Motif ID: FOSL1
Z-value: 2.217
Transcription factors associated with FOSL1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| FOSL1 | ENSG00000175592.4 | FOSL1 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FOSL1 | hg19_v2_chr11_-_65667884_65667895 | 0.87 | 2.5e-08 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.5 | 19.5 | GO:0046586 | regulation of calcium-dependent cell-cell adhesion(GO:0046586) |
| 3.8 | 15.1 | GO:0006218 | uridine catabolic process(GO:0006218) |
| 3.1 | 9.4 | GO:0018153 | isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine(GO:0018153) isopeptide cross-linking(GO:0018262) |
| 3.0 | 9.1 | GO:1904298 | positive regulation of neutrophil degranulation(GO:0043315) cellular response to gravity(GO:0071258) positive regulation of neutrophil activation(GO:1902565) regulation of transcytosis(GO:1904298) positive regulation of transcytosis(GO:1904300) regulation of maternal process involved in parturition(GO:1904301) positive regulation of maternal process involved in parturition(GO:1904303) response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine(GO:1904316) cellular response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine(GO:1904317) |
| 2.5 | 14.8 | GO:0007296 | vitellogenesis(GO:0007296) |
| 2.3 | 9.1 | GO:0033123 | positive regulation of cyclic nucleotide catabolic process(GO:0030807) positive regulation of cAMP catabolic process(GO:0030822) positive regulation of purine nucleotide catabolic process(GO:0033123) |
| 2.2 | 6.6 | GO:0046521 | sphingoid catabolic process(GO:0046521) |
| 1.7 | 10.4 | GO:0072675 | multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675) |
| 1.5 | 12.3 | GO:0031914 | negative regulation of synaptic plasticity(GO:0031914) |
| 1.5 | 42.9 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 1.4 | 8.6 | GO:1903575 | cornified envelope assembly(GO:1903575) |
| 1.3 | 6.4 | GO:0033078 | extrathymic T cell differentiation(GO:0033078) |
| 1.2 | 3.7 | GO:0002541 | activation of plasma proteins involved in acute inflammatory response(GO:0002541) |
| 1.1 | 5.7 | GO:0031959 | mineralocorticoid receptor signaling pathway(GO:0031959) |
| 1.1 | 4.5 | GO:0021812 | neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812) |
| 1.1 | 4.4 | GO:0090362 | positive regulation of platelet-derived growth factor production(GO:0090362) |
| 1.1 | 27.9 | GO:0030502 | negative regulation of bone mineralization(GO:0030502) |
| 1.0 | 8.4 | GO:1900623 | regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625) |
| 0.9 | 3.7 | GO:0035425 | autocrine signaling(GO:0035425) |
| 0.9 | 4.4 | GO:0002159 | desmosome assembly(GO:0002159) |
| 0.7 | 6.4 | GO:2000660 | negative regulation of interleukin-1-mediated signaling pathway(GO:2000660) |
| 0.7 | 2.1 | GO:0045658 | regulation of eosinophil differentiation(GO:0045643) positive regulation of eosinophil differentiation(GO:0045645) regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659) |
| 0.7 | 2.1 | GO:0044028 | DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029) |
| 0.6 | 7.8 | GO:0060020 | Bergmann glial cell differentiation(GO:0060020) |
| 0.6 | 2.6 | GO:0043006 | activation of phospholipase A2 activity by calcium-mediated signaling(GO:0043006) |
| 0.6 | 11.5 | GO:0051546 | keratinocyte migration(GO:0051546) |
| 0.6 | 1.9 | GO:0000117 | regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117) |
| 0.6 | 42.5 | GO:0018149 | peptide cross-linking(GO:0018149) |
| 0.6 | 2.4 | GO:0070384 | Harderian gland development(GO:0070384) |
| 0.6 | 2.9 | GO:2001271 | negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271) |
| 0.6 | 2.2 | GO:0038123 | toll-like receptor TLR1:TLR2 signaling pathway(GO:0038123) response to triacyl bacterial lipopeptide(GO:0071725) cellular response to triacyl bacterial lipopeptide(GO:0071727) |
| 0.5 | 2.7 | GO:0000738 | DNA catabolic process, exonucleolytic(GO:0000738) |
| 0.5 | 2.7 | GO:0006543 | glutamine catabolic process(GO:0006543) |
| 0.5 | 1.6 | GO:0046167 | glycerol-3-phosphate biosynthetic process(GO:0046167) |
| 0.5 | 9.4 | GO:0090179 | planar cell polarity pathway involved in neural tube closure(GO:0090179) |
| 0.5 | 2.5 | GO:0035105 | sterol regulatory element binding protein import into nucleus(GO:0035105) |
| 0.5 | 1.5 | GO:1903028 | positive regulation of opsonization(GO:1903028) |
| 0.5 | 4.7 | GO:0035583 | sequestering of TGFbeta in extracellular matrix(GO:0035583) |
| 0.4 | 2.2 | GO:0036324 | vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324) negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553) negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 0.4 | 1.7 | GO:0060708 | spongiotrophoblast differentiation(GO:0060708) |
| 0.4 | 1.2 | GO:0060721 | spongiotrophoblast cell proliferation(GO:0060720) regulation of spongiotrophoblast cell proliferation(GO:0060721) cell proliferation involved in embryonic placenta development(GO:0060722) regulation of cell proliferation involved in embryonic placenta development(GO:0060723) |
| 0.4 | 11.1 | GO:0006646 | phosphatidylethanolamine biosynthetic process(GO:0006646) |
| 0.4 | 6.1 | GO:0044351 | macropinocytosis(GO:0044351) phagosome-lysosome fusion(GO:0090385) |
| 0.4 | 10.6 | GO:0032060 | bleb assembly(GO:0032060) |
