Motif ID: FOXC1
Z-value: 0.584

Transcription factors associated with FOXC1:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
FOXC1 | ENSG00000054598.5 | FOXC1 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
FOXC1 | hg19_v2_chr6_+_1610681_1610681 | 0.44 | 3.0e-02 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 84 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.9 | 2.7 | GO:2001037 | tongue muscle cell differentiation(GO:0035981) positive regulation of skeletal muscle fiber differentiation(GO:1902811) regulation of tongue muscle cell differentiation(GO:2001035) positive regulation of tongue muscle cell differentiation(GO:2001037) |
0.2 | 2.2 | GO:0038044 | transforming growth factor-beta secretion(GO:0038044) |
0.1 | 1.8 | GO:0032332 | positive regulation of chondrocyte differentiation(GO:0032332) |
0.0 | 1.2 | GO:0010107 | potassium ion import(GO:0010107) |
0.1 | 1.0 | GO:2000543 | positive regulation of gastrulation(GO:2000543) |
0.0 | 0.9 | GO:0036075 | endochondral ossification(GO:0001958) replacement ossification(GO:0036075) |
0.1 | 0.7 | GO:0010908 | regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) positive regulation of proteoglycan biosynthetic process(GO:1902730) |
0.1 | 0.7 | GO:0035583 | sequestering of TGFbeta in extracellular matrix(GO:0035583) |
0.0 | 0.7 | GO:0002089 | lens morphogenesis in camera-type eye(GO:0002089) |
0.2 | 0.6 | GO:1904956 | regulation of endodermal cell fate specification(GO:0042663) regulation of midbrain dopaminergic neuron differentiation(GO:1904956) |
0.1 | 0.6 | GO:0002457 | T cell antigen processing and presentation(GO:0002457) |
0.1 | 0.6 | GO:0070574 | cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574) |
0.1 | 0.6 | GO:0032287 | peripheral nervous system myelin maintenance(GO:0032287) |
0.0 | 0.6 | GO:0019371 | cyclooxygenase pathway(GO:0019371) |
0.0 | 0.6 | GO:0042481 | regulation of odontogenesis(GO:0042481) |
0.0 | 0.6 | GO:0045747 | positive regulation of Notch signaling pathway(GO:0045747) |
0.2 | 0.5 | GO:0000117 | regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117) |
0.2 | 0.5 | GO:2000297 | negative regulation of synapse maturation(GO:2000297) |
0.1 | 0.5 | GO:0090402 | oncogene-induced cell senescence(GO:0090402) |
0.1 | 0.5 | GO:0021842 | directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 25 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.7 | 2.2 | GO:0034685 | integrin alphav-beta6 complex(GO:0034685) |
0.0 | 1.5 | GO:0005604 | basement membrane(GO:0005604) |
0.2 | 0.9 | GO:0030936 | collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936) |
0.0 | 0.9 | GO:0055038 | recycling endosome membrane(GO:0055038) |
0.1 | 0.7 | GO:0070369 | beta-catenin-TCF7L2 complex(GO:0070369) |
0.0 | 0.5 | GO:0035985 | senescence-associated heterochromatin focus(GO:0035985) |
0.0 | 0.5 | GO:0032039 | integrator complex(GO:0032039) |
0.0 | 0.5 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
0.0 | 0.5 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
0.0 | 0.5 | GO:0030673 | axolemma(GO:0030673) |
0.0 | 0.5 | GO:0030140 | trans-Golgi network transport vesicle(GO:0030140) |
0.0 | 0.4 | GO:0042587 | glycogen granule(GO:0042587) PTW/PP1 phosphatase complex(GO:0072357) |
0.0 | 0.4 | GO:0042555 | MCM complex(GO:0042555) |
0.1 | 0.3 | GO:0005588 | collagen type V trimer(GO:0005588) |
0.1 | 0.3 | GO:0036195 | muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195) |
0.1 | 0.3 | GO:0043293 | apoptosome(GO:0043293) |
0.0 | 0.3 | GO:0071144 | SMAD2-SMAD3 protein complex(GO:0071144) |
0.0 | 0.2 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
0.0 | 0.2 | GO:0032280 | symmetric synapse(GO:0032280) |
0.0 | 0.2 | GO:0072557 | IPAF inflammasome complex(GO:0072557) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 46 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.5 | 2.7 | GO:0008401 | retinoic acid 4-hydroxylase activity(GO:0008401) |
0.0 | 2.4 | GO:0001618 | virus receptor activity(GO:0001618) |
0.4 | 1.8 | GO:0004720 | protein-lysine 6-oxidase activity(GO:0004720) |
0.1 | 1.2 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
0.0 | 0.7 | GO:0070016 | gamma-catenin binding(GO:0045295) armadillo repeat domain binding(GO:0070016) |
0.2 | 0.6 | GO:0036134 | thromboxane-A synthase activity(GO:0004796) 12-hydroxyheptadecatrienoic acid synthase activity(GO:0036134) |
0.0 | 0.6 | GO:0039706 | co-receptor binding(GO:0039706) |
0.0 | 0.6 | GO:0008190 | eukaryotic initiation factor 4E binding(GO:0008190) |
0.0 | 0.6 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
0.0 | 0.6 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
0.2 | 0.5 | GO:0005150 | interleukin-1, Type I receptor binding(GO:0005150) |
0.1 | 0.5 | GO:0010465 | nerve growth factor receptor activity(GO:0010465) |
0.0 | 0.5 | GO:0005176 | ErbB-2 class receptor binding(GO:0005176) |
0.0 | 0.5 | GO:0004332 | fructose-bisphosphate aldolase activity(GO:0004332) |
0.0 | 0.5 | GO:0042975 | peroxisome proliferator activated receptor binding(GO:0042975) |
0.0 | 0.5 | GO:0008503 | benzodiazepine receptor activity(GO:0008503) |
0.0 | 0.5 | GO:0000993 | RNA polymerase II core binding(GO:0000993) |
0.1 | 0.4 | GO:0051996 | farnesyl-diphosphate farnesyltransferase activity(GO:0004310) squalene synthase activity(GO:0051996) |
0.1 | 0.4 | GO:0005477 | pyruvate secondary active transmembrane transporter activity(GO:0005477) |
0.1 | 0.4 | GO:0050436 | microfibril binding(GO:0050436) |
Gene overrepresentation in C2:CP category:
Showing 1 to 10 of 10 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 2.2 | PID_INTEGRIN5_PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
0.0 | 1.3 | PID_HIF1_TFPATHWAY | HIF-1-alpha transcription factor network |
0.0 | 1.2 | PID_INTEGRIN_A9B1_PATHWAY | Alpha9 beta1 integrin signaling events |
0.0 | 1.2 | NABA_COLLAGENS | Genes encoding collagen proteins |
0.0 | 1.0 | ST_G_ALPHA_I_PATHWAY | G alpha i Pathway |
0.0 | 1.0 | PID_CDC42_REG_PATHWAY | Regulation of CDC42 activity |
0.0 | 0.7 | PID_WNT_SIGNALING_PATHWAY | Wnt signaling network |
0.0 | 0.6 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
0.0 | 0.5 | PID_ERBB_NETWORK_PATHWAY | ErbB receptor signaling network |
0.0 | 0.3 | SA_PROGRAMMED_CELL_DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 19 of 19 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.0 | 3.3 | REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
0.0 | 2.3 | REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS | Genes involved in Integrin cell surface interactions |
0.0 | 1.2 | REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
0.0 | 1.2 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
0.0 | 1.0 | REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS | Genes involved in G alpha (z) signalling events |
0.0 | 0.9 | REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
0.0 | 0.8 | REACTOME_GLYCOLYSIS | Genes involved in Glycolysis |
0.0 | 0.7 | REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |
0.0 | 0.6 | REACTOME_ZINC_TRANSPORTERS | Genes involved in Zinc transporters |
0.0 | 0.6 | REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT | Genes involved in Regulation of beta-cell development |
0.1 | 0.5 | REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION | Genes involved in APOBEC3G mediated resistance to HIV-1 infection |
0.0 | 0.5 | REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
0.0 | 0.5 | REACTOME_GABA_A_RECEPTOR_ACTIVATION | Genes involved in GABA A receptor activation |
0.0 | 0.4 | REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |
0.0 | 0.4 | REACTOME_UNWINDING_OF_DNA | Genes involved in Unwinding of DNA |
0.0 | 0.4 | REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
0.0 | 0.4 | REACTOME_CHOLESTEROL_BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
0.0 | 0.3 | REACTOME_TIE2_SIGNALING | Genes involved in Tie2 Signaling |
0.0 | 0.1 | REACTOME_TRAF6_MEDIATED_INDUCTION_OF_TAK1_COMPLEX | Genes involved in TRAF6 mediated induction of TAK1 complex |