Motif ID: GLI3

Z-value: 1.373


Transcription factors associated with GLI3:

Gene SymbolEntrez IDGene Name
GLI3 ENSG00000106571.8 GLI3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
GLI3hg19_v2_chr7_-_42276612_422767820.481.8e-02Click!


Activity profile for motif GLI3.

activity profile for motif GLI3


Sorted Z-values histogram for motif GLI3

Sorted Z-values for motif GLI3



Network of associatons between targets according to the STRING database.



First level regulatory network of GLI3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_-_51456344 5.672 ENST00000336334.3
ENST00000593428.1
 KLK5

kallikrein-related peptidase 5

chr19_-_51456321 5.615 ENST00000391809.2
 KLK5
kallikrein-related peptidase 5
chr1_-_153433120 5.164 ENST00000368723.3
 S100A7
S100 calcium binding protein A7
chr20_+_62327996 5.148 ENST00000369996.1
 TNFRSF6B
tumor necrosis factor receptor superfamily, member 6b, decoy
chr19_-_51456198 4.814 ENST00000594846.1
 KLK5
kallikrein-related peptidase 5
chr10_+_88718397 4.663 ENST00000372017.3
 SNCG
synuclein, gamma (breast cancer-specific protein 1)
chr10_+_88718314 4.617 ENST00000348795.4
 SNCG
synuclein, gamma (breast cancer-specific protein 1)
chr18_+_21529811 4.523 ENST00000588004.1
 LAMA3
laminin, alpha 3
chr22_+_31489344 4.307 ENST00000404574.1
 SMTN
smoothelin
chr22_+_31488433 4.142 ENST00000455608.1
 SMTN
smoothelin
chr1_+_150522222 4.035 ENST00000369039.5
 ADAMTSL4
ADAMTS-like 4
chr1_+_45205498 3.991 ENST00000372218.4
 KIF2C
kinesin family member 2C
chr13_-_60738003 3.878 ENST00000400330.1
ENST00000400324.4
 DIAPH3

diaphanous-related formin 3

chr19_-_51472031 3.844 ENST00000391808.1
 KLK6
kallikrein-related peptidase 6
chr1_+_152956549 3.763 ENST00000307122.2
 SPRR1A
small proline-rich protein 1A
chr12_-_57634475 3.473 ENST00000393825.1
 NDUFA4L2
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
chr4_-_57524061 3.293 ENST00000508121.1
 HOPX
HOP homeobox
chr1_+_183155373 3.273 ENST00000493293.1
ENST00000264144.4
 LAMC2

