Motif ID: ETV4_ETS2

Z-value: 1.154

Transcription factors associated with ETV4_ETS2:

Gene SymbolEntrez IDGene Name
ETS2 ENSG00000157557.7 ETS2
ETV4 ENSG00000175832.8 ETV4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ETV4hg19_v2_chr17_-_41623009_41623053,
hg19_v2_chr17_-_41623716_41623800		0.761.6e-05Click!
ETS2hg19_v2_chr21_+_40177755_40177875,
hg19_v2_chr21_+_40177143_40177231		0.321.3e-01Click!


Activity profile for motif ETV4_ETS2.

activity profile for motif ETV4_ETS2


Sorted Z-values histogram for motif ETV4_ETS2

Sorted Z-values for motif ETV4_ETS2



Network of associatons between targets according to the STRING database.



First level regulatory network of ETV4_ETS2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_47324424 3.658 ENST00000437353.1
ENST00000232766.5
ENST00000455924.2
 KLHL18


kelch-like family member 18


chr1_-_205419053 3.036 ENST00000367154.1
 LEMD1
LEM domain containing 1
chr14_-_94421923 2.969 ENST00000555507.1
 ASB2
ankyrin repeat and SOCS box containing 2
chr1_+_150480551 2.288 ENST00000369049.4
ENST00000369047.4
 ECM1

extracellular matrix protein 1

chr1_+_150480576 2.268 ENST00000346569.6
 ECM1
extracellular matrix protein 1
chr18_-_33077556 2.170 ENST00000589273.1
ENST00000586489.1
 INO80C

INO80 complex subunit C

chr12_+_107712173 2.063 ENST00000280758.5
ENST00000420571.2
 BTBD11

BTB (POZ) domain containing 11

chr2_+_110371905 2.006 ENST00000356454.3
 SOWAHC
sosondowah ankyrin repeat domain family member C
chr2_+_234160340 1.999 ENST00000417017.1
ENST00000392020.4
ENST00000392018.1
 ATG16L1


autophagy related 16-like 1 (S. cerevisiae)


chr15_+_74833518 1.917 ENST00000346246.5
 ARID3B
AT rich interactive domain 3B (BRIGHT-like)
chr2_+_234160217 1.866 ENST00000392017.4
ENST00000347464.5
ENST00000444735.1
ENST00000373525.5
ENST00000419681.1
 ATG16L1




autophagy related 16-like 1 (S. cerevisiae)




chr1_-_200589859 1.866 ENST00000367350.4
 KIF14
kinesin family member 14
chr17_+_7942424 1.847 ENST00000573359.1
 ALOX15B
arachidonate 15-lipoxygenase, type B
chr2_-_110371664 1.838 ENST00000545389.1
ENST00000423520.1
 SEPT10

septin 10

chr18_+_21452964 1.762 ENST00000587184.1
 LAMA3
laminin, alpha 3
chr1_+_152881014 1.711 ENST00000368764.3
ENST00000392667.2
 IVL

involucrin

chr17_+_7942335 1.708 ENST00000380183.4
ENST00000572022.1
ENST00000380173.2
 ALOX15B


arachidonate 15-lipoxygenase, type B


chr11_+_13690249 1.685 ENST00000532701.1
 FAR1
fatty acyl CoA reductase 1
chr9_+_116037922 1.673 ENST00000374198.4
 PRPF4
pre-mRNA processing factor 4
chr1_+_169337172 1.648 ENST00000367807.3
ENST00000367808.3
ENST00000329281.2
ENST00000420531.1
 BLZF1



