Motif ID: ETV1_ERF_FEV_ELF1

Z-value: 0.916

Transcription factors associated with ETV1_ERF_FEV_ELF1:

Gene SymbolEntrez IDGene Name
ELF1 ENSG00000120690.9 ELF1
ERF ENSG00000105722.5 ERF
ETV1 ENSG00000006468.9 ETV1
FEV ENSG00000163497.2 FEV

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ELF1hg19_v2_chr13_-_41635512_41635576-0.462.4e-02Click!
ETV1hg19_v2_chr7_-_14029283_140293110.331.2e-01Click!
ERFhg19_v2_chr19_-_42759300_427593240.183.9e-01Click!
FEVhg19_v2_chr2_-_219850277_2198503790.096.8e-01Click!


Activity profile for motif ETV1_ERF_FEV_ELF1.

activity profile for motif ETV1_ERF_FEV_ELF1


Sorted Z-values histogram for motif ETV1_ERF_FEV_ELF1

Sorted Z-values for motif ETV1_ERF_FEV_ELF1



Network of associatons between targets according to the STRING database.



First level regulatory network of ETV1_ERF_FEV_ELF1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_47324424 4.278 ENST00000437353.1
ENST00000232766.5
ENST00000455924.2
 KLHL18


kelch-like family member 18


chr7_+_40174565 3.908 ENST00000309930.5
ENST00000401647.2
ENST00000335693.4
ENST00000413931.1
ENST00000416370.1
ENST00000540834.1
 C7orf10





succinylCoA:glutarate-CoA transferase





chr19_+_16308711 3.080 ENST00000429941.2
ENST00000444449.2
ENST00000589822.1
 AP1M1


adaptor-related protein complex 1, mu 1 subunit


chr1_-_154946825 2.903 ENST00000368453.4
ENST00000368450.1
ENST00000366442.2
 SHC1


SHC (Src homology 2 domain containing) transforming protein 1


chr22_+_19466980 2.684 ENST00000407835.1
ENST00000438587.1
 CDC45

cell division cycle 45

chr1_+_32687971 2.641 ENST00000373586.1
 EIF3I
eukaryotic translation initiation factor 3, subunit I
chr4_+_153701081 2.621 ENST00000451320.2
ENST00000429148.2
ENST00000353617.2
ENST00000405727.2
ENST00000356064.3
 ARFIP1




ADP-ribosylation factor interacting protein 1




chr1_+_169337172 2.570 ENST00000367807.3
ENST00000367808.3
ENST00000329281.2
ENST00000420531.1
 BLZF1



basic leucine zipper nuclear factor 1



chr17_+_1945301 2.533 ENST00000572195.1
 OVCA2
ovarian tumor suppressor candidate 2
chr4_-_153700864 2.443 ENST00000304337.2
 TIGD4
tigger transposable element derived 4
chr15_+_74833518 2.425 ENST00000346246.5
 ARID3B
AT rich interactive domain 3B (BRIGHT-like)
chr5_+_110074685 2.418 ENST00000355943.3
ENST00000447245.2
 SLC25A46

solute carrier family 25, member 46

chr1_-_153113927 2.322 ENST00000368752.4
 SPRR2B
small proline-rich protein 2B
chr21_-_38639601 2.306 ENST00000539844.1
ENST00000476950.1
ENST00000399001.1
 DSCR3


Down syndrome critical region gene 3


chr20_+_30327063 2.303 ENST00000300403.6
ENST00000340513.4
 TPX2

TPX2, microtubule-associated

chr19_+_16308659 2.236 ENST00000590263.1
ENST00000590756.1
ENST00000541844.1
 AP1M1


adaptor-related protein complex 1, mu 1 subunit


chr8_+_145133493 2.137 ENST00000316052.5
ENST00000525936.1
 EXOSC4

exosome component 4

chr17_+_7211280 2.112 ENST00000419711.2
ENST00000571955.1
ENST00000573714.1
 EIF5A


eukaryotic translation initiation factor 5A


chr2_-_9563575 2.083 ENST00000488451.1
ENST00000238091.4
ENST00000355346.4
 ITGB1BP1


integrin beta 1 binding protein 1


chr9_+_116037922 2.044 ENST00000374198.4
 PRPF4
pre-mRNA processing factor 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 580 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 11.1 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.0 9.4 GO:0006413 translational initiation(GO:0006413)
0.1 8.9 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.1 8.6 GO:0070126 mitochondrial translational termination(GO:0070126)
0.2 5.7 GO:0035646 endosome to melanosome transport(GO:0035646) endosome to pigment granule transport(GO:0043485) pigment granule maturation(GO:0048757)
0.7 5.4 GO:0003065 positive regulation of heart rate by epinephrine(GO:0003065)
0.1 5.0 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.1 5.0 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.3 4.7 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.0 4.7 GO:0042254 ribosome biogenesis(GO:0042254)
0.1 4.6 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.6 4.5 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.1 4.3 GO:0006362 transcription elongation from RNA polymerase I promoter(GO:0006362)
0.1 4.1 GO:0006368 transcription elongation from RNA polymerase II promoter(GO:0006368)
0.0 4.0 GO:0006903 vesicle targeting(GO:0006903)
1.3 3.9 GO:0006427 histidyl-tRNA aminoacylation(GO:0006427)
0.2 3.6 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.2 3.5 GO:0045116 protein neddylation(GO:0045116)
0.4 3.4 GO:0017185 peptidyl-lysine hydroxylation(GO:0017185)
0.2 3.4 GO:0043248 proteasome assembly(GO:0043248)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 287 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 10.1 GO:0030131 clathrin adaptor complex(GO:0030131)
0.3 9.1 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 8.2 GO:0001726 ruffle(GO:0001726)
0.0 7.9 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 6.7 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.3 5.8 GO:0030127 COPII vesicle coat(GO:0030127)
0.3 5.7 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.1 5.7 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 5.6 GO:0016607 nuclear speck(GO:0016607)
0.0 5.5 GO:0005840 ribosome(GO:0005840)
0.0 5.1 GO:0001650 fibrillar center(GO:0001650)
0.0 4.8 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 4.6 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.1 4.4 GO:0005876 spindle microtubule(GO:0005876)
0.2 4.1 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.1 4.1 GO:0035371 microtubule plus-end(GO:0035371)
0.3 4.0 GO:0005642 annulate lamellae(GO:0005642)
0.0 3.9 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.3 3.8 GO:1990023 mitotic spindle midzone(GO:1990023)
0.4 3.6 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 387 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 9.7 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 9.4 GO:0005525 GTP binding(GO:0005525)
0.1 6.6 GO:0003743 translation initiation factor activity(GO:0003743)
0.3 6.3 GO:0017070 U6 snRNA binding(GO:0017070)
0.0 5.8 GO:0051015 actin filament binding(GO:0051015)
0.0 5.8 GO:0005198 structural molecule activity(GO:0005198)
0.1 5.6 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 5.0 GO:0045296 cadherin binding(GO:0045296)
0.1 4.6 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
1.3 3.9 GO:0004821 histidine-tRNA ligase activity(GO:0004821)
0.1 3.9 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.2 3.7 GO:0003688 DNA replication origin binding(GO:0003688)
0.2 3.7 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.3 3.6 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.3 3.6 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.5 3.4 GO:0048408 epidermal growth factor binding(GO:0048408)
0.3 3.3 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.3 3.3 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.3 3.1 GO:0035174 histone serine kinase activity(GO:0035174)
0.1 3.0 GO:0001054 RNA polymerase I activity(GO:0001054)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 67 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.7 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.1 6.7 PID_AURORA_A_PATHWAY Aurora A signaling
0.1 5.6 PID_E2F_PATHWAY E2F transcription factor network
0.2 4.9 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.1 4.8 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 4.6 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.1 4.2 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.1 3.9 PID_LKB1_PATHWAY LKB1 signaling events
0.1 3.6 SIG_CHEMOTAXIS Genes related to chemotaxis
0.1 3.3 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.1 2.9 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 2.4 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.1 2.0 PID_ATR_PATHWAY ATR signaling pathway
0.0 2.0 PID_IL1_PATHWAY IL1-mediated signaling events
0.1 1.9 PID_BARD1_PATHWAY BARD1 signaling events
0.0 1.9 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.1 1.8 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.1 1.8 ST_GAQ_PATHWAY G alpha q Pathway
0.0 1.8 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 1.7 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 128 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.2 REACTOME_CDK_MEDIATED_PHOSPHORYLATION_AND_REMOVAL_OF_CDC6 Genes involved in CDK-mediated phosphorylation and removal of Cdc6
0.4 7.1 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 7.1 REACTOME_TRANSLATION Genes involved in Translation
0.1 6.8 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 6.7 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
0.2 6.5 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.1 6.0 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 5.7 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.1 5.0 REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.2 4.5 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.1 4.5 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.2 3.9 REACTOME_CALNEXIN_CALRETICULIN_CYCLE Genes involved in Calnexin/calreticulin cycle
0.1 3.9 REACTOME_PREFOLDIN_MEDIATED_TRANSFER_OF_SUBSTRATE_TO_CCT_TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.2 3.6 REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.1 3.6 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.2 3.4 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.1 3.4 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.1 3.4 REACTOME_RNA_POL_I_TRANSCRIPTION_INITIATION Genes involved in RNA Polymerase I Transcription Initiation
0.3 3.3 REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.2 3.3 REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS Genes involved in Processing of Intronless Pre-mRNAs