Motif ID: GCUGGUG

Z-value: 0.375


Mature miRNA associated with seed GCUGGUG:

NamemiRBase Accession
hsa-miR-138-5p MIMAT0000430



Activity profile for motif GCUGGUG.

activity profile for motif GCUGGUG


Sorted Z-values histogram for motif GCUGGUG

Sorted Z-values for motif GCUGGUG



Network of associatons between targets according to the STRING database.



First level regulatory network of GCUGGUG

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_160473996 0.846 ENST00000498165.1
 PPM1L
protein phosphatase, Mg2+/Mn2+ dependent, 1L
chr15_-_68498376 0.661 ENST00000540479.1
ENST00000395465.3
 CALML4

calmodulin-like 4

chr4_-_23891693 0.616 ENST00000264867.2
 PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr19_-_14316980 0.481 ENST00000361434.3
ENST00000340736.6
 LPHN1

latrophilin 1

chr20_+_42086525 0.474 ENST00000244020.3
 SRSF6
serine/arginine-rich splicing factor 6
chr19_+_13135386 0.471 ENST00000360105.4
ENST00000588228.1
ENST00000591028.1
 NFIX


nuclear factor I/X (CCAAT-binding transcription factor)


chr3_-_13009168 0.431 ENST00000273221.4
 IQSEC1
IQ motif and Sec7 domain 1
chr20_+_54933971 0.416 ENST00000371384.3
ENST00000437418.1
 FAM210B

family with sequence similarity 210, member B

chr6_+_39760783 0.389 ENST00000398904.2
ENST00000538976.1
 DAAM2

dishevelled associated activator of morphogenesis 2

chr1_+_61547894 0.372 ENST00000403491.3
 NFIA
nuclear factor I/A
chr9_+_17579084 0.367 ENST00000380607.4
 SH3GL2
SH3-domain GRB2-like 2
chr16_+_69599861 0.350 ENST00000354436.2
 NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr4_+_41362796 0.348 ENST00000508501.1
ENST00000512946.1
ENST00000313860.7
ENST00000512632.1
ENST00000512820.1
 LIMCH1




LIM and calponin homology domains 1




chr7_+_90225796 0.343 ENST00000380050.3
 CDK14
cyclin-dependent kinase 14
chr19_+_51815102 0.341 ENST00000270642.8
 IGLON5
IgLON family member 5
chr5_+_167718604 0.338 ENST00000265293.4
 WWC1
WW and C2 domain containing 1
chr5_+_139175380 0.322 ENST00000274710.3
 PSD2
pleckstrin and Sec7 domain containing 2
chr3_-_114790179 0.318 ENST00000462705.1
 ZBTB20
zinc finger and BTB domain containing 20
chr1_+_210406121 0.313 ENST00000367012.3
 SERTAD4
SERTA domain containing 4
chr10_+_72164135 0.305 ENST00000373218.4
 EIF4EBP2
eukaryotic translation initiation factor 4E binding protein 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.8 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.2 0.6 GO:1901860 positive regulation of mitochondrial DNA metabolic process(GO:1901860)
0.1 0.5 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.1 0.4 GO:0097477 lateral motor column neuron migration(GO:0097477)
0.0 0.4 GO:1990416 cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.1 0.3 GO:2000364 regulation of STAT protein import into nucleus(GO:2000364) positive regulation of STAT protein import into nucleus(GO:2000366)
0.0 0.3 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.0 0.3 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.0 0.3 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.1 0.2 GO:0015993 L-ascorbic acid transport(GO:0015882) molecular hydrogen transport(GO:0015993) transepithelial L-ascorbic acid transport(GO:0070904)
0.0 0.2 GO:1904694 negative regulation of vascular smooth muscle contraction(GO:1904694)
0.0 0.2 GO:0060235 lens induction in camera-type eye(GO:0060235)
0.0 0.2 GO:0007042 lysosomal lumen acidification(GO:0007042)
0.0 0.2 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.0 0.2 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.0 0.2 GO:0006020 inositol metabolic process(GO:0006020)
0.0 0.2 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)
0.0 0.2 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 0.2 GO:0060033 anatomical structure regression(GO:0060033)
0.1 0.1 GO:0071335 fibroblast growth factor receptor signaling pathway involved in mammary gland specification(GO:0060595) mammary gland bud formation(GO:0060615) submandibular salivary gland formation(GO:0060661) branch elongation involved in salivary gland morphogenesis(GO:0060667) mesenchymal cell differentiation involved in lung development(GO:0060915) hair follicle cell proliferation(GO:0071335) regulation of hair follicle cell proliferation(GO:0071336) positive regulation of hair follicle cell proliferation(GO:0071338)

Gene overrepresentation in cellular_component category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.6 GO:0097440 apical dendrite(GO:0097440)
0.1 0.3 GO:0034657 GID complex(GO:0034657)
0.1 0.3 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.0 0.2 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 0.2 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 0.1 GO:0033553 rDNA heterochromatin(GO:0033553)
0.0 0.1 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.0 0.1 GO:0031213 RSF complex(GO:0031213)
0.0 0.1 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
0.0 0.1 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.8 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.7 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 0.3 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 0.3 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0 0.3 GO:0017049 GTP-Rho binding(GO:0017049)
0.1 0.2 GO:0070890 L-ascorbate:sodium symporter activity(GO:0008520) sodium-dependent multivitamin transmembrane transporter activity(GO:0008523) L-ascorbic acid transporter activity(GO:0015229) sodium-dependent L-ascorbate transmembrane transporter activity(GO:0070890)
0.1 0.2 GO:0070326 very-low-density lipoprotein particle receptor binding(GO:0070326)
0.1 0.2 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
0.0 0.2 GO:0033857 diphosphoinositol-pentakisphosphate kinase activity(GO:0033857)
0.0 0.2 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.0 0.2 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.0 0.2 GO:0017002 activin-activated receptor activity(GO:0017002)
0.0 0.2 GO:1903136 cuprous ion binding(GO:1903136)
0.0 0.1 GO:0017057 glucose-6-phosphate dehydrogenase activity(GO:0004345) 6-phosphogluconolactonase activity(GO:0017057)
0.0 0.1 GO:0043398 HLH domain binding(GO:0043398)
0.0 0.1 GO:0035034 histone acetyltransferase regulator activity(GO:0035034)
0.0 0.1 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.0 0.1 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 0.1 GO:0035241 protein-arginine omega-N monomethyltransferase activity(GO:0035241)
0.0 0.1 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)

Gene overrepresentation in C2:CP category:

Showing 1 to 2 of 2 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.8 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 0.1 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.9 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.9 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.6 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 0.4 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 0.4 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.2 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels