Motif ID: FOXD1_FOXO1_FOXO6_FOXG1_FOXP1

Z-value: 0.959

Transcription factors associated with FOXD1_FOXO1_FOXO6_FOXG1_FOXP1:

Gene SymbolEntrez IDGene Name
FOXD1 ENSG00000251493.2 FOXD1
FOXG1 ENSG00000176165.7 FOXG1
FOXO1 ENSG00000150907.6 FOXO1
FOXO6 ENSG00000204060.4 FOXO6
FOXP1 ENSG00000114861.14 FOXP1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
FOXP1hg19_v2_chr3_-_71632894_71632909-0.193.8e-01Click!
FOXG1hg19_v2_chr14_+_29236269_29236287,
hg19_v2_chr14_+_29234870_29235050		0.154.8e-01Click!
FOXO6hg19_v2_chr1_+_41827594_41827594-0.077.3e-01Click!
FOXO1hg19_v2_chr13_-_41240717_41240735-0.038.7e-01Click!
FOXD1hg19_v2_chr5_-_72744336_727443590.038.8e-01Click!


Activity profile for motif FOXD1_FOXO1_FOXO6_FOXG1_FOXP1.

activity profile for motif FOXD1_FOXO1_FOXO6_FOXG1_FOXP1


Sorted Z-values histogram for motif FOXD1_FOXO1_FOXO6_FOXG1_FOXP1

Sorted Z-values for motif FOXD1_FOXO1_FOXO6_FOXG1_FOXP1



Network of associatons between targets according to the STRING database.



First level regulatory network of FOXD1_FOXO1_FOXO6_FOXG1_FOXP1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_116654376 7.200 ENST00000369500.3
 MAB21L3
mab-21-like 3 (C. elegans)
chr2_-_165424973 3.945 ENST00000543549.1
 GRB14
growth factor receptor-bound protein 14
chr1_+_152486950 2.834 ENST00000368790.3
 CRCT1
cysteine-rich C-terminal 1
chr11_+_117049910 2.703 ENST00000431081.2
ENST00000524842.1
 SIDT2

SID1 transmembrane family, member 2

chr1_-_201096312 2.252 ENST00000449188.2
 ASCL5
achaete-scute family bHLH transcription factor 5
chr18_+_3449330 1.887 ENST00000549253.1
 TGIF1
TGFB-induced factor homeobox 1
chr17_-_8059638 1.777 ENST00000584202.1
ENST00000354903.5
ENST00000577253.1
 PER1


period circadian clock 1


chr12_+_96588279 1.777 ENST00000552142.1
 ELK3
ELK3, ETS-domain protein (SRF accessory protein 2)
chr15_-_60884706 1.678 ENST00000449337.2
 RORA
RAR-related orphan receptor A
chr6_+_101847105 1.666 ENST00000369137.3
ENST00000318991.6
 GRIK2

glutamate receptor, ionotropic, kainate 2

chr10_-_101841588 1.616 ENST00000370418.3
 CPN1
carboxypeptidase N, polypeptide 1
chr1_-_27816556 1.606 ENST00000536657.1
 WASF2
WAS protein family, member 2
chrX_-_106960285 1.588 ENST00000503515.1
ENST00000372397.2
 TSC22D3

TSC22 domain family, member 3

chr12_+_13349650 1.527 ENST00000256951.5
ENST00000431267.2
ENST00000542474.1
ENST00000544053.1
 EMP1



epithelial membrane protein 1



chr5_+_78532003 1.520 ENST00000396137.4
 JMY
junction mediating and regulatory protein, p53 cofactor
chr19_-_45909585 1.462 ENST00000593226.1
ENST00000418234.2
 PPP1R13L

protein phosphatase 1, regulatory subunit 13 like

chr9_-_84303269 1.409 ENST00000418319.1
 TLE1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
chr11_-_34535297 1.360 ENST00000532417.1
 ELF5
E74-like factor 5 (ets domain transcription factor)
chr1_-_45956800 1.360 ENST00000538496.1
 TESK2
testis-specific kinase 2
chr11_+_117049445 1.353 ENST00000324225.4
ENST00000532960.1
 SIDT2

SID1 transmembrane family, member 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 233 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 5.4 GO:0033227 dsRNA transport(GO:0033227)
0.2 3.4 GO:0090179 planar cell polarity pathway involved in neural tube closure(GO:0090179)
0.2 2.9 GO:0007021 tubulin complex assembly(GO:0007021)
0.1 2.9 GO:0046627 negative regulation of insulin receptor signaling pathway(GO:0046627)
0.5 2.7 GO:0071477 hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
0.1 2.7 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.0 2.7 GO:0003254 regulation of membrane depolarization(GO:0003254)
0.1 2.4 GO:0035855 megakaryocyte development(GO:0035855)
0.0 2.3 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.3 2.0 GO:0072675 multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675)
0.3 1.9 GO:0001712 ectodermal cell fate commitment(GO:0001712)
0.2 1.8 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.2 1.7 GO:0097338 response to clozapine(GO:0097338)
0.2 1.7 GO:0097167 circadian regulation of translation(GO:0097167)
0.1 1.7 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.1 1.7 GO:0021694 cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702)
0.1 1.7 GO:0003215 cardiac right ventricle morphogenesis(GO:0003215)
0.3 1.6 GO:0030070 insulin processing(GO:0030070)
0.2 1.6 GO:0098734 macromolecule depalmitoylation(GO:0098734)
0.1 1.6 GO:0048268 clathrin coat assembly(GO:0048268)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 88 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.7 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 4.5 GO:0010008 endosome membrane(GO:0010008)
0.2 3.0 GO:0097512 cardiac myofibril(GO:0097512)
0.1 2.6 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 2.5 GO:0055037 recycling endosome(GO:0055037)
0.2 2.4 GO:0031209 SCAR complex(GO:0031209)
0.0 2.3 GO:0001533 cornified envelope(GO:0001533)
0.0 2.2 GO:0070821 tertiary granule membrane(GO:0070821)
0.0 2.0 GO:0042734 presynaptic membrane(GO:0042734)
0.1 1.9 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 1.9 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.1 1.8 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 1.8 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 1.5 GO:0045171 intercellular bridge(GO:0045171)
0.1 1.4 GO:0097427 microtubule bundle(GO:0097427)
0.0 1.4 GO:0043202 lysosomal lumen(GO:0043202)
0.2 1.2 GO:0044294 dendritic growth cone(GO:0044294)
0.1 1.2 GO:0035976 AP1 complex(GO:0035976)
0.1 1.1 GO:0030478 actin cap(GO:0030478)
0.0 1.1 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 155 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.0 GO:0031490 chromatin DNA binding(GO:0031490)
0.9 5.4 GO:0051032 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.0 3.3 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 3.1 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.1 3.0 GO:0005212 structural constituent of eye lens(GO:0005212)
0.2 2.7 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.8 2.4 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.0 2.4 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 2.3 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.1 2.2 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.1 2.1 GO:0070410 co-SMAD binding(GO:0070410)
0.2 1.9 GO:0008142 oxysterol binding(GO:0008142)
0.1 1.9 GO:0030280 structural constituent of epidermis(GO:0030280)
0.0 1.9 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.2 1.7 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.1 1.7 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.1 1.7 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.2 1.6 GO:0043426 MRF binding(GO:0043426)
0.2 1.6 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.1 1.5 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.3 PID_INSULIN_PATHWAY Insulin Pathway
0.0 3.9 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 3.2 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 3.2 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 2.9 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.0 2.4 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.0 2.2 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.0 1.9 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 1.8 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 1.7 PID_IL3_PATHWAY IL3-mediated signaling events
0.0 1.6 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.1 1.5 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.5 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.4 PID_FOXO_PATHWAY FoxO family signaling
0.0 1.4 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 1.3 PID_P53_REGULATION_PATHWAY p53 pathway
0.0 1.3 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.2 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 1.2 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 1.1 PID_NOTCH_PATHWAY Notch signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.8 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.1 3.4 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 2.3 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 2.0 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.1 1.9 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 1.6 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 1.6 REACTOME_PI3K_AKT_ACTIVATION Genes involved in PI3K/AKT activation
0.0 1.6 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 1.4 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 1.4 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 1.3 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.1 1.3 REACTOME_SIGNALLING_TO_P38_VIA_RIT_AND_RIN Genes involved in Signalling to p38 via RIT and RIN
0.0 1.3 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 1.3 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 1.2 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.0 1.1 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 1.0 REACTOME_PURINE_SALVAGE Genes involved in Purine salvage
0.0 0.9 REACTOME_THE_NLRP3_INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 0.9 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 0.7 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins