Motif ID: FOXC1

Z-value: 0.584


Transcription factors associated with FOXC1:

Gene SymbolEntrez IDGene Name
FOXC1 ENSG00000054598.5 FOXC1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
FOXC1hg19_v2_chr6_+_1610681_16106810.443.0e-02Click!


Activity profile for motif FOXC1.

activity profile for motif FOXC1


Sorted Z-values histogram for motif FOXC1

Sorted Z-values for motif FOXC1



Network of associatons between targets according to the STRING database.



First level regulatory network of FOXC1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_72375167 2.715 ENST00000001146.2
CYP26B1
cytochrome P450, family 26, subfamily B, polypeptide 1
chr8_-_23261589 1.832 ENST00000524168.1
ENST00000523833.2
ENST00000519243.1
ENST00000389131.3
LOXL2



lysyl oxidase-like 2



chr2_-_161056762 1.168 ENST00000428609.2
ENST00000409967.2
ITGB6

integrin, beta 6

chr2_-_161056802 1.013 ENST00000283249.2
ENST00000409872.1
ITGB6

integrin, beta 6

chr8_+_54764346 1.005 ENST00000297313.3
ENST00000344277.6
RGS20

regulator of G-protein signaling 20

chr13_-_61989655 0.920 ENST00000409204.4
PCDH20
protocadherin 20
chr21_+_39628852 0.832 ENST00000398938.2
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr3_-_16524357 0.623 ENST00000432519.1
RFTN1
raftlin, lipid raft linker 1
chr14_-_57272366 0.621 ENST00000554788.1
ENST00000554845.1
ENST00000408990.3
OTX2


orthodenticle homeobox 2


chr4_-_103266626 0.612 ENST00000356736.4
SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr10_+_54074033 0.594 ENST00000373970.3
DKK1
dickkopf WNT signaling pathway inhibitor 1
chr10_+_105314881 0.584 ENST00000437579.1
NEURL
neuralized E3 ubiquitin protein ligase 1
chr14_+_37126765 0.556 ENST00000402703.2
PAX9
paired box 9
chr1_+_12524965 0.555 ENST00000471923.1
VPS13D
vacuolar protein sorting 13 homolog D (S. cerevisiae)
chr6_+_34204642 0.539 ENST00000347617.6
ENST00000401473.3
ENST00000311487.5
ENST00000447654.1
ENST00000395004.3
HMGA1




high mobility group AT-hook 1




chr14_+_76776957 0.523 ENST00000512784.1
ESRRB
estrogen-related receptor beta
chr1_-_94079648 0.506 ENST00000370247.3
BCAR3
breast cancer anti-estrogen resistance 3
chr17_-_57229155 0.501 ENST00000584089.1
SKA2
spindle and kinetochore associated complex subunit 2
chr22_+_46449674 0.489 ENST00000381051.2
FLJ27365
hsa-mir-4763
chr1_-_109935819 0.468 ENST00000538502.1
SORT1
sortilin 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 84 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 2.7 GO:2001037 tongue muscle cell differentiation(GO:0035981) positive regulation of skeletal muscle fiber differentiation(GO:1902811) regulation of tongue muscle cell differentiation(GO:2001035) positive regulation of tongue muscle cell differentiation(GO:2001037)
0.2 2.2 GO:0038044 transforming growth factor-beta secretion(GO:0038044)
0.1 1.8 GO:0032332 positive regulation of chondrocyte differentiation(GO:0032332)
0.0 1.2 GO:0010107 potassium ion import(GO:0010107)
0.1 1.0 GO:2000543 positive regulation of gastrulation(GO:2000543)
0.0 0.9 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.1 0.7 GO:0010908 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.1 0.7 GO:0035583 sequestering of TGFbeta in extracellular matrix(GO:0035583)
0.0 0.7 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.2 0.6 GO:1904956 regulation of endodermal cell fate specification(GO:0042663) regulation of midbrain dopaminergic neuron differentiation(GO:1904956)
0.1 0.6 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.1 0.6 GO:0070574 cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.1 0.6 GO:0032287 peripheral nervous system myelin maintenance(GO:0032287)
0.0 0.6 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.0 0.6 GO:0042481 regulation of odontogenesis(GO:0042481)
0.0 0.6 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)
0.2 0.5 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117)
0.2 0.5 GO:2000297 negative regulation of synapse maturation(GO:2000297)
0.1 0.5 GO:0090402 oncogene-induced cell senescence(GO:0090402)
0.1 0.5 GO:0021842 directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 2.2 GO:0034685 integrin alphav-beta6 complex(GO:0034685)
0.0 1.5 GO:0005604 basement membrane(GO:0005604)
0.2 0.9 GO:0030936 collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936)
0.0 0.9 GO:0055038 recycling endosome membrane(GO:0055038)
0.1 0.7 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 0.5 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.0 0.5 GO:0032039 integrator complex(GO:0032039)
0.0 0.5 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.5 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 0.5 GO:0030673 axolemma(GO:0030673)
0.0 0.5 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.0 0.4 GO:0042587 glycogen granule(GO:0042587) PTW/PP1 phosphatase complex(GO:0072357)
0.0 0.4 GO:0042555 MCM complex(GO:0042555)
0.1 0.3 GO:0005588 collagen type V trimer(GO:0005588)
0.1 0.3 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.1 0.3 GO:0043293 apoptosome(GO:0043293)
0.0 0.3 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.0 0.2 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.0 0.2 GO:0032280 symmetric synapse(GO:0032280)
0.0 0.2 GO:0072557 IPAF inflammasome complex(GO:0072557)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 2.7 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.0 2.4 GO:0001618 virus receptor activity(GO:0001618)
0.4 1.8 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.1 1.2 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.7 GO:0070016 gamma-catenin binding(GO:0045295) armadillo repeat domain binding(GO:0070016)
0.2 0.6 GO:0036134 thromboxane-A synthase activity(GO:0004796) 12-hydroxyheptadecatrienoic acid synthase activity(GO:0036134)
0.0 0.6 GO:0039706 co-receptor binding(GO:0039706)
0.0 0.6 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.6 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.6 GO:0043015 gamma-tubulin binding(GO:0043015)
0.2 0.5 GO:0005150 interleukin-1, Type I receptor binding(GO:0005150)
0.1 0.5 GO:0010465 nerve growth factor receptor activity(GO:0010465)
0.0 0.5 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.0 0.5 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.0 0.5 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 0.5 GO:0008503 benzodiazepine receptor activity(GO:0008503)
0.0 0.5 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.1 0.4 GO:0051996 farnesyl-diphosphate farnesyltransferase activity(GO:0004310) squalene synthase activity(GO:0051996)
0.1 0.4 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.1 0.4 GO:0050436 microfibril binding(GO:0050436)

Gene overrepresentation in C2:CP category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.2 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 1.3 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 1.2 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 1.2 NABA_COLLAGENS Genes encoding collagen proteins
0.0 1.0 ST_G_ALPHA_I_PATHWAY G alpha i Pathway
0.0 1.0 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 0.7 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 0.6 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.5 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 0.3 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.3 REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 2.3 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 1.2 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 1.2 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 1.0 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS Genes involved in G alpha (z) signalling events
0.0 0.9 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 0.8 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.0 0.7 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 0.6 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.0 0.6 REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT Genes involved in Regulation of beta-cell development
0.1 0.5 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 0.5 REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.5 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.0 0.4 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.4 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.0 0.4 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.4 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.3 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 0.1 REACTOME_TRAF6_MEDIATED_INDUCTION_OF_TAK1_COMPLEX Genes involved in TRAF6 mediated induction of TAK1 complex