| 0.4 | 1.6 | GO:0030948 | negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948) |
| 0.4 | 1.9 | GO:0008588 | release of cytoplasmic sequestered NF-kappaB(GO:0008588) |
| 0.4 | 1.5 | GO:0021798 | forebrain dorsal/ventral pattern formation(GO:0021798) mammary gland specification(GO:0060594) |
| 0.4 | 1.4 | GO:0035964 | COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205) |
| 0.3 | 2.8 | GO:0001866 | NK T cell proliferation(GO:0001866) |
| 0.3 | 4.0 | GO:1900029 | positive regulation of ruffle assembly(GO:1900029) |
| 0.3 | 4.5 | GO:0033631 | cell-cell adhesion mediated by integrin(GO:0033631) |
| 0.3 | 1.0 | GO:1902938 | regulation of intracellular calcium activated chloride channel activity(GO:1902938) |
| 0.3 | 1.6 | GO:0071802 | negative regulation of podosome assembly(GO:0071802) |
| 0.3 | 2.5 | GO:0050428 | purine ribonucleoside bisphosphate biosynthetic process(GO:0034036) 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process(GO:0050428) |
| 0.3 | 3.0 | GO:0015014 | heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014) |
| 0.3 | 0.6 | GO:0007406 | negative regulation of neuroblast proliferation(GO:0007406) |
| 0.3 | 0.8 | GO:2001045 | negative regulation of integrin-mediated signaling pathway(GO:2001045) |
| 0.3 | 1.4 | GO:0032792 | negative regulation of CREB transcription factor activity(GO:0032792) regulation of determination of dorsal identity(GO:2000015) |
| 0.3 | 4.7 | GO:0050862 | positive regulation of T cell receptor signaling pathway(GO:0050862) |
| 0.3 | 2.2 | GO:0090043 | regulation of tubulin deacetylation(GO:0090043) |
| 0.3 | 1.3 | GO:0010482 | epidermal cell division(GO:0010481) regulation of epidermal cell division(GO:0010482) |
| 0.3 | 3.6 | GO:0045625 | regulation of T-helper 1 cell differentiation(GO:0045625) |
| 0.3 | 5.6 | GO:0071361 | cellular response to ethanol(GO:0071361) |
| 0.3 | 2.8 | GO:0090050 | positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) |
| 0.3 | 1.0 | GO:0038195 | urokinase plasminogen activator signaling pathway(GO:0038195) |
| 0.3 | 0.8 | GO:0007206 | phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206) |
| 0.2 | 1.0 | GO:0018242 | protein O-linked glycosylation via serine(GO:0018242) |
| 0.2 | 1.2 | GO:1903336 | negative regulation of vacuolar transport(GO:1903336) |
| 0.2 | 3.8 | GO:0045109 | intermediate filament organization(GO:0045109) |
| 0.2 | 1.8 | GO:0035021 | negative regulation of Rac protein signal transduction(GO:0035021) |
| 0.2 | 0.7 | GO:0035606 | peptidyl-cysteine S-trans-nitrosylation(GO:0035606) |
| 0.2 | 4.0 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 0.2 | 3.0 | GO:0035092 | sperm chromatin condensation(GO:0035092) |
| 0.2 | 0.7 | GO:0010949 | negative regulation of intestinal phytosterol absorption(GO:0010949) negative regulation of intestinal cholesterol absorption(GO:0045796) intestinal phytosterol absorption(GO:0060752) negative regulation of intestinal lipid absorption(GO:1904730) |
| 0.2 | 10.1 | GO:0043486 | histone exchange(GO:0043486) |
| 0.2 | 1.4 | GO:1902031 | regulation of NADP metabolic process(GO:1902031) |
| 0.2 | 2.0 | GO:0098734 | macromolecule depalmitoylation(GO:0098734) |
| 0.2 | 8.7 | GO:0007176 | regulation of epidermal growth factor-activated receptor activity(GO:0007176) |
| 0.2 | 9.2 | GO:0061718 | NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718) |
| 0.2 | 1.2 | GO:0030421 | defecation(GO:0030421) |
| 0.2 | 0.4 | GO:0031394 | positive regulation of prostaglandin biosynthetic process(GO:0031394) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280) |
| 0.2 | 2.5 | GO:2001135 | regulation of endocytic recycling(GO:2001135) |
| 0.2 | 2.6 | GO:0060707 | trophoblast giant cell differentiation(GO:0060707) |
| 0.2 | 2.8 | GO:0043517 | positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517) |
| 0.1 | 0.6 | GO:2000286 | receptor internalization involved in canonical Wnt signaling pathway(GO:2000286) |
| 0.1 | 3.9 | GO:0035855 | megakaryocyte development(GO:0035855) |
| 0.1 | 0.8 | GO:0006041 | glucosamine metabolic process(GO:0006041) |
| 0.1 | 2.9 | GO:0003417 | growth plate cartilage development(GO:0003417) |
| 0.1 | 0.4 | GO:0045085 | negative regulation of interleukin-2 biosynthetic process(GO:0045085) |
| 0.1 | 0.4 | GO:0090024 | complement component C5a signaling pathway(GO:0038178) negative regulation of granulocyte chemotaxis(GO:0071623) negative regulation of neutrophil chemotaxis(GO:0090024) negative regulation of neutrophil migration(GO:1902623) |
| 0.1 | 1.7 | GO:0001731 | formation of translation preinitiation complex(GO:0001731) |
| 0.1 | 0.5 | GO:0032455 | nerve growth factor processing(GO:0032455) |
| 0.1 | 0.8 | GO:1902748 | melanocyte migration(GO:0097324) positive regulation of lens fiber cell differentiation(GO:1902748) |
| 0.1 | 2.2 | GO:0001765 | membrane raft assembly(GO:0001765) |
| 0.1 | 2.4 | GO:0071803 | positive regulation of podosome assembly(GO:0071803) |
| 0.1 | 5.0 | GO:0014046 | dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059) |
| 0.1 | 6.5 | GO:1901385 | regulation of voltage-gated calcium channel activity(GO:1901385) |
| 0.1 | 7.7 | GO:0033574 | response to testosterone(GO:0033574) |
| 0.1 | 1.5 | GO:0051639 | actin filament network formation(GO:0051639) |
| 0.1 | 2.4 | GO:0035589 | G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589) |
