Motif ID: FLI1

Z-value: 0.768


Transcription factors associated with FLI1:

Gene SymbolEntrez IDGene Name
FLI1 ENSG00000151702.12 FLI1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
FLI1hg19_v2_chr11_+_128563948_128564003,
hg19_v2_chr11_+_128563652_128563689,
hg19_v2_chr11_+_128634589_128634685
0.555.6e-03Click!


Activity profile for motif FLI1.

activity profile for motif FLI1


Sorted Z-values histogram for motif FLI1

Sorted Z-values for motif FLI1



Network of associatons between targets according to the STRING database.



First level regulatory network of FLI1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_153044083 3.337 ENST00000341611.2
SPRR2B
small proline-rich protein 2B
chr13_-_20805109 2.856 ENST00000241124.6
GJB6
gap junction protein, beta 6, 30kDa
chr1_+_150480551 2.246 ENST00000369049.4
ENST00000369047.4
ECM1

extracellular matrix protein 1

chr1_+_150480576 2.225 ENST00000346569.6
ECM1
extracellular matrix protein 1
chr1_-_153066998 2.135 ENST00000368750.3
SPRR2E
small proline-rich protein 2E
chr5_+_96211643 1.750 ENST00000437043.3
ENST00000510373.1
ERAP2

endoplasmic reticulum aminopeptidase 2

chr1_-_205419053 1.652 ENST00000367154.1
LEMD1
LEM domain containing 1
chr1_-_153029980 1.614 ENST00000392653.2
SPRR2A
small proline-rich protein 2A
chr7_+_100770328 1.538 ENST00000223095.4
ENST00000445463.2
SERPINE1

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

chr1_+_84609944 1.530 ENST00000370685.3
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr1_+_32687971 1.525 ENST00000373586.1
EIF3I
eukaryotic translation initiation factor 3, subunit I
chr2_+_31456874 1.482 ENST00000541626.1
EHD3
EH-domain containing 3
chr16_-_30122717 1.471 ENST00000566613.1
GDPD3
glycerophosphodiester phosphodiesterase domain containing 3
chr1_-_153085984 1.391 ENST00000468739.1
SPRR2F
small proline-rich protein 2F
chr1_+_156785425 1.305 ENST00000392302.2
NTRK1
neurotrophic tyrosine kinase, receptor, type 1
chr19_-_11688500 1.300 ENST00000433365.2
ACP5
acid phosphatase 5, tartrate resistant
chr1_-_153113927 1.250 ENST00000368752.4
SPRR2B
small proline-rich protein 2B
chr5_+_96212185 1.157 ENST00000379904.4
ERAP2
endoplasmic reticulum aminopeptidase 2
chr1_+_17559776 1.102 ENST00000537499.1
ENST00000413717.2
ENST00000536552.1
PADI1


peptidyl arginine deiminase, type I


chr19_-_11688447 1.097 ENST00000590420.1
ACP5
acid phosphatase 5, tartrate resistant

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 437 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.9 GO:0018149 peptide cross-linking(GO:0018149)
0.2 5.0 GO:0030502 negative regulation of bone mineralization(GO:0030502)
0.2 2.9 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.1 2.9 GO:0051602 response to electrical stimulus(GO:0051602)
0.5 2.4 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.0 2.3 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.2 2.1 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.1 2.1 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)
0.1 2.1 GO:0031116 positive regulation of microtubule polymerization(GO:0031116)
0.4 2.0 GO:0044565 dendritic cell proliferation(GO:0044565)
0.2 2.0 GO:1904778 regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.1 1.8 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.1 1.7 GO:0090160 Golgi to lysosome transport(GO:0090160)
0.0 1.7 GO:0031529 ruffle organization(GO:0031529)
0.5 1.6 GO:0032888 regulation of spindle elongation(GO:0032887) regulation of mitotic spindle elongation(GO:0032888) anastral spindle assembly(GO:0055048) protein localization to spindle pole body(GO:0071988) regulation of protein localization to spindle pole body(GO:1902363) positive regulation of protein localization to spindle pole body(GO:1902365) positive regulation of mitotic spindle elongation(GO:1902846)
0.0 1.6 GO:0038096 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096)
0.3 1.5 GO:0006203 dGTP catabolic process(GO:0006203)
0.2 1.5 GO:0097338 response to clozapine(GO:0097338)
0.1 1.5 GO:0003376 sphingosine-1-phosphate signaling pathway(GO:0003376) sphingolipid mediated signaling pathway(GO:0090520)
0.0 1.5 GO:0018279 peptidyl-asparagine modification(GO:0018196) protein N-linked glycosylation via asparagine(GO:0018279)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 184 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 10.5 GO:0001533 cornified envelope(GO:0001533)
0.0 6.7 GO:0005924 cell-substrate adherens junction(GO:0005924)
0.0 4.6 GO:0001726 ruffle(GO:0001726)
0.0 4.5 GO:0031965 nuclear membrane(GO:0031965)
0.2 4.2 GO:0031089 platelet dense granule lumen(GO:0031089)
0.1 3.1 GO:0005876 spindle microtubule(GO:0005876)
0.1 2.8 GO:0005922 connexon complex(GO:0005922)
0.0 2.8 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.1 2.4 GO:0030128 clathrin coat of endocytic vesicle(GO:0030128)
0.0 2.1 GO:0005905 clathrin-coated pit(GO:0005905)
0.1 1.9 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1 1.9 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.1 1.9 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.1 1.9 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 1.9 GO:0035371 microtubule plus-end(GO:0035371)
0.0 1.9 GO:0005884 actin filament(GO:0005884)
0.0 1.8 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.2 1.7 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.5 1.6 GO:0055028 cortical microtubule(GO:0055028)
0.1 1.6 GO:0008091 spectrin(GO:0008091)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 283 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 4.7 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.0 4.6 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 3.6 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 3.2 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 2.7 GO:0051015 actin filament binding(GO:0051015)
0.1 2.2 GO:0030280 structural constituent of epidermis(GO:0030280)
0.1 2.1 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.1 2.1 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.2 2.0 GO:0042731 PH domain binding(GO:0042731)
0.2 2.0 GO:0019237 centromeric DNA binding(GO:0019237)
0.1 1.9 GO:0008199 ferric iron binding(GO:0008199)
0.1 1.8 GO:0051011 microtubule minus-end binding(GO:0051011)
0.0 1.8 GO:0001784 phosphotyrosine binding(GO:0001784)
0.1 1.7 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.1 1.7 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 1.7 GO:0030371 translation repressor activity(GO:0030371)
0.0 1.7 GO:0005178 integrin binding(GO:0005178)
0.0 1.6 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 1.6 GO:0005158 insulin receptor binding(GO:0005158)
0.5 1.5 GO:0035539 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity(GO:0008413) 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity(GO:0035539)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.4 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 5.4 PID_TCR_PATHWAY TCR signaling in naïve CD4+ T cells
0.0 4.3 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 3.6 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.0 3.5 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 2.5 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.1 2.0 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 2.0 PID_LKB1_PATHWAY LKB1 signaling events
0.1 1.7 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 1.7 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 1.7 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 1.5 SIG_CHEMOTAXIS Genes related to chemotaxis
0.0 1.4 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 1.3 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0 1.3 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 1.3 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 1.1 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 1.1 PID_IGF1_PATHWAY IGF1 pathway
0.0 1.1 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 1.0 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 86 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.1 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
0.1 3.2 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.1 3.1 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.1 2.8 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.0 2.2 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 2.1 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 2.1 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 2.0 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 2.0 REACTOME_3_UTR_MEDIATED_TRANSLATIONAL_REGULATION Genes involved in 3' -UTR-mediated translational regulation
0.1 1.9 REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 1.9 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.1 1.7 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 1.7 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.1 1.6 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.1 1.3 REACTOME_CD28_DEPENDENT_VAV1_PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 1.3 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PI3KGAMMA Genes involved in G beta:gamma signalling through PI3Kgamma
0.0 1.3 REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION Genes involved in PPARA Activates Gene Expression
0.1 1.2 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation
0.0 1.2 REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.0 1.2 REACTOME_G_ALPHA1213_SIGNALLING_EVENTS Genes involved in G alpha (12/13) signalling events