Motif ID: GATA6

Z-value: 0.477


Transcription factors associated with GATA6:

Gene SymbolEntrez IDGene Name
GATA6 ENSG00000141448.4 GATA6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
GATA6hg19_v2_chr18_+_19749386_197494040.529.8e-03Click!


Activity profile for motif GATA6.

activity profile for motif GATA6


Sorted Z-values histogram for motif GATA6

Sorted Z-values for motif GATA6



Network of associatons between targets according to the STRING database.



First level regulatory network of GATA6

PNG image of the network

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Top targets:


Showing 1 to 20 of 107 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_102928009 6.227 ENST00000404917.2
ENST00000447231.1
 IL1RL1

interleukin 1 receptor-like 1

chr9_+_33795533 1.095 ENST00000379405.3
 PRSS3
protease, serine, 3
chr17_+_74381343 0.924 ENST00000392496.3
 SPHK1
sphingosine kinase 1
chr20_-_54967187 0.876 ENST00000422322.1
ENST00000371356.2
ENST00000451915.1
ENST00000347343.2
ENST00000395911.1
ENST00000395907.1
ENST00000441357.1
ENST00000456249.1
ENST00000420474.1
ENST00000395909.4
ENST00000395914.1
ENST00000312783.6
ENST00000395915.3
ENST00000395913.3
 AURKA













aurora kinase A













chr6_+_12290586 0.730 ENST00000379375.5
 EDN1
endothelin 1
chrX_+_37865804 0.724 ENST00000297875.2
ENST00000357972.5
 SYTL5

synaptotagmin-like 5

chr18_+_19749386 0.589 ENST00000269216.3
 GATA6
GATA binding protein 6
chr7_+_142457315 0.578 ENST00000486171.1
ENST00000311737.7
 PRSS1

protease, serine, 1 (trypsin 1)

chr1_-_94050668 0.567 ENST00000539242.1
 BCAR3
breast cancer anti-estrogen resistance 3
chr12_+_4430371 0.520 ENST00000179259.4
 C12orf5
chromosome 12 open reading frame 5
chr7_+_155090271 0.516 ENST00000476756.1
 INSIG1
insulin induced gene 1
chr5_+_131409476 0.507 ENST00000296871.2
 CSF2
colony stimulating factor 2 (granulocyte-macrophage)
chr4_-_103266355 0.472 ENST00000424970.2
 SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr1_-_24469602 0.466 ENST00000270800.1
 IL22RA1
interleukin 22 receptor, alpha 1
chr5_+_159848807 0.449 ENST00000352433.5
 PTTG1
pituitary tumor-transforming 1
chr6_-_86099898 0.447 ENST00000455071.1
 RP11-30P6.6
RP11-30P6.6
chr2_-_69098566 0.441 ENST00000295379.1
 BMP10
bone morphogenetic protein 10
chrX_+_107288197 0.387 ENST00000415430.3
 VSIG1
V-set and immunoglobulin domain containing 1
chr2_-_44065889 0.386 ENST00000543989.1
ENST00000405322.1
 ABCG5

ATP-binding cassette, sub-family G (WHITE), member 5

chrX_+_107288239 0.385 ENST00000217957.5
 VSIG1
V-set and immunoglobulin domain containing 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 6.3 GO:0038172 interleukin-33-mediated signaling pathway(GO:0038172)
0.1 1.8 GO:0009235 cobalamin metabolic process(GO:0009235)
0.3 0.9 GO:0046521 sphingoid catabolic process(GO:0046521)
0.3 0.9 GO:0007057 spindle assembly involved in female meiosis I(GO:0007057) positive regulation of oocyte maturation(GO:1900195)
0.2 0.7 GO:0060585 regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.2 0.7 GO:0010949 negative regulation of intestinal phytosterol absorption(GO:0010949) negative regulation of intestinal cholesterol absorption(GO:0045796) intestinal phytosterol absorption(GO:0060752) negative regulation of intestinal lipid absorption(GO:1904730)
0.1 0.7 GO:0070574 cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.0 0.7 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.0 0.7 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.2 0.6 GO:0032911 negative regulation of transforming growth factor beta1 production(GO:0032911)
0.0 0.6 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.2 0.5 GO:1901301 regulation of cargo loading into COPII-coated vesicle(GO:1901301)
0.1 0.5 GO:0032747 positive regulation of interleukin-23 production(GO:0032747) negative regulation of cytolysis(GO:0045918)
0.0 0.5 GO:0070207 protein homotrimerization(GO:0070207)
0.1 0.4 GO:0060298 positive regulation of sarcomere organization(GO:0060298)
0.0 0.3 GO:0051012 microtubule sliding(GO:0051012)
0.0 0.3 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.3 GO:0023041 neuronal signal transduction(GO:0023041)
0.0 0.3 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.0 0.2 GO:0001692 histamine metabolic process(GO:0001692)

Gene overrepresentation in cellular_component category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.5 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 1.1 GO:1904724 tertiary granule lumen(GO:1904724)
0.2 0.9 GO:0001674 female germ cell nucleus(GO:0001674)
0.2 0.7 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.1 0.7 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.1 0.5 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.0 0.5 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.0 0.3 GO:0032437 cuticular plate(GO:0032437)
0.0 0.3 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.3 GO:0031105 septin complex(GO:0031105)

Gene overrepresentation in molecular_function category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.1 6.3 GO:0002113 interleukin-33 binding(GO:0002113)
0.2 0.9 GO:0017050 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.1 0.9 GO:0035174 histone serine kinase activity(GO:0035174)
0.1 0.7 GO:0031708 endothelin B receptor binding(GO:0031708)
0.0 0.7 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.6 GO:0017127 cholesterol transporter activity(GO:0017127)
0.0 0.6 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.1 0.5 GO:0042015 interleukin-20 binding(GO:0042015)
0.0 0.4 GO:0031433 telethonin binding(GO:0031433)
0.1 0.3 GO:0038131 neuregulin receptor activity(GO:0038131)
0.0 0.2 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 0.1 GO:0004998 transferrin receptor activity(GO:0004998)
0.0 0.1 GO:0015265 urea channel activity(GO:0015265)
0.0 0.1 GO:0004340 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.0 0.1 GO:0030250 cyclase activator activity(GO:0010853) guanylate cyclase activator activity(GO:0030250)

Gene overrepresentation in C2:CP category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.9 PID_S1P_META_PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 0.9 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 0.7 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.0 0.6 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 0.5 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.3 REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.0 0.9 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.7 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.7 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.0 0.6 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.5 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 0.5 REACTOME_IL_RECEPTOR_SHC_SIGNALING Genes involved in Interleukin receptor SHC signaling