| 0.1 | 0.7 | GO:0038124 | toll-like receptor TLR6:TLR2 signaling pathway(GO:0038124) response to diacyl bacterial lipopeptide(GO:0071724) cellular response to diacyl bacterial lipopeptide(GO:0071726) |
| 0.1 | 4.6 | GO:0007205 | protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205) positive regulation of release of sequestered calcium ion into cytosol(GO:0051281) |
| 0.1 | 0.8 | GO:0010626 | regulation of Schwann cell proliferation(GO:0010624) negative regulation of Schwann cell proliferation(GO:0010626) |
| 0.1 | 3.4 | GO:0042481 | regulation of odontogenesis(GO:0042481) |
| 0.1 | 2.4 | GO:0070498 | interleukin-1-mediated signaling pathway(GO:0070498) |
| 0.1 | 1.3 | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis(GO:0051044) |
| 0.1 | 7.9 | GO:0050819 | negative regulation of coagulation(GO:0050819) |
| 0.1 | 0.4 | GO:0002572 | pro-T cell differentiation(GO:0002572) |
| 0.1 | 1.2 | GO:0042905 | 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905) |
| 0.1 | 0.4 | GO:0002268 | follicular dendritic cell differentiation(GO:0002268) |
| 0.1 | 0.3 | GO:1901656 | glycoside transport(GO:1901656) |
| 0.1 | 9.1 | GO:0070268 | cornification(GO:0070268) |
| 0.1 | 4.8 | GO:1904837 | beta-catenin-TCF complex assembly(GO:1904837) |
| 0.1 | 1.7 | GO:0071985 | multivesicular body sorting pathway(GO:0071985) |
| 0.1 | 2.0 | GO:0002717 | positive regulation of natural killer cell mediated immunity(GO:0002717) |
| 0.1 | 2.1 | GO:0060512 | prostate gland morphogenesis(GO:0060512) |
| 0.1 | 1.2 | GO:0007084 | mitotic nuclear envelope reassembly(GO:0007084) |
| 0.1 | 0.4 | GO:0060125 | negative regulation of growth hormone secretion(GO:0060125) |
| 0.1 | 10.3 | GO:0030216 | keratinocyte differentiation(GO:0030216) |
| 0.1 | 8.2 | GO:0002062 | chondrocyte differentiation(GO:0002062) |
| 0.1 | 3.3 | GO:0035987 | endodermal cell differentiation(GO:0035987) |
| 0.1 | 0.1 | GO:1990737 | response to manganese-induced endoplasmic reticulum stress(GO:1990737) |
| 0.1 | 0.5 | GO:0035871 | protein K11-linked deubiquitination(GO:0035871) |
| 0.1 | 0.3 | GO:2001288 | positive regulation of caveolin-mediated endocytosis(GO:2001288) |
| 0.1 | 5.2 | GO:0030834 | regulation of actin filament depolymerization(GO:0030834) |
| 0.1 | 0.3 | GO:1903715 | regulation of aerobic respiration(GO:1903715) |
| 0.1 | 0.1 | GO:0060763 | mammary duct terminal end bud growth(GO:0060763) |
| 0.1 | 0.1 | GO:1902897 | regulation of postsynaptic density protein 95 clustering(GO:1902897) |
| 0.1 | 3.0 | GO:0015721 | bile acid and bile salt transport(GO:0015721) |
| 0.1 | 0.5 | GO:0035973 | aggrephagy(GO:0035973) |
| 0.1 | 0.8 | GO:0045793 | positive regulation of cell size(GO:0045793) |
| 0.1 | 0.9 | GO:1900027 | regulation of ruffle assembly(GO:1900027) |
| 0.1 | 0.6 | GO:1904262 | negative regulation of TORC1 signaling(GO:1904262) |
| 0.1 | 0.4 | GO:0046813 | receptor-mediated virion attachment to host cell(GO:0046813) |
| 0.0 | 0.8 | GO:0051480 | regulation of cytosolic calcium ion concentration(GO:0051480) |
| 0.0 | 0.8 | GO:1903541 | regulation of exosomal secretion(GO:1903541) positive regulation of exosomal secretion(GO:1903543) |
| 0.0 | 0.8 | GO:2000114 | regulation of establishment of cell polarity(GO:2000114) |
| 0.0 | 0.6 | GO:0050954 | sensory perception of sound(GO:0007605) sensory perception of mechanical stimulus(GO:0050954) |
| 0.0 | 3.2 | GO:0046847 | filopodium assembly(GO:0046847) |
| 0.0 | 1.0 | GO:0051412 | response to corticosterone(GO:0051412) |
| 0.0 | 1.3 | GO:0010842 | retina layer formation(GO:0010842) |
| 0.0 | 0.5 | GO:0043518 | negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) |
| 0.0 | 0.2 | GO:0000720 | pyrimidine dimer repair by nucleotide-excision repair(GO:0000720) |
| 0.0 | 1.3 | GO:0032461 | positive regulation of protein oligomerization(GO:0032461) |
| 0.0 | 1.5 | GO:0010880 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum(GO:0010880) |
| 0.0 | 1.3 | GO:0071577 | zinc II ion transmembrane transport(GO:0071577) |
| 0.0 | 1.5 | GO:0006308 | DNA catabolic process(GO:0006308) |
| 0.0 | 0.2 | GO:0002036 | regulation of L-glutamate transport(GO:0002036) |
| 0.0 | 1.2 | GO:0006693 | prostanoid metabolic process(GO:0006692) prostaglandin metabolic process(GO:0006693) |
| 0.0 | 0.3 | GO:2000580 | positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582) |
| 0.0 | 0.8 | GO:0036150 | phosphatidylserine acyl-chain remodeling(GO:0036150) |
| 0.0 | 0.8 | GO:0000470 | maturation of LSU-rRNA(GO:0000470) |
| 0.0 | 0.3 | GO:1904714 | regulation of chaperone-mediated autophagy(GO:1904714) |
| 0.0 | 0.8 | GO:0015695 | organic cation transport(GO:0015695) |
| 0.0 | 1.4 | GO:0015949 | nucleobase-containing small molecule interconversion(GO:0015949) |
| 0.0 | 0.8 | GO:0048268 | clathrin coat assembly(GO:0048268) |
| 0.0 | 0.1 | GO:0071651 | positive regulation of chemokine (C-C motif) ligand 5 production(GO:0071651) |
| 0.0 | 0.4 | GO:1902857 | positive regulation of nonmotile primary cilium assembly(GO:1902857) |
| 0.0 | 1.0 | GO:0030224 | monocyte differentiation(GO:0030224) |
| 0.0 | 0.9 | GO:0030308 | negative regulation of cell growth(GO:0030308) |
| 0.0 | 0.3 | GO:0032754 | positive regulation of interleukin-5 production(GO:0032754) |
| 0.0 | 0.6 | GO:0007158 | neuron cell-cell adhesion(GO:0007158) |
| 0.0 | 1.6 | GO:0005978 | glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250) |
| 0.0 | 1.3 | GO:0006968 | cellular defense response(GO:0006968) |
| 0.0 | 1.1 | GO:0036092 | phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092) |
| 0.0 | 1.1 | GO:0006687 | glycosphingolipid metabolic process(GO:0006687) |
| 0.0 | 0.7 | GO:0042769 | DNA damage response, detection of DNA damage(GO:0042769) |
| 0.0 | 0.1 | GO:0042636 | negative regulation of hair cycle(GO:0042636) |
| 0.0 | 1.3 | GO:0030317 | sperm motility(GO:0030317) |
| 0.0 | 0.1 | GO:0038061 | NIK/NF-kappaB signaling(GO:0038061) |
| 0.0 | 0.1 | GO:1990182 | exosomal secretion(GO:1990182) |
| 0.0 | 2.3 | GO:0030509 | BMP signaling pathway(GO:0030509) |
| 0.0 | 1.3 | GO:0000226 | microtubule cytoskeleton organization(GO:0000226) |
| 0.0 | 1.8 | GO:0003231 | cardiac ventricle development(GO:0003231) |
| 0.0 | 0.4 | GO:0016226 | iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163) |
| 0.0 | 0.3 | GO:0045604 | regulation of epidermal cell differentiation(GO:0045604) |
| 0.0 | 0.7 | GO:0021983 | pituitary gland development(GO:0021983) |
| 0.0 | 0.6 | GO:0030866 | cortical actin cytoskeleton organization(GO:0030866) |
| 0.0 | 1.4 | GO:1903955 | positive regulation of protein targeting to mitochondrion(GO:1903955) |
| 0.0 | 0.1 | GO:0032802 | low-density lipoprotein particle receptor catabolic process(GO:0032802) |
| 0.0 | 0.9 | GO:0045860 | positive regulation of protein kinase activity(GO:0045860) |
| 0.0 | 0.2 | GO:0038007 | netrin-activated signaling pathway(GO:0038007) negative regulation of synapse assembly(GO:0051964) |
| 0.0 | 0.5 | GO:0018108 | peptidyl-tyrosine phosphorylation(GO:0018108) |
| 0.0 | 0.4 | GO:0034629 | cellular protein complex localization(GO:0034629) |
| 0.0 | 0.0 | GO:1902202 | regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202) |
| 0.0 | 1.0 | GO:0051965 | positive regulation of synapse assembly(GO:0051965) |
| 0.0 | 1.1 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
| 0.0 | 0.6 | GO:0042058 | regulation of epidermal growth factor receptor signaling pathway(GO:0042058) |
| 0.0 | 1.3 | GO:0051225 | spindle assembly(GO:0051225) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.0 | 15.0 | GO:0005607 | laminin-2 complex(GO:0005607) |
| 3.1 | 25.1 | GO:0005610 | laminin-5 complex(GO:0005610) |
| 1.8 | 10.6 | GO:0070435 | Shc-EGFR complex(GO:0070435) |
| 1.6 | 27.9 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 1.2 | 4.8 | GO:0030934 | anchoring collagen complex(GO:0030934) |
| 1.2 | 8.4 | GO:0035692 | macrophage migration inhibitory factor receptor complex(GO:0035692) |
| 1.2 | 75.8 | GO:0001533 | cornified envelope(GO:0001533) |
| 1.1 | 4.5 | GO:0071062 | alphav-beta3 integrin-vitronectin complex(GO:0071062) |
| 1.1 | 7.5 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
| 0.7 | 2.2 | GO:1990032 | parallel fiber(GO:1990032) |
| 0.5 | 10.1 | GO:0000812 | Swr1 complex(GO:0000812) |
| 0.5 | 1.4 | GO:1990622 | CHOP-ATF3 complex(GO:1990622) |
| 0.4 | 2.2 | GO:0046696 | lipopolysaccharide receptor complex(GO:0046696) |
| 0.4 | 2.4 | GO:0045323 | interleukin-1 receptor complex(GO:0045323) |
| 0.4 | 1.1 | GO:0071159 | NF-kappaB complex(GO:0071159) |
| 0.3 | 11.0 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.3 | 2.5 | GO:0005638 | lamin filament(GO:0005638) |
| 0.3 | 0.8 | GO:0033565 | ESCRT-0 complex(GO:0033565) |
| 0.2 | 4.0 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.2 | 6.4 | GO:0031528 | microvillus membrane(GO:0031528) |
| 0.2 | 5.6 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.2 | 4.1 | GO:0030056 | hemidesmosome(GO:0030056) |
| 0.2 | 4.9 | GO:0005892 | acetylcholine-gated channel complex(GO:0005892) |
| 0.2 | 4.7 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.2 | 0.8 | GO:1990812 | growth cone filopodium(GO:1990812) |
| 0.2 | 3.1 | GO:0042589 | zymogen granule membrane(GO:0042589) |
| 0.2 | 7.5 | GO:0043034 | costamere(GO:0043034) |
| 0.2 | 25.4 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.2 | 1.1 | GO:0032437 | cuticular plate(GO:0032437) |
| 0.2 | 4.6 | GO:0031233 | intrinsic component of external side of plasma membrane(GO:0031233) |
| 0.1 | 2.4 | GO:0008290 | F-actin capping protein complex(GO:0008290) |
| 0.1 | 0.8 | GO:0070545 | PeBoW complex(GO:0070545) |
| 0.1 | 1.3 | GO:0035686 | sperm fibrous sheath(GO:0035686) |
| 0.1 | 1.7 | GO:0030478 | actin cap(GO:0030478) |
| 0.1 | 9.7 | GO:0005902 | microvillus(GO:0005902) |
| 0.1 | 0.9 | GO:0016461 | unconventional myosin complex(GO:0016461) |
| 0.1 | 13.6 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.1 | 0.4 | GO:0033257 | Bcl3/NF-kappaB2 complex(GO:0033257) |
| 0.1 | 0.7 | GO:0097452 | GAIT complex(GO:0097452) |
| 0.1 | 0.4 | GO:0071149 | TEAD-2-YAP complex(GO:0071149) |
| 0.1 | 2.3 | GO:0005852 | eukaryotic translation initiation factor 3 complex(GO:0005852) |
| 0.1 | 1.5 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.1 | 10.5 | GO:0070821 | tertiary granule membrane(GO:0070821) |
| 0.1 | 1.4 | GO:0019774 | proteasome core complex, beta-subunit complex(GO:0019774) |
| 0.1 | 6.7 | GO:0030670 | phagocytic vesicle membrane(GO:0030670) |
| 0.1 | 2.5 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.1 | 0.9 | GO:0070652 | HAUS complex(GO:0070652) |
| 0.1 | 0.9 | GO:0097433 | dense body(GO:0097433) |
| 0.1 | 7.9 | GO:0005604 | basement membrane(GO:0005604) |
| 0.1 | 0.4 | GO:0071817 | MMXD complex(GO:0071817) |
| 0.1 | 2.8 | GO:0016592 | mediator complex(GO:0016592) |
| 0.1 | 0.4 | GO:0005854 | nascent polypeptide-associated complex(GO:0005854) |
| 0.1 | 1.5 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.1 | 3.1 | GO:0031904 | endosome lumen(GO:0031904) |
| 0.1 | 0.3 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
| 0.0 | 0.4 | GO:0005827 | polar microtubule(GO:0005827) |
| 0.0 | 0.6 | GO:0061700 | GATOR2 complex(GO:0061700) |
| 0.0 | 0.2 | GO:0098536 | deuterosome(GO:0098536) |
| 0.0 | 2.9 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.0 | 12.5 | GO:0030027 | lamellipodium(GO:0030027) |
| 0.0 | 0.4 | GO:0030057 | desmosome(GO:0030057) |
| 0.0 | 5.3 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.0 | 1.0 | GO:0005922 | connexon complex(GO:0005922) |
| 0.0 | 2.3 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.0 | 1.6 | GO:0031430 | M band(GO:0031430) |
| 0.0 | 1.5 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.0 | 1.2 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.0 | 0.5 | GO:0031010 | ISWI-type complex(GO:0031010) |
| 0.0 | 2.3 | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment(GO:0005793) |
| 0.0 | 0.2 | GO:0000110 | nucleotide-excision repair factor 1 complex(GO:0000110) |
| 0.0 | 2.0 | GO:0016605 | PML body(GO:0016605) |
| 0.0 | 0.1 | GO:1990037 | Lewy body core(GO:1990037) |
| 0.0 | 0.5 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.0 | 1.3 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 0.0 | 1.6 | GO:0043197 | dendritic spine(GO:0043197) neuron spine(GO:0044309) |
| 0.0 | 1.9 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 2.6 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.0 | 5.0 | GO:0030667 | secretory granule membrane(GO:0030667) |
| 0.0 | 4.5 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.0 | 1.1 | GO:0016235 | aggresome(GO:0016235) |
| 0.0 | 1.0 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.0 | 2.2 | GO:0030658 | transport vesicle membrane(GO:0030658) |
| 0.0 | 0.3 | GO:0005868 | cytoplasmic dynein complex(GO:0005868) |
| 0.0 | 0.4 | GO:0045334 | clathrin-coated endocytic vesicle(GO:0045334) |
| 0.0 | 2.2 | GO:0000922 | spindle pole(GO:0000922) |
| 0.0 | 0.4 | GO:0030665 | clathrin-coated vesicle membrane(GO:0030665) |
| 0.0 | 0.3 | GO:0005771 | multivesicular body(GO:0005771) |
| 0.0 | 2.0 | GO:0019897 | extrinsic component of plasma membrane(GO:0019897) |
| 0.0 | 1.0 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.0 | 0.9 | GO:0005905 | clathrin-coated pit(GO:0005905) |
| 0.0 | 0.6 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.3 | 26.2 | GO:0005134 | interleukin-2 receptor binding(GO:0005134) |
| 3.0 | 15.1 | GO:0004850 | uridine phosphorylase activity(GO:0004850) |
| 2.8 | 8.3 | GO:0005150 | interleukin-1, Type I receptor binding(GO:0005150) |
| 1.7 | 8.6 | GO:0004992 | platelet activating factor receptor activity(GO:0004992) |
| 1.5 | 4.6 | GO:0004947 | bradykinin receptor activity(GO:0004947) |
| 1.5 | 10.6 | GO:0048408 | epidermal growth factor binding(GO:0048408) |
| 1.3 | 9.4 | GO:1990254 | keratin filament binding(GO:1990254) |
| 1.3 | 19.3 | GO:0030280 | structural constituent of epidermis(GO:0030280) |
| 1.1 | 6.6 | GO:0017050 | sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050) |
| 1.1 | 11.1 | GO:0004305 | ethanolamine kinase activity(GO:0004305) |
| 1.1 | 7.5 | GO:0004634 | phosphopyruvate hydratase activity(GO:0004634) |
| 0.9 | 2.8 | GO:0005173 | stem cell factor receptor binding(GO:0005173) |
| 0.9 | 4.7 | GO:0050436 | microfibril binding(GO:0050436) |
| 0.9 | 2.7 | GO:0008859 | exoribonuclease II activity(GO:0008859) |
| 0.8 | 4.1 | GO:0016286 | small conductance calcium-activated potassium channel activity(GO:0016286) |
| 0.8 | 9.1 | GO:0017034 | Rap guanyl-nucleotide exchange factor activity(GO:0017034) |
| 0.7 | 3.0 | GO:0050119 | N-acetylglucosamine deacetylase activity(GO:0050119) |
| 0.6 | 3.2 | GO:0042289 | MHC class II protein binding(GO:0042289) |
| 0.6 | 3.0 | GO:0008508 | bile acid:sodium symporter activity(GO:0008508) |
| 0.5 | 2.7 | GO:0004359 | glutaminase activity(GO:0004359) |
| 0.5 | 4.8 | GO:0005143 | interleukin-12 receptor binding(GO:0005143) |
| 0.5 | 1.6 | GO:0004370 | glycerol kinase activity(GO:0004370) |
| 0.5 | 6.7 | GO:0043184 | vascular endothelial growth factor receptor 2 binding(GO:0043184) |
| 0.5 | 1.4 | GO:0004362 | glutathione-disulfide reductase activity(GO:0004362) |
| 0.4 | 2.2 | GO:0016019 | peptidoglycan receptor activity(GO:0016019) |
| 0.4 | 1.3 | GO:0004618 | phosphoglycerate kinase activity(GO:0004618) |
| 0.3 | 1.7 | GO:0071074 | eukaryotic initiation factor eIF2 binding(GO:0071074) |
| 0.3 | 3.6 | GO:0038132 | neuregulin binding(GO:0038132) |
| 0.3 | 4.6 | GO:0045294 | alpha-catenin binding(GO:0045294) |
| 0.3 | 1.3 | GO:0008426 | protein kinase C inhibitor activity(GO:0008426) |
| 0.3 | 11.0 | GO:0050431 | transforming growth factor beta binding(GO:0050431) |
| 0.3 | 20.2 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.3 | 0.9 | GO:0017082 | mineralocorticoid receptor activity(GO:0017082) |
| 0.3 | 9.0 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.3 | 5.5 | GO:0044548 | S100 protein binding(GO:0044548) |
| 0.3 | 1.0 | GO:0004530 | deoxyribonuclease I activity(GO:0004530) |
| 0.2 | 4.5 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
| 0.2 | 2.4 | GO:0004704 | NF-kappaB-inducing kinase activity(GO:0004704) |
| 0.2 | 1.4 | GO:0004473 | malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473) |
| 0.2 | 1.2 | GO:0047374 | methylumbelliferyl-acetate deacetylase activity(GO:0047374) |
| 0.2 | 6.1 | GO:0017160 | Ral GTPase binding(GO:0017160) |
| 0.2 | 5.6 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
| 0.2 | 2.5 | GO:0019531 | oxalate transmembrane transporter activity(GO:0019531) |
| 0.2 | 4.9 | GO:0022848 | acetylcholine-gated cation channel activity(GO:0022848) |
| 0.2 | 2.0 | GO:0008474 | palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599) |
| 0.2 | 0.4 | GO:0031893 | vasopressin receptor binding(GO:0031893) |
| 0.2 | 12.3 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.2 | 13.3 | GO:0019212 | phosphatase inhibitor activity(GO:0019212) |
| 0.2 | 0.7 | GO:0043891 | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891) |
| 0.2 | 1.8 | GO:0004332 | fructose-bisphosphate aldolase activity(GO:0004332) |
| 0.2 | 6.4 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
| 0.2 | 1.0 | GO:1903135 | cupric ion binding(GO:1903135) |
| 0.2 | 0.6 | GO:0001069 | regulatory region RNA binding(GO:0001069) |
| 0.1 | 1.6 | GO:0019784 | NEDD8-specific protease activity(GO:0019784) |
| 0.1 | 3.5 | GO:0030275 | LRR domain binding(GO:0030275) |
| 0.1 | 4.5 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.1 | 4.0 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.1 | 4.0 | GO:0015035 | protein disulfide oxidoreductase activity(GO:0015035) |
| 0.1 | 1.9 | GO:0001206 | transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206) |
| 0.1 | 0.4 | GO:0004878 | complement component C5a receptor activity(GO:0004878) |
| 0.1 | 2.4 | GO:0003708 | retinoic acid receptor activity(GO:0003708) |
| 0.1 | 0.8 | GO:0019215 | intermediate filament binding(GO:0019215) |
| 0.1 | 0.7 | GO:0072542 | protein phosphatase activator activity(GO:0072542) |
| 0.1 | 1.1 | GO:0071532 | ankyrin repeat binding(GO:0071532) |
| 0.1 | 2.4 | GO:0045028 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 0.1 | 2.3 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
| 0.1 | 1.9 | GO:0048156 | tau protein binding(GO:0048156) |
| 0.1 | 2.1 | GO:0055106 | ubiquitin-protein transferase regulator activity(GO:0055106) |
| 0.1 | 1.2 | GO:0047035 | testosterone dehydrogenase (NAD+) activity(GO:0047035) |
| 0.1 | 1.6 | GO:0035612 | AP-2 adaptor complex binding(GO:0035612) |
| 0.1 | 7.4 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.1 | 2.5 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.1 | 1.3 | GO:0019855 | calcium channel inhibitor activity(GO:0019855) |
| 0.1 | 9.8 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.1 | 1.3 | GO:0005041 | low-density lipoprotein receptor activity(GO:0005041) |
| 0.1 | 0.8 | GO:0019534 | toxin transporter activity(GO:0019534) |
| 0.1 | 3.6 | GO:0051019 | mitogen-activated protein kinase binding(GO:0051019) |
| 0.1 | 8.3 | GO:0031490 | chromatin DNA binding(GO:0031490) |
| 0.1 | 19.9 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 0.8 | GO:0035256 | G-protein coupled glutamate receptor binding(GO:0035256) |
| 0.1 | 0.7 | GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135) |
| 0.1 | 0.9 | GO:0099602 | acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602) |
| 0.1 | 1.3 | GO:0008253 | 5'-nucleotidase activity(GO:0008253) |
| 0.1 | 59.2 | GO:0005198 | structural molecule activity(GO:0005198) |
| 0.1 | 1.1 | GO:0004065 | arylsulfatase activity(GO:0004065) |
| 0.1 | 1.8 | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) |
| 0.1 | 1.7 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.1 | 1.4 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.1 | 0.8 | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205) |
| 0.0 | 1.9 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 0.0 | 1.5 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.0 | 1.5 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
| 0.0 | 0.9 | GO:0008200 | ion channel inhibitor activity(GO:0008200) |
| 0.0 | 0.2 | GO:0023024 | MHC class I protein complex binding(GO:0023024) |
| 0.0 | 2.7 | GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980) |
| 0.0 | 0.4 | GO:0070530 | K63-linked polyubiquitin binding(GO:0070530) |
| 0.0 | 1.3 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.0 | 1.1 | GO:0005104 | fibroblast growth factor receptor binding(GO:0005104) |
| 0.0 | 0.7 | GO:0017127 | cholesterol transporter activity(GO:0017127) |
| 0.0 | 1.2 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.0 | 0.4 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.0 | 0.7 | GO:0001158 | enhancer sequence-specific DNA binding(GO:0001158) |
| 0.0 | 1.5 | GO:0043531 | ADP binding(GO:0043531) |
| 0.0 | 5.0 | GO:0008201 | heparin binding(GO:0008201) |
| 0.0 | 2.1 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.0 | 0.5 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.0 | 0.2 | GO:1990599 | 3' overhang single-stranded DNA endodeoxyribonuclease activity(GO:1990599) |
