Motif ID: FOXD3_FOXI1_FOXF1

Z-value: 1.818

Transcription factors associated with FOXD3_FOXI1_FOXF1:

Gene SymbolEntrez IDGene Name
FOXD3 ENSG00000187140.4 FOXD3
FOXF1 ENSG00000103241.5 FOXF1
FOXI1 ENSG00000168269.7 FOXI1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
FOXI1hg19_v2_chr5_+_169532896_1695329170.546.0e-03Click!
FOXD3hg19_v2_chr1_+_63788730_63788730-0.491.6e-02Click!
FOXF1hg19_v2_chr16_+_86544113_86544145-0.252.4e-01Click!


Activity profile for motif FOXD3_FOXI1_FOXF1.

activity profile for motif FOXD3_FOXI1_FOXF1


Sorted Z-values histogram for motif FOXD3_FOXI1_FOXF1

Sorted Z-values for motif FOXD3_FOXI1_FOXF1



Network of associatons between targets according to the STRING database.



First level regulatory network of FOXD3_FOXI1_FOXF1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_-_71551652 17.828 ENST00000546561.1
 TSPAN8
tetraspanin 8
chr12_-_25348007 11.794 ENST00000354189.5
ENST00000545133.1
ENST00000554347.1
ENST00000395987.3
ENST00000320267.9
ENST00000395990.2
ENST00000537577.1
 CASC1






cancer susceptibility candidate 1






chr4_+_165675197 7.849 ENST00000515485.1
 RP11-294O2.2
RP11-294O2.2
chr11_-_108464465 7.399 ENST00000525344.1
 EXPH5
exophilin 5
chr11_+_27076764 6.769 ENST00000525090.1
 BBOX1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr20_+_9049682 6.704 ENST00000334005.3
ENST00000378473.3
 PLCB4

phospholipase C, beta 4

chr3_-_167371740 6.682 ENST00000466760.1
ENST00000479765.1
 WDR49

WD repeat domain 49

chr1_+_104159999 6.635 ENST00000414303.2
ENST00000423678.1
 AMY2A

amylase, alpha 2A (pancreatic)

chr11_-_108464321 6.435 ENST00000265843.4
 EXPH5
exophilin 5
chr13_+_36050881 6.133 ENST00000537702.1
 NBEA
neurobeachin
chr16_-_28621353 5.961 ENST00000567512.1
 SULT1A1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
chr4_+_165675269 5.749 ENST00000507311.1
 RP11-294O2.2
RP11-294O2.2
chr12_-_71551868 5.422 ENST00000247829.3
 TSPAN8
tetraspanin 8
chr4_-_84035905 4.996 ENST00000311507.4
 PLAC8
placenta-specific 8
chr12_-_68696652 4.941 ENST00000539972.1
 MDM1
Mdm1 nuclear protein homolog (mouse)
chr4_-_84035868 4.889 ENST00000426923.2
ENST00000509973.1
 PLAC8

placenta-specific 8

chr3_-_19988462 4.722 ENST00000344838.4
 EFHB
EF-hand domain family, member B
chr20_+_31823792 4.703 ENST00000375413.4
ENST00000354297.4
ENST00000375422.2
 BPIFA1


BPI fold containing family A, member 1


chr12_-_39734783 4.444 ENST00000552961.1
 KIF21A
kinesin family member 21A
chr13_+_50589390 4.123 ENST00000360473.4
ENST00000312942.1
 KCNRG

