Motif ID: GLIS3

Z-value: 0.294


Transcription factors associated with GLIS3:

Gene SymbolEntrez IDGene Name
GLIS3 ENSG00000107249.17 GLIS3



Activity profile for motif GLIS3.

activity profile for motif GLIS3


Sorted Z-values histogram for motif GLIS3

Sorted Z-values for motif GLIS3



Network of associatons between targets according to the STRING database.



First level regulatory network of GLIS3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_172386517 0.573 ENST00000519522.1
 RPL26L1
ribosomal protein L26-like 1
chr7_+_65958693 0.252 ENST00000445681.1
ENST00000452565.1
 GS1-124K5.4

GS1-124K5.4

chr11_-_68671264 0.203 ENST00000362034.2
 MRPL21
mitochondrial ribosomal protein L21
chr6_+_89791507 0.184 ENST00000354922.3
 PNRC1
proline-rich nuclear receptor coactivator 1
chr17_-_33446820 0.180 ENST00000592577.1
ENST00000590016.1
ENST00000345365.6
ENST00000360276.3
ENST00000357906.3
 RAD51D




RAD51 paralog D




chr6_+_24495067 0.175 ENST00000357578.3
ENST00000546278.1
ENST00000491546.1
 ALDH5A1


aldehyde dehydrogenase 5 family, member A1


chr20_-_23969416 0.169 ENST00000335694.4
 GGTLC1
gamma-glutamyltransferase light chain 1
chr8_-_29120580 0.166 ENST00000524189.1
 KIF13B
kinesin family member 13B
chrX_-_132549506 0.157 ENST00000370828.3
 GPC4
glypican 4
chr1_+_107599267 0.150 ENST00000361318.5
ENST00000370078.1
 PRMT6

protein arginine methyltransferase 6

chr4_-_74904398 0.149 ENST00000296026.4
 CXCL3
chemokine (C-X-C motif) ligand 3
chr15_+_84116106 0.139 ENST00000535412.1
ENST00000324537.5
 SH3GL3

SH3-domain GRB2-like 3

chr7_+_150758304 0.122 ENST00000482950.1
ENST00000463414.1
ENST00000310317.5
 SLC4A2


solute carrier family 4 (anion exchanger), member 2


chr17_-_3819751 0.115 ENST00000225538.3
 P2RX1
purinergic receptor P2X, ligand-gated ion channel, 1
chr20_-_44718538 0.112 ENST00000290231.6
ENST00000372291.3
 NCOA5

nuclear receptor coactivator 5

chr1_-_92371839 0.111 ENST00000370399.2
 TGFBR3
transforming growth factor, beta receptor III
chr12_+_1929421 0.110 ENST00000543818.1
 LRTM2
leucine-rich repeats and transmembrane domains 2
chr17_-_5015129 0.107 ENST00000575898.1
ENST00000416429.2
 ZNF232

zinc finger protein 232

chr17_+_48912744 0.105 ENST00000311378.4
 WFIKKN2
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2
chr6_+_44191290 0.103 ENST00000371755.3
ENST00000371740.5
ENST00000371731.1
ENST00000393841.1
 SLC29A1



solute carrier family 29 (equilibrative nucleoside transporter), member 1



chr6_+_44191507 0.101 ENST00000371724.1
ENST00000371713.1
 SLC29A1

solute carrier family 29 (equilibrative nucleoside transporter), member 1

chr20_+_18447771 0.100 ENST00000377603.4
 POLR3F
polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa
chr8_+_118147498 0.100 ENST00000519688.1
ENST00000456015.2
 SLC30A8

solute carrier family 30 (zinc transporter), member 8

chr8_-_74791051 0.094 ENST00000453587.2
ENST00000602969.1
ENST00000602593.1
ENST00000419880.3
ENST00000517608.1
 UBE2W




ubiquitin-conjugating enzyme E2W (putative)




chr12_+_132568814 0.093 ENST00000454179.2
ENST00000389560.2
ENST00000443539.2
ENST00000392352.1
 EP400NL



EP400 N-terminal like



chr19_-_38397228 0.093 ENST00000447313.2
 WDR87
WD repeat domain 87
chr21_+_38071430 0.091 ENST00000290399.6
 SIM2
single-minded family bHLH transcription factor 2
chr7_-_50518022 0.083 ENST00000356889.4
ENST00000420829.1
ENST00000448788.1
ENST00000395556.2
ENST00000422854.1
ENST00000435566.1
ENST00000433017.1
 FIGNL1






fidgetin-like 1






chr5_+_172386419 0.082 ENST00000265100.2
ENST00000519239.1
 RPL26L1

ribosomal protein L26-like 1

chr17_-_77925806 0.082 ENST00000574241.2
 TBC1D16
TBC1 domain family, member 16
chr20_+_61867235 0.081 ENST00000342412.6
ENST00000217169.3
 BIRC7

