Motif ID: FIGLA

Z-value: 0.631


Transcription factors associated with FIGLA:

Gene SymbolEntrez IDGene Name
FIGLA ENSG00000183733.6 FIGLA

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
FIGLAhg19_v2_chr2_-_71017775_710177750.321.2e-01Click!


Activity profile for motif FIGLA.

activity profile for motif FIGLA


Sorted Z-values histogram for motif FIGLA

Sorted Z-values for motif FIGLA



Network of associatons between targets according to the STRING database.



First level regulatory network of FIGLA

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_-_39211463 1.822 ENST00000542910.1
ENST00000398477.1
 KRTAP2-2

keratin associated protein 2-2

chr17_+_39382900 1.572 ENST00000377721.3
ENST00000455970.2
 KRTAP9-2

keratin associated protein 9-2

chr17_-_39280419 1.493 ENST00000394014.1
 KRTAP4-12
keratin associated protein 4-12
chr17_+_39261584 1.237 ENST00000391415.1
 KRTAP4-9
keratin associated protein 4-9
chr6_-_39290316 0.921 ENST00000425054.2
ENST00000373227.4
ENST00000373229.5
ENST00000437525.2
 KCNK16



potassium channel, subfamily K, member 16



chr3_+_49059038 0.856 ENST00000451378.2
 NDUFAF3
NADH dehydrogenase (ubiquinone) complex I, assembly factor 3
chr20_+_44441215 0.811 ENST00000356455.4
ENST00000405520.1
 UBE2C

ubiquitin-conjugating enzyme E2C

chr20_+_44441304 0.806 ENST00000352551.5
 UBE2C
ubiquitin-conjugating enzyme E2C
chr11_+_118175596 0.784 ENST00000528600.1
 CD3E
CD3e molecule, epsilon (CD3-TCR complex)
chr17_+_39411636 0.775 ENST00000394008.1
 KRTAP9-9
keratin associated protein 9-9
chr11_+_118175132 0.774 ENST00000361763.4
 CD3E
CD3e molecule, epsilon (CD3-TCR complex)
chr1_-_230561475 0.737 ENST00000391860.1
 PGBD5
piggyBac transposable element derived 5
chr11_-_123525289 0.640 ENST00000392770.2
ENST00000299333.3
ENST00000530277.1
 SCN3B


sodium channel, voltage-gated, type III, beta subunit


chr17_+_48133459 0.613 ENST00000320031.8
 ITGA3
integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
chr2_+_42104692 0.586 ENST00000398796.2
ENST00000442214.1
 AC104654.1

AC104654.1

chr7_-_99698338 0.569 ENST00000354230.3
ENST00000425308.1
 MCM7

minichromosome maintenance complex component 7

chr1_-_11120057 0.550 ENST00000376957.2
 SRM
spermidine synthase
chr6_+_41888926 0.500 ENST00000230340.4
 BYSL
bystin-like
chr11_+_118958689 0.495 ENST00000535253.1
ENST00000392841.1
 HMBS

hydroxymethylbilane synthase

chr4_-_139163491 0.477 ENST00000280612.5
 SLC7A11
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 76 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.7 GO:0031424 keratinization(GO:0031424)
0.3 1.6 GO:0002669 positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
0.2 1.6 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
0.1 1.0 GO:0048630 skeletal muscle tissue growth(GO:0048630)
0.1 0.8 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.0 0.7 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.1 0.6 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.1 0.6 GO:0007525 somatic muscle development(GO:0007525)
0.1 0.6 GO:0060373 regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373)
0.1 0.6 GO:0008295 spermidine biosynthetic process(GO:0008295)
0.0 0.6 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782)
0.0 0.6 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.0 0.6 GO:0035024 negative regulation of Rho protein signal transduction(GO:0035024)
0.1 0.5 GO:1903691 positive regulation of wound healing, spreading of epidermal cells(GO:1903691)
0.1 0.5 GO:0001661 conditioned taste aversion(GO:0001661)
0.0 0.5 GO:0090050 peptidyl-lysine deacetylation(GO:0034983) positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.0 0.5 GO:0061436 establishment of skin barrier(GO:0061436)
0.1 0.4 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.1 0.4 GO:0046985 positive regulation of hemoglobin biosynthetic process(GO:0046985)
0.1 0.4 GO:0002803 positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.3 GO:0045095 keratin filament(GO:0045095)
0.0 1.7 GO:0005680 anaphase-promoting complex(GO:0005680)
0.1 1.6 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.0 1.0 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.7 GO:0034709 methylosome(GO:0034709)
0.2 0.6 GO:0034667 integrin alpha3-beta1 complex(GO:0034667)
0.0 0.6 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.6 GO:0042555 MCM complex(GO:0042555)
0.0 0.6 GO:0031011 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.1 0.4 GO:0097149 centralspindlin complex(GO:0097149)
0.1 0.4 GO:0097209 epidermal lamellar body(GO:0097209)
0.0 0.4 GO:0035976 AP1 complex(GO:0035976)
0.0 0.4 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.1 0.3 GO:0005607 laminin-2 complex(GO:0005607)
0.0 0.3 GO:0097443 sorting endosome(GO:0097443)
0.0 0.3 GO:0032433 filopodium tip(GO:0032433)
0.0 0.2 GO:0060200 clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.0 0.2 GO:0031074 nucleocytoplasmic shuttling complex(GO:0031074)
0.0 0.2 GO:0008537 proteasome activator complex(GO:0008537)
0.0 0.2 GO:0061689 tricellular tight junction(GO:0061689)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.7 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.1 1.6 GO:0042608 T cell receptor binding(GO:0042608)
0.0 1.0 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 0.8 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.0 0.8 GO:0001968 fibronectin binding(GO:0001968)
0.2 0.6 GO:0008859 exoribonuclease II activity(GO:0008859)
0.2 0.6 GO:0004766 spermidine synthase activity(GO:0004766)
0.1 0.6 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.0 0.6 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.1 0.5 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.0 0.5 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.1 0.4 GO:0044020 histone methyltransferase activity (H4-R3 specific)(GO:0044020)
0.0 0.4 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.0 0.4 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 0.4 GO:0004385 guanylate kinase activity(GO:0004385)
0.1 0.3 GO:0016603 glutaminyl-peptide cyclotransferase activity(GO:0016603)
0.1 0.3 GO:0060961 phospholipase D inhibitor activity(GO:0060961)
0.0 0.3 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.0 0.3 GO:0004340 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.0 0.3 GO:0038085 vascular endothelial growth factor binding(GO:0038085)

Gene overrepresentation in C2:CP category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.1 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 1.0 PID_ERBB2_ERBB3_PATHWAY ErbB2/ErbB3 signaling events
0.0 0.7 PID_ATR_PATHWAY ATR signaling pathway
0.0 0.6 PID_IL23_PATHWAY IL23-mediated signaling events
0.0 0.4 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0 0.3 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 0.2 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.7 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.1 1.6 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 1.2 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 1.1 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.1 1.0 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.1 0.9 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.6 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.0 0.6 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.6 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.6 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.5 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.5 REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 0.3 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.3 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.3 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.0 0.3 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.0 0.2 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 0.2 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.2 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.2 REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling