Motif ID: FOXM1_TBL1XR1

Z-value: 1.160

Transcription factors associated with FOXM1_TBL1XR1:

Gene SymbolEntrez IDGene Name
FOXM1 ENSG00000111206.8 FOXM1
TBL1XR1 ENSG00000177565.11 TBL1XR1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
TBL1XR1hg19_v2_chr3_-_176914238_176914277-0.252.3e-01Click!
FOXM1hg19_v2_chr12_-_2986107_2986258-0.019.8e-01Click!


Activity profile for motif FOXM1_TBL1XR1.

activity profile for motif FOXM1_TBL1XR1


Sorted Z-values histogram for motif FOXM1_TBL1XR1

Sorted Z-values for motif FOXM1_TBL1XR1



Network of associatons between targets according to the STRING database.



First level regulatory network of FOXM1_TBL1XR1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_142247606 1.872 ENST00000390361.3
 TRBV7-3
T cell receptor beta variable 7-3
chr4_+_159443090 1.562 ENST00000343542.5
ENST00000470033.1
 RXFP1

relaxin/insulin-like family peptide receptor 1

chr7_+_142031986 1.423 ENST00000547918.2
 TRBV7-1
T cell receptor beta variable 7-1 (non-functional)
chr1_-_158301312 1.378 ENST00000368168.3
 CD1B
CD1b molecule
chrX_-_63450480 1.378 ENST00000362002.2
 ASB12
ankyrin repeat and SOCS box containing 12
chrX_-_65259900 1.344 ENST00000412866.2
 VSIG4
V-set and immunoglobulin domain containing 4
chr19_-_51893827 1.297 ENST00000574814.1
 CTD-2616J11.4
chromosome 19 open reading frame 84
chrX_-_65259914 1.287 ENST00000374737.4
ENST00000455586.2
 VSIG4

V-set and immunoglobulin domain containing 4

chr12_-_8218997 1.284 ENST00000307637.4
 C3AR1
complement component 3a receptor 1
chr3_+_19189946 1.267 ENST00000328405.2
 KCNH8
potassium voltage-gated channel, subfamily H (eag-related), member 8
chr11_-_123756334 1.213 ENST00000528595.1
ENST00000375026.2
 TMEM225

transmembrane protein 225

chr8_-_7274385 1.188 ENST00000318157.2
 DEFB4B
defensin, beta 4B
chr1_+_47264711 1.180 ENST00000371923.4
ENST00000271153.4
ENST00000371919.4
 CYP4B1


cytochrome P450, family 4, subfamily B, polypeptide 1


chr5_+_96211643 1.163 ENST00000437043.3
ENST00000510373.1
 ERAP2

endoplasmic reticulum aminopeptidase 2

chr12_-_71182695 1.124 ENST00000342084.4
 PTPRR
protein tyrosine phosphatase, receptor type, R
chr2_-_119605253 1.108 ENST00000295206.6
 EN1
engrailed homeobox 1
chr7_-_122339162 1.108 ENST00000340112.2
 RNF133
ring finger protein 133
chrX_+_49296814 1.105 ENST00000420398.2
 GAGE12C
G antigen 12C
chr2_-_169746878 1.096 ENST00000282074.2
 SPC25
SPC25, NDC80 kinetochore complex component
chr6_-_32784687 1.094 ENST00000447394.1
ENST00000438763.2
 HLA-DOB

major histocompatibility complex, class II, DO beta


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 1,010 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.9 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 6.3 GO:0006958 complement activation, classical pathway(GO:0006958)
0.2 4.1 GO:0032703 negative regulation of interleukin-2 production(GO:0032703)
0.2 2.4 GO:0042738 exogenous drug catabolic process(GO:0042738)
0.2 2.3 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.1 2.2 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.2 2.1 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.2 2.1 GO:0048003 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.0 2.1 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.1 2.0 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)
0.3 1.9 GO:0052551 response to defense-related nitric oxide production by other organism involved in symbiotic interaction(GO:0052551) response to defense-related host nitric oxide production(GO:0052565)
0.1 1.9 GO:0016540 protein autoprocessing(GO:0016540)
0.1 1.9 GO:0050974 detection of mechanical stimulus involved in sensory perception(GO:0050974)
0.0 1.9 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991)
0.2 1.8 GO:0045345 positive regulation of MHC class I biosynthetic process(GO:0045345)
0.0 1.8 GO:0097435 fibril organization(GO:0097435)
0.0 1.8 GO:0007062 sister chromatid cohesion(GO:0007062)
0.4 1.7 GO:0001970 positive regulation of activation of membrane attack complex(GO:0001970)
0.2 1.7 GO:1903385 regulation of homophilic cell adhesion(GO:1903385)
0.1 1.6 GO:0006030 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 314 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.5 GO:0072562 blood microparticle(GO:0072562)
0.0 3.7 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 3.5 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 3.2 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 2.5 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 2.3 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.1 2.2 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 2.2 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.2 2.1 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1 2.0 GO:0010369 chromocenter(GO:0010369)
0.0 2.0 GO:0005923 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.2 1.9 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.3 1.8 GO:0031262 Ndc80 complex(GO:0031262)
0.1 1.7 GO:0030686 90S preribosome(GO:0030686)
0.1 1.6 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.1 1.6 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 1.5 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 1.5 GO:0005796 Golgi lumen(GO:0005796)
0.2 1.4 GO:0042272 nuclear RNA export factor complex(GO:0042272)
0.2 1.4 GO:0005579 membrane attack complex(GO:0005579)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 581 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.9 GO:0004984 olfactory receptor activity(GO:0004984)
0.1 6.4 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 3.3 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 3.2 GO:0050840 extracellular matrix binding(GO:0050840)
0.2 2.4 GO:0005436 sodium:phosphate symporter activity(GO:0005436)
0.1 2.3 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.1 2.2 GO:0004383 guanylate cyclase activity(GO:0004383)
0.2 2.1 GO:0030884 lipid antigen binding(GO:0030882) endogenous lipid antigen binding(GO:0030883) exogenous lipid antigen binding(GO:0030884)
0.0 2.0 GO:0015459 potassium channel regulator activity(GO:0015459)
0.2 1.8 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)
0.1 1.7 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.0 1.7 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.3 1.6 GO:0005223 intracellular cGMP activated cation channel activity(GO:0005223)
0.1 1.6 GO:0004568 chitinase activity(GO:0004568)
0.0 1.6 GO:0036459 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459)
0.2 1.5 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.1 1.5 GO:0004875 complement receptor activity(GO:0004875)
0.1 1.4 GO:0042608 T cell receptor binding(GO:0042608)
0.1 1.4 GO:0005132 type I interferon receptor binding(GO:0005132)
0.1 1.4 GO:0003688 DNA replication origin binding(GO:0003688)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.0 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 3.6 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 2.7 PID_IL23_PATHWAY IL23-mediated signaling events
0.1 2.5 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 2.5 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.0 2.4 PID_ATR_PATHWAY ATR signaling pathway
0.1 2.3 PID_CONE_PATHWAY Visual signal transduction: Cones
0.0 2.3 PID_PTP1B_PATHWAY Signaling events mediated by PTP1B
0.0 2.2 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 1.9 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.8 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.0 1.8 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 1.6 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 1.4 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.0 1.3 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 1.3 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.0 0.9 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 0.8 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 0.8 PID_IL6_7_PATHWAY IL6-mediated signaling events
0.1 0.7 PID_CD40_PATHWAY CD40/CD40L signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 110 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.7 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 6.5 REACTOME_OLFACTORY_SIGNALING_PATHWAY Genes involved in Olfactory Signaling Pathway
0.1 4.8 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.0 3.4 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 3.2 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.0 2.7 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 2.6 REACTOME_BETA_DEFENSINS Genes involved in Beta defensins
0.1 2.6 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.1 2.2 REACTOME_POL_SWITCHING Genes involved in Polymerase switching
0.0 2.1 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 2.0 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.1 1.9 REACTOME_ACYL_CHAIN_REMODELLING_OF_PI Genes involved in Acyl chain remodelling of PI
0.1 1.9 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.1 1.8 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.1 1.8 REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS Genes involved in Activation of ATR in response to replication stress
0.0 1.8 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 1.8 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 1.8 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 1.6 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.0 1.6 REACTOME_LIGAND_GATED_ION_CHANNEL_TRANSPORT Genes involved in Ligand-gated ion channel transport