Motif ID: FOSL1

Z-value: 2.217


Transcription factors associated with FOSL1:

Gene SymbolEntrez IDGene Name
FOSL1 ENSG00000175592.4 FOSL1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
FOSL1hg19_v2_chr11_-_65667884_656678950.872.5e-08Click!


Activity profile for motif FOSL1.

activity profile for motif FOSL1


Sorted Z-values histogram for motif FOSL1

Sorted Z-values for motif FOSL1



Network of associatons between targets according to the STRING database.



First level regulatory network of FOSL1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_-_36019123 17.587 ENST00000588674.1
ENST00000452271.2
ENST00000518157.1
 SBSN


suprabasin


chr1_+_150480551 14.037 ENST00000369049.4
ENST00000369047.4
 ECM1

extracellular matrix protein 1

chr1_+_150480576 13.869 ENST00000346569.6
 ECM1
extracellular matrix protein 1
chr18_+_21452964 13.046 ENST00000587184.1
 LAMA3
laminin, alpha 3
chr18_+_21452804 11.145 ENST00000269217.6
 LAMA3
laminin, alpha 3
chr6_+_47666275 11.024 ENST00000327753.3
ENST00000283303.2
 GPR115

G protein-coupled receptor 115

chr17_-_39769005 10.788 ENST00000301653.4
ENST00000593067.1
 KRT16

keratin 16

chr1_-_153029980 10.720 ENST00000392653.2
 SPRR2A
small proline-rich protein 2A
chr12_+_13349650 10.575 ENST00000256951.5
ENST00000431267.2
ENST00000542474.1
ENST00000544053.1
 EMP1



epithelial membrane protein 1



chr1_+_183155373 10.495 ENST00000493293.1
ENST00000264144.4
 LAMC2

laminin, gamma 2

chr1_-_153013588 10.470 ENST00000360379.3
 SPRR2D
small proline-rich protein 2D
chr1_+_152956549 9.937 ENST00000307122.2
 SPRR1A
small proline-rich protein 1A
chr19_+_35645817 9.806 ENST00000423817.3
 FXYD5
FXYD domain containing ion transport regulator 5
chr19_+_35645618 9.728 ENST00000392218.2
ENST00000543307.1
ENST00000392219.2
ENST00000541435.2
ENST00000590686.1
ENST00000342879.3
ENST00000588699.1
 FXYD5






FXYD domain containing ion transport regulator 5






chr1_+_152881014 9.433 ENST00000368764.3
ENST00000392667.2
 IVL

involucrin

chr1_-_153066998 9.394 ENST00000368750.3
 SPRR2E
small proline-rich protein 2E
chr13_+_78109884 8.614 ENST00000377246.3
ENST00000349847.3
 SCEL

sciellin

chr5_+_135394840 8.514 ENST00000503087.1
 TGFBI
transforming growth factor, beta-induced, 68kDa
chr2_+_113875466 8.275 ENST00000361779.3
ENST00000259206.5
ENST00000354115.2
 IL1RN


