Motif ID: GATA5

Z-value: 0.519


Transcription factors associated with GATA5:

Gene SymbolEntrez IDGene Name
GATA5 ENSG00000130700.6 GATA5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
GATA5hg19_v2_chr20_-_61051026_61051057-0.472.0e-02Click!


Activity profile for motif GATA5.

activity profile for motif GATA5


Sorted Z-values histogram for motif GATA5

Sorted Z-values for motif GATA5



Network of associatons between targets according to the STRING database.



First level regulatory network of GATA5

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_110723134 2.090 ENST00000510800.1
ENST00000512148.1
 CFI

complement factor I

chr4_-_110723194 2.036 ENST00000394635.3
 CFI
complement factor I
chr4_-_110723335 1.906 ENST00000394634.2
 CFI
complement factor I
chr10_+_118187379 1.300 ENST00000369230.3
 PNLIPRP3
pancreatic lipase-related protein 3
chr4_+_72897521 1.288 ENST00000308744.6
ENST00000344413.5
 NPFFR2

neuropeptide FF receptor 2

chr17_+_1633755 0.992 ENST00000545662.1
 WDR81
WD repeat domain 81
chr6_-_32557610 0.887 ENST00000360004.5
 HLA-DRB1
major histocompatibility complex, class II, DR beta 1
chr1_+_79115503 0.877 ENST00000370747.4
ENST00000438486.1
ENST00000545124.1
 IFI44


interferon-induced protein 44


chr8_+_40010989 0.692 ENST00000315792.3
 C8orf4
chromosome 8 open reading frame 4
chr1_+_104159999 0.609 ENST00000414303.2
ENST00000423678.1
 AMY2A

amylase, alpha 2A (pancreatic)

chr5_+_140227048 0.606 ENST00000532602.1
 PCDHA9
protocadherin alpha 9
chr6_+_31916733 0.557 ENST00000483004.1
 CFB
complement factor B
chr5_+_140261703 0.477 ENST00000409494.1
ENST00000289272.2
 PCDHA13

protocadherin alpha 13

chr10_+_7745232 0.443 ENST00000358415.4
 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr6_+_42018614 0.442 ENST00000465926.1
ENST00000482432.1
 TAF8

TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa

chr1_-_108743471 0.436 ENST00000569674.1
 SLC25A24
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24
chr10_+_7745303 0.398 ENST00000429820.1
ENST00000379587.4
 ITIH2

inter-alpha-trypsin inhibitor heavy chain 2

chr19_-_52133588 0.380 ENST00000570106.2
 SIGLEC5
sialic acid binding Ig-like lectin 5
chr6_-_32908765 0.376 ENST00000416244.2
 HLA-DMB
major histocompatibility complex, class II, DM beta
chr1_+_86934526 0.356 ENST00000394711.1
 CLCA1
chloride channel accessory 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.7 GO:0030449 regulation of complement activation(GO:0030449)
0.3 1.3 GO:0002399 MHC class II protein complex assembly(GO:0002399)
0.0 1.3 GO:2000479 regulation of cAMP-dependent protein kinase activity(GO:2000479)
0.0 0.8 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.1 0.7 GO:1900020 regulation of protein kinase C activity(GO:1900019) positive regulation of protein kinase C activity(GO:1900020)
0.1 0.6 GO:0044245 polysaccharide digestion(GO:0044245)
0.0 0.4 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.0 0.4 GO:0015866 ADP transport(GO:0015866)
0.1 0.3 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
0.1 0.3 GO:0090370 negative regulation of cholesterol efflux(GO:0090370)
0.0 0.3 GO:2000622 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.0 0.3 GO:0007000 nucleolus organization(GO:0007000)
0.0 0.3 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.0 0.3 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.0 0.3 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.0 0.3 GO:0006751 glutathione catabolic process(GO:0006751)
0.0 0.3 GO:0042789 mRNA transcription from RNA polymerase II promoter(GO:0042789)
0.1 0.2 GO:0030186 melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.1 0.2 GO:0060721 spongiotrophoblast cell proliferation(GO:0060720) regulation of spongiotrophoblast cell proliferation(GO:0060721) cell proliferation involved in embryonic placenta development(GO:0060722) regulation of cell proliferation involved in embryonic placenta development(GO:0060723)
0.0 0.2 GO:0006957 complement activation, alternative pathway(GO:0006957)

Gene overrepresentation in cellular_component category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.5 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 0.4 GO:0042589 zymogen granule membrane(GO:0042589)
0.0 0.3 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.0 0.2 GO:0070288 intracellular ferritin complex(GO:0008043) ferritin complex(GO:0070288)
0.0 0.1 GO:0005960 glycine cleavage complex(GO:0005960)
0.0 0.1 GO:0043564 Ku70:Ku80 complex(GO:0043564)
0.0 0.1 GO:0005579 membrane attack complex(GO:0005579)
0.0 0.0 GO:0032437 cuticular plate(GO:0032437)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.0 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 1.3 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 1.3 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.1 1.2 GO:0031628 opioid receptor binding(GO:0031628)
0.0 0.7 GO:0005112 Notch binding(GO:0005112)
0.0 0.7 GO:0001848 complement binding(GO:0001848)
0.2 0.6 GO:0016160 amylase activity(GO:0016160)
0.0 0.4 GO:0015217 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.0 0.4 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.1 0.3 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.1 0.3 GO:0046538 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.0 0.3 GO:0035368 selenocysteine insertion sequence binding(GO:0035368)
0.0 0.3 GO:0001042 RNA polymerase I core binding(GO:0001042)
0.0 0.3 GO:0032395 MHC class II receptor activity(GO:0032395)
0.0 0.3 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.0 0.3 GO:0034185 apolipoprotein binding(GO:0034185)
0.0 0.2 GO:0000702 oxidized base lesion DNA N-glycosylase activity(GO:0000702)
0.0 0.2 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.0 0.2 GO:0004359 glutaminase activity(GO:0004359)
0.0 0.2 GO:0008172 S-methyltransferase activity(GO:0008172)

Gene overrepresentation in C2:CP category:

Showing 1 to 2 of 2 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.9 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 0.6 ST_G_ALPHA_S_PATHWAY G alpha s Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 4 of 4 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.7 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.0 1.1 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1 0.6 REACTOME_DIGESTION_OF_DIETARY_CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.0 0.3 REACTOME_CALNEXIN_CALRETICULIN_CYCLE Genes involved in Calnexin/calreticulin cycle