potassium channel regulator


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 342 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 25.2 GO:1900047 negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
0.6 14.9 GO:0003334 keratinocyte development(GO:0003334)
1.0 11.0 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.5 9.9 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.4 9.4 GO:0006068 ethanol catabolic process(GO:0006068)
0.0 8.7 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 8.6 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.9 6.6 GO:0044245 polysaccharide digestion(GO:0044245)
0.4 6.6 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260)
0.1 5.8 GO:0006536 glutamate metabolic process(GO:0006536)
0.2 5.7 GO:0072189 ureter development(GO:0072189)
0.2 5.1 GO:0021670 lateral ventricle development(GO:0021670)
0.4 4.9 GO:0046600 negative regulation of centriole replication(GO:0046600)
0.1 4.8 GO:0046324 regulation of glucose import(GO:0046324)
1.2 4.7 GO:0042710 biofilm formation(GO:0042710) single-species biofilm formation(GO:0044010) single-species biofilm formation in or on host organism(GO:0044407) regulation of single-species biofilm formation(GO:1900190) negative regulation of single-species biofilm formation(GO:1900191) regulation of single-species biofilm formation in or on host organism(GO:1900228) negative regulation of single-species biofilm formation in or on host organism(GO:1900229)
0.0 4.5 GO:0002223 stimulatory C-type lectin receptor signaling pathway(GO:0002223)
0.0 4.4 GO:0043647 inositol phosphate metabolic process(GO:0043647)
0.1 4.2 GO:0036150 phosphatidylserine acyl-chain remodeling(GO:0036150)
1.0 4.0 GO:0001970 positive regulation of activation of membrane attack complex(GO:0001970)
0.2 3.9 GO:0060972 left/right pattern formation(GO:0060972)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 149 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 13.8 GO:0009986 cell surface(GO:0009986)
0.0 10.4 GO:0032993 protein-DNA complex(GO:0032993)
0.1 9.7 GO:0035578 azurophil granule lumen(GO:0035578)
0.1 7.0 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.1 6.1 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 4.9 GO:0097014 axoneme(GO:0005930) ciliary plasm(GO:0097014)
1.0 4.8 GO:0005879 axonemal microtubule(GO:0005879)
0.1 4.8 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 4.3 GO:0005814 centriole(GO:0005814)
0.5 4.2 GO:0005579 membrane attack complex(GO:0005579)
0.0 3.6 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 3.5 GO:0097542 ciliary tip(GO:0097542)
0.0 3.3 GO:0005811 lipid particle(GO:0005811)
0.0 3.1 GO:0042641 actomyosin(GO:0042641)
0.4 3.0 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.1 3.0 GO:0002080 acrosomal membrane(GO:0002080)
0.0 3.0 GO:0036064 ciliary basal body(GO:0036064)
0.0 2.9 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.1 2.8 GO:0030286 dynein complex(GO:0030286)
0.1 2.7 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 214 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 18.7 GO:0005178 integrin binding(GO:0005178)
0.1 11.4 GO:0017137 Rab GTPase binding(GO:0017137)
2.8 11.0 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
1.3 9.4 GO:0050294 flavonol 3-sulfotransferase activity(GO:0047894) steroid sulfotransferase activity(GO:0050294)
0.6 7.8 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.2 7.4 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
1.7 6.6 GO:0016160 amylase activity(GO:0016160)
1.3 6.3 GO:0047820 D-glutamate cyclase activity(GO:0047820)
0.1 5.4 GO:0070888 E-box binding(GO:0070888)
0.0 5.1 GO:0051082 unfolded protein binding(GO:0051082)
0.7 5.0 GO:0052739 phosphatidylserine 1-acylhydrolase activity(GO:0052739)
1.6 4.8 GO:0031862 prostanoid receptor binding(GO:0031862)
0.2 4.8 GO:0070330 aromatase activity(GO:0070330)
0.0 4.7 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.6 4.2 GO:0050682 AF-2 domain binding(GO:0050682)
0.2 3.9 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.1 3.9 GO:0008009 chemokine activity(GO:0008009)
0.1 3.8 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 3.7 GO:0070410 co-SMAD binding(GO:0070410)
0.0 3.7 GO:0004402 histone acetyltransferase activity(GO:0004402)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 13.2 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 9.3 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 6.2 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 4.1 PID_BMP_PATHWAY BMP receptor signaling
0.0 3.7 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 3.5 PID_CDC42_PATHWAY CDC42 signaling events
0.1 3.2 PID_FOXO_PATHWAY FoxO family signaling
0.1 3.1 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 3.1 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.0 2.8 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 2.3 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 1.9 PID_E2F_PATHWAY E2F transcription factor network
0.0 1.9 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 1.8 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 1.8 ST_G_ALPHA_I_PATHWAY G alpha i Pathway
0.0 1.6 PID_CD8_TCR_PATHWAY TCR signaling in naïve CD8+ T cells
0.1 1.5 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 1.5 PID_ATR_PATHWAY ATR signaling pathway
0.1 1.3 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 1.2 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 65 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 13.0 REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.3 9.4 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.1 8.3 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.7 6.6 REACTOME_DIGESTION_OF_DIETARY_CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.1 5.6 REACTOME_COMPLEMENT_CASCADE Genes involved in Complement cascade
0.1 5.5 REACTOME_PLC_BETA_MEDIATED_EVENTS Genes involved in PLC beta mediated events
0.1 4.4 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.1 4.1 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.2 3.5 REACTOME_RECYCLING_OF_BILE_ACIDS_AND_SALTS Genes involved in Recycling of bile acids and salts
0.1 3.3 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 3.2 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 3.1 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.0 3.0 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 2.9 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 2.8 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 2.2 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.2 2.1 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.1 1.9 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.2 1.8 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.1 1.8 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters