Motif ID: GCUACAU

Z-value: 0.461


Mature miRNA associated with seed GCUACAU:

NamemiRBase Accession
hsa-miR-221-3p MIMAT0000278
hsa-miR-222-3p MIMAT0000279



Activity profile for motif GCUACAU.

activity profile for motif GCUACAU


Sorted Z-values histogram for motif GCUACAU

Sorted Z-values for motif GCUACAU



Network of associatons between targets according to the STRING database.



First level regulatory network of GCUACAU

PNG image of the network

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Top targets:


Showing 1 to 20 of 189 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_55524085 1.250 ENST00000412167.2
ENST00000288135.5
 KIT

v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

chr5_+_140254884 1.032 ENST00000398631.2
 PCDHA12
protocadherin alpha 12
chr5_+_140227048 1.029 ENST00000532602.1
 PCDHA9
protocadherin alpha 9
chr5_+_140248518 1.024 ENST00000398640.2
 PCDHA11
protocadherin alpha 11
chr5_+_140213815 0.998 ENST00000525929.1
ENST00000378125.3
 PCDHA7

protocadherin alpha 7

chr9_-_3525968 0.978 ENST00000382004.3
ENST00000302303.1
ENST00000449190.1
 RFX3


regulatory factor X, 3 (influences HLA class II expression)


chr5_+_140220769 0.959 ENST00000531613.1
ENST00000378123.3
 PCDHA8

protocadherin alpha 8

chr6_+_16129308 0.886 ENST00000356840.3
ENST00000349606.4
 MYLIP

myosin regulatory light chain interacting protein

chr16_+_28303804 0.696 ENST00000341901.4
 SBK1
SH3 domain binding kinase 1
chr2_-_213403565 0.668 ENST00000342788.4
ENST00000436443.1
 ERBB4

v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4

chr1_+_114472222 0.648 ENST00000369558.1
ENST00000369561.4
 HIPK1

homeodomain interacting protein kinase 1

chr14_+_74111578 0.614 ENST00000554113.1
ENST00000555631.2
ENST00000553645.2
ENST00000311089.3
ENST00000555919.3
ENST00000554339.1
ENST00000554871.1
 DNAL1






dynein, axonemal, light chain 1






chr9_+_976964 0.604 ENST00000190165.2
 DMRT3
doublesex and mab-3 related transcription factor 3
chr5_+_140165876 0.503 ENST00000504120.2
ENST00000394633.3
ENST00000378133.3
 PCDHA1


protocadherin alpha 1


chr5_+_140306478 0.500 ENST00000253807.2
 PCDHAC1
protocadherin alpha subfamily C, 1
chr6_+_17281573 0.465 ENST00000379052.5
 RBM24
RNA binding motif protein 24
chr12_-_56652111 0.440 ENST00000267116.7
 ANKRD52
ankyrin repeat domain 52
chr5_+_140345820 0.435 ENST00000289269.5
 PCDHAC2
protocadherin alpha subfamily C, 2
chr16_+_69599861 0.434 ENST00000354436.2
 NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr2_-_24149977 0.425 ENST00000238789.5
 ATAD2B
ATPase family, AAA domain containing 2B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.2 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.4 1.2 GO:0038109 response to stem cell factor(GO:0036215) cellular response to stem cell factor stimulus(GO:0036216) Kit signaling pathway(GO:0038109) erythropoietin-mediated signaling pathway(GO:0038162)
0.3 1.0 GO:0002071 glandular epithelial cell maturation(GO:0002071) type B pancreatic cell maturation(GO:0072560)
0.1 0.9 GO:0032803 regulation of low-density lipoprotein particle receptor catabolic process(GO:0032803)
0.2 0.7 GO:2000364 regulation of STAT protein import into nucleus(GO:2000364) positive regulation of STAT protein import into nucleus(GO:2000366)
0.1 0.6 GO:0060235 lens induction in camera-type eye(GO:0060235)
0.0 0.6 GO:0036158 outer dynein arm assembly(GO:0036158)
0.1 0.5 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.0 0.5 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
0.1 0.3 GO:1900365 positive regulation of mRNA polyadenylation(GO:1900365)
0.0 0.3 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.1 0.2 GO:0061181 regulation of chondrocyte development(GO:0061181)
0.0 0.2 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.0 0.2 GO:2000312 regulation of kainate selective glutamate receptor activity(GO:2000312)
0.0 0.2 GO:0071350 interleukin-15-mediated signaling pathway(GO:0035723) cellular response to interleukin-15(GO:0071350)
0.0 0.2 GO:0006620 posttranslational protein targeting to membrane(GO:0006620)
0.0 0.2 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.0 0.2 GO:1900119 positive regulation of execution phase of apoptosis(GO:1900119)
0.0 0.1 GO:0098582 innate vocalization behavior(GO:0098582)
0.0 0.1 GO:0002337 B-1a B cell differentiation(GO:0002337)

Gene overrepresentation in cellular_component category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.8 GO:0042629 mast cell granule(GO:0042629)
0.1 0.6 GO:0036157 outer dynein arm(GO:0036157)
0.0 0.4 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 0.3 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.0 0.3 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.2 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.0 0.2 GO:0044614 nuclear pore cytoplasmic filaments(GO:0044614)
0.0 0.2 GO:0042272 nuclear RNA export factor complex(GO:0042272)
0.0 0.2 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.1 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.0 0.1 GO:0031213 RSF complex(GO:0031213)
0.0 0.1 GO:0072487 MSL complex(GO:0072487)
0.0 0.1 GO:0061700 GATOR2 complex(GO:0061700)
0.0 0.0 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.8 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0 0.6 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 0.6 GO:0030371 translation repressor activity(GO:0030371)
0.0 0.4 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 0.4 GO:0001056 RNA polymerase III activity(GO:0001056)
0.0 0.4 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.1 0.3 GO:0005499 vitamin D binding(GO:0005499)
0.0 0.3 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 0.3 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.2 GO:0042289 MHC class II protein binding(GO:0042289)
0.0 0.2 GO:0042954 lipoprotein transporter activity(GO:0042954)
0.0 0.2 GO:0043559 insulin binding(GO:0043559)
0.0 0.2 GO:0039706 co-receptor binding(GO:0039706)
0.0 0.2 GO:0046527 glucosyltransferase activity(GO:0046527)
0.0 0.1 GO:0004923 leukemia inhibitory factor receptor activity(GO:0004923)
0.0 0.1 GO:0034046 poly(G) binding(GO:0034046)
0.0 0.1 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.0 0.1 GO:0016215 stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)
0.0 0.1 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.0 0.1 GO:0005168 neurotrophin TRKA receptor binding(GO:0005168)

Gene overrepresentation in C2:CP category:

Showing 1 to 3 of 3 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.4 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 0.4 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 0.2 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 4 of 4 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.6 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.5 REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.0 0.4 REACTOME_RNA_POL_III_CHAIN_ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 0.2 REACTOME_BINDING_AND_ENTRY_OF_HIV_VIRION Genes involved in Binding and entry of HIV virion