| 0.0 | 0.1 | GO:0052836 | inositol 5-diphosphate pentakisphosphate 5-kinase activity(GO:0052836) inositol diphosphate tetrakisphosphate kinase activity(GO:0052839) |
| 0.0 | 0.1 | GO:0034648 | histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648) |
| 0.0 | 2.6 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.0 | 0.0 | GO:0005171 | hepatocyte growth factor receptor binding(GO:0005171) |
| 0.0 | 0.6 | GO:0004190 | aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001) |
| 0.0 | 0.1 | GO:0033592 | RNA strand annealing activity(GO:0033592) |
| 0.0 | 1.8 | GO:0019838 | growth factor binding(GO:0019838) |
| 0.0 | 0.1 | GO:1990460 | leptin receptor binding(GO:1990460) |
| 0.0 | 0.4 | GO:0046965 | retinoid X receptor binding(GO:0046965) |
| 0.0 | 1.4 | GO:0002039 | p53 binding(GO:0002039) |
| 0.0 | 6.8 | GO:0005525 | GTP binding(GO:0005525) |
| 0.0 | 0.3 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
| 0.0 | 0.5 | GO:0016702 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702) |
| 0.0 | 2.8 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.0 | 0.1 | GO:0000340 | RNA 7-methylguanosine cap binding(GO:0000340) |
| 0.0 | 4.0 | GO:0030246 | carbohydrate binding(GO:0030246) |
| 0.0 | 0.1 | GO:0015271 | outward rectifier potassium channel activity(GO:0015271) |
| 0.0 | 0.8 | GO:0005548 | phospholipid transporter activity(GO:0005548) |
| 0.0 | 1.0 | GO:0008083 | growth factor activity(GO:0008083) |
| 0.0 | 0.2 | GO:0008432 | JUN kinase binding(GO:0008432) |
| 0.0 | 0.5 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.0 | 1.0 | GO:0070491 | repressing transcription factor binding(GO:0070491) |
| 0.0 | 0.1 | GO:0042609 | CD4 receptor binding(GO:0042609) |
| 0.0 | 0.3 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.0 | 1.4 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.0 | 0.3 | GO:0001530 | lipopolysaccharide binding(GO:0001530) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 45.2 | PID_INTEGRIN4_PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.5 | 30.7 | PID_FRA_PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.4 | 4.8 | ST_IL_13_PATHWAY | Interleukin 13 (IL-13) Pathway |
| 0.3 | 9.3 | SA_TRKA_RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
| 0.3 | 9.1 | ST_G_ALPHA_S_PATHWAY | G alpha s Pathway |
| 0.3 | 5.6 | PID_LPA4_PATHWAY | LPA4-mediated signaling events |
| 0.3 | 14.5 | PID_RAS_PATHWAY | Regulation of Ras family activation |
| 0.3 | 8.4 | SA_MMP_CYTOKINE_CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.2 | 19.7 | PID_INTEGRIN1_PATHWAY | Beta1 integrin cell surface interactions |
| 0.2 | 6.2 | PID_S1P_S1P1_PATHWAY | S1P1 pathway |
| 0.2 | 1.5 | PID_TCR_RAS_PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.2 | 10.0 | PID_IL1_PATHWAY | IL1-mediated signaling events |
| 0.2 | 3.6 | PID_ECADHERIN_KERATINOCYTE_PATHWAY | E-cadherin signaling in keratinocytes |
| 0.1 | 3.6 | PID_IL27_PATHWAY | IL27-mediated signaling events |
| 0.1 | 28.3 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 1.8 | PID_PI3KCI_PATHWAY | Class I PI3K signaling events |
| 0.1 | 3.3 | PID_UPA_UPAR_PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.1 | 8.8 | PID_HIF1_TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.1 | 5.9 | PID_AURORA_B_PATHWAY | Aurora B signaling |
| 0.1 | 4.0 | SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.1 | 2.4 | PID_RETINOIC_ACID_PATHWAY | Retinoic acid receptors-mediated signaling |
| 0.1 | 1.3 | PID_ARF6_DOWNSTREAM_PATHWAY | Arf6 downstream pathway |
| 0.1 | 4.3 | PID_ATF2_PATHWAY | ATF-2 transcription factor network |
| 0.1 | 5.3 | PID_REG_GR_PATHWAY | Glucocorticoid receptor regulatory network |
| 0.1 | 1.6 | PID_REELIN_PATHWAY | Reelin signaling pathway |
| 0.1 | 1.7 | PID_GLYPICAN_1PATHWAY | Glypican 1 network |
| 0.0 | 15.4 | NABA_SECRETED_FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 2.5 | PID_ILK_PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 1.4 | PID_ECADHERIN_NASCENT_AJ_PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.0 | 1.1 | PID_FGF_PATHWAY | FGF signaling pathway |
| 0.0 | 0.6 | PID_IL8_CXCR1_PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.0 | 1.5 | PID_HEDGEHOG_GLI_PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.0 | 1.8 | PID_TGFBR_PATHWAY | TGF-beta receptor signaling |
| 0.0 | 4.8 | PID_P53_DOWNSTREAM_PATHWAY | Direct p53 effectors |
| 0.0 | 0.4 | PID_ERB_GENOMIC_PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 1.6 | PID_CXCR4_PATHWAY | CXCR4-mediated signaling events |
| 0.0 | 6.1 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 0.4 | PID_ERBB4_PATHWAY | ErbB4 signaling events |
| 0.0 | 1.0 | PID_LKB1_PATHWAY | LKB1 signaling events |
| 0.0 | 0.3 | PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY | Signaling mediated by p38-alpha and p38-beta |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 15.1 | REACTOME_PYRIMIDINE_CATABOLISM | Genes involved in Pyrimidine catabolism |
| 0.5 | 11.1 | REACTOME_SYNTHESIS_OF_PE | Genes involved in Synthesis of PE |
| 0.4 | 8.4 | REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.4 | 5.6 | REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY | Genes involved in Adenylate cyclase activating pathway |
