Motif ID: FOXL1

Z-value: 1.020


Transcription factors associated with FOXL1:

Gene SymbolEntrez IDGene Name
FOXL1 ENSG00000176678.4 FOXL1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
FOXL1hg19_v2_chr16_+_86612112_86612123-0.281.9e-01Click!


Activity profile for motif FOXL1.

activity profile for motif FOXL1


Sorted Z-values histogram for motif FOXL1

Sorted Z-values for motif FOXL1



Network of associatons between targets according to the STRING database.



First level regulatory network of FOXL1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_100356551 7.532 ENST00000209665.4
 ADH7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr4_-_100356844 5.052 ENST00000437033.2
 ADH7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr6_+_131958436 3.562 ENST00000357639.3
ENST00000543135.1
ENST00000427148.2
ENST00000358229.5
 ENPP3



ectonucleotide pyrophosphatase/phosphodiesterase 3



chr5_-_35938674 3.562 ENST00000397366.1
ENST00000513623.1
ENST00000514524.1
ENST00000397367.2
 CAPSL



calcyphosine-like



chr5_-_41261540 3.057 ENST00000263413.3
 C6
complement component 6
chr9_-_34397800 2.779 ENST00000297623.2
 C9orf24
chromosome 9 open reading frame 24
chr4_-_100356291 2.740 ENST00000476959.1
ENST00000482593.1
 ADH7

alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide

chr5_+_94727048 2.615 ENST00000283357.5
 FAM81B
family with sequence similarity 81, member B
chr3_+_8543533 2.601 ENST00000454244.1
 LMCD1
LIM and cysteine-rich domains 1
chr5_-_110062384 2.364 ENST00000429839.2
 TMEM232
transmembrane protein 232
chr4_-_70505358 2.303 ENST00000457664.2
ENST00000604629.1
ENST00000604021.1
 UGT2A2


UDP glucuronosyltransferase 2 family, polypeptide A2


chr18_-_24722995 2.285 ENST00000581714.1
 CHST9
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9
chr12_+_69742121 2.267 ENST00000261267.2
ENST00000549690.1
ENST00000548839.1
 LYZ


lysozyme


chr13_-_39564993 2.254 ENST00000423210.1
 STOML3
stomatin (EPB72)-like 3
chr6_+_112408768 2.251 ENST00000368656.2
ENST00000604268.1
 FAM229B

family with sequence similarity 229, member B

chr5_+_140227048 2.131 ENST00000532602.1
 PCDHA9
protocadherin alpha 9
chr5_-_110062349 2.054 ENST00000511883.2
ENST00000455884.2
 TMEM232

transmembrane protein 232

chr10_-_28270795 2.017 ENST00000545014.1
 ARMC4
armadillo repeat containing 4
chr12_+_20963647 1.988 ENST00000381545.3
 SLCO1B3
solute carrier organic anion transporter family, member 1B3
chr4_+_70861647 1.983 ENST00000246895.4
ENST00000381060.2
 STATH

statherin


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 265 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.1 15.3 GO:0010430 fatty acid omega-oxidation(GO:0010430)
0.0 7.3 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 4.7 GO:0016266 O-glycan processing(GO:0016266)
1.1 4.4 GO:0001970 positive regulation of activation of membrane attack complex(GO:0001970)
0.2 3.8 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.2 3.7 GO:0036158 outer dynein arm assembly(GO:0036158)
0.1 3.7 GO:0043252 sodium-independent organic anion transport(GO:0043252)
1.2 3.6 GO:0030505 inorganic diphosphate transport(GO:0030505)
0.2 3.5 GO:0010826 negative regulation of centrosome duplication(GO:0010826)
0.1 3.4 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
0.0 2.9 GO:0031295 T cell costimulation(GO:0031295)
0.0 2.8 GO:0042073 intraciliary transport(GO:0042073)
0.4 2.5 GO:0016098 monoterpenoid metabolic process(GO:0016098)
0.1 2.2 GO:0070986 left/right axis specification(GO:0070986)
0.1 2.1 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.3 2.0 GO:0071461 cellular response to redox state(GO:0071461)
0.1 2.0 GO:0035640 exploration behavior(GO:0035640)
0.1 1.7 GO:0046541 saliva secretion(GO:0046541)
0.5 1.6 GO:0034059 response to anoxia(GO:0034059)
0.2 1.6 GO:0015889 cobalamin transport(GO:0015889)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 100 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.0 GO:0035580 specific granule lumen(GO:0035580)
0.5 4.3 GO:0005579 membrane attack complex(GO:0005579)
0.0 4.3 GO:0097014 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.0 4.2 GO:0005796 Golgi lumen(GO:0005796)
0.2 3.9 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 3.9 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 3.5 GO:0035578 azurophil granule lumen(GO:0035578)
0.0 2.3 GO:0009925 basal plasma membrane(GO:0009925)
0.0 2.3 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 2.1 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 2.1 GO:0005814 centriole(GO:0005814)
0.1 1.9 GO:0097225 sperm midpiece(GO:0097225)
0.0 1.9 GO:0016459 myosin complex(GO:0016459)
0.0 1.7 GO:0005801 cis-Golgi network(GO:0005801)
0.0 1.5 GO:0031970 mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.1 1.4 GO:0036038 MKS complex(GO:0036038)
0.3 1.3 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.1 1.3 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.4 1.1 GO:0035354 Toll-like receptor 1-Toll-like receptor 2 protein complex(GO:0035354)
0.1 1.1 GO:0036157 outer dynein arm(GO:0036157)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 174 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.6 14.5 GO:0004031 aldehyde oxidase activity(GO:0004031)
0.2 3.9 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.6 3.2 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
0.1 2.6 GO:0008392 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.1 2.5 GO:0001968 fibronectin binding(GO:0001968)
0.4 2.3 GO:0047756 chondroitin 4-sulfotransferase activity(GO:0047756)
0.1 2.3 GO:0045504 dynein heavy chain binding(GO:0045504)
0.1 2.1 GO:0003796 lysozyme activity(GO:0003796)
0.0 2.1 GO:0003774 motor activity(GO:0003774)
0.2 2.0 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0 2.0 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.6 1.9 GO:0046848 hydroxyapatite binding(GO:0046848)
0.1 1.7 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 1.7 GO:0042605 peptide antigen binding(GO:0042605)
0.0 1.7 GO:0043014 alpha-tubulin binding(GO:0043014)
0.1 1.6 GO:0031419 cobalamin binding(GO:0031419)
0.0 1.5 GO:0008009 chemokine activity(GO:0008009)
0.1 1.4 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1 1.4 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.0 1.4 GO:0034987 immunoglobulin receptor binding(GO:0034987)

Gene overrepresentation in C2:CP category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.4 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 2.1 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 1.9 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 1.7 PID_CMYB_PATHWAY C-MYB transcription factor network
0.0 1.2 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.0 1.1 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.0 1.1 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 0.7 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 0.7 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.6 PID_ERBB4_PATHWAY ErbB4 signaling events
0.0 0.6 PID_TRAIL_PATHWAY TRAIL signaling pathway
0.0 0.3 ST_ADRENERGIC Adrenergic Pathway
0.0 0.3 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 0.2 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 0.2 PID_IL1_PATHWAY IL1-mediated signaling events
0.0 0.2 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.0 0.1 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.0 0.0 ST_GAQ_PATHWAY G alpha q Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 15.7 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.1 6.5 REACTOME_COMPLEMENT_CASCADE Genes involved in Complement cascade
0.2 4.9 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.2 3.8 REACTOME_XENOBIOTICS Genes involved in Xenobiotics
0.2 3.7 REACTOME_RECYCLING_OF_BILE_ACIDS_AND_SALTS Genes involved in Recycling of bile acids and salts
0.1 3.3 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1 3.1 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 2.9 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 1.6 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.1 1.5 REACTOME_ACYL_CHAIN_REMODELLING_OF_PS Genes involved in Acyl chain remodelling of PS
0.0 1.5 REACTOME_BETA_DEFENSINS Genes involved in Beta defensins
0.0 1.5 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 1.5 REACTOME_IRON_UPTAKE_AND_TRANSPORT Genes involved in Iron uptake and transport
0.1 1.3 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 1.3 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 1.3 REACTOME_AMYLOIDS Genes involved in Amyloids
0.1 1.2 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.1 1.1 REACTOME_LIPID_DIGESTION_MOBILIZATION_AND_TRANSPORT Genes involved in Lipid digestion, mobilization, and transport
0.1 1.0 REACTOME_DIGESTION_OF_DIETARY_CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.0 1.0 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation