Motif ID: FOXK1_FOXP2_FOXB1_FOXP3

Z-value: 0.970

Transcription factors associated with FOXK1_FOXP2_FOXB1_FOXP3:

Gene SymbolEntrez IDGene Name
FOXB1 ENSG00000171956.5 FOXB1
FOXK1 ENSG00000164916.9 FOXK1
FOXP2 ENSG00000128573.18 FOXP2
FOXP3 ENSG00000049768.10 FOXP3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
FOXP2hg19_v2_chr7_+_114055052_1140553780.395.7e-02Click!
FOXK1hg19_v2_chr7_+_4721885_4721945-0.395.8e-02Click!
FOXB1hg19_v2_chr15_+_60296421_60296464-0.341.0e-01Click!
FOXP3hg19_v2_chrX_-_49121165_49121288-0.272.0e-01Click!


Activity profile for motif FOXK1_FOXP2_FOXB1_FOXP3.

activity profile for motif FOXK1_FOXP2_FOXB1_FOXP3


Sorted Z-values histogram for motif FOXK1_FOXP2_FOXB1_FOXP3

Sorted Z-values for motif FOXK1_FOXP2_FOXB1_FOXP3



Network of associatons between targets according to the STRING database.



First level regulatory network of FOXK1_FOXP2_FOXB1_FOXP3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr20_-_7921090 7.539 ENST00000378789.3
 HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr12_-_71551652 6.445 ENST00000546561.1
 TSPAN8
tetraspanin 8
chr12_-_71551868 4.286 ENST00000247829.3
 TSPAN8
tetraspanin 8
chr1_-_161337662 4.066 ENST00000367974.1
 C1orf192
chromosome 1 open reading frame 192
chr4_+_165675197 3.705 ENST00000515485.1
 RP11-294O2.2
RP11-294O2.2
chr13_+_50589390 3.441 ENST00000360473.4
ENST00000312942.1
 KCNRG

potassium channel regulator

chr6_-_87804815 3.270 ENST00000369582.2
 CGA
glycoprotein hormones, alpha polypeptide
chr4_+_165675269 3.076 ENST00000507311.1
 RP11-294O2.2
RP11-294O2.2
chr13_-_39564993 3.057 ENST00000423210.1
 STOML3
stomatin (EPB72)-like 3
chr2_-_158345462 2.912 ENST00000439355.1
ENST00000540637.1
 CYTIP

cytohesin 1 interacting protein

chr1_+_12806141 2.735 ENST00000288048.5
 C1orf158
chromosome 1 open reading frame 158
chr9_+_27109392 2.550 ENST00000406359.4
 TEK
TEK tyrosine kinase, endothelial
chr7_-_16921601 2.349 ENST00000402239.3
ENST00000310398.2
ENST00000414935.1
 AGR3


anterior gradient 3


chr17_+_68071458 2.318 ENST00000589377.1
 KCNJ16
potassium inwardly-rectifying channel, subfamily J, member 16
chr17_+_68071389 2.307 ENST00000283936.1
ENST00000392671.1
 KCNJ16

potassium inwardly-rectifying channel, subfamily J, member 16

chr2_+_71162995 2.255 ENST00000234396.4
 ATP6V1B1
ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1
chr2_+_71163051 2.255 ENST00000412314.1
 ATP6V1B1
ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1
chr5_-_35938674 2.159 ENST00000397366.1
ENST00000513623.1
ENST00000514524.1
ENST00000397367.2
 CAPSL



calcyphosine-like



chr2_+_42104692 2.093 ENST00000398796.2
ENST00000442214.1
 AC104654.1

AC104654.1

chr5_-_16509101 1.964 ENST00000399793.2
 FAM134B
family with sequence similarity 134, member B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 399 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 6.9 GO:0009441 glycolate metabolic process(GO:0009441)
0.1 6.7 GO:1900047 negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
0.1 4.3 GO:0090383 phagosome acidification(GO:0090383)
0.2 3.6 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260)
1.2 3.5 GO:0010430 fatty acid omega-oxidation(GO:0010430)
0.5 3.4 GO:0048014 Tie signaling pathway(GO:0048014)
0.1 3.3 GO:0010107 potassium ion import(GO:0010107)
0.0 3.2 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
1.0 3.0 GO:1904899 regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
0.0 3.0 GO:0016266 O-glycan processing(GO:0016266)
0.1 2.5 GO:0060972 left/right pattern formation(GO:0060972)
0.0 2.3 GO:0001895 retina homeostasis(GO:0001895)
0.1 2.1 GO:0003334 keratinocyte development(GO:0003334)
0.0 2.1 GO:0006958 complement activation, classical pathway(GO:0006958)
0.1 2.0 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.1 1.7 GO:0045078 positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.5 1.6 GO:0002071 glandular epithelial cell maturation(GO:0002071) type B pancreatic cell maturation(GO:0072560)
0.2 1.5 GO:1990822 basic amino acid transmembrane transport(GO:1990822)
0.1 1.5 GO:0042738 exogenous drug catabolic process(GO:0042738)
0.1 1.4 GO:0001867 complement activation, lectin pathway(GO:0001867)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 108 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.9 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 5.4 GO:0005796 Golgi lumen(GO:0005796)
0.3 4.5 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 4.3 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 4.0 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 3.6 GO:0072562 blood microparticle(GO:0072562)
0.1 3.4 GO:0009925 basal plasma membrane(GO:0009925)
0.0 2.7 GO:0016363 nuclear matrix(GO:0016363)
0.1 2.0 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 1.9 GO:0036064 ciliary basal body(GO:0036064)
0.0 1.7 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 1.6 GO:0035577 azurophil granule membrane(GO:0035577)
0.1 1.3 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 1.2 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.1 1.1 GO:0036038 MKS complex(GO:0036038)
0.0 1.1 GO:0005814 centriole(GO:0005814)
0.1 1.0 GO:0005833 hemoglobin complex(GO:0005833)
0.1 0.9 GO:0001940 male pronucleus(GO:0001940)
0.1 0.9 GO:0036157 outer dynein arm(GO:0036157)
0.0 0.8 GO:0042599 lamellar body(GO:0042599)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 218 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.5 7.5 GO:0016899 oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.0 4.6 GO:0005178 integrin binding(GO:0005178)
0.0 4.1 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.2 3.7 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 3.7 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.8 3.0 GO:0016623 oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623)
0.2 3.0 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.1 2.5 GO:0008392 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.1 2.2 GO:0004000 adenosine deaminase activity(GO:0004000)
0.2 2.1 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 1.6 GO:0005044 scavenger receptor activity(GO:0005044)
0.1 1.5 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.1 1.5 GO:0002162 dystroglycan binding(GO:0002162)
0.0 1.5 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 1.5 GO:0048487 beta-tubulin binding(GO:0048487)
0.3 1.3 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.0 1.3 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.3 1.2 GO:0016160 amylase activity(GO:0016160)
0.4 1.1 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.2 1.1 GO:0050682 AF-2 domain binding(GO:0050682)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.2 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 2.2 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 1.9 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 1.6 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0 1.5 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 1.4 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 1.0 PID_SHP2_PATHWAY SHP2 signaling
0.0 0.9 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 0.9 PID_IL8_CXCR2_PATHWAY IL8- and CXCR2-mediated signaling events
0.0 0.8 PID_ALK2_PATHWAY ALK2 signaling events
0.0 0.8 PID_PTP1B_PATHWAY Signaling events mediated by PTP1B
0.0 0.7 PID_CONE_PATHWAY Visual signal transduction: Cones
0.0 0.7 PID_IL6_7_PATHWAY IL6-mediated signaling events
0.0 0.7 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 0.7 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.7 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 0.5 PID_CD40_PATHWAY CD40/CD40L signaling
0.0 0.5 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 0.5 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 0.5 PID_AURORA_A_PATHWAY Aurora A signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.1 REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.2 4.6 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.1 4.5 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.3 3.8 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.1 3.6 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 3.6 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.2 3.3 REACTOME_ANDROGEN_BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.1 1.6 REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.2 1.5 REACTOME_DIGESTION_OF_DIETARY_CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.0 1.5 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.1 1.4 REACTOME_XENOBIOTICS Genes involved in Xenobiotics
0.0 1.4 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 1.3 REACTOME_THE_ROLE_OF_NEF_IN_HIV1_REPLICATION_AND_DISEASE_PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0 1.2 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 1.1 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 1.0 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.9 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.8 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.7 REACTOME_IRON_UPTAKE_AND_TRANSPORT Genes involved in Iron uptake and transport
0.0 0.6 REACTOME_IRAK1_RECRUITS_IKK_COMPLEX Genes involved in IRAK1 recruits IKK complex