Motif ID: FOSL2_SMARCC1

Z-value: 2.514

Transcription factors associated with FOSL2_SMARCC1:

Gene SymbolEntrez IDGene Name
FOSL2 ENSG00000075426.7 FOSL2
SMARCC1 ENSG00000173473.6 SMARCC1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
FOSL2hg19_v2_chr2_+_28618532_286186100.869.6e-08Click!
SMARCC1hg19_v2_chr3_-_47823298_47823423-0.386.5e-02Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of FOSL2_SMARCC1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_+_21452964 27.694 ENST00000587184.1
LAMA3
laminin, alpha 3
chr18_+_21452804 23.882 ENST00000269217.6
LAMA3
laminin, alpha 3
chr1_+_150480551 22.057 ENST00000369049.4
ENST00000369047.4
ECM1

extracellular matrix protein 1

chr1_+_150480576 21.798 ENST00000346569.6
ECM1
extracellular matrix protein 1
chr19_-_36019123 20.683 ENST00000588674.1
ENST00000452271.2
ENST00000518157.1
SBSN


suprabasin


chr17_-_39769005 17.313 ENST00000301653.4
ENST00000593067.1
KRT16

keratin 16

chr1_-_153521597 12.912 ENST00000368712.1
S100A3
S100 calcium binding protein A3
chr2_+_113875466 12.033 ENST00000361779.3
ENST00000259206.5
ENST00000354115.2
IL1RN


interleukin 1 receptor antagonist


chr1_-_153029980 11.249 ENST00000392653.2
SPRR2A
small proline-rich protein 2A
chr11_-_65667997 10.488 ENST00000312562.2
ENST00000534222.1
FOSL1

FOS-like antigen 1

chr6_+_74405804 10.487 ENST00000287097.5
CD109
CD109 molecule
chr1_-_153521714 10.353 ENST00000368713.3
S100A3
S100 calcium binding protein A3
chr6_+_74405501 10.349 ENST00000437994.2
ENST00000422508.2
CD109

CD109 molecule

chr1_-_153113927 9.842 ENST00000368752.4
SPRR2B
small proline-rich protein 2B
chr15_-_74504560 9.400 ENST00000449139.2
STRA6
stimulated by retinoic acid 6
chr19_-_51472823 9.381 ENST00000310157.2
KLK6
kallikrein-related peptidase 6
chr11_-_65667884 9.008 ENST00000448083.2
ENST00000531493.1
ENST00000532401.1
FOSL1


FOS-like antigen 1


chr11_-_62323702 8.326 ENST00000530285.1
AHNAK
AHNAK nucleoprotein
chr12_-_95510743 8.245 ENST00000551521.1
FGD6
FYVE, RhoGEF and PH domain containing 6
chr6_+_47666275 8.027 ENST00000327753.3
ENST00000283303.2
GPR115

G protein-coupled receptor 115


Gene overrepresentation in biological_process category:

Showing 1 to 20 of 290 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.3 66.9 GO:0031581 hemidesmosome assembly(GO:0031581)
1.7 43.8 GO:0030502 negative regulation of bone mineralization(GO:0030502)
0.3 34.9 GO:0070268 cornification(GO:0070268)
1.1 20.3 GO:0051546 keratinocyte migration(GO:0051546)
3.2 19.5 GO:0007296 vitellogenesis(GO:0007296)
3.1 18.4 GO:0072675 multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675)
1.1 16.9 GO:0001660 fever generation(GO:0001660)
0.2 15.1 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
1.8 14.8 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
2.8 14.0 GO:0061143 alveolar primary septum development(GO:0061143)
3.3 13.1 GO:0033123 positive regulation of cyclic nucleotide catabolic process(GO:0030807) positive regulation of cAMP catabolic process(GO:0030822) positive regulation of purine nucleotide catabolic process(GO:0033123)
3.2 12.7 GO:0006218 uridine catabolic process(GO:0006218)
0.2 12.1 GO:0061718 NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
2.2 11.2 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
2.8 11.1 GO:0090362 positive regulation of platelet-derived growth factor production(GO:0090362)
1.8 10.6 GO:1903575 cornified envelope assembly(GO:1903575)
0.2 10.4 GO:0043268 positive regulation of potassium ion transport(GO:0043268)
0.4 10.1 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.2 9.4 GO:0045745 positive regulation of G-protein coupled receptor protein signaling pathway(GO:0045745)
0.2 8.8 GO:0043486 histone exchange(GO:0043486)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 130 entries
Log-likelihood per target Total log-likelihoodTermDescription
6.6 52.4 GO:0005610 laminin-5 complex(GO:0005610)
0.0 49.2 GO:0005615 extracellular space(GO:0005615)
2.4 43.9 GO:0031089 platelet dense granule lumen(GO:0031089)
0.6 36.5 GO:0001533 cornified envelope(GO:0001533)
0.1 32.3 GO:0030027 lamellipodium(GO:0030027)
0.2 28.0 GO:0005882 intermediate filament(GO:0005882)
0.0 22.9 GO:0005730 nucleolus(GO:0005730)
0.6 22.7 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.2 19.8 GO:0042734 presynaptic membrane(GO:0042734)
0.2 18.4 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 17.5 GO:0031012 extracellular matrix(GO:0031012)
0.0 12.2 GO:0005912 adherens junction(GO:0005912)
1.4 11.2 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.1 10.5 GO:0070821 tertiary granule membrane(GO:0070821)
1.4 10.0 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 9.7 GO:0030667 secretory granule membrane(GO:0030667)
0.2 9.5 GO:0043034 costamere(GO:0043034)
2.9 8.8 GO:0005607 laminin-2 complex(GO:0005607)
0.4 8.8 GO:0000812 Swr1 complex(GO:0000812)
0.8 8.6 GO:0071438 invadopodium membrane(GO:0071438)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 199 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 77.0 GO:0005198 structural molecule activity(GO:0005198)
0.2 55.1 GO:0004252 serine-type endopeptidase activity(GO:0004252)
5.5 43.9 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.6 21.9 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.2 20.7 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 20.1 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 14.1 GO:0044325 ion channel binding(GO:0044325)
0.2 13.3 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
1.1 13.1 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
2.5 12.7 GO:0004850 uridine phosphorylase activity(GO:0004850)
4.0 12.0 GO:0005150 interleukin-1, Type I receptor binding(GO:0005150)
0.3 11.8 GO:0051183 vitamin transporter activity(GO:0051183)
2.2 11.2 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.6 11.2 GO:0031994 insulin-like growth factor I binding(GO:0031994)
1.0 10.1 GO:0004305 ethanolamine kinase activity(GO:0004305)
1.4 10.0 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.5 9.9 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.1 8.8 GO:0019212 phosphatase inhibitor activity(GO:0019212)
0.3 7.6 GO:0017160 Ral GTPase binding(GO:0017160)
2.5 7.4 GO:0030377 urokinase plasminogen activator receptor activity(GO:0030377)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.0 68.0 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.2 46.8 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.6 41.8 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 25.7 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.3 21.8 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.1 21.3 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.5 15.4 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.3 15.1 PID_RAS_PATHWAY Regulation of Ras family activation
0.5 14.9 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.4 11.2 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.2 9.8 PID_IL1_PATHWAY IL1-mediated signaling events
0.2 9.4 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.1 8.9 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 7.6 NABA_COLLAGENS Genes encoding collagen proteins
0.1 7.1 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.1 5.6 PID_LKB1_PATHWAY LKB1 signaling events
0.1 5.3 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.2 5.1 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.2 4.6 PID_S1P_S1P1_PATHWAY S1P1 pathway
0.1 4.1 PID_BCR_5PATHWAY BCR signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 82 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 59.1 REACTOME_CELL_JUNCTION_ORGANIZATION Genes involved in Cell junction organization
0.3 22.3 REACTOME_INTEGRIN_ALPHAIIB_BETA3_SIGNALING Genes involved in Integrin alphaIIb beta3 signaling
0.3 15.9 REACTOME_IL1_SIGNALING Genes involved in Interleukin-1 signaling
0.5 14.2 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.3 13.0 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.7 12.7 REACTOME_PYRIMIDINE_CATABOLISM Genes involved in Pyrimidine catabolism
0.0 11.7 REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS Genes involved in G alpha (q) signalling events
0.3 10.3 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.4 10.1 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE
0.2 7.4 REACTOME_POST_TRANSLATIONAL_MODIFICATION_SYNTHESIS_OF_GPI_ANCHORED_PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.1 7.4 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.3 6.5 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.1 5.6 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 5.2 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.2 5.1 REACTOME_REGULATION_OF_IFNA_SIGNALING Genes involved in Regulation of IFNA signaling
0.1 5.0 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 4.9 REACTOME_ACTIVATION_OF_GENES_BY_ATF4 Genes involved in Activation of Genes by ATF4
0.1 4.8 REACTOME_CELL_SURFACE_INTERACTIONS_AT_THE_VASCULAR_WALL Genes involved in Cell surface interactions at the vascular wall
0.2 4.6 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 4.6 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants