Motif ID: FOXO4

Z-value: 0.825


Transcription factors associated with FOXO4:

Gene SymbolEntrez IDGene Name
FOXO4 ENSG00000184481.12 FOXO4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
FOXO4hg19_v2_chrX_+_70316005_70316047-0.511.2e-02Click!


Activity profile for motif FOXO4.

activity profile for motif FOXO4


Sorted Z-values histogram for motif FOXO4

Sorted Z-values for motif FOXO4



Network of associatons between targets according to the STRING database.



First level regulatory network of FOXO4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_27109392 3.177 ENST00000406359.4
 TEK
TEK tyrosine kinase, endothelial
chr13_-_39564993 2.056 ENST00000423210.1
 STOML3
stomatin (EPB72)-like 3
chr20_-_21494654 1.774 ENST00000377142.4
 NKX2-2
NK2 homeobox 2
chr2_+_42104692 1.177 ENST00000398796.2
ENST00000442214.1
 AC104654.1

AC104654.1

chr5_-_110062384 1.174 ENST00000429839.2
 TMEM232
transmembrane protein 232
chr5_-_110062349 1.153 ENST00000511883.2
ENST00000455884.2
 TMEM232

transmembrane protein 232

chr12_-_68696652 1.116 ENST00000539972.1
 MDM1
Mdm1 nuclear protein homolog (mouse)
chr12_-_111358372 1.106 ENST00000548438.1
ENST00000228841.8
 MYL2

myosin, light chain 2, regulatory, cardiac, slow

chr6_-_152489484 1.101 ENST00000354674.4
ENST00000539504.1
 SYNE1

spectrin repeat containing, nuclear envelope 1

chr17_+_17876127 1.023 ENST00000582416.1
ENST00000313838.8
ENST00000411504.2
ENST00000581264.1
ENST00000399187.1
ENST00000479684.2
ENST00000584166.1
ENST00000585108.1
ENST00000399182.1
ENST00000579977.1
 LRRC48









leucine rich repeat containing 48









chr22_+_45809560 1.021 ENST00000342894.3
ENST00000538017.1
 RIBC2

RIB43A domain with coiled-coils 2

chr2_+_58655461 0.943 ENST00000429095.1
ENST00000429664.1
ENST00000452840.1
 AC007092.1


long intergenic non-protein coding RNA 1122


chr13_+_24144509 0.907 ENST00000248484.4
 TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr1_+_63989004 0.902 ENST00000371088.4
 EFCAB7
EF-hand calcium binding domain 7
chr8_-_72459885 0.889 ENST00000523987.1
 RP11-1102P16.1
Uncharacterized protein
chr11_-_114466471 0.876 ENST00000424261.2
 NXPE4
neurexophilin and PC-esterase domain family, member 4
chr6_-_31651817 0.836 ENST00000375863.3
ENST00000375860.2
 LY6G5C

lymphocyte antigen 6 complex, locus G5C

chr8_-_133772794 0.801 ENST00000519187.1
ENST00000523829.1
ENST00000356838.3
ENST00000377901.4
ENST00000519304.1
 TMEM71




transmembrane protein 71




chr4_-_70518941 0.758 ENST00000286604.4
ENST00000505512.1
ENST00000514019.1
 UGT2A1

UGT2A1
UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus

UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus
chr7_-_25702669 0.758 ENST00000446840.1
 AC003090.1
AC003090.1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 76 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 3.3 GO:0048014 Tie signaling pathway(GO:0048014)
0.6 1.8 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.1 1.2 GO:0043985 histone H4-R3 methylation(GO:0043985)
0.1 1.1 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.1 1.1 GO:0090292 nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.1 1.1 GO:0046600 negative regulation of centriole replication(GO:0046600)
0.0 1.1 GO:0034389 lipid particle organization(GO:0034389)
0.0 0.9 GO:0032740 positive regulation of interleukin-17 production(GO:0032740)
0.2 0.8 GO:0072658 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 0.8 GO:0052695 cellular glucuronidation(GO:0052695)
0.0 0.8 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.1 0.7 GO:0032625 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.1 0.7 GO:0016584 nucleosome positioning(GO:0016584)
0.0 0.7 GO:0098828 positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828)
0.0 0.6 GO:0016486 peptide hormone processing(GO:0016486)
0.1 0.5 GO:2000729 positive regulation of mesenchymal cell proliferation involved in ureter development(GO:2000729)
0.1 0.5 GO:0086097 phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097)
0.1 0.5 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.1 0.5 GO:0006447 regulation of translational initiation by iron(GO:0006447)
0.0 0.5 GO:0021520 spinal cord motor neuron cell fate specification(GO:0021520)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.7 GO:0009925 basal plasma membrane(GO:0009925)
0.1 1.1 GO:0097512 cardiac myofibril(GO:0097512)
0.1 1.1 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.2 0.7 GO:0031213 RSF complex(GO:0031213)
0.0 0.7 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.7 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.7 GO:0030286 dynein complex(GO:0030286)
0.1 0.5 GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.0 0.4 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0 0.4 GO:0043220 Schmidt-Lanterman incisure(GO:0043220)
0.0 0.4 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.4 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 0.3 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.2 GO:0001652 granular component(GO:0001652)
0.0 0.2 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.0 0.2 GO:0042272 nuclear RNA export factor complex(GO:0042272)
0.0 0.2 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.0 0.2 GO:1990130 Iml1 complex(GO:1990130)
0.0 0.2 GO:0072588 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588)
0.0 0.2 GO:0043020 NADPH oxidase complex(GO:0043020)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.1 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.0 1.7 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 1.3 GO:0005521 lamin binding(GO:0005521)
0.0 1.0 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.8 GO:0032036 myosin heavy chain binding(GO:0032036)
0.0 0.8 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 0.8 GO:0030507 spectrin binding(GO:0030507)
0.0 0.6 GO:0019956 chemokine binding(GO:0019956)
0.2 0.5 GO:0001596 angiotensin type I receptor activity(GO:0001596)
0.1 0.5 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.1 0.5 GO:0004111 creatine kinase activity(GO:0004111)
0.0 0.5 GO:0097100 supercoiled DNA binding(GO:0097100)
0.0 0.5 GO:0051879 Hsp90 protein binding(GO:0051879)
0.1 0.4 GO:0004914 interleukin-5 receptor activity(GO:0004914)
0.1 0.4 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.0 0.4 GO:0005549 odorant binding(GO:0005549)
0.0 0.4 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.4 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.4 GO:0001223 transcription coactivator binding(GO:0001223)
0.1 0.3 GO:0033858 N-acetylgalactosamine kinase activity(GO:0033858)

Gene overrepresentation in C2:CP category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.4 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 1.0 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.0 0.8 PID_ATM_PATHWAY ATM pathway
0.0 0.4 ST_IL_13_PATHWAY Interleukin 13 (IL-13) Pathway
0.0 0.4 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 0.3 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.2 PID_ALK2_PATHWAY ALK2 signaling events
0.0 0.1 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.0 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 1.2 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 1.1 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.8 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.8 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.7 REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.0 0.7 REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 0.7 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.0 0.7 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 0.6 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.0 0.5 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 0.5 REACTOME_INITIAL_TRIGGERING_OF_COMPLEMENT Genes involved in Initial triggering of complement
0.0 0.5 REACTOME_IL_RECEPTOR_SHC_SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 0.5 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.5 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 0.4 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 0.4 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.0 0.4 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.3 REACTOME_COMMON_PATHWAY Genes involved in Common Pathway
0.0 0.3 REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING Genes involved in Role of second messengers in netrin-1 signaling