Motif ID: FOXA1

Z-value: 1.105


Transcription factors associated with FOXA1:

Gene SymbolEntrez IDGene Name
FOXA1 ENSG00000129514.4 FOXA1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
FOXA1hg19_v2_chr14_-_38064198_380642390.414.8e-02Click!


Activity profile for motif FOXA1.

activity profile for motif FOXA1


Sorted Z-values histogram for motif FOXA1

Sorted Z-values for motif FOXA1



Network of associatons between targets according to the STRING database.



First level regulatory network of FOXA1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr20_+_31823792 8.548 ENST00000375413.4
ENST00000354297.4
ENST00000375422.2
 BPIFA1


BPI fold containing family A, member 1


chr4_+_165675197 7.314 ENST00000515485.1
 RP11-294O2.2
RP11-294O2.2
chr12_-_71551868 6.116 ENST00000247829.3
 TSPAN8
tetraspanin 8
chr12_-_71551652 5.695 ENST00000546561.1
 TSPAN8
tetraspanin 8
chr4_+_165675269 5.458 ENST00000507311.1
 RP11-294O2.2
RP11-294O2.2
chr10_+_51549498 3.807 ENST00000358559.2
ENST00000298239.6
 MSMB

microseminoprotein, beta-

chr13_+_50589390 3.383 ENST00000360473.4
ENST00000312942.1
 KCNRG

potassium channel regulator

chr5_+_156712372 3.028 ENST00000541131.1
 CYFIP2
cytoplasmic FMR1 interacting protein 2
chr2_+_71163051 2.702 ENST00000412314.1
 ATP6V1B1
ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1
chr2_+_71162995 2.697 ENST00000234396.4
 ATP6V1B1
ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1
chr11_-_108464465 2.600 ENST00000525344.1
 EXPH5
exophilin 5
chr11_-_124622134 2.586 ENST00000326621.5
 VSIG2
V-set and immunoglobulin domain containing 2
chr9_-_89562104 2.578 ENST00000298743.7
 GAS1
growth arrest-specific 1
chr3_-_148939835 2.485 ENST00000264613.6
 CP
ceruloplasmin (ferroxidase)
chr3_-_45957088 2.434 ENST00000539217.1
 LZTFL1
leucine zipper transcription factor-like 1
chr11_-_124622083 2.342 ENST00000403470.1
 VSIG2
V-set and immunoglobulin domain containing 2
chr21_-_43735446 2.205 ENST00000398431.2
 TFF3
trefoil factor 3 (intestinal)
chr17_+_79953310 2.173 ENST00000582355.2
 ASPSCR1
alveolar soft part sarcoma chromosome region, candidate 1
chr11_-_108464321 2.166 ENST00000265843.4
 EXPH5
exophilin 5
chr20_+_31755934 2.154 ENST00000354932.5
 BPIFA2
BPI fold containing family A, member 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 90 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 11.7 GO:1900047 negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
2.1 8.5 GO:0042710 biofilm formation(GO:0042710) single-species biofilm formation(GO:0044010) single-species biofilm formation in or on host organism(GO:0044407) regulation of single-species biofilm formation(GO:1900190) negative regulation of single-species biofilm formation(GO:1900191) regulation of single-species biofilm formation in or on host organism(GO:1900228) negative regulation of single-species biofilm formation in or on host organism(GO:1900229)
0.1 4.9 GO:0090383 phagosome acidification(GO:0090383)
0.2 4.8 GO:0003334 keratinocyte development(GO:0003334)
1.5 4.4 GO:1903568 negative regulation of protein localization to cilium(GO:1903565) regulation of protein localization to ciliary membrane(GO:1903567) negative regulation of protein localization to ciliary membrane(GO:1903568)
1.4 4.2 GO:1904899 regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
0.8 3.4 GO:0072134 hyaluranon cable assembly(GO:0036118) nephrogenic mesenchyme morphogenesis(GO:0072134) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106) allantois development(GO:1905069)
0.2 3.4 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260)
0.1 3.4 GO:0072189 ureter development(GO:0072189)
0.3 3.0 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.2 2.6 GO:0060628 regulation of ER to Golgi vesicle-mediated transport(GO:0060628)
0.2 2.5 GO:0090360 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.1 2.5 GO:0006825 copper ion transport(GO:0006825)
0.1 2.1 GO:0021527 ventral spinal cord interneuron differentiation(GO:0021514) spinal cord association neuron differentiation(GO:0021527)
0.3 1.9 GO:0044245 polysaccharide digestion(GO:0044245)
0.0 1.9 GO:0019730 antimicrobial humoral response(GO:0019730)
0.0 1.9 GO:0046324 regulation of glucose import(GO:0046324)
0.4 1.8 GO:0018032 protein amidation(GO:0018032)
0.6 1.7 GO:0010430 fatty acid omega-oxidation(GO:0010430)
0.3 1.6 GO:0060005 vestibular reflex(GO:0060005)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 12.9 GO:0009986 cell surface(GO:0009986)
0.4 5.4 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 3.9 GO:0016363 nuclear matrix(GO:0016363)
0.1 2.6 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 2.4 GO:0072562 blood microparticle(GO:0072562)
0.0 2.1 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 1.4 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 1.3 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 1.2 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 1.1 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 1.0 GO:0008023 transcription elongation factor complex(GO:0008023)
0.1 0.9 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.0 0.9 GO:0042599 lamellar body(GO:0042599)
0.3 0.8 GO:0032302 MutSbeta complex(GO:0032302)
0.1 0.8 GO:0005579 membrane attack complex(GO:0005579)
0.0 0.8 GO:0005922 connexon complex(GO:0005922)
0.0 0.7 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.7 GO:0042589 zymogen granule membrane(GO:0042589)
0.2 0.6 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237) alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.0 0.6 GO:0097431 mitotic spindle pole(GO:0097431)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.8 GO:0005178 integrin binding(GO:0005178)
0.0 5.7 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 5.1 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.4 4.2 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.3 3.4 GO:0070700 BMP receptor binding(GO:0070700)
0.3 2.5 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1 2.1 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.5 1.9 GO:0016160 amylase activity(GO:0016160)
0.4 1.8 GO:0004504 peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598)
0.4 1.7 GO:0004031 aldehyde oxidase activity(GO:0004031)
0.1 1.7 GO:0070410 co-SMAD binding(GO:0070410)
0.0 1.5 GO:0008013 beta-catenin binding(GO:0008013)
0.2 1.4 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.4 1.2 GO:0031859 platelet activating factor receptor binding(GO:0031859)
0.2 1.0 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.2 0.9 GO:0050309 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.1 0.9 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.0 0.9 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.9 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.3 0.8 GO:0000404 heteroduplex DNA loop binding(GO:0000404) double-strand/single-strand DNA junction binding(GO:0000406) dinucleotide repeat insertion binding(GO:0032181)

Gene overrepresentation in C2:CP category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.9 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 4.2 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 4.2 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K
0.0 3.9 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.2 3.4 PID_ALK2_PATHWAY ALK2 signaling events
0.0 3.0 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 2.7 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 2.6 PID_IL6_7_PATHWAY IL6-mediated signaling events
0.0 1.9 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.4 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 1.2 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 1.0 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.9 PID_CD40_PATHWAY CD40/CD40L signaling
0.0 0.3 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.4 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.0 4.5 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 2.5 REACTOME_IRON_UPTAKE_AND_TRANSPORT Genes involved in Iron uptake and transport
0.2 1.9 REACTOME_DIGESTION_OF_DIETARY_CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.1 1.7 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.0 1.7 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 1.6 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 1.3 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 1.2 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.0 1.2 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 1.2 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.1 1.0 REACTOME_DSCAM_INTERACTIONS Genes involved in DSCAM interactions
0.0 0.9 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.9 REACTOME_GLUCOSE_TRANSPORT Genes involved in Glucose transport
0.0 0.8 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.0 0.8 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.8 REACTOME_COMPLEMENT_CASCADE Genes involved in Complement cascade
0.0 0.6 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.0 0.6 REACTOME_SIGNALING_BY_NOTCH1 Genes involved in Signaling by NOTCH1
0.0 0.5 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators