Motif ID: FOXN1

Z-value: 0.759


Transcription factors associated with FOXN1:

Gene SymbolEntrez IDGene Name
FOXN1 ENSG00000109101.3 FOXN1



Activity profile for motif FOXN1.

activity profile for motif FOXN1


Sorted Z-values histogram for motif FOXN1

Sorted Z-values for motif FOXN1



Network of associatons between targets according to the STRING database.



First level regulatory network of FOXN1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_28113217 3.748 ENST00000444339.2
 RBKS
ribokinase
chr15_+_71184931 2.433 ENST00000560369.1
ENST00000260382.5
 LRRC49

leucine rich repeat containing 49

chr4_+_81256871 2.363 ENST00000358105.3
ENST00000508675.1
 C4orf22

chromosome 4 open reading frame 22

chr1_+_245133656 2.271 ENST00000366521.3
 EFCAB2
EF-hand calcium binding domain 2
chr15_+_71185148 2.160 ENST00000443425.2
ENST00000560755.1
 LRRC49

leucine rich repeat containing 49

chr9_+_34458771 1.947 ENST00000437363.1
ENST00000242317.4
 DNAI1

dynein, axonemal, intermediate chain 1

chr5_+_76506706 1.941 ENST00000340978.3
ENST00000346042.3
ENST00000264917.5
ENST00000342343.4
ENST00000333194.4
 PDE8B




phosphodiesterase 8B




chr7_+_76751926 1.854 ENST00000285871.4
ENST00000431197.1
 CCDC146

coiled-coil domain containing 146

chr17_+_62075703 1.720 ENST00000577953.1
ENST00000582540.1
ENST00000579184.1
ENST00000425164.3
ENST00000412177.1
ENST00000539996.1
ENST00000583891.1
ENST00000580752.1
 C17orf72







chromosome 17 open reading frame 72







chr14_+_65016620 1.689 ENST00000298705.1
 PPP1R36
protein phosphatase 1, regulatory subunit 36
chr5_-_100238956 1.615 ENST00000231461.5
 ST8SIA4
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
chrY_+_22737678 1.540 ENST00000382772.3
 EIF1AY
eukaryotic translation initiation factor 1A, Y-linked
chr17_+_11501748 1.508 ENST00000262442.4
ENST00000579828.1
 DNAH9

dynein, axonemal, heavy chain 9

chr19_+_14544099 1.364 ENST00000242783.6
ENST00000586557.1
ENST00000590097.1
 PKN1


protein kinase N1


chr7_-_120498357 1.364 ENST00000415871.1
ENST00000222747.3
ENST00000430985.1
 TSPAN12


tetraspanin 12


chr9_-_99381660 1.265 ENST00000375240.3
ENST00000463569.1
 CDC14B

cell division cycle 14B

chr15_+_78556809 1.200 ENST00000343789.3
ENST00000394852.3
 DNAJA4

DnaJ (Hsp40) homolog, subfamily A, member 4

chr22_-_31741757 1.183 ENST00000215919.3
 PATZ1
POZ (BTB) and AT hook containing zinc finger 1
chr2_-_28113965 1.104 ENST00000302188.3
 RBKS
ribokinase
chr10_+_104180580 1.101 ENST00000425536.1
 FBXL15
F-box and leucine-rich repeat protein 15

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 85 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 4.9 GO:0019303 D-ribose catabolic process(GO:0019303)
0.1 2.4 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.1 1.9 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.1 1.9 GO:0036158 outer dynein arm assembly(GO:0036158)
0.0 1.9 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 1.8 GO:0003341 cilium movement(GO:0003341)
0.0 1.7 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.1 1.5 GO:0035721 intraciliary retrograde transport(GO:0035721)
0.2 1.4 GO:0035407 histone H3-T11 phosphorylation(GO:0035407)
0.0 1.4 GO:0010842 retina layer formation(GO:0010842)
0.0 1.4 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 1.1 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.0 1.0 GO:0031954 positive regulation of protein autophosphorylation(GO:0031954)
0.1 0.8 GO:0010637 negative regulation of mitochondrial fusion(GO:0010637)
0.1 0.8 GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480)
0.1 0.8 GO:0061088 regulation of sequestering of zinc ion(GO:0061088)
0.0 0.8 GO:0003334 keratinocyte development(GO:0003334)
0.0 0.8 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.2 0.7 GO:0016256 N-glycan processing to lysosome(GO:0016256)
0.1 0.7 GO:0050915 sensory perception of sour taste(GO:0050915)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.3 GO:0005801 cis-Golgi network(GO:0005801)
0.0 2.5 GO:0005814 centriole(GO:0005814)
0.2 1.9 GO:0036157 outer dynein arm(GO:0036157)
0.0 1.9 GO:0030286 dynein complex(GO:0030286)
0.0 1.9 GO:0072686 mitotic spindle(GO:0072686)
0.0 1.6 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 1.4 GO:0034451 centriolar satellite(GO:0034451)
0.0 1.2 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 1.2 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 1.0 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.0 1.0 GO:0016328 lateral plasma membrane(GO:0016328)
0.1 0.8 GO:0030991 intraciliary transport particle A(GO:0030991)
0.1 0.8 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.7 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.0 0.7 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.5 GO:0000242 pericentriolar material(GO:0000242)
0.1 0.4 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 0.4 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.4 GO:0000124 SAGA complex(GO:0000124)
0.0 0.4 GO:0032391 photoreceptor connecting cilium(GO:0032391)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 54 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.1 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.1 3.7 GO:0045503 dynein light chain binding(GO:0045503)
0.2 2.0 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0 1.9 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 1.5 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.2 1.4 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.1 1.4 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 1.3 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 1.2 GO:0038132 neuregulin binding(GO:0038132)
0.0 1.1 GO:0051393 alpha-actinin binding(GO:0051393)
0.0 1.0 GO:0070034 telomerase RNA binding(GO:0070034)
0.0 1.0 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 1.0 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 0.8 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.0 0.8 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.8 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.8 GO:0071889 14-3-3 protein binding(GO:0071889)
0.2 0.7 GO:0005136 interleukin-4 receptor binding(GO:0005136)
0.2 0.7 GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
0.2 0.7 GO:0032408 MutLbeta complex binding(GO:0032406) MutSbeta complex binding(GO:0032408)

Gene overrepresentation in C2:CP category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.2 PID_PLK1_PATHWAY PLK1 signaling events
0.0 1.7 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 1.4 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.8 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 0.5 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.0 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 1.3 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.8 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.0 0.8 REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.7 REACTOME_BASE_FREE_SUGAR_PHOSPHATE_REMOVAL_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0 0.7 REACTOME_POST_NMDA_RECEPTOR_ACTIVATION_EVENTS Genes involved in Post NMDA receptor activation events
0.1 0.6 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 0.6 REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.0 0.5 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.5 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 0.4 REACTOME_SOS_MEDIATED_SIGNALLING Genes involved in SOS-mediated signalling
0.0 0.3 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 0.3 REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 0.2 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.2 REACTOME_NFKB_IS_ACTIVATED_AND_SIGNALS_SURVIVAL Genes involved in NF-kB is activated and signals survival