Motif ID: GATA2

Z-value: 0.803


Transcription factors associated with GATA2:

Gene SymbolEntrez IDGene Name
GATA2 ENSG00000179348.7 GATA2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
GATA2hg19_v2_chr3_-_128212016_1282120510.414.8e-02Click!


Activity profile for motif GATA2.

activity profile for motif GATA2


Sorted Z-values histogram for motif GATA2

Sorted Z-values for motif GATA2



Network of associatons between targets according to the STRING database.



First level regulatory network of GATA2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_-_51466681 2.206 ENST00000456750.2
 KLK6
kallikrein-related peptidase 6
chr19_-_51456321 2.115 ENST00000391809.2
 KLK5
kallikrein-related peptidase 5
chr19_-_51456344 1.970 ENST00000336334.3
ENST00000593428.1
 KLK5

kallikrein-related peptidase 5

chr1_+_150480576 1.457 ENST00000346569.6
 ECM1
extracellular matrix protein 1
chr10_+_118187379 1.381 ENST00000369230.3
 PNLIPRP3
pancreatic lipase-related protein 3
chr11_-_125366089 1.343 ENST00000366139.3
ENST00000278919.3
 FEZ1

fasciculation and elongation protein zeta 1 (zygin I)

chr18_-_29340827 1.304 ENST00000269205.5
 SLC25A52
solute carrier family 25, member 52
chr19_-_51487071 1.228 ENST00000391807.1
ENST00000593904.1
 KLK7

kallikrein-related peptidase 7

chr2_-_235405168 1.172 ENST00000339728.3
 ARL4C
ADP-ribosylation factor-like 4C
chr18_-_31628558 1.128 ENST00000535384.1
 NOL4
nucleolar protein 4
chr1_+_120839412 1.124 ENST00000355228.4
 FAM72B
family with sequence similarity 72, member B
chr12_-_8815215 1.122 ENST00000544889.1
ENST00000543369.1
 MFAP5

microfibrillar associated protein 5

chr4_+_75310851 0.951 ENST00000395748.3
ENST00000264487.2
 AREG

amphiregulin

chr12_-_8815299 0.940 ENST00000535336.1
 MFAP5
microfibrillar associated protein 5
chr1_-_153066998 0.914 ENST00000368750.3
 SPRR2E
small proline-rich protein 2E
chr11_+_35201826 0.896 ENST00000531873.1
 CD44
CD44 molecule (Indian blood group)
chr2_+_113885138 0.879 ENST00000409930.3
 IL1RN
interleukin 1 receptor antagonist
chr1_+_84630053 0.874 ENST00000394838.2
ENST00000370682.3
ENST00000432111.1
 PRKACB


protein kinase, cAMP-dependent, catalytic, beta


chr12_-_10978957 0.871 ENST00000240619.2
 TAS2R10
taste receptor, type 2, member 10
chr1_+_74701062 0.868 ENST00000326637.3
 TNNI3K
TNNI3 interacting kinase

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 280 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 5.3 GO:0002803 positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803)
0.0 4.5 GO:0070268 cornification(GO:0070268)
0.1 2.3 GO:0016540 protein autoprocessing(GO:0016540)
0.2 2.1 GO:1903944 regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.0 2.1 GO:0060216 definitive hemopoiesis(GO:0060216)
0.2 1.7 GO:0034465 response to carbon monoxide(GO:0034465)
0.1 1.6 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.1 1.5 GO:0030502 negative regulation of bone mineralization(GO:0030502)
0.2 1.4 GO:0097338 response to clozapine(GO:0097338)
0.1 1.3 GO:1902902 negative regulation of autophagosome assembly(GO:1902902)
0.1 1.3 GO:0070141 response to UV-A(GO:0070141)
0.0 1.3 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 1.3 GO:0032456 endocytic recycling(GO:0032456)
0.1 1.1 GO:0038060 nitric oxide-cGMP-mediated signaling pathway(GO:0038060)
0.0 1.1 GO:0061718 NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.1 1.0 GO:0060744 thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744)
0.1 1.0 GO:0019368 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 1.0 GO:0007340 acrosome reaction(GO:0007340)
0.1 0.9 GO:0051012 microtubule sliding(GO:0051012)
0.1 0.9 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 113 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 5.7 GO:0097209 epidermal lamellar body(GO:0097209)
0.1 3.5 GO:0001533 cornified envelope(GO:0001533)
0.0 2.3 GO:0031430 M band(GO:0031430)
0.1 2.1 GO:0031265 CD95 death-inducing signaling complex(GO:0031265) ripoptosome(GO:0097342)
0.1 2.1 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.1 1.8 GO:0031089 platelet dense granule lumen(GO:0031089)
0.0 1.7 GO:0030175 filopodium(GO:0030175)
0.1 1.5 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 1.5 GO:0002102 podosome(GO:0002102)
0.1 1.2 GO:0044327 dendritic spine head(GO:0044327)
0.0 1.2 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.2 1.1 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 1.1 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 1.1 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 1.1 GO:0005901 caveola(GO:0005901)
0.0 1.0 GO:0035577 azurophil granule membrane(GO:0035577)
0.1 0.9 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.1 0.9 GO:0030478 actin cap(GO:0030478)
0.0 0.9 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 0.9 GO:0048786 presynaptic active zone(GO:0048786)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 195 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 9.4 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 3.1 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 2.5 GO:0005123 death receptor binding(GO:0005123)
0.1 2.2 GO:0030280 structural constituent of epidermis(GO:0030280)
0.2 1.7 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.2 1.7 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.0 1.6 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 1.4 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.1 1.3 GO:0004806 triglyceride lipase activity(GO:0004806)
0.1 1.3 GO:0005523 tropomyosin binding(GO:0005523)
0.2 1.1 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 1.1 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 1.1 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.0 1.1 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 1.1 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.1 1.0 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.3 0.9 GO:0005150 interleukin-1, Type I receptor binding(GO:0005150)
0.1 0.9 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.1 0.9 GO:0031013 troponin I binding(GO:0031013)
0.1 0.9 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.7 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.1 2.1 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 2.1 PID_NOTCH_PATHWAY Notch signaling pathway
0.0 1.4 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 1.4 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 1.4 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 1.3 PID_IL3_PATHWAY IL3-mediated signaling events
0.0 1.3 PID_IL1_PATHWAY IL1-mediated signaling events
0.0 1.3 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 1.2 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 1.1 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 1.0 NABA_COLLAGENS Genes encoding collagen proteins
0.0 0.9 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.9 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.7 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.0 0.7 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 0.7 PID_TNF_PATHWAY TNF receptor signaling pathway
0.0 0.6 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.6 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.6 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.5 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.0 2.2 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 2.1 REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.1 1.8 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 1.6 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 1.6 REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.0 1.4 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.0 1.4 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 1.0 REACTOME_RECYCLING_PATHWAY_OF_L1 Genes involved in Recycling pathway of L1
0.0 1.0 REACTOME_AMYLOIDS Genes involved in Amyloids
0.0 0.9 REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTERGRINS_ Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0 0.9 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS Genes involved in G alpha (z) signalling events
0.0 0.9 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.8 REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.0 0.8 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.8 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.8 REACTOME_IL1_SIGNALING Genes involved in Interleukin-1 signaling
0.0 0.7 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.6 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE
0.0 0.6 REACTOME_REGULATION_OF_IFNA_SIGNALING Genes involved in Regulation of IFNA signaling