Motif ID: FOSL2_SMARCC1
Z-value: 2.514


Transcription factors associated with FOSL2_SMARCC1:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
FOSL2 | ENSG00000075426.7 | FOSL2 |
SMARCC1 | ENSG00000173473.6 | SMARCC1 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
FOSL2 | hg19_v2_chr2_+_28618532_28618610 | 0.86 | 9.6e-08 | Click! |
SMARCC1 | hg19_v2_chr3_-_47823298_47823423 | -0.38 | 6.5e-02 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 290 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
2.3 | 66.9 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
1.7 | 43.8 | GO:0030502 | negative regulation of bone mineralization(GO:0030502) |
0.3 | 34.9 | GO:0070268 | cornification(GO:0070268) |
1.1 | 20.3 | GO:0051546 | keratinocyte migration(GO:0051546) |
3.2 | 19.5 | GO:0007296 | vitellogenesis(GO:0007296) |
3.1 | 18.4 | GO:0072675 | multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675) |
1.1 | 16.9 | GO:0001660 | fever generation(GO:0001660) |
0.2 | 15.1 | GO:0045669 | positive regulation of osteoblast differentiation(GO:0045669) |
1.8 | 14.8 | GO:0031914 | negative regulation of synaptic plasticity(GO:0031914) |
2.8 | 14.0 | GO:0061143 | alveolar primary septum development(GO:0061143) |
3.3 | 13.1 | GO:0033123 | positive regulation of cyclic nucleotide catabolic process(GO:0030807) positive regulation of cAMP catabolic process(GO:0030822) positive regulation of purine nucleotide catabolic process(GO:0033123) |
3.2 | 12.7 | GO:0006218 | uridine catabolic process(GO:0006218) |
0.2 | 12.1 | GO:0061718 | NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718) |
2.2 | 11.2 | GO:0061767 | negative regulation of lung blood pressure(GO:0061767) |
2.8 | 11.1 | GO:0090362 | positive regulation of platelet-derived growth factor production(GO:0090362) |
1.8 | 10.6 | GO:1903575 | cornified envelope assembly(GO:1903575) |
0.2 | 10.4 | GO:0043268 | positive regulation of potassium ion transport(GO:0043268) |
0.4 | 10.1 | GO:0006646 | phosphatidylethanolamine biosynthetic process(GO:0006646) |
0.2 | 9.4 | GO:0045745 | positive regulation of G-protein coupled receptor protein signaling pathway(GO:0045745) |
0.2 | 8.8 | GO:0043486 | histone exchange(GO:0043486) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 130 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
6.6 | 52.4 | GO:0005610 | laminin-5 complex(GO:0005610) |
0.0 | 49.2 | GO:0005615 | extracellular space(GO:0005615) |
2.4 | 43.9 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
0.6 | 36.5 | GO:0001533 | cornified envelope(GO:0001533) |
0.1 | 32.3 | GO:0030027 | lamellipodium(GO:0030027) |
0.2 | 28.0 | GO:0005882 | intermediate filament(GO:0005882) |
0.0 | 22.9 | GO:0005730 | nucleolus(GO:0005730) |
0.6 | 22.7 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
0.2 | 19.8 | GO:0042734 | presynaptic membrane(GO:0042734) |
0.2 | 18.4 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
0.1 | 17.5 | GO:0031012 | extracellular matrix(GO:0031012) |
0.0 | 12.2 | GO:0005912 | adherens junction(GO:0005912) |
1.4 | 11.2 | GO:0071144 | SMAD2-SMAD3 protein complex(GO:0071144) |
0.1 | 10.5 | GO:0070821 | tertiary granule membrane(GO:0070821) |
1.4 | 10.0 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
0.0 | 9.7 | GO:0030667 | secretory granule membrane(GO:0030667) |
0.2 | 9.5 | GO:0043034 | costamere(GO:0043034) |
2.9 | 8.8 | GO:0005607 | laminin-2 complex(GO:0005607) |
0.4 | 8.8 | GO:0000812 | Swr1 complex(GO:0000812) |
0.8 | 8.6 | GO:0071438 | invadopodium membrane(GO:0071438) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 199 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 77.0 | GO:0005198 | structural molecule activity(GO:0005198) |
0.2 | 55.1 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
5.5 | 43.9 | GO:0005134 | interleukin-2 receptor binding(GO:0005134) |
0.6 | 21.9 | GO:0050431 | transforming growth factor beta binding(GO:0050431) |
0.2 | 20.7 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
0.1 | 20.1 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
0.1 | 14.1 | GO:0044325 | ion channel binding(GO:0044325) |
0.2 | 13.3 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
1.1 | 13.1 | GO:0017034 | Rap guanyl-nucleotide exchange factor activity(GO:0017034) |
2.5 | 12.7 | GO:0004850 | uridine phosphorylase activity(GO:0004850) |
4.0 | 12.0 | GO:0005150 | interleukin-1, Type I receptor binding(GO:0005150) |
0.3 | 11.8 | GO:0051183 | vitamin transporter activity(GO:0051183) |
2.2 | 11.2 | GO:0031962 | mineralocorticoid receptor binding(GO:0031962) |
0.6 | 11.2 | GO:0031994 | insulin-like growth factor I binding(GO:0031994) |
1.0 | 10.1 | GO:0004305 | ethanolamine kinase activity(GO:0004305) |
1.4 | 10.0 | GO:0004634 | phosphopyruvate hydratase activity(GO:0004634) |
0.5 | 9.9 | GO:0005149 | interleukin-1 receptor binding(GO:0005149) |
0.1 | 8.8 | GO:0019212 | phosphatase inhibitor activity(GO:0019212) |
0.3 | 7.6 | GO:0017160 | Ral GTPase binding(GO:0017160) |
2.5 | 7.4 | GO:0030377 | urokinase plasminogen activator receptor activity(GO:0030377) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 51 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
3.0 | 68.0 | PID_INTEGRIN4_PATHWAY | Alpha6 beta4 integrin-ligand interactions |
0.2 | 46.8 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
0.6 | 41.8 | PID_FRA_PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
0.1 | 25.7 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
0.3 | 21.8 | PID_RET_PATHWAY | Signaling events regulated by Ret tyrosine kinase |
0.1 | 21.3 | NABA_SECRETED_FACTORS | Genes encoding secreted soluble factors |
0.5 | 15.4 | ST_G_ALPHA_S_PATHWAY | G alpha s Pathway |
0.3 | 15.1 | PID_RAS_PATHWAY | Regulation of Ras family activation |
0.5 | 14.9 | SA_MMP_CYTOKINE_CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
0.4 | 11.2 | PID_SMAD2_3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
0.2 | 9.8 | PID_IL1_PATHWAY | IL1-mediated signaling events |
0.2 | 9.4 | PID_ALPHA_SYNUCLEIN_PATHWAY | Alpha-synuclein signaling |
0.1 | 8.9 | PID_HIF1_TFPATHWAY | HIF-1-alpha transcription factor network |
0.1 | 7.6 | NABA_COLLAGENS | Genes encoding collagen proteins |
0.1 | 7.1 | PID_CASPASE_PATHWAY | Caspase cascade in apoptosis |
0.1 | 5.6 | PID_LKB1_PATHWAY | LKB1 signaling events |
0.1 | 5.3 | PID_CD8_TCR_DOWNSTREAM_PATHWAY | Downstream signaling in naïve CD8+ T cells |
0.2 | 5.1 | PID_NFKAPPAB_CANONICAL_PATHWAY | Canonical NF-kappaB pathway |
0.2 | 4.6 | PID_S1P_S1P1_PATHWAY | S1P1 pathway |
0.1 | 4.1 | PID_BCR_5PATHWAY | BCR signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 82 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.5 | 59.1 | REACTOME_CELL_JUNCTION_ORGANIZATION | Genes involved in Cell junction organization |
0.3 | 22.3 | REACTOME_INTEGRIN_ALPHAIIB_BETA3_SIGNALING | Genes involved in Integrin alphaIIb beta3 signaling |
0.3 | 15.9 | REACTOME_IL1_SIGNALING | Genes involved in Interleukin-1 signaling |
0.5 | 14.2 | REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
0.3 | 13.0 | REACTOME_GLYCOLYSIS | Genes involved in Glycolysis |
0.7 | 12.7 | REACTOME_PYRIMIDINE_CATABOLISM | Genes involved in Pyrimidine catabolism |
0.0 | 11.7 | REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS | Genes involved in G alpha (q) signalling events |
0.3 | 10.3 | REACTOME_SIGNALING_BY_NODAL | Genes involved in Signaling by NODAL |
0.4 | 10.1 | REACTOME_SYNTHESIS_OF_PE | Genes involved in Synthesis of PE |
0.2 | 7.4 | REACTOME_POST_TRANSLATIONAL_MODIFICATION_SYNTHESIS_OF_GPI_ANCHORED_PROTEINS | Genes involved in Post-translational modification: synthesis of GPI-anchored proteins |
0.1 | 7.4 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
0.3 | 6.5 | REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
0.1 | 5.6 | REACTOME_SMOOTH_MUSCLE_CONTRACTION | Genes involved in Smooth Muscle Contraction |
0.0 | 5.2 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
0.2 | 5.1 | REACTOME_REGULATION_OF_IFNA_SIGNALING | Genes involved in Regulation of IFNA signaling |
0.1 | 5.0 | REACTOME_HS_GAG_BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
0.1 | 4.9 | REACTOME_ACTIVATION_OF_GENES_BY_ATF4 | Genes involved in Activation of Genes by ATF4 |
0.1 | 4.8 | REACTOME_CELL_SURFACE_INTERACTIONS_AT_THE_VASCULAR_WALL | Genes involved in Cell surface interactions at the vascular wall |
0.2 | 4.6 | REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
0.1 | 4.6 | REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |