Motif ID: GLI2
Z-value: 0.554
Transcription factors associated with GLI2:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| GLI2 | ENSG00000074047.16 | GLI2 |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 217 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.0 | GO:0006939 | smooth muscle contraction(GO:0006939) |
| 0.5 | 1.8 | GO:0010900 | negative regulation of phosphatidylcholine catabolic process(GO:0010900) |
| 0.1 | 1.4 | GO:0007144 | female meiosis I(GO:0007144) |
| 0.1 | 1.3 | GO:0016540 | protein autoprocessing(GO:0016540) |
| 0.0 | 1.2 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.4 | 1.1 | GO:0015920 | lipopolysaccharide transport(GO:0015920) |
| 0.1 | 1.1 | GO:0036066 | protein O-linked fucosylation(GO:0036066) |
| 0.0 | 1.1 | GO:0050690 | regulation of defense response to virus by virus(GO:0050690) |
| 0.0 | 1.1 | GO:0018149 | peptide cross-linking(GO:0018149) |
| 0.1 | 1.0 | GO:0010820 | positive regulation of T cell chemotaxis(GO:0010820) |
| 0.0 | 0.9 | GO:0032060 | bleb assembly(GO:0032060) |
| 0.0 | 0.8 | GO:0030388 | fructose 1,6-bisphosphate metabolic process(GO:0030388) |
| 0.2 | 0.7 | GO:0018352 | protein-pyridoxal-5-phosphate linkage(GO:0018352) |
| 0.1 | 0.7 | GO:1904627 | response to phorbol 13-acetate 12-myristate(GO:1904627) cellular response to phorbol 13-acetate 12-myristate(GO:1904628) |
| 0.0 | 0.7 | GO:0001829 | trophectodermal cell differentiation(GO:0001829) |
| 0.0 | 0.7 | GO:0060216 | definitive hemopoiesis(GO:0060216) |
| 0.0 | 0.7 | GO:0043525 | positive regulation of neuron apoptotic process(GO:0043525) |
| 0.2 | 0.6 | GO:0017186 | peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase(GO:0017186) |
| 0.1 | 0.6 | GO:0071484 | response to high light intensity(GO:0009644) cellular response to light intensity(GO:0071484) |
| 0.1 | 0.6 | GO:1905098 | negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 70 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.9 | GO:0042627 | chylomicron(GO:0042627) |
| 0.0 | 1.9 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.0 | 1.8 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.0 | 1.4 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.0 | 1.1 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.0 | 1.1 | GO:0030669 | clathrin-coated endocytic vesicle membrane(GO:0030669) |
| 0.1 | 0.9 | GO:0005610 | laminin-5 complex(GO:0005610) |
| 0.0 | 0.9 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.0 | 0.9 | GO:0002102 | podosome(GO:0002102) |
| 0.0 | 0.8 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
| 0.0 | 0.8 | GO:0005666 | DNA-directed RNA polymerase III complex(GO:0005666) |
| 0.0 | 0.8 | GO:0031528 | microvillus membrane(GO:0031528) |
| 0.0 | 0.8 | GO:0005640 | nuclear outer membrane(GO:0005640) |
| 0.1 | 0.7 | GO:0031262 | Ndc80 complex(GO:0031262) |
| 0.0 | 0.6 | GO:0005892 | acetylcholine-gated channel complex(GO:0005892) |
| 0.0 | 0.6 | GO:0030673 | axolemma(GO:0030673) |
| 0.2 | 0.5 | GO:0016938 | kinesin I complex(GO:0016938) |
| 0.1 | 0.5 | GO:0071546 | pi-body(GO:0071546) |
| 0.0 | 0.5 | GO:0044327 | dendritic spine head(GO:0044327) |
| 0.0 | 0.5 | GO:0031229 | integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 143 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.8 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.2 | 1.8 | GO:0060228 | phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228) |
| 0.0 | 1.8 | GO:0017048 | Rho GTPase binding(GO:0017048) |
| 0.1 | 1.3 | GO:0047134 | protein-disulfide reductase activity(GO:0047134) |
| 0.1 | 1.2 | GO:0050786 | RAGE receptor binding(GO:0050786) |
| 0.3 | 1.0 | GO:0070506 | high-density lipoprotein particle receptor activity(GO:0070506) |
| 0.1 | 0.9 | GO:0030280 | structural constituent of epidermis(GO:0030280) |
| 0.1 | 0.8 | GO:0070915 | lysophosphatidic acid receptor activity(GO:0070915) |
| 0.1 | 0.8 | GO:0004332 | fructose-bisphosphate aldolase activity(GO:0004332) |
| 0.0 | 0.8 | GO:0016676 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.2 | 0.7 | GO:0098770 | FBXO family protein binding(GO:0098770) |
| 0.1 | 0.7 | GO:0004882 | androgen receptor activity(GO:0004882) |
| 0.0 | 0.7 | GO:0015301 | anion:anion antiporter activity(GO:0015301) |
| 0.0 | 0.7 | GO:0003899 | DNA-directed RNA polymerase activity(GO:0003899) |
| 0.2 | 0.6 | GO:0016603 | glutaminyl-peptide cyclotransferase activity(GO:0016603) |
| 0.1 | 0.6 | GO:0005176 | ErbB-2 class receptor binding(GO:0005176) |
| 0.0 | 0.6 | GO:0035612 | AP-2 adaptor complex binding(GO:0035612) |
| 0.0 | 0.6 | GO:0022848 | acetylcholine-gated cation channel activity(GO:0022848) |
| 0.0 | 0.6 | GO:0071949 | FAD binding(GO:0071949) |
| 0.1 | 0.5 | GO:0033906 | hyaluronoglucuronidase activity(GO:0033906) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 24 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.7 | PID_ALPHA_SYNUCLEIN_PATHWAY | Alpha-synuclein signaling |
| 0.1 | 1.4 | SA_G2_AND_M_PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.0 | 1.3 | PID_FOXM1_PATHWAY | FOXM1 transcription factor network |
| 0.0 | 1.3 | PID_CDC42_PATHWAY | CDC42 signaling events |
| 0.0 | 1.0 | PID_RET_PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.0 | 0.9 | PID_INTEGRIN4_PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.0 | 0.9 | PID_GLYPICAN_1PATHWAY | Glypican 1 network |
| 0.0 | 0.9 | PID_ER_NONGENOMIC_PATHWAY | Plasma membrane estrogen receptor signaling |
| 0.0 | 0.8 | PID_P38_GAMMA_DELTA_PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.0 | 0.8 | PID_AMB2_NEUTROPHILS_PATHWAY | amb2 Integrin signaling |
| 0.0 | 0.7 | PID_ATR_PATHWAY | ATR signaling pathway |
| 0.0 | 0.6 | PID_ALK2_PATHWAY | ALK2 signaling events |
| 0.0 | 0.6 | SA_PTEN_PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.0 | 0.4 | PID_MAPK_TRK_PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.0 | 0.4 | PID_REELIN_PATHWAY | Reelin signaling pathway |
| 0.0 | 0.4 | PID_IL2_STAT5_PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.0 | 0.3 | PID_DNA_PK_PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.0 | 0.3 | PID_ERB_GENOMIC_PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 0.3 | PID_SMAD2_3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 0.3 | PID_LIS1_PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 45 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.4 | REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.0 | 1.2 | REACTOME_G1_PHASE | Genes involved in G1 Phase |
| 0.0 | 1.1 | REACTOME_PACKAGING_OF_TELOMERE_ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.0 | 1.0 | REACTOME_HDL_MEDIATED_LIPID_TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.0 | 0.8 | REACTOME_GLYCOLYSIS | Genes involved in Glycolysis |
| 0.0 | 0.8 | REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.0 | 0.7 | REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.0 | 0.7 | REACTOME_CHOLESTEROL_BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.0 | 0.7 | REACTOME_KINESINS | Genes involved in Kinesins |
| 0.0 | 0.7 | REACTOME_NEP_NS2_INTERACTS_WITH_THE_CELLULAR_EXPORT_MACHINERY | Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery |
| 0.1 | 0.6 | REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |
| 0.0 | 0.6 | REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS | Genes involved in Presynaptic nicotinic acetylcholine receptors |
| 0.0 | 0.6 | REACTOME_LAGGING_STRAND_SYNTHESIS | Genes involved in Lagging Strand Synthesis |
| 0.0 | 0.5 | REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
| 0.0 | 0.5 | REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.0 | 0.5 | REACTOME_PURINE_SALVAGE | Genes involved in Purine salvage |
| 0.0 | 0.5 | REACTOME_PEROXISOMAL_LIPID_METABOLISM | Genes involved in Peroxisomal lipid metabolism |
| 0.0 | 0.5 | REACTOME_ELONGATION_ARREST_AND_RECOVERY | Genes involved in Elongation arrest and recovery |
| 0.0 | 0.4 | REACTOME_G0_AND_EARLY_G1 | Genes involved in G0 and Early G1 |
| 0.0 | 0.4 | REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS | Genes involved in Elevation of cytosolic Ca2+ levels |