laminin, gamma 2

chr15_+_90728145 3.148 ENST00000561085.1
ENST00000379122.3
ENST00000332496.6
 SEMA4B


sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B


chr11_+_69061594 3.020 ENST00000441339.2
ENST00000308946.3
ENST00000535407.1
 MYEOV


myeloma overexpressed



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 454 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.7 16.1 GO:0002803 positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803)
0.2 10.3 GO:0014046 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.3 10.1 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 8.4 GO:0006939 smooth muscle contraction(GO:0006939)
2.0 8.0 GO:0010900 negative regulation of phosphatidylcholine catabolic process(GO:0010900)
0.5 6.9 GO:0036066 protein O-linked fucosylation(GO:0036066)
0.7 6.8 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.5 5.2 GO:0010820 positive regulation of T cell chemotaxis(GO:0010820)
0.1 5.1 GO:0006910 phagocytosis, recognition(GO:0006910)
0.1 5.0 GO:0031338 regulation of vesicle fusion(GO:0031338)
1.6 4.8 GO:0015920 lipopolysaccharide transport(GO:0015920)
0.1 4.7 GO:0060113 inner ear receptor cell differentiation(GO:0060113)
0.8 4.0 GO:0032487 regulation of Rap protein signal transduction(GO:0032487)
0.4 3.9 GO:0019368 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.2 3.8 GO:0016540 protein autoprocessing(GO:0016540)
0.1 3.8 GO:0018149 peptide cross-linking(GO:0018149)
1.2 3.7 GO:0018153 isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine(GO:0018153) isopeptide cross-linking(GO:0018262)
0.1 3.7 GO:0071243 cellular response to arsenic-containing substance(GO:0071243)
0.1 3.6 GO:0050690 regulation of defense response to virus by virus(GO:0050690)
0.4 3.5 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 176 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.3 16.1 GO:0097209 epidermal lamellar body(GO:0097209)
0.0 10.3 GO:0015629 actin cytoskeleton(GO:0015629)
0.1 8.8 GO:0035578 azurophil granule lumen(GO:0035578)
0.2 7.9 GO:0035371 microtubule plus-end(GO:0035371)
0.3 7.6 GO:0042627 chylomicron(GO:0042627)
0.0 7.4 GO:0005882 intermediate filament(GO:0005882)
0.0 6.9 GO:0030424 axon(GO:0030424)
0.1 6.4 GO:0001533 cornified envelope(GO:0001533)
0.3 6.2 GO:0005614 interstitial matrix(GO:0005614)
0.2 5.3 GO:0031528 microvillus membrane(GO:0031528)
0.1 4.7 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.6 4.5 GO:0005610 laminin-5 complex(GO:0005610)
0.1 4.5 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.2 4.2 GO:0005922 connexon complex(GO:0005922)
0.4 3.5 GO:0000796 condensin complex(GO:0000796)
0.2 3.5 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
1.1 3.3 GO:0005607 laminin-2 complex(GO:0005607)
0.0 3.0 GO:0030117 membrane coat(GO:0030117) coated membrane(GO:0048475)
0.0 2.8 GO:0043198 dendritic shaft(GO:0043198)
0.3 2.6 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 302 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 21.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 9.1 GO:0017048 Rho GTPase binding(GO:0017048)
0.1 8.4 GO:0008307 structural constituent of muscle(GO:0008307)
0.8 7.6 GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.7 6.8 GO:0019237 centromeric DNA binding(GO:0019237)
0.0 6.1 GO:0008017 microtubule binding(GO:0008017)
0.0 6.0 GO:0017137 Rab GTPase binding(GO:0017137)
0.3 5.8 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 5.7 GO:0051015 actin filament binding(GO:0051015)
0.2 5.2 GO:0050786 RAGE receptor binding(GO:0050786)
1.6 4.8 GO:0070506 high-density lipoprotein particle receptor activity(GO:0070506)
0.0 4.7 GO:0005525 GTP binding(GO:0005525)
0.1 4.5 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.1 4.4 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 4.4 GO:0008201 heparin binding(GO:0008201)
0.1 4.3 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 4.2 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.4 3.9 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.3 3.8 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.3 3.8 GO:0030280 structural constituent of epidermis(GO:0030280)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 65 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 14.5 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 10.6 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 9.9 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.4 8.8 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 8.5 PID_CDC42_PATHWAY CDC42 signaling events
0.1 5.6 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.1 4.5 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.1 4.1 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 3.7 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.1 3.7 ST_P38_MAPK_PATHWAY p38 MAPK Pathway
0.2 3.2 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 3.1 ST_FAS_SIGNALING_PATHWAY Fas Signaling Pathway
0.1 3.0 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.2 2.9 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 2.8 PID_P73PATHWAY p73 transcription factor network
0.1 2.6 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 2.5 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 2.5 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 2.3 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.1 2.2 PID_ALK1_PATHWAY ALK1 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 99 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 11.6 REACTOME_CELL_JUNCTION_ORGANIZATION Genes involved in Cell junction organization
0.2 7.3 REACTOME_KINESINS Genes involved in Kinesins
0.2 4.8 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.2 4.5 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.2 4.2 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.0 3.9 REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS Genes involved in G alpha (q) signalling events
0.2 3.8 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.1 3.7 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 3.7 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 3.6 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 3.4 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.1 3.3 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.1 3.2 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1 3.0 REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.1 2.9 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 2.9 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 2.8 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.1 2.7 REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 2.6 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 2.6 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK