Motif ID: GCM1

Z-value: 0.619


Transcription factors associated with GCM1:

Gene SymbolEntrez IDGene Name
GCM1 ENSG00000137270.10 GCM1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
GCM1hg19_v2_chr6_-_53013620_53013644-0.321.3e-01Click!


Activity profile for motif GCM1.

activity profile for motif GCM1


Sorted Z-values histogram for motif GCM1

Sorted Z-values for motif GCM1



Network of associatons between targets according to the STRING database.



First level regulatory network of GCM1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_57547454 1.122 ENST00000556376.2
 HOPX
HOP homeobox
chr4_-_57547870 1.118 ENST00000381260.3
ENST00000420433.1
ENST00000554144.1
ENST00000557328.1
 HOPX



HOP homeobox



chr2_+_90108504 1.015 ENST00000390271.2
 IGKV6D-41
immunoglobulin kappa variable 6D-41 (non-functional)
chr2_+_90060377 0.841 ENST00000436451.2
 IGKV6D-21
immunoglobulin kappa variable 6D-21 (non-functional)
chr3_+_10206545 0.827 ENST00000256458.4
 IRAK2
interleukin-1 receptor-associated kinase 2
chr20_+_361261 0.805 ENST00000217233.3
 TRIB3
tribbles pseudokinase 3
chr2_-_89459813 0.799 ENST00000390256.2
 IGKV6-21
immunoglobulin kappa variable 6-21 (non-functional)
chr12_-_122238464 0.778 ENST00000546227.1
 RHOF
ras homolog family member F (in filopodia)
chr9_+_131182697 0.775 ENST00000372838.4
ENST00000411852.1
 CERCAM

cerebral endothelial cell adhesion molecule

chr20_-_1306351 0.762 ENST00000381812.1
 SDCBP2
syndecan binding protein (syntenin) 2
chr20_-_1306391 0.733 ENST00000339987.3
 SDCBP2
syndecan binding protein (syntenin) 2
chr11_+_13690249 0.712 ENST00000532701.1
 FAR1
fatty acyl CoA reductase 1
chr18_+_21529811 0.662 ENST00000588004.1
 LAMA3
laminin, alpha 3
chr17_-_7493390 0.648 ENST00000538513.2
ENST00000570788.1
ENST00000250055.2
 SOX15


SRY (sex determining region Y)-box 15


chr14_+_24540046 0.609 ENST00000397016.2
ENST00000537691.1
ENST00000560356.1
ENST00000558450.1
 CPNE6



copine VI (neuronal)



chr14_-_24732368 0.537 ENST00000544573.1
 TGM1
transglutaminase 1
chr9_+_17579084 0.527 ENST00000380607.4
 SH3GL2
SH3-domain GRB2-like 2
chr22_+_22936998 0.526 ENST00000390303.2
 IGLV3-32
immunoglobulin lambda variable 3-32 (non-functional)
chr22_-_20256054 0.501 ENST00000043402.7
 RTN4R
reticulon 4 receptor
chr11_+_111126707 0.493 ENST00000280325.4
 C11orf53
chromosome 11 open reading frame 53

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 57 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.5 GO:0002377 immunoglobulin production(GO:0002377)
0.1 2.5 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.1 1.5 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 1.2 GO:0023041 neuronal signal transduction(GO:0023041)
0.0 1.1 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.2 1.0 GO:1901503 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.0 0.8 GO:0045717 negative regulation of fatty acid biosynthetic process(GO:0045717)
0.0 0.8 GO:0034162 toll-like receptor 9 signaling pathway(GO:0034162)
0.1 0.7 GO:2000252 negative regulation of feeding behavior(GO:2000252)
0.2 0.6 GO:0048627 myoblast development(GO:0048627)
0.0 0.6 GO:0097084 vascular smooth muscle cell development(GO:0097084)
0.2 0.5 GO:0043163 cell envelope organization(GO:0043163) external encapsulating structure organization(GO:0045229)
0.1 0.5 GO:2000230 negative regulation of pancreatic stellate cell proliferation(GO:2000230)
0.1 0.5 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.1 0.3 GO:0046947 hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
0.1 0.3 GO:0045226 extracellular polysaccharide biosynthetic process(GO:0045226) extracellular polysaccharide metabolic process(GO:0046379)
0.1 0.3 GO:1902728 mineralocorticoid receptor signaling pathway(GO:0031959) positive regulation of skeletal muscle satellite cell proliferation(GO:1902724) positive regulation of growth factor dependent skeletal muscle satellite cell proliferation(GO:1902728)
0.1 0.3 GO:0045903 positive regulation of translational fidelity(GO:0045903)
0.0 0.3 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.0 0.3 GO:1900623 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)

Gene overrepresentation in cellular_component category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.6 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.2 1.5 GO:0005610 laminin-5 complex(GO:0005610)
0.1 1.2 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 1.0 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.1 0.4 GO:1903440 calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440)
0.0 0.3 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.0 0.3 GO:0035976 AP1 complex(GO:0035976)
0.0 0.3 GO:0033270 paranode region of axon(GO:0033270)
0.0 0.3 GO:0071565 nBAF complex(GO:0071565)
0.0 0.2 GO:0016012 sarcoglycan complex(GO:0016012)
0.0 0.2 GO:0097512 cardiac myofibril(GO:0097512)
0.0 0.1 GO:0000811 GINS complex(GO:0000811)
0.0 0.1 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 1.2 GO:0038131 neuregulin receptor activity(GO:0038131)
0.2 1.0 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.0 0.9 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 0.8 GO:0055106 ubiquitin-protein transferase regulator activity(GO:0055106)
0.1 0.5 GO:0050692 DBD domain binding(GO:0050692)
0.1 0.5 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 0.5 GO:0033130 acetylcholine receptor binding(GO:0033130)
0.1 0.4 GO:0097643 amylin receptor activity(GO:0097643)
0.0 0.4 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.1 0.3 GO:0033823 procollagen-lysine 5-dioxygenase activity(GO:0008475) procollagen glucosyltransferase activity(GO:0033823)
0.1 0.3 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.0 0.3 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.0 0.3 GO:1990932 5.8S rRNA binding(GO:1990932)
0.0 0.3 GO:0005143 interleukin-12 receptor binding(GO:0005143)
0.0 0.3 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.3 GO:0070403 NAD+ binding(GO:0070403)
0.1 0.2 GO:0005483 soluble NSF attachment protein activity(GO:0005483)
0.1 0.2 GO:0070644 vitamin D response element binding(GO:0070644)
0.1 0.2 GO:0004962 endothelin receptor activity(GO:0004962)
0.0 0.2 GO:0005220 inositol hexakisphosphate binding(GO:0000822) inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)

Gene overrepresentation in C2:CP category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.5 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 1.2 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.0 0.8 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 0.8 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.0 0.3 ST_IL_13_PATHWAY Interleukin 13 (IL-13) Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.5 REACTOME_CELL_JUNCTION_ORGANIZATION Genes involved in Cell junction organization
0.0 1.0 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.1 0.8 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.1 0.8 REACTOME_IRAK2_MEDIATED_ACTIVATION_OF_TAK1_COMPLEX_UPON_TLR7_8_OR_9_STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0 0.5 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 0.5 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.0 0.3 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.3 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.0 0.2 REACTOME_CALNEXIN_CALRETICULIN_CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.2 REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.1 REACTOME_BINDING_AND_ENTRY_OF_HIV_VIRION Genes involved in Binding and entry of HIV virion