| 0.4 | 10.6 | REACTOME_SHC1_EVENTS_IN_EGFR_SIGNALING | Genes involved in SHC1 events in EGFR signaling |
| 0.3 | 39.3 | REACTOME_CELL_JUNCTION_ORGANIZATION | Genes involved in Cell junction organization |
| 0.3 | 4.9 | REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS | Genes involved in Presynaptic nicotinic acetylcholine receptors |
| 0.3 | 4.5 | REACTOME_REVERSIBLE_HYDRATION_OF_CARBON_DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |
| 0.2 | 6.7 | REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.2 | 3.9 | REACTOME_IL_6_SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.2 | 9.1 | REACTOME_RAP1_SIGNALLING | Genes involved in Rap1 signalling |
| 0.2 | 3.1 | REACTOME_NFKB_IS_ACTIVATED_AND_SIGNALS_SURVIVAL | Genes involved in NF-kB is activated and signals survival |
| 0.2 | 9.9 | REACTOME_GLYCOLYSIS | Genes involved in Glycolysis |
| 0.2 | 2.2 | REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 | Genes involved in IKK complex recruitment mediated by RIP1 |
| 0.2 | 4.4 | REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.2 | 6.6 | REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.2 | 8.4 | REACTOME_IL1_SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.1 | 1.3 | REACTOME_PURINE_CATABOLISM | Genes involved in Purine catabolism |
| 0.1 | 3.1 | REACTOME_ACTIVATION_OF_RAC | Genes involved in Activation of Rac |
| 0.1 | 1.5 | REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.1 | 1.7 | REACTOME_RECYCLING_OF_BILE_ACIDS_AND_SALTS | Genes involved in Recycling of bile acids and salts |
| 0.1 | 9.1 | REACTOME_INTERFERON_GAMMA_SIGNALING | Genes involved in Interferon gamma signaling |
| 0.1 | 3.7 | REACTOME_FORMATION_OF_FIBRIN_CLOT_CLOTTING_CASCADE | Genes involved in Formation of Fibrin Clot (Clotting Cascade) |
| 0.1 | 2.7 | REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.1 | 0.7 | REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY | Genes involved in Regulation of the Fanconi anemia pathway |
| 0.1 | 2.9 | REACTOME_SYNTHESIS_OF_PA | Genes involved in Synthesis of PA |
| 0.1 | 3.8 | REACTOME_SIGNAL_TRANSDUCTION_BY_L1 | Genes involved in Signal transduction by L1 |
| 0.1 | 0.8 | REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |
| 0.1 | 3.0 | REACTOME_HS_GAG_BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.1 | 1.1 | REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES | Genes involved in The activation of arylsulfatases |
| 0.1 | 4.8 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
| 0.1 | 1.1 | REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION | Genes involved in FGFR1 ligand binding and activation |
| 0.1 | 1.2 | REACTOME_TAK1_ACTIVATES_NFKB_BY_PHOSPHORYLATION_AND_ACTIVATION_OF_IKKS_COMPLEX | Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex |
| 0.1 | 2.2 | REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.1 | 4.4 | REACTOME_AMYLOIDS | Genes involved in Amyloids |
| 0.1 | 3.6 | REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.1 | 2.7 | REACTOME_INTERFERON_ALPHA_BETA_SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 1.3 | REACTOME_ACTIVATION_OF_GENES_BY_ATF4 | Genes involved in Activation of Genes by ATF4 |
| 0.1 | 1.4 | REACTOME_REGULATION_OF_AMPK_ACTIVITY_VIA_LKB1 | Genes involved in Regulation of AMPK activity via LKB1 |
| 0.1 | 0.8 | REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.0 | 1.3 | REACTOME_ZINC_TRANSPORTERS | Genes involved in Zinc transporters |
| 0.0 | 4.0 | REACTOME_L1CAM_INTERACTIONS | Genes involved in L1CAM interactions |
| 0.0 | 1.5 | REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |
| 0.0 | 1.0 | REACTOME_GAP_JUNCTION_ASSEMBLY | Genes involved in Gap junction assembly |
| 0.0 | 2.5 | REACTOME_MEIOTIC_SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.0 | 2.6 | REACTOME_SMOOTH_MUSCLE_CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.0 | 1.2 | REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION | Genes involved in Extracellular matrix organization |
| 0.0 | 4.9 | REACTOME_POTASSIUM_CHANNELS | Genes involved in Potassium Channels |
| 0.0 | 0.6 | REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.0 | 1.2 | REACTOME_G1_PHASE | Genes involved in G1 Phase |
| 0.0 | 0.8 | REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
| 0.0 | 0.4 | REACTOME_TRANSPORT_OF_ORGANIC_ANIONS | Genes involved in Transport of organic anions |
| 0.0 | 0.7 | REACTOME_G0_AND_EARLY_G1 | Genes involved in G0 and Early G1 |
| 0.0 | 4.9 | REACTOME_G_ALPHA_I_SIGNALLING_EVENTS | Genes involved in G alpha (i) signalling events |
| 0.0 | 1.8 | REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.0 | 1.6 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 1.2 | REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.0 | 0.2 | REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTERGRINS_ | Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins |
| 0.0 | 0.9 | REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.0 | 1.2 | REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.0 | 0.7 | REACTOME_LIPID_DIGESTION_MOBILIZATION_AND_TRANSPORT | Genes involved in Lipid digestion, mobilization, and transport |
| 0.0 | 0.5 | REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS | Genes involved in Trafficking of AMPA receptors |
