Motif ID: FOSB

Z-value: 0.530


Transcription factors associated with FOSB:

Gene SymbolEntrez IDGene Name
FOSB ENSG00000125740.9 FOSB

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
FOSBhg19_v2_chr19_+_45971246_45971265-0.377.8e-02Click!


Activity profile for motif FOSB.

activity profile for motif FOSB


Sorted Z-values histogram for motif FOSB

Sorted Z-values for motif FOSB



Network of associatons between targets according to the STRING database.



First level regulatory network of FOSB

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_160231451 0.886 ENST00000495887.1
 DCAF8
DDB1 and CUL4 associated factor 8
chr7_+_23286182 0.749 ENST00000258733.4
ENST00000381990.2
ENST00000409458.3
ENST00000539136.1
ENST00000453162.2
 GPNMB




glycoprotein (transmembrane) nmb




chr6_+_33043703 0.749 ENST00000418931.2
ENST00000535465.1
 HLA-DPB1

major histocompatibility complex, class II, DP beta 1

chr19_-_35981358 0.749 ENST00000484218.2
ENST00000338897.3
 KRTDAP

keratinocyte differentiation-associated protein

chr16_+_71560154 0.743 ENST00000539698.3
 CHST4
carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4
chr16_+_71560023 0.725 ENST00000572450.1
 CHST4
carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4
chr9_-_130637244 0.647 ENST00000373156.1
 AK1
adenylate kinase 1
chr4_-_100356551 0.530 ENST00000209665.4
 ADH7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr4_-_100356844 0.517 ENST00000437033.2
 ADH7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr16_+_69600209 0.516 ENST00000566899.1
 NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr2_-_238499303 0.507 ENST00000409576.1
 RAB17
RAB17, member RAS oncogene family
chr4_-_100356291 0.498 ENST00000476959.1
ENST00000482593.1
 ADH7

alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide

chr11_-_119066545 0.467 ENST00000415318.1
 CCDC153
coiled-coil domain containing 153
chr8_+_99076750 0.467 ENST00000545282.1
 C8orf47
chromosome 8 open reading frame 47
chr17_-_39769005 0.459 ENST00000301653.4
ENST00000593067.1
 KRT16

keratin 16

chr11_-_108408895 0.458 ENST00000443411.1
ENST00000533052.1
 EXPH5

exophilin 5

chr14_+_73525265 0.455 ENST00000525161.1
 RBM25
RNA binding motif protein 25
chrX_+_133371077 0.425 ENST00000517294.1
ENST00000370809.4
 CCDC160

coiled-coil domain containing 160

chr13_-_36429763 0.423 ENST00000379893.1
 DCLK1
doublecortin-like kinase 1
chr17_+_30771279 0.405 ENST00000261712.3
ENST00000578213.1
ENST00000457654.2
ENST00000579451.1
 PSMD11



proteasome (prosome, macropain) 26S subunit, non-ATPase, 11




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 1.5 GO:0010430 fatty acid omega-oxidation(GO:0010430)
0.1 1.5 GO:0006477 protein sulfation(GO:0006477)
0.2 1.2 GO:0071461 cellular response to redox state(GO:0071461)
0.0 1.1 GO:0070884 regulation of calcineurin-NFAT signaling cascade(GO:0070884)
0.2 1.0 GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
0.0 1.0 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 0.7 GO:0061436 establishment of skin barrier(GO:0061436)
0.0 0.7 GO:0031954 positive regulation of protein autophosphorylation(GO:0031954)
0.1 0.6 GO:0043376 regulation of CD8-positive, alpha-beta T cell differentiation(GO:0043376)
0.0 0.4 GO:1990118 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 0.4 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.4 GO:0003334 keratinocyte development(GO:0003334)
0.0 0.4 GO:0016540 protein autoprocessing(GO:0016540)
0.1 0.3 GO:0044805 late nucleophagy(GO:0044805)
0.0 0.3 GO:0032489 regulation of Cdc42 protein signal transduction(GO:0032489)
0.0 0.3 GO:1903237 negative regulation of leukocyte tethering or rolling(GO:1903237)
0.0 0.3 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)
0.0 0.3 GO:0050884 neuromuscular process controlling posture(GO:0050884)
0.1 0.2 GO:0018153 isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine(GO:0018153) isopeptide cross-linking(GO:0018262)
0.1 0.2 GO:1902310 regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:0060734) positive regulation of peptidyl-serine dephosphorylation(GO:1902310)

Gene overrepresentation in cellular_component category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.7 GO:0031228 intrinsic component of Golgi membrane(GO:0031228)
0.0 0.9 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 0.7 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 0.7 GO:0042599 lamellar body(GO:0042599)
0.0 0.5 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.1 0.4 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.0 0.4 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.1 0.3 GO:0097447 dendritic tree(GO:0097447)
0.0 0.3 GO:0005577 fibrinogen complex(GO:0005577)
0.1 0.2 GO:0020005 symbiont-containing vacuole(GO:0020003) symbiont-containing vacuole membrane(GO:0020005)
0.0 0.2 GO:1990796 photoreceptor cell terminal bouton(GO:1990796)
0.0 0.2 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.2 GO:0005638 lamin filament(GO:0005638)
0.0 0.2 GO:1990635 proximal dendrite(GO:1990635)
0.0 0.2 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0 0.2 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.1 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
0.0 0.1 GO:0070826 paraferritin complex(GO:0070826)
0.0 0.1 GO:0045323 interleukin-1 receptor complex(GO:0045323)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 1.5 GO:0004031 aldehyde oxidase activity(GO:0004031)
0.2 1.5 GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.1 1.2 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0 0.9 GO:0019003 GDP binding(GO:0019003)
0.0 0.8 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 0.7 GO:0045545 syndecan binding(GO:0045545)
0.0 0.7 GO:0042605 peptide antigen binding(GO:0042605)
0.0 0.6 GO:0004017 adenylate kinase activity(GO:0004017)
0.0 0.4 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.0 0.4 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.3 GO:0099602 acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.0 0.3 GO:0017081 chloride channel regulator activity(GO:0017081)
0.0 0.3 GO:0017049 GTP-Rho binding(GO:0017049)
0.1 0.2 GO:0035379 carbon dioxide transmembrane transporter activity(GO:0035379)
0.1 0.2 GO:1904455 ubiquitin-specific protease activity involved in negative regulation of ERAD pathway(GO:1904455)
0.1 0.2 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.1 0.2 GO:0008746 NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652)
0.0 0.2 GO:0051120 hepoxilin A3 synthase activity(GO:0051120)
0.0 0.2 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.0 0.2 GO:0072542 protein phosphatase activator activity(GO:0072542)

Gene overrepresentation in C2:CP category:

Showing 1 to 3 of 3 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.1 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 1.0 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 0.2 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.5 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.0 0.6 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 0.6 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 0.4 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.2 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.2 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling