Motif ID: FOXO3_FOXD2

Z-value: 0.689

Transcription factors associated with FOXO3_FOXD2:

Gene SymbolEntrez IDGene Name
FOXD2 ENSG00000186564.5 FOXD2
FOXO3 ENSG00000118689.10 FOXO3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
FOXO3hg19_v2_chr6_+_108881012_108881038,
hg19_v2_chr6_+_108882069_108882087		-0.242.6e-01Click!
FOXD2hg19_v2_chr1_+_47901689_479016890.164.6e-01Click!


Activity profile for motif FOXO3_FOXD2.

activity profile for motif FOXO3_FOXD2


Sorted Z-values histogram for motif FOXO3_FOXD2

Sorted Z-values for motif FOXO3_FOXD2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOXO3_FOXD2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_-_71551652 8.666 ENST00000546561.1
 TSPAN8
tetraspanin 8
chr12_-_71551868 4.777 ENST00000247829.3
 TSPAN8
tetraspanin 8
chr14_-_65769392 3.710 ENST00000555736.1
 CTD-2509G16.5
CTD-2509G16.5
chr4_+_165675197 2.973 ENST00000515485.1
 RP11-294O2.2
RP11-294O2.2
chr3_+_113616317 2.809 ENST00000440446.2
ENST00000488680.1
 GRAMD1C

GRAM domain containing 1C

chr13_-_39564993 2.753 ENST00000423210.1
 STOML3
stomatin (EPB72)-like 3
chr13_+_50589390 2.697 ENST00000360473.4
ENST00000312942.1
 KCNRG

potassium channel regulator

chr14_+_56585048 2.534 ENST00000267460.4
 PELI2
pellino E3 ubiquitin protein ligase family member 2
chr1_-_161337662 2.523 ENST00000367974.1
 C1orf192
chromosome 1 open reading frame 192
chr10_+_51549498 2.477 ENST00000358559.2
ENST00000298239.6
 MSMB

microseminoprotein, beta-

chr4_+_165675269 2.254 ENST00000507311.1
 RP11-294O2.2
RP11-294O2.2
chr5_-_42811986 2.017 ENST00000511224.1
ENST00000507920.1
ENST00000510965.1
 SEPP1


selenoprotein P, plasma, 1


chr1_+_227127981 1.941 ENST00000366778.1
ENST00000366777.3
ENST00000458507.2
 ADCK3


aarF domain containing kinase 3


chr1_+_12806141 1.906 ENST00000288048.5
 C1orf158
chromosome 1 open reading frame 158
chr1_+_104159999 1.804 ENST00000414303.2
ENST00000423678.1
 AMY2A

amylase, alpha 2A (pancreatic)

chr1_+_20512568 1.743 ENST00000375099.3
 UBXN10
UBX domain protein 10
chr17_-_6735035 1.732 ENST00000338694.2
 TEKT1
tektin 1
chr17_-_6735012 1.724 ENST00000535086.1
 TEKT1
tektin 1
chr3_+_69928256 1.710 ENST00000394355.2
 MITF
microphthalmia-associated transcription factor
chr6_+_135502408 1.691 ENST00000341911.5
ENST00000442647.2
ENST00000316528.8
 MYB


v-myb avian myeloblastosis viral oncogene homolog



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 227 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.9 GO:1900047 negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
1.4 4.2 GO:1904899 regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
0.0 4.1 GO:0001895 retina homeostasis(GO:0001895)
0.2 3.5 GO:0060294 cilium movement involved in cell motility(GO:0060294)
0.0 3.3 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 3.2 GO:0030318 melanocyte differentiation(GO:0030318)
0.2 3.0 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260)
0.1 2.9 GO:0090383 phagosome acidification(GO:0090383)
0.9 2.8 GO:0010430 fatty acid omega-oxidation(GO:0010430)
0.1 2.8 GO:0003334 keratinocyte development(GO:0003334)
0.1 2.8 GO:1904886 beta-catenin destruction complex disassembly(GO:1904886)
0.0 2.4 GO:0048678 response to axon injury(GO:0048678)
0.1 2.1 GO:0090360 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.4 2.0 GO:0045074 interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.3 2.0 GO:0001712 ectodermal cell fate commitment(GO:0001712)
0.1 2.0 GO:0016576 histone dephosphorylation(GO:0016576)
0.1 1.9 GO:0070986 left/right axis specification(GO:0070986)
0.3 1.8 GO:0044245 polysaccharide digestion(GO:0044245)
0.1 1.8 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 1.8 GO:0015721 bile acid and bile salt transport(GO:0015721)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 84 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.3 GO:0036126 sperm flagellum(GO:0036126)
0.0 4.3 GO:0016363 nuclear matrix(GO:0016363)
0.0 4.0 GO:0032993 protein-DNA complex(GO:0032993)
0.2 3.1 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.1 2.5 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.1 2.2 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 2.2 GO:0005796 Golgi lumen(GO:0005796)
0.0 1.7 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0 1.7 GO:0097014 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.0 1.7 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.1 1.6 GO:0042599 lamellar body(GO:0042599)
0.2 1.5 GO:0044294 dendritic growth cone(GO:0044294)
0.0 1.5 GO:0031526 brush border membrane(GO:0031526)
0.0 1.5 GO:0035577 azurophil granule membrane(GO:0035577)
0.0 1.3 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 1.1 GO:0036157 outer dynein arm(GO:0036157)
0.0 1.1 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 1.1 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 1.0 GO:0031304 intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
0.0 1.0 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 151 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 4.8 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 4.7 GO:0005178 integrin binding(GO:0005178)
0.1 4.6 GO:0070888 E-box binding(GO:0070888)
0.3 4.2 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.1 2.9 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 2.8 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.6 2.4 GO:0004031 aldehyde oxidase activity(GO:0004031)
0.0 2.4 GO:0030165 PDZ domain binding(GO:0030165)
0.0 2.2 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 2.0 GO:0008013 beta-catenin binding(GO:0008013)
0.5 1.8 GO:0016160 amylase activity(GO:0016160)
0.0 1.7 GO:0050681 androgen receptor binding(GO:0050681)
0.0 1.7 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.4 1.6 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.1 1.6 GO:0070700 BMP receptor binding(GO:0070700)
0.1 1.6 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.3 1.5 GO:0005119 smoothened binding(GO:0005119)
0.1 1.5 GO:0035198 miRNA binding(GO:0035198)
0.0 1.4 GO:0070410 co-SMAD binding(GO:0070410)
0.0 1.4 GO:0002039 p53 binding(GO:0002039)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.6 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 3.9 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.1 1.8 PID_ALK2_PATHWAY ALK2 signaling events
0.0 1.8 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 1.8 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 1.7 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.6 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 1.4 PID_MYC_PATHWAY C-MYC pathway
0.0 1.4 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 1.3 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 1.2 PID_PI3KCI_AKT_PATHWAY Class I PI3K signaling events mediated by Akt
0.0 1.2 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.0 1.0 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 1.0 PID_E2F_PATHWAY E2F transcription factor network
0.0 0.8 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.7 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 0.7 PID_CONE_PATHWAY Visual signal transduction: Cones
0.0 0.6 PID_VEGFR1_PATHWAY VEGFR1 specific signals
0.0 0.6 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 0.6 PID_ARF6_PATHWAY Arf6 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.8 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.3 3.0 REACTOME_DIGESTION_OF_DIETARY_CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.1 3.0 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.1 2.9 REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.2 2.8 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.1 2.5 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 1.9 REACTOME_CYCLIN_E_ASSOCIATED_EVENTS_DURING_G1_S_TRANSITION_ Genes involved in Cyclin E associated events during G1/S transition
0.1 1.6 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.1 1.5 REACTOME_INITIAL_TRIGGERING_OF_COMPLEMENT Genes involved in Initial triggering of complement
0.1 1.4 REACTOME_RECYCLING_OF_BILE_ACIDS_AND_SALTS Genes involved in Recycling of bile acids and salts
0.0 1.4 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 1.3 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 1.2 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.1 1.1 REACTOME_IRAK1_RECRUITS_IKK_COMPLEX Genes involved in IRAK1 recruits IKK complex
0.0 1.0 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.9 REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 0.9 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.8 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.8 REACTOME_PURINE_SALVAGE Genes involved in Purine salvage
0.0 0.8 REACTOME_ENERGY_DEPENDENT_REGULATION_OF_MTOR_BY_LKB1_AMPK Genes involved in Energy dependent regulation of mTOR by LKB1-AMPK