baculoviral IAP repeat containing 7

chr7_+_23636992 0.081 ENST00000307471.3
ENST00000409765.1
 CCDC126

coiled-coil domain containing 126

chr19_-_49828438 0.076 ENST00000454748.3
ENST00000598828.1
ENST00000335875.4
 SLC6A16


solute carrier family 6, member 16


chr18_+_3451584 0.075 ENST00000551541.1
 TGIF1
TGFB-induced factor homeobox 1
chr16_-_3285144 0.074 ENST00000431561.3
ENST00000396870.4
 ZNF200

zinc finger protein 200

chr19_+_13875316 0.069 ENST00000319545.8
ENST00000593245.1
ENST00000040663.6
 MRI1


methylthioribose-1-phosphate isomerase 1


chr8_+_11627148 0.068 ENST00000436750.3
 NEIL2
nei endonuclease VIII-like 2 (E. coli)
chr1_-_157108266 0.068 ENST00000326786.4
 ETV3
ets variant 3
chr6_+_24495185 0.068 ENST00000348925.2
 ALDH5A1
aldehyde dehydrogenase 5 family, member A1
chr19_+_46850251 0.067 ENST00000012443.4
 PPP5C
protein phosphatase 5, catalytic subunit
chr10_+_105314881 0.067 ENST00000437579.1
 NEURL
neuralized E3 ubiquitin protein ligase 1
chr19_+_44488330 0.065 ENST00000591532.1
ENST00000407951.2
ENST00000270014.2
ENST00000590615.1
ENST00000586454.1
 ZNF155




zinc finger protein 155




chr19_+_46850320 0.064 ENST00000391919.1
 PPP5C
protein phosphatase 5, catalytic subunit
chr22_-_50964849 0.063 ENST00000543927.1
ENST00000423348.1
 SCO2

SCO2 cytochrome c oxidase assembly protein

chr11_+_68671310 0.062 ENST00000255078.3
ENST00000539224.1
 IGHMBP2

immunoglobulin mu binding protein 2

chr8_-_12051576 0.060 ENST00000524571.2
ENST00000533852.2
ENST00000533513.1
ENST00000448228.2
ENST00000534520.1
ENST00000321602.8
 FAM86B1





family with sequence similarity 86, member B1





chr19_-_48673552 0.060 ENST00000536218.1
ENST00000596549.1
 LIG1

ligase I, DNA, ATP-dependent

chr8_+_11627205 0.059 ENST00000455213.2
ENST00000403422.3
ENST00000528323.1
ENST00000284503.6
 NEIL2



nei endonuclease VIII-like 2 (E. coli)



chr5_-_137090028 0.056 ENST00000314940.4
 HNRNPA0
heterogeneous nuclear ribonucleoprotein A0
chr22_-_31742218 0.056 ENST00000266269.5
ENST00000405309.3
ENST00000351933.4
 PATZ1


POZ (BTB) and AT hook containing zinc finger 1


chr9_-_116061476 0.054 ENST00000441031.3
 RNF183
ring finger protein 183
chr3_+_120626919 0.048 ENST00000273666.6
ENST00000471454.1
ENST00000472879.1
ENST00000497029.1
ENST00000492541.1
 STXBP5L




syntaxin binding protein 5-like




chr1_-_53018654 0.048 ENST00000257177.4
ENST00000355809.4
ENST00000528642.1
ENST00000470626.1
ENST00000371544.3
 ZCCHC11




zinc finger, CCHC domain containing 11




chr20_-_18447667 0.047 ENST00000262547.5
ENST00000329494.5
ENST00000357236.4
 DZANK1


double zinc ribbon and ankyrin repeat domains 1


chr18_+_3451646 0.046 ENST00000345133.5
ENST00000330513.5
ENST00000549546.1
 TGIF1


TGFB-induced factor homeobox 1


chr19_-_56092187 0.045 ENST00000325421.4
ENST00000592239.1
 ZNF579

zinc finger protein 579

chr1_-_160254913 0.043 ENST00000608310.1
ENST00000440949.3
ENST00000368072.5
ENST00000556710.1
 DCAF8
PEX19

DCAF8
DDB1 and CUL4 associated factor 8
peroxisomal biogenesis factor 19

DDB1- and CUL4-associated factor 8
chr2_+_219824357 0.036 ENST00000302625.4
 CDK5R2
cyclin-dependent kinase 5, regulatory subunit 2 (p39)
chr17_+_46018872 0.036 ENST00000583599.1
ENST00000434554.2
ENST00000225573.4
ENST00000544840.1
ENST00000534893.1
 PNPO




pyridoxamine 5'-phosphate oxidase




chr1_+_1950763 0.033 ENST00000378585.4
 GABRD
gamma-aminobutyric acid (GABA) A receptor, delta
chr1_-_157108130 0.032 ENST00000368192.4
 ETV3
ets variant 3
chr16_+_30006615 0.029 ENST00000563197.1
 INO80E
INO80 complex subunit E
chr12_+_132312931 0.029 ENST00000360564.1
ENST00000545671.1
ENST00000545790.1
 MMP17


matrix metallopeptidase 17 (membrane-inserted)


chrX_+_118370211 0.029 ENST00000217971.7
 PGRMC1
progesterone receptor membrane component 1
chr3_-_160167540 0.025 ENST00000496222.1
ENST00000471396.1
ENST00000471155.1
ENST00000309784.4
 TRIM59



tripartite motif containing 59



chr11_+_68451943 0.025 ENST00000265643.3
 GAL
galanin/GMAP prepropeptide
chr13_-_20767037 0.025 ENST00000382848.4
 GJB2
gap junction protein, beta 2, 26kDa
chrX_+_118370288 0.024 ENST00000535419.1
 PGRMC1
progesterone receptor membrane component 1
chr9_-_139658965 0.024 ENST00000316144.5
 LCN15
lipocalin 15
chr17_+_7792101 0.020 ENST00000358181.4
ENST00000330494.7
 CHD3

chromodomain helicase DNA binding protein 3

chr2_-_211168332 0.020 ENST00000341685.4
 MYL1
myosin, light chain 1, alkali; skeletal, fast
chr22_+_50628999 0.015 ENST00000395827.1
 TRABD
TraB domain containing
chr17_+_5389605 0.014 ENST00000576988.1
ENST00000576570.1
ENST00000573759.1
 MIS12


MIS12 kinetochore complex component


chr10_+_71389983 0.014 ENST00000373279.4
 C10orf35
chromosome 10 open reading frame 35
chr12_-_57400227 0.012 ENST00000300101.2
 ZBTB39
zinc finger and BTB domain containing 39
chr19_+_11909329 0.010 ENST00000323169.5
ENST00000450087.1
 ZNF491

zinc finger protein 491

chr1_+_22964073 0.009 ENST00000402322.1
 C1QA
complement component 1, q subcomponent, A chain
chr2_+_220379052 0.008 ENST00000347842.3
ENST00000358078.4
 ASIC4

acid-sensing (proton-gated) ion channel family member 4

chr20_-_62103862 0.008 ENST00000344462.4
ENST00000357249.2
ENST00000359125.2
ENST00000360480.3
ENST00000370224.1
ENST00000344425.5
ENST00000354587.3
ENST00000359689.1
 KCNQ2







potassium voltage-gated channel, KQT-like subfamily, member 2







chr1_-_42800860 0.008 ENST00000445886.1
ENST00000361346.1
ENST00000361776.1
 FOXJ3


forkhead box J3


chr11_+_57308979 0.007 ENST00000457912.1
 SMTNL1
smoothelin-like 1
chr15_+_91478493 0.007 ENST00000418476.2
 UNC45A
unc-45 homolog A (C. elegans)
chr15_-_43882353 0.006 ENST00000453080.1
ENST00000360301.4
ENST00000360135.4
ENST00000417085.1
ENST00000431962.1
ENST00000334933.4
ENST00000381879.4
ENST00000420765.1
 PPIP5K1







diphosphoinositol pentakisphosphate kinase 1







chr17_-_73179046 0.006 ENST00000314523.7
ENST00000420826.2
 SUMO2

small ubiquitin-like modifier 2

chr22_+_18834324 0.005 ENST00000342005.4
 AC008132.13
Uncharacterized protein
chr1_-_42801540 0.005 ENST00000372573.1
 FOXJ3
forkhead box J3
chr4_+_164265035 0.003 ENST00000338566.3
 NPY5R
neuropeptide Y receptor Y5
chr1_+_110527308 0.003 ENST00000369799.5
 AHCYL1
adenosylhomocysteinase-like 1
chr17_-_73178599 0.003 ENST00000578238.1
 SUMO2
small ubiquitin-like modifier 2
chr2_-_241737128 0.002 ENST00000404283.3
 KIF1A
kinesin family member 1A
chr14_+_22931924 0.000 ENST00000390477.2
 TRDC
T cell receptor delta constant

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0034970 histone H3-R2 methylation(GO:0034970)
0.0 0.2 GO:0015862 uridine transport(GO:0015862)
0.0 0.2 GO:0009450 acetate metabolic process(GO:0006083) glutamate decarboxylation to succinate(GO:0006540) gamma-aminobutyric acid catabolic process(GO:0009450)
0.0 0.1 GO:0007181 transforming growth factor beta receptor complex assembly(GO:0007181)
0.0 0.1 GO:0002351 serotonin production involved in inflammatory response(GO:0002351) serotonin secretion involved in inflammatory response(GO:0002442) serotonin secretion by platelet(GO:0002554)
0.0 0.1 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.0 0.2 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)
0.0 0.2 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.0 0.2 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383)
0.0 0.0 GO:0021718 superior olivary nucleus development(GO:0021718) superior olivary nucleus maturation(GO:0021722)
0.0 0.1 GO:0033567 DNA replication, Okazaki fragment processing(GO:0033567)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.0 0.1 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.0 0.2 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.0 0.1 GO:1990635 proximal dendrite(GO:1990635)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0035241 protein-arginine omega-N monomethyltransferase activity(GO:0035241)
0.0 0.2 GO:1904929 coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway(GO:1904929)
0.0 0.2 GO:0000150 recombinase activity(GO:0000150)
0.0 0.1 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.0 0.0 GO:0016534 cyclin-dependent protein kinase 5 activator activity(GO:0016534)
0.0 0.0 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.0 0.1 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)