Motif ID: ETV6

Z-value: 0.500


Transcription factors associated with ETV6:

Gene SymbolEntrez IDGene Name
ETV6 ENSG00000139083.6 ETV6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ETV6hg19_v2_chr12_+_11802753_118028340.321.2e-01Click!


Activity profile for motif ETV6.

activity profile for motif ETV6


Sorted Z-values histogram for motif ETV6

Sorted Z-values for motif ETV6



Network of associatons between targets according to the STRING database.



First level regulatory network of ETV6

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_+_77225071 0.652 ENST00000439557.2
ENST00000545553.1
 MON1B

MON1 secretory trafficking family member B

chr13_-_29292956 0.476 ENST00000266943.6
 SLC46A3
solute carrier family 46, member 3
chr22_+_24891210 0.463 ENST00000382760.2
 UPB1
ureidopropionase, beta
chr16_+_67226019 0.440 ENST00000379378.3
 E2F4
E2F transcription factor 4, p107/p130-binding
chr19_+_7069690 0.413 ENST00000439035.2
 ZNF557
zinc finger protein 557
chr11_+_70244510 0.364 ENST00000346329.3
ENST00000301843.8
ENST00000376561.3
 CTTN


cortactin


chr19_+_7069426 0.345 ENST00000252840.6
ENST00000414706.1
 ZNF557

zinc finger protein 557

chr20_+_49575342 0.342 ENST00000244051.1
 MOCS3
molybdenum cofactor synthesis 3
chr6_-_42946888 0.318 ENST00000244546.4
 PEX6
peroxisomal biogenesis factor 6
chr16_-_3493528 0.313 ENST00000301744.4
 ZNF597
zinc finger protein 597
chr6_-_42946947 0.300 ENST00000304611.8
 PEX6
peroxisomal biogenesis factor 6
chr16_+_23652773 0.289 ENST00000563998.1
ENST00000568589.1
ENST00000568272.1
 DCTN5


dynactin 5 (p25)


chr17_-_42277203 0.259 ENST00000587097.1
 ATXN7L3
ataxin 7-like 3
chr17_+_45908974 0.252 ENST00000269025.4
 LRRC46
leucine rich repeat containing 46
chr17_+_26989109 0.248 ENST00000314616.6
ENST00000347486.4
 SUPT6H

suppressor of Ty 6 homolog (S. cerevisiae)

chr2_+_65454926 0.235 ENST00000542850.1
ENST00000377982.4
 ACTR2

ARP2 actin-related protein 2 homolog (yeast)

chr1_-_43855444 0.226 ENST00000372455.4
 MED8
mediator complex subunit 8
chr17_+_37844331 0.223 ENST00000578199.1
ENST00000406381.2
 ERBB2

v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2

chr6_+_170615819 0.222 ENST00000476287.1
ENST00000252510.9
 FAM120B

family with sequence similarity 120B

chr2_+_189156586 0.221 ENST00000409830.1
 GULP1
GULP, engulfment adaptor PTB domain containing 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 73 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 0.7 GO:0019085 early viral transcription(GO:0019085)
0.2 0.6 GO:0016561 protein import into peroxisome matrix, translocation(GO:0016561)
0.1 0.5 GO:0019482 beta-alanine metabolic process(GO:0019482)
0.1 0.4 GO:0018032 protein amidation(GO:0018032)
0.1 0.4 GO:0016344 meiotic chromosome movement towards spindle pole(GO:0016344)
0.0 0.4 GO:0006930 substrate-dependent cell migration, cell extension(GO:0006930)
0.0 0.4 GO:0044458 motile cilium assembly(GO:0044458)
0.0 0.4 GO:0035357 peroxisome proliferator activated receptor signaling pathway(GO:0035357)
0.1 0.3 GO:0018307 tRNA wobble position uridine thiolation(GO:0002143) enzyme active site formation(GO:0018307)
0.1 0.3 GO:1900224 positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry(GO:1900224)
0.1 0.3 GO:1901668 regulation of superoxide dismutase activity(GO:1901668)
0.1 0.3 GO:1903751 regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903750) negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903751)
0.0 0.3 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.0 0.3 GO:1904886 beta-catenin destruction complex disassembly(GO:1904886)
0.1 0.2 GO:0000354 cis assembly of pre-catalytic spliceosome(GO:0000354)
0.1 0.2 GO:1902310 regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:0060734) positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
0.1 0.2 GO:0032888 regulation of spindle elongation(GO:0032887) regulation of mitotic spindle elongation(GO:0032888) anastral spindle assembly(GO:0055048) protein localization to spindle pole body(GO:0071988) regulation of protein localization to spindle pole body(GO:1902363) positive regulation of protein localization to spindle pole body(GO:1902365) positive regulation of mitotic spindle elongation(GO:1902846)
0.1 0.2 GO:1904327 protein localization to cytosolic proteasome complex(GO:1904327) protein localization to cytosolic proteasome complex involved in ERAD pathway(GO:1904379)
0.1 0.2 GO:0006408 snRNA export from nucleus(GO:0006408) positive regulation of RNA export from nucleus(GO:0046833)
0.1 0.2 GO:0097359 UDP-glucosylation(GO:0097359)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.5 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.1 0.4 GO:0031515 tRNA (m1A) methyltransferase complex(GO:0031515)
0.0 0.4 GO:1990023 mitotic spindle midzone(GO:1990023)
0.0 0.4 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 0.3 GO:0032444 activin responsive factor complex(GO:0032444)
0.0 0.3 GO:1990130 Iml1 complex(GO:1990130)
0.0 0.3 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.0 0.3 GO:0071682 endocytic vesicle lumen(GO:0071682)
0.1 0.2 GO:0055028 cortical microtubule(GO:0055028)
0.1 0.2 GO:0005846 nuclear cap binding complex(GO:0005846)
0.0 0.2 GO:0005602 complement component C1 complex(GO:0005602)
0.0 0.2 GO:0071818 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.0 0.2 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.0 0.2 GO:0071439 clathrin coat of trans-Golgi network vesicle(GO:0030130) clathrin complex(GO:0071439)
0.0 0.2 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.2 GO:0000124 SAGA complex(GO:0000124)
0.0 0.2 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.2 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 0.1 GO:0044753 amphisome(GO:0044753)
0.0 0.1 GO:1990622 CHOP-ATF3 complex(GO:1990622)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.6 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.1 0.4 GO:0004504 peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598)
0.0 0.4 GO:0005522 profilin binding(GO:0005522)
0.1 0.3 GO:0004492 methylmalonyl-CoA decarboxylase activity(GO:0004492)
0.1 0.3 GO:0016429 tRNA (adenine) methyltransferase activity(GO:0016426) tRNA (adenine-N1-)-methyltransferase activity(GO:0016429)
0.1 0.3 GO:0004792 thiosulfate sulfurtransferase activity(GO:0004792)
0.0 0.3 GO:0000990 transcription factor activity, core RNA polymerase binding(GO:0000990)
0.0 0.3 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.1 0.2 GO:0009019 tRNA (guanine-N1-)-methyltransferase activity(GO:0009019)
0.1 0.2 GO:0003980 UDP-glucose:glycoprotein glucosyltransferase activity(GO:0003980)
0.0 0.2 GO:0000702 oxidized base lesion DNA N-glycosylase activity(GO:0000702)
0.0 0.2 GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.0 0.2 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.0 0.2 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.0 0.2 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.0 0.2 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
0.0 0.2 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.0 0.2 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.0 0.2 GO:0051011 microtubule minus-end binding(GO:0051011)
0.0 0.2 GO:0015643 toxic substance binding(GO:0015643)

Gene overrepresentation in C2:CP category:

Showing 1 to 2 of 2 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.4 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.4 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.8 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 0.5 REACTOME_PYRIMIDINE_CATABOLISM Genes involved in Pyrimidine catabolism
0.0 0.5 REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 0.2 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.2 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.0 0.2 REACTOME_CALNEXIN_CALRETICULIN_CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.2 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 0.1 REACTOME_NFKB_IS_ACTIVATED_AND_SIGNALS_SURVIVAL Genes involved in NF-kB is activated and signals survival
0.0 0.1 REACTOME_IRAK2_MEDIATED_ACTIVATION_OF_TAK1_COMPLEX_UPON_TLR7_8_OR_9_STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0 0.1 REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease