS Genes involved in Elevation of cytosolic Ca2+ levels