Motif ID: GCM2

Z-value: 0.774


Transcription factors associated with GCM2:

Gene SymbolEntrez IDGene Name
GCM2 ENSG00000124827.6 GCM2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
GCM2hg19_v2_chr6_-_10882174_108822740.281.8e-01Click!


Activity profile for motif GCM2.

activity profile for motif GCM2


Sorted Z-values histogram for motif GCM2

Sorted Z-values for motif GCM2



Network of associatons between targets according to the STRING database.



First level regulatory network of GCM2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_86511549 1.109 ENST00000533902.2
 PRSS23
protease, serine, 23
chr1_-_223537401 1.080 ENST00000343846.3
ENST00000454695.2
ENST00000484758.2
 SUSD4


sushi domain containing 4


chr5_-_54281407 1.063 ENST00000381403.4
 ESM1
endothelial cell-specific molecule 1
chr1_-_223537475 1.009 ENST00000344029.6
ENST00000494793.2
ENST00000366878.4
ENST00000366877.3
 SUSD4



sushi domain containing 4



chr15_-_75248954 0.926 ENST00000499788.2
 RPP25
ribonuclease P/MRP 25kDa subunit
chr11_-_118023490 0.888 ENST00000324727.4
 SCN4B
sodium channel, voltage-gated, type IV, beta subunit
chr15_-_93632421 0.887 ENST00000329082.7
 RGMA
repulsive guidance molecule family member a
chr14_+_75536335 0.852 ENST00000554763.1
ENST00000439583.2
ENST00000526130.1
ENST00000525046.1
 ZC2HC1C



zinc finger, C2HC-type containing 1C



chr14_+_75536280 0.822 ENST00000238686.8
 ZC2HC1C
zinc finger, C2HC-type containing 1C
chr17_+_53342311 0.745 ENST00000226067.5
 HLF
hepatic leukemia factor
chr15_-_45670924 0.731 ENST00000396659.3
 GATM
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr20_+_42086525 0.731 ENST00000244020.3
 SRSF6
serine/arginine-rich splicing factor 6
chr14_+_77648167 0.724 ENST00000554346.1
ENST00000298351.4
 TMEM63C

transmembrane protein 63C

chr14_-_67982146 0.687 ENST00000557779.1
ENST00000557006.1
 TMEM229B

transmembrane protein 229B

chr9_-_130635741 0.666 ENST00000223836.10
 AK1
adenylate kinase 1
chr14_+_21359558 0.652 ENST00000304639.3
 RNASE3
ribonuclease, RNase A family, 3
chr14_-_67981916 0.636 ENST00000357461.2
 TMEM229B
transmembrane protein 229B
chr15_+_78556809 0.621 ENST00000343789.3
ENST00000394852.3
 DNAJA4

DnaJ (Hsp40) homolog, subfamily A, member 4

chr15_+_43809797 0.604 ENST00000399453.1
ENST00000300231.5
 MAP1A

microtubule-associated protein 1A

chr16_+_28996364 0.602 ENST00000564277.1
 LAT
linker for activation of T cells

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 94 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.2 GO:0006958 complement activation, classical pathway(GO:0006958)
0.2 1.2 GO:1902202 regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202)
0.0 1.0 GO:0043303 mast cell activation involved in immune response(GO:0002279) mast cell degranulation(GO:0043303)
0.1 0.9 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.0 0.9 GO:0048681 negative regulation of axon regeneration(GO:0048681)
0.0 0.9 GO:0086016 AV node cell action potential(GO:0086016) AV node cell to bundle of His cell signaling(GO:0086027)
0.2 0.7 GO:1903691 positive regulation of wound healing, spreading of epidermal cells(GO:1903691)
0.1 0.7 GO:0045074 interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.1 0.7 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.1 0.7 GO:0006600 creatine metabolic process(GO:0006600)
0.1 0.7 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.1 0.6 GO:0045819 positive regulation of glycogen catabolic process(GO:0045819)
0.0 0.6 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.0 0.5 GO:0015824 proline transport(GO:0015824)
0.0 0.5 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.0 0.5 GO:0016446 somatic hypermutation of immunoglobulin genes(GO:0016446)
0.0 0.5 GO:0031507 heterochromatin assembly(GO:0031507)
0.1 0.4 GO:0015882 L-ascorbic acid transport(GO:0015882) transepithelial L-ascorbic acid transport(GO:0070904)
0.1 0.4 GO:1901842 negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.1 0.4 GO:0060120 auditory receptor cell fate commitment(GO:0009912) inner ear receptor cell fate commitment(GO:0060120)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.0 GO:0042629 mast cell granule(GO:0042629)
0.1 0.9 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.0 0.9 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.1 0.6 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.0 0.6 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 0.5 GO:0032389 MutLalpha complex(GO:0032389)
0.0 0.5 GO:0005677 chromatin silencing complex(GO:0005677)
0.0 0.5 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.1 0.4 GO:1990393 3M complex(GO:1990393)
0.0 0.4 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.0 0.3 GO:0061689 tricellular tight junction(GO:0061689)
0.0 0.3 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.3 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0 0.2 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.0 0.2 GO:0098839 postsynaptic density membrane(GO:0098839)
0.0 0.2 GO:0043020 NADPH oxidase complex(GO:0043020)
0.0 0.2 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0 0.2 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.1 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0 0.1 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 1.2 GO:0005171 hepatocyte growth factor receptor binding(GO:0005171)
0.1 0.9 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.1 0.9 GO:0004526 ribonuclease P activity(GO:0004526)
0.1 0.9 GO:1990459 transferrin receptor binding(GO:1990459)
0.0 0.8 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.0 0.7 GO:0016769 transferase activity, transferring nitrogenous groups(GO:0016769)
0.0 0.7 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.0 0.7 GO:0036002 pre-mRNA binding(GO:0036002)
0.1 0.6 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.1 0.5 GO:0032138 single base insertion or deletion binding(GO:0032138)
0.0 0.5 GO:0050693 LBD domain binding(GO:0050693)
0.0 0.5 GO:0004017 adenylate kinase activity(GO:0004017)
0.0 0.5 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.0 0.5 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.0 0.5 GO:0015248 sterol transporter activity(GO:0015248)
0.1 0.4 GO:0070890 L-ascorbate:sodium symporter activity(GO:0008520) L-ascorbic acid transporter activity(GO:0015229) sodium-dependent L-ascorbate transmembrane transporter activity(GO:0070890)
0.1 0.4 GO:0032093 SAM domain binding(GO:0032093)
0.1 0.4 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.0 0.4 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0 0.4 GO:0004969 histamine receptor activity(GO:0004969)

Gene overrepresentation in C2:CP category:

Showing 1 to 4 of 4 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.3 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.1 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 1.1 ST_GA12_PATHWAY G alpha 12 Pathway
0.0 0.5 PID_CONE_PATHWAY Visual signal transduction: Cones

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.1 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.0 1.0 REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.9 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.9 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing
0.0 0.4 REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 0.4 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.3 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 0.3 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.3 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 0.3 REACTOME_A_TETRASACCHARIDE_LINKER_SEQUENCE_IS_REQUIRED_FOR_GAG_SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.0 0.2 REACTOME_POST_NMDA_RECEPTOR_ACTIVATION_EVENTS Genes involved in Post NMDA receptor activation events
0.0 0.2 REACTOME_PYRIMIDINE_CATABOLISM Genes involved in Pyrimidine catabolism