interleukin 1 receptor antagonist


chr13_+_78109804 8.268 ENST00000535157.1
 SCEL
sciellin

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 189 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 42.9 GO:0031581 hemidesmosome assembly(GO:0031581)
0.6 42.5 GO:0018149 peptide cross-linking(GO:0018149)
1.1 27.9 GO:0030502 negative regulation of bone mineralization(GO:0030502)
6.5 19.5 GO:0046586 regulation of calcium-dependent cell-cell adhesion(GO:0046586)
3.8 15.1 GO:0006218 uridine catabolic process(GO:0006218)
2.5 14.8 GO:0007296 vitellogenesis(GO:0007296)
1.5 12.3 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.6 11.5 GO:0051546 keratinocyte migration(GO:0051546)
0.4 11.1 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.4 10.6 GO:0032060 bleb assembly(GO:0032060)
1.7 10.4 GO:0072675 multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675)
0.1 10.3 GO:0030216 keratinocyte differentiation(GO:0030216)
0.2 10.1 GO:0043486 histone exchange(GO:0043486)
3.1 9.4 GO:0018153 isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine(GO:0018153) isopeptide cross-linking(GO:0018262)
0.5 9.4 GO:0090179 planar cell polarity pathway involved in neural tube closure(GO:0090179)
0.2 9.2 GO:0061718 NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
3.0 9.1 GO:1904298 positive regulation of neutrophil degranulation(GO:0043315) cellular response to gravity(GO:0071258) positive regulation of neutrophil activation(GO:1902565) regulation of transcytosis(GO:1904298) positive regulation of transcytosis(GO:1904300) regulation of maternal process involved in parturition(GO:1904301) positive regulation of maternal process involved in parturition(GO:1904303) response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine(GO:1904316) cellular response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine(GO:1904317)
2.3 9.1 GO:0033123 positive regulation of cyclic nucleotide catabolic process(GO:0030807) positive regulation of cAMP catabolic process(GO:0030822) positive regulation of purine nucleotide catabolic process(GO:0033123)
0.1 9.1 GO:0070268 cornification(GO:0070268)
0.2 8.7 GO:0007176 regulation of epidermal growth factor-activated receptor activity(GO:0007176)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 91 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 75.8 GO:0001533 cornified envelope(GO:0001533)
1.6 27.9 GO:0031089 platelet dense granule lumen(GO:0031089)
0.2 25.4 GO:0005882 intermediate filament(GO:0005882)
3.1 25.1 GO:0005610 laminin-5 complex(GO:0005610)
5.0 15.0 GO:0005607 laminin-2 complex(GO:0005607)
0.1 13.6 GO:0042734 presynaptic membrane(GO:0042734)
0.0 12.5 GO:0030027 lamellipodium(GO:0030027)
0.3 11.0 GO:0031092 platelet alpha granule membrane(GO:0031092)
1.8 10.6 GO:0070435 Shc-EGFR complex(GO:0070435)
0.1 10.5 GO:0070821 tertiary granule membrane(GO:0070821)
0.5 10.1 GO:0000812 Swr1 complex(GO:0000812)
0.1 9.7 GO:0005902 microvillus(GO:0005902)
1.2 8.4 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.1 7.9 GO:0005604 basement membrane(GO:0005604)
1.1 7.5 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.2 7.5 GO:0043034 costamere(GO:0043034)
0.1 6.7 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.2 6.4 GO:0031528 microvillus membrane(GO:0031528)
0.2 5.6 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 5.3 GO:0032587 ruffle membrane(GO:0032587)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 133 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 59.2 GO:0005198 structural molecule activity(GO:0005198)
3.3 26.2 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.3 20.2 GO:0017080 sodium channel regulator activity(GO:0017080)
0.1 19.9 GO:0004252 serine-type endopeptidase activity(GO:0004252)
1.3 19.3 GO:0030280 structural constituent of epidermis(GO:0030280)
3.0 15.1 GO:0004850 uridine phosphorylase activity(GO:0004850)
0.2 13.3 GO:0019212 phosphatase inhibitor activity(GO:0019212)
0.2 12.3 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
1.1 11.1 GO:0004305 ethanolamine kinase activity(GO:0004305)
0.3 11.0 GO:0050431 transforming growth factor beta binding(GO:0050431)
1.5 10.6 GO:0048408 epidermal growth factor binding(GO:0048408)
0.1 9.8 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
1.3 9.4 GO:1990254 keratin filament binding(GO:1990254)
0.8 9.1 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.3 9.0 GO:0005540 hyaluronic acid binding(GO:0005540)
1.7 8.6 GO:0004992 platelet activating factor receptor activity(GO:0004992)
2.8 8.3 GO:0005150 interleukin-1, Type I receptor binding(GO:0005150)
0.1 8.3 GO:0031490 chromatin DNA binding(GO:0031490)
1.1 7.5 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.1 7.4 GO:0050840 extracellular matrix binding(GO:0050840)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.0 45.2 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.5 30.7 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 28.3 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.2 19.7 PID_INTEGRIN1_PATHWAY Beta1 integrin cell surface interactions
0.0 15.4 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.3 14.5 PID_RAS_PATHWAY Regulation of Ras family activation
0.2 10.0 PID_IL1_PATHWAY IL1-mediated signaling events
0.3 9.3 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.3 9.1 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.1 8.8 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.3 8.4 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.2 6.2 PID_S1P_S1P1_PATHWAY S1P1 pathway
0.0 6.1 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 5.9 PID_AURORA_B_PATHWAY Aurora B signaling
0.3 5.6 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.1 5.3 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.4 4.8 ST_IL_13_PATHWAY Interleukin 13 (IL-13) Pathway
0.0 4.8 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.1 4.3 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.1 4.0 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 39.3 REACTOME_CELL_JUNCTION_ORGANIZATION Genes involved in Cell junction organization
0.9 15.1 REACTOME_PYRIMIDINE_CATABOLISM Genes involved in Pyrimidine catabolism
0.5 11.1 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE
0.4 10.6 REACTOME_SHC1_EVENTS_IN_EGFR_SIGNALING Genes involved in SHC1 events in EGFR signaling
0.2 9.9 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.2 9.1 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.1 9.1 REACTOME_INTERFERON_GAMMA_SIGNALING Genes involved in Interferon gamma signaling
0.4 8.4 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.2 8.4 REACTOME_IL1_SIGNALING Genes involved in Interleukin-1 signaling
0.2 6.7 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.2 6.6 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.4 5.6 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.3 4.9 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 4.9 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
0.0 4.9 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.1 4.8 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.3 4.5 REACTOME_REVERSIBLE_HYDRATION_OF_CARBON_DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.2 4.4 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 4.4 REACTOME_AMYLOIDS Genes involved in Amyloids
0.0 4.0 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions