Motif ID: FOXA2_FOXJ3
Z-value: 0.748
Transcription factors associated with FOXA2_FOXJ3:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| FOXA2 | ENSG00000125798.10 | FOXA2 |
| FOXJ3 | ENSG00000198815.4 | FOXJ3 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FOXA2 | hg19_v2_chr20_-_22566089_22566097, hg19_v2_chr20_-_22565101_22565223 | -0.17 | 4.2e-01 | Click! |
| FOXJ3 | hg19_v2_chr1_-_42801540_42801562, hg19_v2_chr1_-_42800860_42800912, hg19_v2_chr1_-_42800614_42800649 | 0.16 | 4.6e-01 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 100 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.2 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.1 | 2.5 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 0.1 | 1.4 | GO:0046541 | saliva secretion(GO:0046541) |
| 0.1 | 1.3 | GO:0046600 | negative regulation of centriole replication(GO:0046600) |
| 0.1 | 1.0 | GO:0048014 | Tie signaling pathway(GO:0048014) |
| 0.1 | 1.0 | GO:0043985 | histone H4-R3 methylation(GO:0043985) |
| 0.0 | 0.9 | GO:0035589 | G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589) |
| 0.0 | 0.8 | GO:0060044 | negative regulation of cardiac muscle cell proliferation(GO:0060044) |
| 0.1 | 0.7 | GO:0035095 | behavioral response to nicotine(GO:0035095) |
| 0.0 | 0.7 | GO:2000144 | positive regulation of DNA-templated transcription, initiation(GO:2000144) |
| 0.0 | 0.7 | GO:0035036 | sperm-egg recognition(GO:0035036) |
| 0.1 | 0.6 | GO:0021764 | amygdala development(GO:0021764) |
| 0.0 | 0.6 | GO:0036149 | phosphatidylinositol acyl-chain remodeling(GO:0036149) |
| 0.0 | 0.6 | GO:0045954 | positive regulation of natural killer cell mediated cytotoxicity(GO:0045954) |
| 0.0 | 0.6 | GO:0052695 | cellular glucuronidation(GO:0052695) |
| 0.0 | 0.6 | GO:0051894 | positive regulation of focal adhesion assembly(GO:0051894) |
| 0.0 | 0.6 | GO:0016486 | peptide hormone processing(GO:0016486) |
| 0.2 | 0.5 | GO:0070428 | negative regulation of interleukin-23 production(GO:0032707) regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070428) |
| 0.1 | 0.5 | GO:1901341 | activation of store-operated calcium channel activity(GO:0032237) positive regulation of store-operated calcium channel activity(GO:1901341) |
| 0.1 | 0.5 | GO:0046604 | positive regulation of mitotic centrosome separation(GO:0046604) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 34 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.0 | GO:0005814 | centriole(GO:0005814) |
| 0.0 | 0.9 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.0 | 0.7 | GO:0042588 | zymogen granule(GO:0042588) |
| 0.0 | 0.7 | GO:0005892 | acetylcholine-gated channel complex(GO:0005892) |
| 0.1 | 0.5 | GO:0046696 | lipopolysaccharide receptor complex(GO:0046696) |
| 0.1 | 0.5 | GO:0019907 | cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907) |
| 0.0 | 0.5 | GO:0032045 | guanyl-nucleotide exchange factor complex(GO:0032045) |
| 0.0 | 0.5 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.1 | 0.4 | GO:0036195 | muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195) |
| 0.0 | 0.4 | GO:0036157 | outer dynein arm(GO:0036157) |
| 0.0 | 0.4 | GO:0044292 | dendrite terminus(GO:0044292) |
| 0.0 | 0.4 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
| 0.1 | 0.3 | GO:0042765 | GPI-anchor transamidase complex(GO:0042765) |
| 0.0 | 0.3 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.0 | 0.3 | GO:0032591 | dendritic spine membrane(GO:0032591) |
| 0.1 | 0.2 | GO:0043293 | apoptosome(GO:0043293) |
| 0.0 | 0.2 | GO:0034673 | inhibin-betaglycan-ActRII complex(GO:0034673) |
| 0.0 | 0.2 | GO:0005945 | 6-phosphofructokinase complex(GO:0005945) |
| 0.0 | 0.2 | GO:1990130 | Iml1 complex(GO:1990130) |
| 0.0 | 0.2 | GO:0071953 | elastic fiber(GO:0071953) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 65 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 1.6 | GO:0046848 | hydroxyapatite binding(GO:0046848) |
| 0.1 | 1.0 | GO:0008970 | phosphatidylcholine 1-acylhydrolase activity(GO:0008970) |
| 0.0 | 0.9 | GO:0045028 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 0.1 | 0.8 | GO:0097371 | MDM2/MDM4 family protein binding(GO:0097371) |
| 0.0 | 0.8 | GO:0070888 | E-box binding(GO:0070888) |
| 0.1 | 0.7 | GO:0060072 | large conductance calcium-activated potassium channel activity(GO:0060072) |
| 0.0 | 0.7 | GO:0015279 | store-operated calcium channel activity(GO:0015279) |
| 0.0 | 0.7 | GO:0022848 | acetylcholine-gated cation channel activity(GO:0022848) |
| 0.0 | 0.7 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.1 | 0.6 | GO:0008430 | selenium binding(GO:0008430) |
| 0.1 | 0.5 | GO:0050682 | AF-2 domain binding(GO:0050682) |
| 0.1 | 0.5 | GO:0001875 | lipopolysaccharide receptor activity(GO:0001875) |
| 0.0 | 0.5 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
| 0.0 | 0.5 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.1 | 0.4 | GO:0034875 | oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875) |
| 0.1 | 0.4 | GO:0047756 | chondroitin 4-sulfotransferase activity(GO:0047756) |
| 0.1 | 0.4 | GO:0050294 | flavonol 3-sulfotransferase activity(GO:0047894) steroid sulfotransferase activity(GO:0050294) |
| 0.0 | 0.4 | GO:0004024 | alcohol dehydrogenase activity, zinc-dependent(GO:0004024) |
| 0.0 | 0.4 | GO:0015386 | potassium:proton antiporter activity(GO:0015386) |
| 0.0 | 0.4 | GO:0045505 | dynein intermediate chain binding(GO:0045505) |
Gene overrepresentation in C2:CP category:
Showing 1 to 6 of 6 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.2 | PID_ANGIOPOIETIN_RECEPTOR_PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.0 | 0.8 | PID_CONE_PATHWAY | Visual signal transduction: Cones |
| 0.0 | 0.8 | PID_IL6_7_PATHWAY | IL6-mediated signaling events |
| 0.0 | 0.5 | PID_NETRIN_PATHWAY | Netrin-mediated signaling events |
| 0.0 | 0.4 | PID_WNT_CANONICAL_PATHWAY | Canonical Wnt signaling pathway |
| 0.0 | 0.2 | SA_PROGRAMMED_CELL_DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 20 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.0 | REACTOME_TIE2_SIGNALING | Genes involved in Tie2 Signaling |
| 0.0 | 0.8 | REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.0 | 0.7 | REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS | Genes involved in Presynaptic nicotinic acetylcholine receptors |
| 0.0 | 0.6 | REACTOME_GLYCOPROTEIN_HORMONES | Genes involved in Glycoprotein hormones |
| 0.0 | 0.6 | REACTOME_ACYL_CHAIN_REMODELLING_OF_PI | Genes involved in Acyl chain remodelling of PI |
| 0.0 | 0.6 | REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE | Genes involved in Beta-catenin phosphorylation cascade |
| 0.0 | 0.6 | REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.0 | 0.6 | REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.0 | 0.6 | REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.0 | 0.5 | REACTOME_GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.0 | 0.4 | REACTOME_ETHANOL_OXIDATION | Genes involved in Ethanol oxidation |
| 0.0 | 0.4 | REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING | Genes involved in Role of second messengers in netrin-1 signaling |
| 0.0 | 0.4 | REACTOME_XENOBIOTICS | Genes involved in Xenobiotics |
| 0.0 | 0.4 | REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_7ALPHA_HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol |
| 0.0 | 0.4 | REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS | Genes involved in Viral Messenger RNA Synthesis |
| 0.0 | 0.3 | REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 0.0 | 0.3 | REACTOME_REGULATION_OF_COMPLEMENT_CASCADE | Genes involved in Regulation of Complement cascade |
| 0.0 | 0.3 | REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.0 | 0.1 | REACTOME_RECYCLING_OF_BILE_ACIDS_AND_SALTS | Genes involved in Recycling of bile acids and salts |
| 0.0 | 0.1 | REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 | Genes involved in IKK complex recruitment mediated by RIP1 |
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