Motif ID: FOXA3_FOXC2

Z-value: 0.516

Transcription factors associated with FOXA3_FOXC2:

Gene SymbolEntrez IDGene Name
FOXA3 ENSG00000170608.2 FOXA3
FOXC2 ENSG00000176692.4 FOXC2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
FOXC2hg19_v2_chr16_+_86600857_866009210.125.8e-01Click!
FOXA3hg19_v2_chr19_+_46367518_46367567-0.029.3e-01Click!


Activity profile for motif FOXA3_FOXC2.

activity profile for motif FOXA3_FOXC2


Sorted Z-values histogram for motif FOXA3_FOXC2

Sorted Z-values for motif FOXA3_FOXC2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOXA3_FOXC2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr20_+_31823792 5.716 ENST00000375413.4
ENST00000354297.4
ENST00000375422.2
 BPIFA1


BPI fold containing family A, member 1


chr11_+_27076764 2.339 ENST00000525090.1
 BBOX1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr5_+_156712372 2.004 ENST00000541131.1
 CYFIP2
cytoplasmic FMR1 interacting protein 2
chr20_+_31870927 1.786 ENST00000253354.1
 BPIFB1
BPI fold containing family B, member 1
chr11_-_108464465 1.639 ENST00000525344.1
 EXPH5
exophilin 5
chr11_-_108464321 1.371 ENST00000265843.4
 EXPH5
exophilin 5
chr7_+_142829162 1.272 ENST00000291009.3
 PIP
prolactin-induced protein
chr13_+_50589390 1.005 ENST00000360473.4
ENST00000312942.1
 KCNRG

potassium channel regulator

chr1_-_207095324 0.897 ENST00000530505.1
ENST00000367091.3
ENST00000442471.2
 FAIM3


Fas apoptotic inhibitory molecule 3


chr17_+_79953310 0.863 ENST00000582355.2
 ASPSCR1
alveolar soft part sarcoma chromosome region, candidate 1
chr1_-_146696901 0.848 ENST00000369272.3
ENST00000441068.2
 FMO5

flavin containing monooxygenase 5

chr20_+_9049682 0.842 ENST00000334005.3
ENST00000378473.3
 PLCB4

phospholipase C, beta 4

chr17_+_72426891 0.717 ENST00000392627.1
 GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr13_-_36429763 0.704 ENST00000379893.1
 DCLK1
doublecortin-like kinase 1
chr4_+_165675197 0.689 ENST00000515485.1
 RP11-294O2.2
RP11-294O2.2
chr9_-_75567962 0.656 ENST00000297785.3
ENST00000376939.1
 ALDH1A1

aldehyde dehydrogenase 1 family, member A1

chr13_-_39564993 0.640 ENST00000423210.1
 STOML3
stomatin (EPB72)-like 3
chr1_+_104293028 0.625 ENST00000370079.3
 AMY1C
amylase, alpha 1C (salivary)
chr13_-_86373536 0.599 ENST00000400286.2
 SLITRK6
SLIT and NTRK-like family, member 6
chrX_+_9431324 0.596 ENST00000407597.2
ENST00000424279.1
ENST00000536365.1
ENST00000441088.1
ENST00000380961.1
ENST00000415293.1
 TBL1X





transducin (beta)-like 1X-linked






Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 70 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 5.7 GO:0042710 biofilm formation(GO:0042710) single-species biofilm formation(GO:0044010) single-species biofilm formation in or on host organism(GO:0044407) regulation of single-species biofilm formation(GO:1900190) negative regulation of single-species biofilm formation(GO:1900191) regulation of single-species biofilm formation in or on host organism(GO:1900228) negative regulation of single-species biofilm formation in or on host organism(GO:1900229)
0.1 3.0 GO:0003334 keratinocyte development(GO:0003334)
0.2 2.3 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.2 1.9 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.2 1.8 GO:0034144 negative regulation of toll-like receptor 4 signaling pathway(GO:0034144)
0.0 1.3 GO:0070233 negative regulation of T cell apoptotic process(GO:0070233)
0.1 1.0 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260)
0.3 0.8 GO:1903568 negative regulation of protein localization to cilium(GO:1903565) regulation of protein localization to ciliary membrane(GO:1903567) negative regulation of protein localization to ciliary membrane(GO:1903568)
0.0 0.8 GO:0060972 left/right pattern formation(GO:0060972)
0.0 0.8 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.2 0.7 GO:0072134 hyaluranon cable assembly(GO:0036118) nephrogenic mesenchyme morphogenesis(GO:0072134) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106) allantois development(GO:1905069)
0.2 0.7 GO:0006001 fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624)
0.1 0.7 GO:0006848 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.0 0.7 GO:0072189 ureter development(GO:0072189)
0.0 0.7 GO:0030318 melanocyte differentiation(GO:0030318)
0.1 0.6 GO:0060005 vestibular reflex(GO:0060005)
0.0 0.6 GO:0021527 spinal cord association neuron differentiation(GO:0021527)
0.1 0.5 GO:0044245 polysaccharide digestion(GO:0044245)
0.1 0.4 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.0 0.4 GO:0090204 protein localization to nuclear pore(GO:0090204)

Gene overrepresentation in cellular_component category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.7 GO:0044292 dendrite terminus(GO:0044292)
0.0 0.6 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.1 0.3 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
0.1 0.3 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237) alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.1 0.3 GO:0038038 G-protein coupled receptor homodimeric complex(GO:0038038)
0.0 0.2 GO:0005579 membrane attack complex(GO:0005579)
0.0 0.2 GO:0042589 zymogen granule membrane(GO:0042589)
0.0 0.1 GO:1990130 Iml1 complex(GO:1990130)
0.0 0.1 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.0 0.1 GO:0098575 lumenal side of lysosomal membrane(GO:0098575)
0.0 0.1 GO:0097255 R2TP complex(GO:0097255)
0.0 0.1 GO:0000836 Hrd1p ubiquitin ligase complex(GO:0000836)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.6 GO:0017137 Rab GTPase binding(GO:0017137)
0.6 2.3 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.1 1.3 GO:0019864 IgG binding(GO:0019864)
0.0 1.3 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.1 0.8 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.2 0.7 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.1 0.7 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.1 0.7 GO:0070700 BMP receptor binding(GO:0070700)
0.0 0.6 GO:0070888 E-box binding(GO:0070888)
0.1 0.5 GO:0016160 amylase activity(GO:0016160)
0.0 0.5 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.1 0.3 GO:0051499 D-aminoacyl-tRNA deacylase activity(GO:0051499) D-tyrosyl-tRNA(Tyr) deacylase activity(GO:0051500)
0.1 0.3 GO:0031859 platelet activating factor receptor binding(GO:0031859)
0.1 0.3 GO:0005174 CD40 receptor binding(GO:0005174)
0.1 0.3 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
0.0 0.3 GO:0052739 phosphatidylserine 1-acylhydrolase activity(GO:0052739)
0.0 0.3 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.0 0.3 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 0.3 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.0 0.3 GO:0005545 1-phosphatidylinositol binding(GO:0005545)

Gene overrepresentation in C2:CP category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.9 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 1.0 PID_IL6_7_PATHWAY IL6-mediated signaling events
0.0 0.9 ST_G_ALPHA_I_PATHWAY G alpha i Pathway
0.0 0.8 PID_ALK2_PATHWAY ALK2 signaling events
0.0 0.6 PID_CD40_PATHWAY CD40/CD40L signaling
0.0 0.3 PID_NFKAPPAB_ATYPICAL_PATHWAY Atypical NF-kappaB pathway
0.0 0.1 ST_STAT3_PATHWAY STAT3 Pathway
0.0 0.1 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.1 REACTOME_DIGESTION_OF_DIETARY_CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.0 0.7 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.0 0.7 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.6 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.4 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.3 REACTOME_TRYPTOPHAN_CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.3 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.2 REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING Genes involved in Role of second messengers in netrin-1 signaling