basic leucine zipper nuclear factor 1




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 510 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.5 GO:0030502 negative regulation of bone mineralization(GO:0030502)
0.0 5.3 GO:0045047 protein targeting to ER(GO:0045047)
0.6 3.9 GO:0044034 negative stranded viral RNA replication(GO:0039689) multi-organism biosynthetic process(GO:0044034)
0.5 3.6 GO:0051122 hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122)
0.2 3.5 GO:0033622 integrin activation(GO:0033622)
1.1 3.3 GO:0006427 histidyl-tRNA aminoacylation(GO:0006427)
0.0 3.2 GO:0007266 Rho protein signal transduction(GO:0007266)
0.4 3.1 GO:0017185 peptidyl-lysine hydroxylation(GO:0017185)
0.1 3.1 GO:0031581 hemidesmosome assembly(GO:0031581)
0.5 2.8 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.1 2.5 GO:0045332 phospholipid translocation(GO:0045332)
0.1 2.3 GO:0006294 nucleotide-excision repair, preincision complex assembly(GO:0006294)
0.1 2.2 GO:0006491 N-glycan processing(GO:0006491)
0.4 2.1 GO:1901503 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.2 2.1 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.0 2.1 GO:0070126 mitochondrial translational termination(GO:0070126)
0.0 2.1 GO:0051444 negative regulation of ubiquitin-protein transferase activity(GO:0051444)
0.7 2.0 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.5 2.0 GO:0044837 assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837)
0.4 2.0 GO:0019918 peptidyl-arginine methylation, to symmetrical-dimethyl arginine(GO:0019918)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 229 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.0 GO:0030027 lamellipodium(GO:0030027)
0.0 6.3 GO:0005759 mitochondrial matrix(GO:0005759)
0.1 6.0 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 6.0 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 4.3 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.4 4.2 GO:0097443 sorting endosome(GO:0097443)
0.2 4.2 GO:0031089 platelet dense granule lumen(GO:0031089)
0.0 4.1 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 4.1 GO:0005925 focal adhesion(GO:0005925)
0.2 3.8 GO:0030127 COPII vesicle coat(GO:0030127)
0.2 3.8 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 3.8 GO:0032587 ruffle membrane(GO:0032587)
0.4 3.2 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0 3.2 GO:0055038 recycling endosome membrane(GO:0055038)
0.4 3.1 GO:0005610 laminin-5 complex(GO:0005610)
0.1 2.8 GO:0030119 AP-type membrane coat adaptor complex(GO:0030119)
0.2 2.5 GO:0030478 actin cap(GO:0030478)
0.1 2.3 GO:0042589 zymogen granule membrane(GO:0042589)
0.1 2.3 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 2.3 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 331 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 15.4 GO:0005525 GTP binding(GO:0005525)
0.0 7.3 GO:0019787 ubiquitin-like protein transferase activity(GO:0019787)
0.0 7.0 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 6.2 GO:0005198 structural molecule activity(GO:0005198)
0.6 4.6 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.1 4.6 GO:0003743 translation initiation factor activity(GO:0003743)
1.2 3.6 GO:0016165 linoleate 13S-lipoxygenase activity(GO:0016165)
1.1 3.3 GO:0004821 histidine-tRNA ligase activity(GO:0004821)
0.0 2.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 2.3 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 2.2 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.1 2.2 GO:0017049 GTP-Rho binding(GO:0017049)
0.1 2.2 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 2.2 GO:0005080 protein kinase C binding(GO:0005080)
0.0 2.2 GO:0008565 protein transporter activity(GO:0008565)
0.4 2.0 GO:0035243 protein-arginine omega-N symmetric methyltransferase activity(GO:0035243)
0.4 2.0 GO:0070815 peptidyl-lysine 5-dioxygenase activity(GO:0070815)
0.2 1.9 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.2 1.9 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.2 1.9 GO:1901567 icosanoid binding(GO:0050542) fatty acid derivative binding(GO:1901567)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 74 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.9 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 7.2 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 4.1 PID_TCR_PATHWAY TCR signaling in naïve CD4+ T cells
0.1 3.9 ST_INTERLEUKIN_4_PATHWAY Interleukin 4 (IL-4) Pathway
0.2 3.8 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 3.6 PID_IL8_CXCR2_PATHWAY IL8- and CXCR2-mediated signaling events
0.2 3.3 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.1 3.3 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 3.3 SIG_CHEMOTAXIS Genes related to chemotaxis
0.0 3.2 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.1 2.8 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.1 2.7 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 2.7 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 2.4 PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY EGF receptor (ErbB1) signaling pathway
0.0 2.4 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 2.0 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 1.9 PID_LKB1_PATHWAY LKB1 signaling events
0.0 1.8 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.1 1.7 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 1.7 PID_IL1_PATHWAY IL1-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 102 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.5 REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.1 5.1 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 4.4 REACTOME_INTEGRIN_ALPHAIIB_BETA3_SIGNALING Genes involved in Integrin alphaIIb beta3 signaling
0.0 4.4 REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.1 3.5 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.2 3.3 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 3.1 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 3.1 REACTOME_CELL_JUNCTION_ORGANIZATION Genes involved in Cell junction organization
0.2 3.0 REACTOME_CALNEXIN_CALRETICULIN_CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 2.9 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 2.5 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 2.5 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 2.4 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.1 2.3 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1 2.2 REACTOME_REGULATION_OF_SIGNALING_BY_CBL Genes involved in Regulation of signaling by CBL
0.0 2.2 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
0.0 2.2 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.1 2.1 REACTOME_NEF_MEDIATES_DOWN_MODULATION_OF_CELL_SURFACE_RECEPTORS_BY_RECRUITING_THEM_TO_CLATHRIN_ADAPTERS Genes involved in Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
0.0 2.1 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 2.0 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor