Motif ID: GATA1_GATA4
Z-value: 0.916
Transcription factors associated with GATA1_GATA4:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| GATA1 | ENSG00000102145.9 | GATA1 |
| GATA4 | ENSG00000136574.13 | GATA4 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GATA1 | hg19_v2_chrX_+_48644962_48644983 | 0.57 | 3.5e-03 | Click! |
| GATA4 | hg19_v2_chr8_+_11534462_11534475 | 0.48 | 1.6e-02 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 255 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.0 | GO:0070268 | cornification(GO:0070268) |
| 0.2 | 5.1 | GO:0009235 | cobalamin metabolic process(GO:0009235) |
| 0.6 | 4.5 | GO:0002784 | regulation of antimicrobial peptide production(GO:0002784) regulation of antibacterial peptide production(GO:0002786) |
| 0.6 | 3.5 | GO:0038172 | interleukin-33-mediated signaling pathway(GO:0038172) |
| 0.0 | 3.5 | GO:0050829 | defense response to Gram-negative bacterium(GO:0050829) |
| 0.1 | 3.0 | GO:0071481 | cellular response to X-ray(GO:0071481) |
| 0.3 | 2.9 | GO:0070574 | cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574) |
| 0.0 | 2.8 | GO:0007173 | epidermal growth factor receptor signaling pathway(GO:0007173) |
| 0.0 | 2.6 | GO:0003254 | regulation of membrane depolarization(GO:0003254) |
| 0.1 | 2.5 | GO:0006607 | NLS-bearing protein import into nucleus(GO:0006607) |
| 0.0 | 2.1 | GO:0050690 | regulation of defense response to virus by virus(GO:0050690) |
| 0.2 | 2.0 | GO:1903944 | regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944) |
| 0.2 | 1.7 | GO:0051597 | response to methylmercury(GO:0051597) |
| 0.5 | 1.6 | GO:0046521 | sphingoid catabolic process(GO:0046521) |
| 0.3 | 1.5 | GO:0071477 | hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477) |
| 0.1 | 1.5 | GO:0044241 | lipid digestion(GO:0044241) |
| 0.0 | 1.5 | GO:0046627 | negative regulation of insulin receptor signaling pathway(GO:0046627) negative regulation of cellular response to insulin stimulus(GO:1900077) |
| 0.2 | 1.4 | GO:0051012 | microtubule sliding(GO:0051012) |
| 0.0 | 1.4 | GO:0033046 | negative regulation of sister chromatid segregation(GO:0033046) negative regulation of mitotic sister chromatid segregation(GO:0033048) negative regulation of mitotic sister chromatid separation(GO:2000816) |
| 0.0 | 1.4 | GO:0001570 | vasculogenesis(GO:0001570) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 78 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.8 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.6 | 4.5 | GO:0097209 | epidermal lamellar body(GO:0097209) |
| 0.0 | 3.4 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.0 | 3.3 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.5 | 3.0 | GO:0097129 | cyclin D2-CDK4 complex(GO:0097129) |
| 0.0 | 2.6 | GO:0072686 | mitotic spindle(GO:0072686) |
| 0.0 | 2.5 | GO:0043197 | dendritic spine(GO:0043197) |
| 0.1 | 2.0 | GO:0031265 | CD95 death-inducing signaling complex(GO:0031265) ripoptosome(GO:0097342) |
| 0.0 | 1.7 | GO:0005604 | basement membrane(GO:0005604) |
| 0.0 | 1.7 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.1 | 1.4 | GO:0042105 | alpha-beta T cell receptor complex(GO:0042105) |
| 0.1 | 1.2 | GO:0033093 | Weibel-Palade body(GO:0033093) |
| 0.0 | 1.2 | GO:0016235 | aggresome(GO:0016235) |
| 0.0 | 1.2 | GO:0070821 | tertiary granule membrane(GO:0070821) |
| 0.1 | 1.1 | GO:0031362 | anchored component of external side of plasma membrane(GO:0031362) |
| 0.0 | 1.1 | GO:0031229 | integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) |
| 0.2 | 1.0 | GO:0048237 | rough endoplasmic reticulum lumen(GO:0048237) |
| 0.0 | 1.0 | GO:0097431 | mitotic spindle pole(GO:0097431) |
| 0.0 | 1.0 | GO:0097228 | sperm principal piece(GO:0097228) |
| 0.1 | 0.9 | GO:0031314 | extrinsic component of mitochondrial inner membrane(GO:0031314) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 165 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 14.1 | GO:0005198 | structural molecule activity(GO:0005198) |
| 0.0 | 11.9 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 1.2 | 3.5 | GO:0002113 | interleukin-33 binding(GO:0002113) |
| 0.6 | 3.4 | GO:0042015 | interleukin-20 binding(GO:0042015) |
| 0.2 | 2.9 | GO:0036312 | phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312) |
| 0.0 | 2.9 | GO:1990782 | protein tyrosine kinase binding(GO:1990782) |
| 0.0 | 2.9 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.1 | 2.6 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.1 | 2.1 | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.1 | 2.0 | GO:0097200 | death receptor binding(GO:0005123) cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200) |
| 0.0 | 1.8 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.0 | 1.8 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.3 | 1.6 | GO:0017050 | sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050) |
| 0.0 | 1.6 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.0 | 1.6 | GO:0004869 | cysteine-type endopeptidase inhibitor activity(GO:0004869) |
| 0.1 | 1.5 | GO:0015379 | potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820) |
| 0.0 | 1.5 | GO:0005504 | fatty acid binding(GO:0005504) |
| 0.0 | 1.5 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 1.4 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
| 0.2 | 1.3 | GO:0030197 | extracellular matrix constituent, lubricant activity(GO:0030197) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 40 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.2 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 5.0 | NABA_SECRETED_FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 4.9 | PID_TCR_PATHWAY | TCR signaling in naïve CD4+ T cells |
| 0.1 | 3.1 | PID_IL2_STAT5_PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.0 | 3.1 | PID_HIF1_TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.1 | 2.0 | SA_FAS_SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.0 | 1.9 | PID_INSULIN_PATHWAY | Insulin Pathway |
| 0.0 | 1.9 | PID_INTEGRIN2_PATHWAY | Beta2 integrin cell surface interactions |
| 0.1 | 1.6 | PID_S1P_META_PATHWAY | Sphingosine 1-phosphate (S1P) pathway |
| 0.0 | 1.6 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 1.5 | PID_MYC_ACTIV_PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 1.4 | PID_FCER1_PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 0.0 | 1.3 | PID_FAK_PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.0 | 1.2 | PID_CDC42_REG_PATHWAY | Regulation of CDC42 activity |
| 0.0 | 1.2 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 1.2 | PID_PLK1_PATHWAY | PLK1 signaling events |
| 0.0 | 1.0 | PID_ALK1_PATHWAY | ALK1 signaling events |
| 0.0 | 1.0 | PID_HES_HEY_PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 1.0 | PID_P75_NTR_PATHWAY | p75(NTR)-mediated signaling |
| 0.0 | 0.9 | PID_INTEGRIN_A9B1_PATHWAY | Alpha9 beta1 integrin signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 41 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.1 | REACTOME_G1_PHASE | Genes involved in G1 Phase |
| 0.1 | 3.0 | REACTOME_THE_ROLE_OF_NEF_IN_HIV1_REPLICATION_AND_DISEASE_PATHOGENESIS | Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis |
| 0.0 | 3.0 | REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.1 | 2.9 | REACTOME_ZINC_TRANSPORTERS | Genes involved in Zinc transporters |
| 0.1 | 2.5 | REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.0 | 2.1 | REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS | Genes involved in G alpha (q) signalling events |
| 0.1 | 2.0 | REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.0 | 2.0 | REACTOME_LIPID_DIGESTION_MOBILIZATION_AND_TRANSPORT | Genes involved in Lipid digestion, mobilization, and transport |
| 0.0 | 1.8 | REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 | Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 |
| 0.0 | 1.7 | REACTOME_GLUCOSE_TRANSPORT | Genes involved in Glucose transport |
| 0.0 | 1.6 | REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.0 | 1.6 | REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK | Genes involved in NRAGE signals death through JNK |
| 0.0 | 1.5 | REACTOME_CHOLESTEROL_BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.0 | 1.5 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 1.3 | REACTOME_TIE2_SIGNALING | Genes involved in Tie2 Signaling |
| 0.0 | 1.3 | REACTOME_GLYCOLYSIS | Genes involved in Glycolysis |
| 0.0 | 1.0 | REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |
| 0.0 | 0.8 | REACTOME_SIGNAL_ATTENUATION | Genes involved in Signal attenuation |
| 0.1 | 0.7 | REACTOME_METAL_ION_SLC_TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 0.0 | 0.7 | REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE | Genes involved in Dopamine Neurotransmitter Release Cycle |
|
|
|