Motif ID: FOXJ2
Z-value: 0.633
Transcription factors associated with FOXJ2:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| FOXJ2 | ENSG00000065970.4 | FOXJ2 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FOXJ2 | hg19_v2_chr12_+_8185288_8185339 | 0.35 | 9.0e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 1.1 | GO:0009786 | regulation of asymmetric cell division(GO:0009786) |
| 0.3 | 1.3 | GO:1903285 | negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) positive regulation of peroxidase activity(GO:2000470) |
| 0.2 | 1.0 | GO:0061767 | negative regulation of lung blood pressure(GO:0061767) |
| 0.2 | 0.8 | GO:0046035 | CMP salvage(GO:0006238) CMP biosynthetic process(GO:0009224) CMP metabolic process(GO:0046035) |
| 0.2 | 1.6 | GO:1900623 | regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625) |
| 0.2 | 0.8 | GO:1904075 | trophectodermal cell proliferation(GO:0001834) regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075) |
| 0.2 | 0.6 | GO:0071894 | histone H2B conserved C-terminal lysine ubiquitination(GO:0071894) |
| 0.1 | 0.7 | GO:0071477 | hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477) |
| 0.1 | 1.3 | GO:0030951 | establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951) |
| 0.1 | 0.4 | GO:0044028 | DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029) |
| 0.1 | 0.9 | GO:0050689 | negative regulation of defense response to virus by host(GO:0050689) |
| 0.1 | 0.3 | GO:1903542 | negative regulation of exosomal secretion(GO:1903542) |
| 0.1 | 0.4 | GO:0007509 | mesoderm migration involved in gastrulation(GO:0007509) |
| 0.1 | 0.4 | GO:1901842 | negative regulation of high voltage-gated calcium channel activity(GO:1901842) |
| 0.1 | 0.4 | GO:0071874 | cellular response to norepinephrine stimulus(GO:0071874) |
| 0.1 | 2.2 | GO:0006346 | methylation-dependent chromatin silencing(GO:0006346) |
| 0.1 | 1.0 | GO:0090050 | positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) |
| 0.1 | 0.4 | GO:0046668 | regulation of retinal cell programmed cell death(GO:0046668) |
| 0.1 | 0.5 | GO:0019264 | glycine biosynthetic process from serine(GO:0019264) |
| 0.1 | 0.3 | GO:0035262 | gonad morphogenesis(GO:0035262) |
| 0.1 | 3.2 | GO:0060216 | definitive hemopoiesis(GO:0060216) |
| 0.1 | 0.3 | GO:0042357 | thiamine diphosphate metabolic process(GO:0042357) |
| 0.1 | 0.4 | GO:0006931 | substrate-dependent cell migration, cell attachment to substrate(GO:0006931) |
| 0.1 | 0.4 | GO:0014718 | positive regulation of satellite cell activation involved in skeletal muscle regeneration(GO:0014718) |
| 0.1 | 0.5 | GO:1905150 | regulation of voltage-gated sodium channel activity(GO:1905150) |
| 0.1 | 0.2 | GO:1902227 | negative regulation of macrophage colony-stimulating factor signaling pathway(GO:1902227) negative regulation of response to macrophage colony-stimulating factor(GO:1903970) negative regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903973) |
| 0.1 | 0.3 | GO:0006438 | valyl-tRNA aminoacylation(GO:0006438) |
| 0.1 | 0.2 | GO:0098746 | fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746) |
| 0.0 | 0.3 | GO:2000158 | positive regulation of ubiquitin-specific protease activity(GO:2000158) |
| 0.0 | 0.3 | GO:0034392 | negative regulation of smooth muscle cell apoptotic process(GO:0034392) |
| 0.0 | 0.2 | GO:1990523 | response to vitamin K(GO:0032571) bone regeneration(GO:1990523) |
| 0.0 | 0.8 | GO:0071803 | positive regulation of podosome assembly(GO:0071803) |
| 0.0 | 0.7 | GO:0033141 | positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141) |
| 0.0 | 0.7 | GO:0051775 | response to redox state(GO:0051775) |
| 0.0 | 0.1 | GO:0046452 | dihydrofolate metabolic process(GO:0046452) |
| 0.0 | 0.6 | GO:0043517 | positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517) |
| 0.0 | 0.1 | GO:0051490 | negative regulation of filopodium assembly(GO:0051490) |
| 0.0 | 0.1 | GO:1904381 | Golgi apparatus mannose trimming(GO:1904381) |
| 0.0 | 0.1 | GO:0090063 | positive regulation of microtubule nucleation(GO:0090063) |
| 0.0 | 0.1 | GO:0038098 | sequestering of BMP from receptor via BMP binding(GO:0038098) |
| 0.0 | 0.2 | GO:0060737 | prostate epithelial cord elongation(GO:0060523) prostate gland morphogenetic growth(GO:0060737) |
| 0.0 | 0.3 | GO:0008090 | retrograde axonal transport(GO:0008090) |
| 0.0 | 0.8 | GO:0022400 | regulation of rhodopsin mediated signaling pathway(GO:0022400) |
| 0.0 | 0.3 | GO:0030916 | otic vesicle formation(GO:0030916) |
| 0.0 | 0.4 | GO:0048368 | lateral mesoderm development(GO:0048368) |
| 0.0 | 0.1 | GO:0051684 | maintenance of Golgi location(GO:0051684) |
| 0.0 | 0.4 | GO:0006071 | glycerol metabolic process(GO:0006071) |
| 0.0 | 1.7 | GO:0007585 | respiratory gaseous exchange(GO:0007585) |
| 0.0 | 0.2 | GO:0032057 | negative regulation of translational initiation in response to stress(GO:0032057) |
| 0.0 | 0.4 | GO:0002089 | lens morphogenesis in camera-type eye(GO:0002089) |
| 0.0 | 0.1 | GO:0090625 | mRNA cleavage involved in gene silencing by siRNA(GO:0090625) |
| 0.0 | 0.4 | GO:0007252 | I-kappaB phosphorylation(GO:0007252) |
| 0.0 | 0.3 | GO:0090435 | protein localization to nuclear envelope(GO:0090435) |
| 0.0 | 0.5 | GO:0010447 | response to acidic pH(GO:0010447) |
| 0.0 | 0.0 | GO:1903762 | positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1903762) positive regulation of ventricular cardiac muscle cell action potential(GO:1903947) positive regulation of membrane repolarization during ventricular cardiac muscle cell action potential(GO:1905026) positive regulation of membrane repolarization during cardiac muscle cell action potential(GO:1905033) |
| 0.0 | 0.2 | GO:0071787 | endoplasmic reticulum tubular network assembly(GO:0071787) |
| 0.0 | 0.1 | GO:0043932 | ossification involved in bone remodeling(GO:0043932) |
| 0.0 | 0.3 | GO:1904706 | negative regulation of vascular smooth muscle cell proliferation(GO:1904706) |
| 0.0 | 0.3 | GO:0060746 | maternal behavior(GO:0042711) parental behavior(GO:0060746) |
| 0.0 | 0.3 | GO:0072540 | T-helper 17 cell lineage commitment(GO:0072540) |
| 0.0 | 0.1 | GO:2000334 | blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334) |
| 0.0 | 0.3 | GO:0002227 | innate immune response in mucosa(GO:0002227) |
| 0.0 | 0.2 | GO:0060391 | positive regulation of SMAD protein import into nucleus(GO:0060391) |
| 0.0 | 0.4 | GO:0042730 | fibrinolysis(GO:0042730) |
| 0.0 | 1.1 | GO:0030574 | collagen catabolic process(GO:0030574) |
| 0.0 | 0.1 | GO:2000601 | positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601) |
| 0.0 | 0.1 | GO:0048341 | paraxial mesoderm formation(GO:0048341) |
| 0.0 | 0.2 | GO:0034587 | piRNA metabolic process(GO:0034587) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 0.9 | GO:1990423 | RZZ complex(GO:1990423) |
| 0.2 | 1.6 | GO:0035692 | macrophage migration inhibitory factor receptor complex(GO:0035692) |
| 0.2 | 0.7 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
| 0.1 | 1.1 | GO:0005587 | collagen type IV trimer(GO:0005587) |
| 0.1 | 3.2 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.1 | 0.4 | GO:0097058 | CRLF-CLCF1 complex(GO:0097058) |
| 0.1 | 1.1 | GO:0036449 | microtubule minus-end(GO:0036449) |
| 0.1 | 1.0 | GO:0071144 | SMAD2-SMAD3 protein complex(GO:0071144) |
| 0.1 | 0.8 | GO:0035867 | alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867) |
| 0.1 | 0.4 | GO:0071149 | TEAD-2-YAP complex(GO:0071149) |
| 0.1 | 0.4 | GO:0005943 | phosphatidylinositol 3-kinase complex, class IA(GO:0005943) |
| 0.1 | 0.3 | GO:0031673 | H zone(GO:0031673) |
| 0.1 | 0.5 | GO:0070552 | BRISC complex(GO:0070552) |
| 0.0 | 0.4 | GO:1990761 | growth cone lamellipodium(GO:1990761) growth cone filopodium(GO:1990812) |
| 0.0 | 1.5 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.0 | 0.8 | GO:0042622 | photoreceptor outer segment membrane(GO:0042622) |
| 0.0 | 1.4 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.0 | 0.7 | GO:0008290 | F-actin capping protein complex(GO:0008290) |
| 0.0 | 0.3 | GO:0097208 | alveolar lamellar body(GO:0097208) |
| 0.0 | 0.2 | GO:0060200 | clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201) |
| 0.0 | 0.2 | GO:1990393 | 3M complex(GO:1990393) |
| 0.0 | 0.4 | GO:0030126 | COPI vesicle coat(GO:0030126) |
| 0.0 | 0.1 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.0 | 0.4 | GO:0008385 | IkappaB kinase complex(GO:0008385) |
| 0.0 | 0.1 | GO:0000221 | vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221) |
| 0.0 | 0.2 | GO:0005851 | eukaryotic translation initiation factor 2B complex(GO:0005851) |
| 0.0 | 0.3 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 0.0 | 0.2 | GO:0072687 | meiotic spindle(GO:0072687) |
| 0.0 | 0.7 | GO:0016592 | mediator complex(GO:0016592) |
| 0.0 | 0.2 | GO:0097550 | transcriptional preinitiation complex(GO:0097550) |
| 0.0 | 0.2 | GO:0005869 | dynactin complex(GO:0005869) |
| 0.0 | 0.1 | GO:0009331 | glycerol-3-phosphate dehydrogenase complex(GO:0009331) |
| 0.0 | 0.3 | GO:0031932 | TORC2 complex(GO:0031932) |
| 0.0 | 0.1 | GO:0072669 | tRNA-splicing ligase complex(GO:0072669) |
| 0.0 | 1.7 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.0 | 0.4 | GO:0051233 | spindle midzone(GO:0051233) |
| 0.0 | 0.1 | GO:0032584 | growth cone membrane(GO:0032584) |
| 0.0 | 0.3 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.0 | 0.5 | GO:0005790 | smooth endoplasmic reticulum(GO:0005790) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.3 | GO:0060961 | phospholipase D inhibitor activity(GO:0060961) |
| 0.2 | 0.6 | GO:0005173 | stem cell factor receptor binding(GO:0005173) |
| 0.2 | 1.0 | GO:0031962 | mineralocorticoid receptor binding(GO:0031962) |
| 0.1 | 1.3 | GO:0019237 | centromeric DNA binding(GO:0019237) |
| 0.1 | 0.9 | GO:0046703 | natural killer cell lectin-like receptor binding(GO:0046703) |
| 0.1 | 0.5 | GO:0008732 | glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732) |
| 0.1 | 0.8 | GO:0004849 | uridine kinase activity(GO:0004849) |
| 0.1 | 0.3 | GO:0008169 | C-methyltransferase activity(GO:0008169) |
| 0.1 | 0.4 | GO:0005127 | ciliary neurotrophic factor receptor binding(GO:0005127) |
| 0.1 | 0.8 | GO:0043855 | intracellular cyclic nucleotide activated cation channel activity(GO:0005221) cyclic nucleotide-gated ion channel activity(GO:0043855) |
| 0.1 | 0.7 | GO:0015379 | potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820) |
| 0.1 | 0.3 | GO:0004832 | valine-tRNA ligase activity(GO:0004832) |
| 0.1 | 2.2 | GO:0008327 | methyl-CpG binding(GO:0008327) |
| 0.0 | 0.3 | GO:0035800 | deubiquitinase activator activity(GO:0035800) |
| 0.0 | 0.3 | GO:0060230 | lipoprotein lipase activator activity(GO:0060230) |
| 0.0 | 1.6 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.0 | 0.7 | GO:0005132 | type I interferon receptor binding(GO:0005132) |
| 0.0 | 0.4 | GO:0035005 | 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005) |
| 0.0 | 0.4 | GO:0051425 | PTB domain binding(GO:0051425) |
| 0.0 | 4.2 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.0 | 0.3 | GO:0016778 | diphosphotransferase activity(GO:0016778) |
| 0.0 | 0.7 | GO:0002162 | dystroglycan binding(GO:0002162) |
| 0.0 | 0.2 | GO:0005157 | macrophage colony-stimulating factor receptor binding(GO:0005157) |
| 0.0 | 0.2 | GO:0035614 | snRNA stem-loop binding(GO:0035614) |
| 0.0 | 0.4 | GO:0030280 | structural constituent of epidermis(GO:0030280) |
| 0.0 | 0.2 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
| 0.0 | 0.2 | GO:0008597 | calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597) |
| 0.0 | 0.8 | GO:0000993 | RNA polymerase II core binding(GO:0000993) |
| 0.0 | 0.2 | GO:0038052 | RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052) |
| 0.0 | 0.4 | GO:0031432 | titin binding(GO:0031432) |
| 0.0 | 0.4 | GO:0043522 | leucine zipper domain binding(GO:0043522) |
| 0.0 | 0.1 | GO:0052590 | sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity(GO:0052590) sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity(GO:0052591) |
| 0.0 | 0.8 | GO:0005159 | insulin-like growth factor receptor binding(GO:0005159) |
| 0.0 | 0.1 | GO:0004301 | epoxide hydrolase activity(GO:0004301) |
| 0.0 | 0.4 | GO:0001134 | transcription factor activity, transcription factor recruiting(GO:0001134) |
| 0.0 | 0.9 | GO:0051879 | Hsp90 protein binding(GO:0051879) |
| 0.0 | 0.3 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 0.0 | 0.1 | GO:0004046 | aminoacylase activity(GO:0004046) |
| 0.0 | 0.1 | GO:0016742 | hydroxymethyl-, formyl- and related transferase activity(GO:0016742) cyclohydrolase activity(GO:0019238) |
| 0.0 | 0.1 | GO:0071532 | ankyrin repeat binding(GO:0071532) |
| 0.0 | 0.1 | GO:0070892 | lipoteichoic acid receptor activity(GO:0070892) |
| 0.0 | 0.1 | GO:0004571 | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) |
| 0.0 | 0.1 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.6 | SA_MMP_CYTOKINE_CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 3.2 | PID_NOTCH_PATHWAY | Notch signaling pathway |
| 0.0 | 1.0 | PID_SMAD2_3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 0.7 | PID_CIRCADIAN_PATHWAY | Circadian rhythm pathway |
| 0.0 | 0.8 | PID_RHODOPSIN_PATHWAY | Visual signal transduction: Rods |
| 0.0 | 1.5 | PID_AURORA_B_PATHWAY | Aurora B signaling |
| 0.0 | 1.1 | NABA_COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 1.3 | PID_ER_NONGENOMIC_PATHWAY | Plasma membrane estrogen receptor signaling |
| 0.0 | 0.9 | PID_ALPHA_SYNUCLEIN_PATHWAY | Alpha-synuclein signaling |
| 0.0 | 0.4 | PID_GLYPICAN_1PATHWAY | Glypican 1 network |
| 0.0 | 0.8 | PID_KIT_PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.0 | 0.3 | PID_IL8_CXCR2_PATHWAY | IL8- and CXCR2-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.6 | REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.0 | 1.3 | REACTOME_KINESINS | Genes involved in Kinesins |
| 0.0 | 1.0 | REACTOME_SIGNALING_BY_NODAL | Genes involved in Signaling by NODAL |
| 0.0 | 0.4 | REACTOME_THE_NLRP3_INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.0 | 0.7 | REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.0 | 0.8 | REACTOME_PYRIMIDINE_METABOLISM | Genes involved in Pyrimidine metabolism |
| 0.0 | 0.4 | REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.0 | 0.2 | REACTOME_IRAK2_MEDIATED_ACTIVATION_OF_TAK1_COMPLEX_UPON_TLR7_8_OR_9_STIMULATION | Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation |
| 0.0 | 1.4 | REACTOME_AMYLOIDS | Genes involved in Amyloids |
| 0.0 | 1.1 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
| 0.0 | 0.4 | REACTOME_SIGNALING_BY_CONSTITUTIVELY_ACTIVE_EGFR | Genes involved in Signaling by constitutively active EGFR |
